Article
Respiratory System
Jason Weatherald, Brianne Philipenko, David Montani, Pierantonio Laveneziana
Summary: CPET is a common tool for differential diagnosis of dyspnoea, with ventilatory inefficiency being a hallmark characteristic of pulmonary vascular diseases. Understanding the mechanisms and diagnostic implications of ventilatory inefficiency is crucial in managing patients with these conditions.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Multidisciplinary Sciences
Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans
Summary: This study shows that deficiency of AMPK-alpha 1/alpha 2 in smooth muscles can cause persistent pulmonary hypertension in newborns. The findings provide important insights into the mechanism of pulmonary hypertension.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov
Summary: Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure and vascular remodeling. Circulating osteopontin has been suggested as a biomarker of PH progression and right ventricular dysfunction. Preclinical studies have shown that osteopontin plays a role in PH pathogenesis by modulating various cellular processes. This article provides an overview of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as the potential of targeting osteopontin for PH management.
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Agriculture, Dairy & Animal Science
S. Bahadoran, H. Hassanpour, S. Arab, S. Abbasnia, A. Kiani
Summary: Cold stress can cause PHS in broiler chickens, potentially by increasing metabolic activity through thyroid hormones (T3 and T4). The study found that plasma T3 concentration was significantly higher in the PHS group at 21 days, along with higher gene expression of certain proteins in the right ventricle tissues compared to controls. Furthermore, at 35 days, only THR beta gene expression was higher in the PHS group.
Article
Respiratory System
Laura K. Gell, Daniel Vena, Raichel M. Alex, Ali Azarbarzin, Nicole Calianese, Lauren B. Hess, Luigi Taranto-Montemurro, David P. White, Andrew Wellman, Scott A. Sands
Summary: Contrary to the prevailing view, this study found that patients with obstructive sleep apnoea predominantly exhibit drive-dependent event pathophysiology, as opposed to the classic model of decreased respiratory muscle tone. Lower drive is associated with lower flow, decreased genioglossus muscle activity, and increased event risk. Therefore, preventing the decline of ventilatory drive is considered an important target for intervention in obstructive sleep apnoea.
Review
Cardiac & Cardiovascular Systems
Miranda K. Culley, Stephen Y. Chan
Summary: This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. It proposes that endothelial senescence may serve as a unifying mechanism for pulmonary hypertension and highlights the link between aging and this disease. Additionally, it presents potential opportunities and barriers for targeting senescence in the diagnosis and treatment of pulmonary hypertension.
CIRCULATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Sunil Sharma, Robert Stansbury, Benjamin Hackett, Henrik Fox
Summary: Obstructive sleep apnea (OSA) and pulmonary hypertension (PH) are known to be associated, with limited understanding of the relationship which appears to be bidirectional. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. Further research on the mechanisms of this relationship is important.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Environmental Sciences
Rafael Moreno-Gomez-Toledano
Summary: Plastic waste pollution is a major environmental issue, and the substitute molecules like bisphenol F or S may pose similar health risks as bisphenol A, significantly impacting renal and cardiovascular diseases.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cardiac & Cardiovascular Systems
Vivek Jani, M. Imran Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory Milburn, Devin Nissen, Ilton M. Cubero M. Salazar, Olivia Hanselman, Monica Mukherjee, Marc K. Halushka, Kenneth B. Margulies, Kenneth S. Campbell, Thomas C. Irving, David A. Kass, Steven Hsu
Summary: Right ventricular contractile dysfunction commonly occurs in patients with heart failure with reduced ejection fraction and pulmonary hypertension. Standard clinical indices may not reflect aspects of underlying myocyte dysfunction. This study investigates the mechanical properties of RV myocytes in HFrEF-PH patients and identifies potential underlying mechanisms.
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew B. Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan, Yan Ru Su, Thomas Blackwell, Deepak K. Gupta, Megha H. Talati, Santhi Gladson, Erica J. Carrier, James D. West, Anna R. Hemnes
Summary: This study investigates whether a well-accepted murine model of HFpEF displays features of PH, and identifies potential pathways driving early remodeling of the pulmonary vasculature in HFpEF.
CIRCULATION RESEARCH
(2023)
Review
Medicine, General & Internal
Marta Banaszkiewicz, Aleksandra Gasecka, Szymon Darocha, Michal Florczyk, Arkadiusz Pietrasik, Piotr Kedzierski, Michal Pilka, Adam Torbicki, Marcin Kurzyna
Summary: Pulmonary hypertension is a serious hemodynamic condition that can lead to right heart failure and death if not properly treated. The prognosis of pulmonary hypertension depends on various factors, and biomarkers provide information about disease severity, treatment response, and prognosis. However, due to the complexity of the condition, a single biomarker is not sufficient for evaluating different types of pulmonary hypertension patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Javier Bermejo, Ana Gonzalez-Mansilla, Teresa Mombiela, Ana I. Fernandez, Pablo Martinez-Legazpi, Raquel Yotti, Rocio Garcia-Orta, Pedro L. Sanchez-Fernandez, Mario Castano, Javier Segovia-Cubero, Pilar Escribano-Subias, J. Alberto San Roman, Xavier Borras, Angel Alonso-Gomez, Javier Botas, Maria G. Crespo-Leiro, Sonia Velasco, Antoni Bayes-Genis, Amador Lopez, Roberto Munoz-Aguilera, Manuel Jimenez-Navarro, Jose R. Gonzalez-Juanatey, Arturo Evangelista, Jaime Elizaga, Javier Martin-Moreiras, Jose M. Gonzalez-Santos, Eduardo Moreno-Escobar, Francisco Fernandez-Aviles
Summary: The study reveals that the presence of pulmonary hypertension following successful correction of valvular heart disease is associated with a higher mortality rate, which is related to factors such as pulmonary vascular resistance, diabetes mellitus, and residual effective valve area. These findings have significant implications for individualizing valve correction procedures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Jessica H. Huston, Sanjiv J. Shah
Summary: The development of pulmonary hypertension in patients with heart failure due to left heart disease is common and has adverse prognostic implications. However, there are currently no known specific treatments for this condition. Diagnostic criteria and clinical classification for pulmonary hypertension due to left heart disease are still evolving, posing challenges for researchers. The pathobiology of this condition is not well understood, but factors such as increased wall stress and endothelial dysfunction are believed to contribute to pulmonary vascular remodeling. Further investigation is needed to better understand the drivers of this condition and develop effective prevention and treatment strategies.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)