Review
Cardiac & Cardiovascular Systems
Longmei Yan, Yuzhen Ai, Yaxuan Xing, Biqing Wang, Anran Gao, Qiwu Xu, Hongzheng Li, Keji Chen, Jingchun Zhang
Summary: This study aims to evaluate the efficacy and safety of citalopram in the treatment of elderly chronic HF combined with depression. The meta-analysis results show that citalopram treatment has benefits for HAMD-24 and LVEF, with a decrease in GDS score and improvement in NT-proBNP. However, there is no significant effect on HAMD-17, MADRS, and LVEDD compared to the control group. No obvious adverse drug reactions were observed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Yuwu Shi, Yiwen Wang, Junhong Chen, Chi Lu, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu
Summary: The study found that the angiotensin receptor neprilysin inhibitor (ARNI) had no significant adverse effects on renal function in patients with heart failure (HF), and it could reduce the risk of worsening renal function and hyperkalemia.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Taihei Suzuki, Hiroki Nishiwaki, Yoshitaka Watanabe, Yoshifusa Abe, Hisashi Noma, Erika Ota, Hirokazu Honda, Takeshi Hasegawa
Summary: This study aims to evaluate the effects of discontinuing renin-angiotensin system (RAS) inhibitor medication on the clinical outcomes of patients. It will include a systematic review and analysis of relevant randomized controlled trials to assess the impact of discontinuing RAS inhibitors on primary outcomes such as death, cardiovascular disease, and blood pressure.
Review
Biochemistry & Molecular Biology
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Summary: Despite recent advances in HF therapy, CV mortality, morbidity, and HFH remain challenges. Vericiguat activates sGC to improve CV function and has shown efficacy in reducing CV death and HFH in HFrEF patients. However, it has no therapeutic effect on HFpEF. Common adverse events of vericiguat include hypotension, syncope, and anemia. Larger studies are needed to investigate the potential effect in HFpEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Julian Hoevelmann, Elani Muller, Ameer Hohlfeld, Michael Bohm, Karen Sliwa, Mark E. Engel, Charle Andre Viljoen
Summary: Peripartum cardiomyopathy (PPCM) is a significant cause of maternal morbidity and mortality worldwide, with complications including heart failure, thromboembolic events, arrhythmias, and death. This study aims to systematically review and meta-analyze data on the complications and outcomes of women with PPCM from 2000 to June 2021.
Review
Medical Laboratory Technology
Jorge Diaz-Garzon, Pilar Fernandez-Calle, Sverre Sandberg, Mustafa Ozcurumez, William A. Bartlett, Abdurrahman Coskun, Anna Carobene, Carmen Perich, Margarita Simon, Fernando Marques, Beatriz Boned, Elisabet Gonzalez-Lao, Federica Braga, Aasne K. Aarsand
Summary: This study provides robust estimates for cardiac-specific troponin I and troponin T applicable for different sampling intervals and states of health. Long-term CVI estimates were higher than short-term estimates, and estimates from diseased subjects were similar to those from healthy individuals in all settings.
CLINICAL CHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Jan Gaertner, Tanja Fusi-Schmidhauser, Stephanie Stock, Waldemar Siemens, Vera Vennedey
Summary: For the treatment of breathlessness in heart failure, opioids are commonly recommended but lack strong evidence. This systematic review of randomized controlled trials suggests that opioids have limited efficacy and may cause adverse effects. Therefore, opioids should be considered as a last resort and only used when other treatments have failed or in emergencies.
Article
Cardiac & Cardiovascular Systems
Cara Jordan, Sarah J. Charman, Alan Mark Batterham, Darren Flynn, David Houghton, Linda Errington, Guy MacGowan, Leah Avery
Summary: This study conducted a systematic review and meta-analysis to evaluate the habitual physical activity levels of patients with heart failure (HF) and the quality of reporting of device-assessed physical activity. The results showed that patients with HF have low levels of physical activity, which has implications for targeting physical activity interventions in this population.
Review
Cardiac & Cardiovascular Systems
Adolfo Martinez Salazar, Khalid Saeed Al-Asad, Rohan M. Prasad, Gabriel Panama, Sandeep Banga, Matthew Wilcox
Summary: Pulmonary hypertension (PH) is a progressive disease with a high morbidity and mortality. The treatment is based on the type of PH. Pulmonary artery denervation (PADN) has been studied as a novel therapeutic option in these patients.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sophia Emmons-Bell, Catherine Johnson, Gregory Roth
Summary: Studies on the epidemiology of heart failure in the general population provide valuable information for disease burden assessments, research, public health policies, and healthcare delivery. This systematic review analyzed population-based studies published between 1990 and 2020 to determine the prevalence, incidence, and survival rates of heart failure. The results showed substantial variations in heart failure prevalence, incidence, and survival across different countries and studies. The study concluded that heart failure remains a prevalent disease among older adults with a high risk of death within one year.
Review
Cardiac & Cardiovascular Systems
Marianne Lucena da Silva, Nathalia Lima Costa, Raquel Henriques Jacomo, Aline Teixeira Alves, Renata Amanajas de Melo, Katiane da Costa Cunha
Summary: This study analyzed the sexual activity of patients with heart failure and found that these patients experience alterations in their sexual activities, especially males who are more prone to develop erectile dysfunction.
Review
Medicine, General & Internal
Aniello Maiese, Paola Frati, Fabio Del Duca, Paola Santoro, Alice Chiara Manetti, Raffaele La Russa, Marco Di Paolo, Emanuela Turillazzi, Vittorio Fineschi
Summary: This systematic review analyzed the potential impacts of COVID-19 on the heart, revealing that SARS-CoV-2 can cause irreversible changes in the heart, increasing cardiac risks in surviving patients. Postmortem analysis is an essential tool to understand the pathological changes caused by COVID-19.
Review
Biochemistry & Molecular Biology
Noppachai Siranart, Khamik Laohasurayotin, Tanattida Phanthong, Walit Sowalertrat, Aekarach Ariyachaipanich, Ronpichai Chokesuwattanaskul
Summary: In recent years, the use of biomarkers in diagnosing heart failure patients has significantly increased. Natriuretic peptides are currently the most commonly used biomarker for diagnosing and predicting outcomes in heart failure patients. Proenkephalin (PENK) activates delta-opioid receptors in cardiac tissue, leading to decreased myocardial contractility and heart rate. However, this meta-analysis aims to assess the association between PENK levels at admission and the prognosis of heart failure patients, including all-cause mortality, rehospitalization, and declining renal function. High PENK levels have been found to be linked to a worsened prognosis in heart failure patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jinyu Liu, Dong Liu, Xuepeng Gong, Anhua Wei, Ruxu You
Summary: This study aims to evaluate the cost-effectiveness of empagliflozin in treating heart failure. The findings suggest that add-on empagliflozin is cost-effective for patients with HFrEF in several countries, including China, Japan, Korea, Singapore, Thailand, and Australia. However, for patients with HFpEF, add-on empagliflozin is cost-effective in China and Australia, but not in the United States and Thailand.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Shutang Zhao, Xiren Wang
Summary: This study systematically reviewed the relationship between enteral nutrition and serum inflammatory factors and cardiac function in elderly patients with heart failure (HF), aiming to provide new medical evidence for clinical treatment. The findings are expected to offer compelling evidence and improved guidance in clinic settings for the application of enteral nutrition in elderly patients with HF.
