Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Medicine, General & Internal
Nadia Aspromonte, Luigi Cappannoli, Pietro Scicchitano, Francesco Massari, Ivan Pantano, Massimo Massetti, Filippo Crea, Roberto Valle
Summary: The study found that low pre-discharge BNP levels were associated with low rates of cardiovascular events in HF patients, independently of the frequency of follow-up. Additionally, age, creatinine, and BNP were identified as independent predictors of events in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Pang-Yen Liu, Chin Lin, Chin-Sheng Lin, Wen-Hui Fang, Chia-Cheng Lee, Chih-Hung Wang, Dung-Jang Tsai
Summary: The study aimed to develop an AI-ECG system to predict BNP/pBNP values in patients with cardiovascular diseases (CVDs) and compare their values for future mortality. The results showed that the AI-ECG accurately predicted BNP/pBNP values, and pBNP was a better predictor of future mortality.
Article
Cardiac & Cardiovascular Systems
Jiebin Hou, Xin Zhang, Zhen Wu, Yang Liu, Yabin Zhang, Jiahui Zhao, Xiaohua Wang, Hongyu Chen, Guang Yang, Qiang Ma, Qingli Cheng, Qiangguo Ao
Summary: Elderly patients with chronic heart failure (CHF) have a higher incidence of acute kidney injury (AKI), which can lead to poor prognosis. The relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP) in elderly CHF patients has been analyzed in a retrospective cohort study. The results suggest that a decreased change in NT-proBNP during AKI can reduce the risk of more severe AKI and improve survival outcomes. However, an excessive decrease in NT-proBNP is a risk factor for non-recovery of renal function following AKI, especially in elderly survivors with low baseline NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Javed Butler, Faiez Zannad, Gerasimos Filippatos, Joao Pedro Ferreira, Stuart J. Pocock, Naveed Sattar, Subodh Verma, Ola Vedin, Tomoko Iwata, Martina Brueckmann, Milton Packer, Stefan D. Anker
Summary: In this study, the associations between NT-proBNP and hscTnT biomarkers and clinical outcomes in heart failure patients were evaluated. Higher baseline NT-proBNP and hs-cTnT concentrations were associated with more comorbidities and worse heart failure severity. Empagliflozin treatment consistently reduced the risk for cardiovascular events and reduced the decline of eGFR across different levels of NT-proBNP and hs-cTnT. Furthermore, empagliflozin modestly lowered NT-proBNP levels.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Yu Deng, Si-Jing Cheng, Wei Hua, Min-Si Cai, Ni-Xiao Zhang, Hong-Xia Niu, Xu-Hua Chen, Min Gu, Chi Cai, Xi Liu, Hao Huang, Shu Zhang
Summary: This study investigated the association between NT-proBNP and outcomes in heart failure patients with implantable cardioverter-defibrillator (ICD), finding that elevated NT-proBNP levels were associated with increased mortality, but not with the occurrence of first appropriate shock due to sustained ventricular tachycardia/ventricular fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hsin-Chia Lin, Shu-Chien Huang, Mei-Hwan Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-An Chen, Chun-Wei Lu, Yih-Sharng Chen, Shuenn-Nan Chiu
Summary: The role of preoperative N-terminal pro-brain natriuretic peptide level in patient outcomes after the Fontan operation was investigated in this study. The results showed that high preoperative N-terminal pro-brain natriuretic peptide was associated with poor outcomes after the operation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Pamela Nogueira Cavalcante, Gabriel Kanhouche, Vitor Emer Egypto Rosa, Carlos M. Campos, Mariana Pezzute Lopes, Maria Antonieta Albanez A. de M. Lopes, Roney Orismar Sampaio, Fabio Sandoli de Brito Jr, Flavio Tarasoutchi, Alexandre Antonio Cunha Abizaid
Summary: B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers released in response to increased ventricular and atrial wall stress. Studies have shown that elevated levels of these biomarkers are correlated with the severity of aortic stenosis (AS) and can predict the need for intervention. They play a crucial role in risk stratification and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Karola S. Jering, Brian L. Claggett, Marc A. Pfeffer, Christopher B. Granger, Lars Kober, Eldrin F. Lewis, Aldo P. Maggioni, Douglas L. Mann, John J. V. McMurray, Margaret F. Prescott, Jean L. Rouleau, Scott D. Solomon, Phillippe Gabriel Steg, Dirk von Lewinski, Eugene Braunwald
Summary: NT-proBNP is an important prognostic factor in patients with acute myocardial infarction and certain risk factors. It is associated with heart failure, death, and atherosclerotic events, and this predictive information is independent of hs-cTnT.
CIRCULATION-HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Silvia Spoto, Josepmaria Argemi, Roberta Di Costanzo, Juan Jose Gavira Gomez, Nahikari Salterain Gonzales, Stefania Basili, Roberto Cangemi, Antonio Abbate, Luciana Locorriere, Francesco Masini, Giulia Testorio, Rodolfo Calarco, Giulia Battifoglia, Fabio Mangiacapra, Marta Fogolari, Sebastiano Costantino, Silvia Angeletti
Summary: Acute heart failure (AHF) is a major cause of hospitalization and mortality worldwide. This study compared the levels of NT-proBNP, MR-proADM, and CRP between patients with AHF and those without AHF and sepsis, and assessed the diagnostic and prognostic value of a multimarker approach in AHF patients. The results showed that MR-proADM and NT-proBNP levels were significantly higher in AHF patients compared to controls, and the combined use of these biomarkers provided predictive value for mortality and re-admission for AHF.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Kaizu Xu, Meifang Wu, Meinv Huang, Xiuping Zhuo, Yujuan Weng, Xi Chen
Summary: This study evaluated the efficacy of CA125 combined with NT-proBNP in predicting AHF following STEMI. The results showed that elevated CA125 and NT-proBNP are independent predictors of AHF in STEMI patients, and their combination can improve the recognition efficiency of AHF.
Article
Peripheral Vascular Disease
Charles D. Nicoli, Timothy B. Plante, D. Leann Long, Suzanne E. Judd, Leslie A. McClure, Pankaj Arora, Mary Cushman
Summary: The REGARDS study found that NT-proBNP was not associated with incident hypertension, with consistent results across different demographic groups.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Chemistry, Analytical
Han-Long Liu, Yen-Ta Tseng, Mei-Chu Lai, Lai-Kwan Chau
Summary: In this study, a fiber optic nanogold-linked immunosorbent assay (FONLISA) method was developed for the rapid, sensitive, and low-cost detection of the important blood biomarker for heart failure, N-terminal pro-brain natriuretic peptide (NT-proBNP). The method utilizes a sandwich immunoassay approach and detects the analyte through changes in light intensity caused by AuNPs on the fiber core surface. The method exhibits a wide dynamic range and a low limit of detection, and shows good correlation with a commercial laboratory-based method. This method has the potential to be used as a point-of-care testing tool.
Review
Medicine, General & Internal
Edoardo Sciatti, Anna Merlo, Claudio Scangiuzzi, Raul Limonta, Mauro Gori, Emilia D'Elia, Alberto Aimo, Giuseppe Vergaro, Michele Emdin, Michele Senni
Summary: In recent years, there has been a growing interest in using multiple biomarkers, such as soluble suppression of tumorigenicity-2 (sST2), to stratify the risk and identify pathophysiological processes associated with heart failure. sST2 is produced in response to myocardial stress and is associated with both cardiac and immune cells. This article aims to review the prognostic value of sST2 in chronic and acute heart failure and provides a flowchart for its potential use in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Satomi Ishihara, Shinya Hiramitsu, Koshiro Kanaoka, Mizuri Taki, Hitoshi Nakagawa, Tomoya Ueda, Ayako Seno, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Tomohito Ohtani, Makoto Watanabe, Rika Kawakami, Yasushi Sakata, Kazuomi Kario, Yoshihiko Saito
Summary: This study developed a simple conversion formula between BNP and NT-proBNP, potentially useful in clinical practice, and validated its effectiveness.
CIRCULATION JOURNAL
(2022)
Article
Physiology
Mara Paneroni, Simonetta Scalvini, Ugo Corra, Marta Lovagnini, Roberto Maestri, Antonio Mazza, Rosa Raimondo, Piergiuseppe Agostoni, Maria Teresa La Rovere
Summary: Short-term comprehensive cardiac rehabilitation can improve the performance of routine activities of daily living in elderly chronic heart failure patients, but does not change the oxygen uptake of these activities. There is also a decrease in the demand for peak heart rate and ventilation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Marco Merlo, Piero Gentile, Aldostefano Porcari, Anna Palmisano, Davide Vignale, Paola Sormani, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Paolo Della Bella, Simone Sala, Enrico Ammirati, Gianfranco Sinagra, Antonio Esposito, Patrizia Pedrotti
Summary: This study evaluated the diagnostic sensitivity of cardiac magnetic resonance imaging based on Lake Louise criteria in patients with acute myocarditis. The results showed that using updated Lake Louise criteria increased the sensitivity of the diagnosis. It was also found that septal abnormalities were more common in patients with complicated acute myocarditis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Federica Toto, Elisabetta Salvioni, Damiano Magri, Susanna Sciomer, Massimo Piepoli, Roberto Badagliacca, Arianna Galotta, Nikita Baracchini, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Pasquale Perrone Filardi, Annamaria Iorio, Michele Senni, Michele Correale, Mariantonietta Cicoira, Enrico Perna, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Francesco Bandera, Maurizio Bussotti, Massimo Mapelli, Manlio Cipriani, Alice Bonomi, Goncalo Cunha, Federica Re, Carlo Vignati, Andrea Garascia, Carlo Lombardi, Angela B. Scardovi, Andrea Passantino, Michele Emdin, Claudio Passino, Caterina Santolamazza, Davide Girola, Denise Zaffalon, Dario Vizza, Fabiana De Martino, Piergiuseppe Agostoni
Summary: This study aimed to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF patients and found that it does not influence patients' outcome.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto F. E. Pedretti, Dominique Hansen, Marco Ambrosetti, Maria Back, Thomas Berger, Mariana Cordeiro Ferreira, Veronique Cornelissen, Constantinos H. Davos, Wolfram Doehner, Carmen de Pablo Y. Zarzosa, Ines Frederix, Andrea Greco, Donata Kurpas, Matthias Michal, Elena Osto, Susanne Pedersen, Rita Esmeralda Salvador, Maria Simonenko, Patrizia Steca, David R. Thompson, Matthias Wilhelm, Ana Abreu
Summary: Optimal patient adherence to treatment is crucial for successful secondary prevention of cardiovascular disease (CVD). However, unsatisfactory adherence rates have been consistently observed for CVD risk factors and treatment. This consensus document provides a modern reappraisal of adherence to optimal treatment and offers simple, practical, and feasible suggestions to achieve this goal in the clinical setting, focusing on evidence-based concepts.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Piero Gentile, Matteo Palazzini, Andrea Tedeschi, Enrico Ammirati, Enrico Perna, Alessandro Verde, Luciana D'angelo, Gabriella Masciocco, Andrea Garascia
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marisa Varrenti, Enrico Ammirati, Paola Sormani, Claudio Moro, Saverio D'elia, Paolo Bernasconi, Claudia Raineri, Giuseppina Quattrocchi, Angela Milazzo, Alberto Maestroni, Maria Grazia Valsecchi, Andrea Garascia, Fabrizio Oliva, Cristina Giannattasio, Paolo G. Camici, Patrizia Pedrotti
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Giada Colombo, Davide Marchetti, Piero Gentile, Luciana D'angelo, Gabriella Masciocco, Francesca Macera, Lucia Occhi, Francesco Musca, Enrico Perna, Antonella Moreo, Fabrizio Oliva, Andrea Garascia, Marco Metra, Enrico Ammirati
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Matteo Palazzini, Enrico Ammirati, Laura Lupi, Andrea Garascia, Piero Gentile, Patrizia Pedrotti, Cristina Giannattasio, Michele Ciabatti, Valentina Rossi, Frank Ruschitzka, Aitor Uribarri, Chiara Vecchio, Daniele Nassiacos, Alberto Cereda, Gabriele Tumminiello, Nicolas Piriou, Miriam Stucchi, Giovanni Peretto, Michele Galasso, Simone Sala, Paolo Camici, Florent Huang, Umberto Ianni, Antonio Procopio, Gianluigi Saponara, Paolo Cimaglia, Daniela Tomasoni, Francesco Moroni, Annalisa Turco, Giuseppe Di Tano, Entela Bollano, Claudio Moro, Antonio Abbate, Roberta Dalla Bona, Italo Porto, Stefano Carugo, Jeness Campodonico, Gianluca Pontone, Aurelia Grosu, Marianna Adamo, Jorge Salamanca, Krzysztof Ozieransky, Loren Sardo Infirri, Antonio Cannata, Eric Adler, Gianfranco Sinagra, Marco Metra, Maurizio Pieroni
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Review
Medicine, General & Internal
Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W. Kuss, Ana Tzvetkova, Wolfram C. Poller, Carsten Skurk, Arash Haghikia
Summary: In the field of clinical immunology, the outbreak of COVID-19 has driven studies on the role of inflammation in cardiovascular diseases. Advanced molecular genetic methods have been used to explore the diagnostic significance of these diseases and to identify immunological interactions at organ and system levels. Additionally, research has shown the influence of emotional stress on viral and cardiovascular disorders through brain-immune system interactions. However, there are challenges that need to be addressed before these findings can be fully applied in the clinical arena.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Enrico Ammirati, Christophe Vandenbriele, Angelo Nascimbene
CIRCULATION-HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Enrico Ammirati, Laura Lupi, Matteo Palazzini, Michele Ciabatti, Valentina A. Rossi, Piero Gentile, Aitor Uribarri, Chiara R. Vecchio, Daniele Nassiacos, Alberto Cereda, Cristina Conca, Gabriele Tumminello, Nicolas Piriou, Coline Lelarge, Patrizia Pedrotti, Miriam Stucchi, Giovanni Peretto, Michele Galasso, Florent Huang, Umberto Ianni, Antonio Procopio, Gianluigi Saponara, Paolo Cimaglia, Daniela Tomasoni, Francesco Moroni, Annalisa Turco, Simone Sala, Giuseppe Di Tano, Entela Bollano, Claudio Moro, Antonio Abbate, Roberta Della Bona, Italo Porto, Stefano Carugo, Jeness Campodonico, Gianluca Pontone, Aurelia Grosu, Leonardo Bolognese, Jorge Salamanca, Pablo Diez-Villanueva, Krzysztof Ozieranski, Agata Tyminska, Loren Sardo Infirri, Daniel Bromage, Antonio Cannata, Kimberly N. Hong, Marianna Adamo, Giuseppina Quattrocchi, Alberto Foa, Luciano Potena, Andrea Garascia, Cristina Giannattasio, Eric D. Adler, Gianfranco Sinagra, Frank Ruschitzka, Paolo G. Camici, Marco Metra, Maurizio Pieroni
CIRCULATION-HEART FAILURE
(2023)
Letter
Medicine, General & Internal
Edoardo Conte, Olivia Leoni, Enrico Ammirati, Massimo Imazio, Antonio Brucato
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea Tedeschi, Massimiliano Camilli, Enrico Ammirati, Piero Gentile, Matteo Palazzini, Nicolina Conti, Alessandro Verde, Gabriella Masciocco, Grazia Foti, Cristina Giannattasio, Andrea Garascia
Summary: Although immune checkpoint inhibitors have greatly improved cancer therapy, they can lead to immune-related adverse events, with myocarditis being the most severe complication. Clinical suspicion arises from symptoms and increases in cardiac biomarkers or electrocardiographic manifestations. While echocardiography and cardiac magnetic resonance imaging are recommended, endomyocardial biopsy remains the gold standard for diagnosis. Treatment currently relies on glucocorticoids, but interest in other immunosuppressive agents is growing. Some case reports suggest the safety of rechallenging low-grade myocarditis, highlighting the need for further studies in this area.
Article
Cardiac & Cardiovascular Systems
Piergiuseppe Agostoni, Francesca Romana Pluchinotta, Elisabetta Salvioni, Massimo Mapelli, Arianna Galotta, Alice Bonomi, Damiano Magri, Enrico Perna, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Roberto Badagliacca, Pasquale Perrone Filardi, Anna Apostolo, Michele Senni, Annamaria Iorio, Michele Correale, Jeness Campodonico, Pietro Palermo, Mariantonietta Cicoira, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Mauro Contini, Beatrice Pezzuto, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Cosimo Carriere, Marco Cittar, Maria Vittoria Matassini, Andrea Salzano, Antonio Cittadini, Marco Mase, Francesco Bandera, Maurizio Bussotti, Irene Mattavelli, Federica Re, Carlo Vignati, Carlo Lombardi, Angela B. Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Andrea Di Lenarda, Claudio Passino, Caterina Santolamazza, Federica Moscucci, Denise Zaffalon, Massimo Piepoli, MECKI Score Res Grp
Summary: The study found that heart failure patients with improved ejection fraction have distinct clinical characteristics, biology, and prognosis compared to patients with persistently reduced ejection fraction. Despite having milder symptoms, HFimpEF patients still face risks of adverse outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Critical Care Medicine
Enrico Ammirati, Esther Vorovich, Alain Combes
INTENSIVE CARE MEDICINE
(2023)