Article
Neurosciences
Vlad S. Kuzmin, Alexandra D. Ivanova, Viktoria M. Potekhina, Daria V. Samoilova, Konstantin S. Ushenin, Anastasia A. Shvetsova, Alexey M. Petrov
Summary: This study traced the postnatal changes in electrophysiology of pulmonary vein (PV) and superior vena cava (SVC) myocardium, revealing that they undergo opposite changes during postnatal development, resulting in increased proarrhythmicity in PV in adults.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Veterinary Sciences
Karin Kristrom, Erika Karlstam, Tove Nielsen, Anne Lagerqvist, Mark Dirven
Summary: This case report presents a 5-month-old Maine coon cat with congenital pulmonary vein stenosis resulting in severe left-sided congestive heart failure and post-capillary pulmonary hypertension without left atrial enlargement.
VETERINARY SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Chunle Wang, Xia Xie, Huanwei Zhuang, Zhonghua Huang, Chukwuemeka Daniel Iroegbu, Mi Tang, Chengming Fan, Jinfu Yang
Summary: Total anomalous pulmonary venous connection (TAPVC) is a rare and critical congenital heart disease characterized by the failure of the left and right pulmonary veins to drain into the left atrium. Surgical repair is recommended upon diagnosis, especially in cases with pulmonary venous drainage obstruction(s). However, some patients with TAPVC can survive to adulthood without surgical treatment. Here, we present a case of a 46-year-old female with TAPVC, where the four pulmonary veins drain into the innominate vein via the vertical vein. The patient underwent successful surgical correction and had an excellent postoperative recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pediatrics
Edward Y. Lee, Sara O. Vargas, Kathy J. Jenkins, Ryan Callahan, Halley J. Park, Zachary Gauthier, Abbey J. Winant
Summary: This study evaluated extravascular findings on thoracic MDCT angiography in children with secondary PVS due to TAPVC repair, finding characteristic abnormalities such as ground-glass opacity, septal thickening, pleural thickening, and a soft tissue mass in the distribution of affected pulmonary veins. Excellent interobserver agreement was observed in detecting these abnormalities.
Article
Cardiac & Cardiovascular Systems
Rong Liufu, Xiaobing Liu, Tao Liu, Jimei Chen, Shusheng Wen, Jianzheng Cen, Jian Zhuang
Summary: This study aimed to review surgical experiences in patients with infracardiac total anomalous pulmonary venous connection(TAPVC). Both sutureless and conventional repairs for patients with infracardiac TAPVC achieved favourable postoperative outcomes. There was no death in the sutureless repair group, and sutureless repair was associated with lower mortality and lower incidence of restenosis in pulmonary veins and anastomosis compared to conventional repair.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhihong Zhao, Yonggang Chen, Bin Wu, Gaodong Qiu, Liangjie Hong, Xinhua Chen, Xingwei Zhang
Summary: This study evaluated the safety and effectiveness of a pulsed electric field ablation system in isolating pulmonary veins and superior vena cava in a porcine model. The results showed that the system could achieve transmural tissue damage without causing stenosis or nerve dysfunction.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Medicine, General & Internal
V. Priyadharshini Bala, S. Deepak Barathi, Ramkumar Govindarajalou, M. Selvaganesan
Summary: Total anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiovascular malformation that can cause obstruction and present with symptoms such as cyanosis, tachycardia, or respiratory distress in neonates. Cardiac CT and MRI are valuable tools for delineating the anatomy and drainage pathway of anomalous pulmonary veins, while MDCT angiography can be a preferred imaging method due to its noninvasive nature and fast image acquisition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
V. S. Kuz'min, A. A. Kobylina, K. B. Pustovit, A. D. Ivanova, D. Abramochkin
Summary: Cardiac-specific microRNA miR-133a-3p modulates adrenergic signaling, leading to increased cAMP accumulation and enhanced intracellular beta-adrenergic signaling, which contributes to the occurrence of proarrhythmic ectopy.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Pierre Bredeloux, Come Pasqualin, Romain Bordy, Veronique Maupoil, Ian Findlay
Summary: This article summarizes the physiological phenomena underlying ectopic electrical activity in animal pulmonary veins and emphasizes the importance of activating multiple signaling pathways for the initiation of triggered or automatic activity. It also gathers information about the large-scale structure of cardiac muscle sleeves and discusses the contribution of cellular heterogeneity to the generation of arrythmogenic phenomena and the distinction between pulmonary vein and left atrial heart muscle.
Article
Cardiac & Cardiovascular Systems
Zhangwei Wang, Nan Ding, Hanlu Yi, Yaobin Zhu, Zhiqiang Li, Daole Yan, Xiaofeng Li, Song Bai
Summary: This study aimed to analyze the surgical outcomes of biventricular correction for TAPVC and identify the risk factors for postoperative mortality and PVO. The study found that prolonged CPB time was an independent risk factor for early postoperative mortality, while emergency surgery, preoperative PH, and prolonged CPB time were independent risk factors for postoperative PVO.
JOURNAL OF CARDIAC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Zhangwei Wang, Nan Ding, Hanlu Yi, Yaobin Zhu, Zhiqiang Li, Daole Yan, Xiaofeng Li, Song Bai
Summary: The sutureless technique was initially used for treating postoperative pulmonary vein obstruction (PVO) in TAPVC patients, but has now been widely used as the primary treatment for high-risk TAPVC children. Compared to traditional surgery, the sutureless technique significantly reduces the incidence of postoperative PVO and associated complications.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Rossillo, Gianluca Borio, Sabina Vittadello, Gian Luca Spadaro, Carlo Bonanno, Antonio Raviele, Francesco Caprioglio
Summary: This article describes the first case of using pulsed-field ablation (PFA) to treat focal atrial tachycardia (FAT) in a pediatric patient. PFA ablation, with its novel nonthermal energy source, reduces the risk of complications. The results demonstrate that PFA can effectively correct FAT, making it a good alternative to RFA ablation.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Ji Hyun Kim, Sora Kim, Taeyoung Yu, Woo Seok Yang, Seong Wook Hong
Summary: The prone position is commonly used in spinal surgery, but it can affect patients' hemodynamic circulation. In a case using a Jackson spine table, the patient developed arrhythmia during the prone position. Therefore, understanding the physiological changes and possible complications caused by the prone position is necessary for early diagnosis and management.
Article
Cardiac & Cardiovascular Systems
Tristram D. Bahnson, Anna Giczewska, Daniel B. Mark, Andrea M. Russo, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, Jeanne E. Poole, Kerry L. Lee, Douglas L. Packer
Summary: According to the CABANA trial, catheter ablation is most effective in younger patients, while no prognostic benefits were observed in the oldest patients. Catheter ablation is more effective than drug therapy in preventing atrial fibrillation recurrence, with few complications regardless of age.
Editorial Material
Cardiac & Cardiovascular Systems
Rajesh Venkataraman, Pranav Loyalka, Carlos Encarnacion, Hazim J. Safi, Faisal H. Cheema, Keshava Rajagopal
Summary: A 71-year-old woman with a history of atrial fibrillation underwent a catheter-based ablation procedure and later developed dyspnea and left-sided pleural effusion. Diagnostic evaluation revealed left-sided pulmonary venous occlusion, and she underwent left pneumonectomy with left atrial appendage occlusion. This is a novel report of occluded pulmonary venous drainage of an entire lung necessitating pneumonectomy.
ANNALS OF THORACIC SURGERY
(2023)
Review
Pediatrics
Jef Van den Eynde, Simone Bartelse, Friso M. Rijnberg, Shelby Kutty, Monique R. M. Jongbloed, Christiaan de Bruin, Mark G. Hazekamp, Saskia Le Cessie, Arno A. W. Roest
Summary: This study mapped the somatic growth patterns of single ventricle patients after Fontan palliation and summarized key modifiers that may improve growth. The findings provide guidance for optimizing somatic growth strategies and can serve as a benchmark for clinical follow-up.
Article
Cardiac & Cardiovascular Systems
Odilia Woudstra, Doris Skoric-Milosavljevic, Barbara J. M. Mulder, Folkert J. Meijboom, Marco C. Post, Monique R. M. Jongbloed, Arie P. J. van Dijk, Joost P. van Melle, Thelma C. Konings, Alex Postma, Connie R. Bezzina, Berto J. Bouma, Michael W. T. Tanck
Summary: Research suggests that common genetic variants may contribute to the heterogeneity in clinical course and improve risk stratification in patients with transposition of the great arteries after atrial switch operation. These findings support the hypothesis that incorporating genetic variants into risk assessment may be beneficial.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jef van den Eynde, Roel L. F. van der Palen, Ingmar Knobbe, Bart Straver, Lauran Stoger, Gabriella Ricciardi, Thelma C. Konings, Monique R. M. Jongbloed, Mark G. Hazekamp
Summary: This study retrospectively analyzed 14 rare cases of using the modified Yacoub aortocoronary flap technique in coronary transfer surgery, and found that it can serve as an effective bail-out option with excellent results among hospital survivors.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Justin Wallet, Yoshitaka Kimura, Nico A. Blom, Sumche Man, Monique R. M. Jongbloed, Katja Zeppenfeld
Summary: This study found that the presence of R'' wave in lead V1 and/or a negative terminal QRS portion (NTP) duration >= 80 ms in lead aVF on sinus rhythm electrocardiogram (ECG) can serve as indicators for detecting slow conducting anatomical isthmus (SCAI 3) in repaired tetralogy of Fallot (rTOF) patients and predicting their risk of ventricular tachycardia (VT).
Article
Cardiac & Cardiovascular Systems
Marieke Nederend, Philippine Kies, Madelien Regeer, Hubert W. Vliegen, Bart J. A. Mertens, Danielle Robbers-Visser, Berto J. Bouma, Laurens F. Tops, Martin J. Schalij, Monique R. M. Jongbloed, Anastasia D. Egorova
Summary: This study investigates the tolerability and effects of sacubitril/valsartan in adult patients with sRV failure. The results show that treatment with sacubitril/valsartan is associated with a low rate of adverse effects and leads to persistent improvement in 6-minute walking distance, NT-proBNP levels, and echocardiographic parameters of sRV function.
Review
Cardiac & Cardiovascular Systems
Leo J. Engele, Roel L. F. van der Palen, Anastasia D. Egorova, Margot M. Bartelings, Lambertus J. Wisse, Claire A. Glashan, Philippine Kies, Hubert W. Vliegen, Mark G. Hazekamp, Barbara J. M. Mulder, Marco C. De Ruiter, Berto J. Bouma, Monique R. M. Jongbloed
Summary: This study investigated the changes in fibrosis and innervation state in the hearts of patients with transposition of the great arteries (TGA) and correlated the findings with clinical literature. The results showed that diffuse interstitial fibrosis was already present in newborn TGA hearts, and the amount of fibrosis was significantly higher in hearts after surgical correction. Additionally, there was a decrease in nerve innervation after the arterial switch operation (ASO).
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Ralph M. L. Neijenhuis, Madelien V. Regeer, Frank van der Kley, Hubert W. Vliegen, Monique R. M. Jongbloed, Philippine Kies, Martin J. Schalij, J. Wouter Jukema, Anastasia D. Egorova
Summary: Baffle leaks, a common complication after the atrial switch procedure, can have significant implications on the hemodynamic course and prognosis of patients. Our report highlights three cases of baffle leaks in patients with systemic right ventricular failure, with successful percutaneous closure in two cases and conservative management in one case. These cases underscore the importance of a patient-tailored approach when addressing baffle leaks.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Marieke Nederend, J. Lauran Stoger, Anastasia D. Egorova, Daniela Q. C. M. Barge-Schaapveld, Monique R. M. Jongbloed
Summary: This article presents a follow-up report of an adult patient after Fontan palliation, who experienced multiple late complications, including refractory protein losing enteropathy. Genetic evaluation identified a variant of uncertain significance in the BRAF gene associated with Noonan spectrum disorders, which are notorious for lymphedema and protein losing enteropathy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Medicine, General & Internal
Abdelhak El Bouziani, Lars S. Witte, Berto J. Bouma, Monique R. M. Jongbloed, Danielle Robbers-Visser, Bart Straver, Marcel A. M. Beijk, Philippine Kies, David R. Koolbergen, Frank van der Kley, Martin J. Schalij, Robbert J. de Winter, Anastasia D. Egorova
Summary: Transcatheter valve interventions have become a valid alternative to conventional surgical treatment in selected acquired heart disease patients. However, there is a lack of literature on percutaneous atrioventricular (AV) valve interventions in adult congenital heart disease (ACHD) patients, including technical aspects, hemodynamic effects, and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ralph M. L. Neijenhuis, Marieke Nederend, Monique R. M. Jongbloed, Philippine Kies, Joris I. Rotmans, Hubert W. Vliegen, J. Wouter Jukema, Anastasia D. Egorova
Summary: This study described the initial experience with dapagliflozin in patients with systemic right ventricular (sRV) failure, focusing on its tolerability and short-term effects on clinical outcomes. The results showed that dapagliflozin exhibited good tolerability and had a positive impact on cardiac function and renal function. However, large-scale prospective studies are needed to thoroughly evaluate the effects of SGLT2i in the growing sRV failure population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
H. Sophia Chen, Lieke van Roon, Jan Schoones, Katja Zeppenfeld, Marco C. Deruiter, Monique R. M. Jongbloed
Summary: Cardiac sympathetic hyperinnervation occurs mainly in the borderzone three days after myocardial infarction and remains present for at least 3 months. It is most commonly studied in male rats with permanent left anterior descending (LAD) ligation. The amount of hyperinnervation differs greatly between studies, possibly due to the differential quantification methods.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tjerry Hut, Arno Roest, Duco Gaillard, Mark Hazekamp, Pieter van den Boogaard, Hildo Lamb, Lucia Kroft, Monique Jongbloed, Jos Westenberg, Jolanda Wentzel, Friso Rijnberg, Sasa Kenjeres
Summary: Virtual expansion of Fontan conduits from 16 mm to 24-32 mm based on patient-specific flow significantly improves TCPC efficiency, while thrombosis risk remains low.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marieke Nederend, Monique R. M. Jongbloed, Philippine Kies, Hubert W. Vliegen, Laurens Tops, Martin J. Schalij, Anastasia D. Egorova
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Friso M. Rijnberg, Jos J. M. Westenberg, Hans C. van Assen, Joe F. Juffermans, Lucia J. M. Kroft, Pieter J. van den Boogaard, Covadonga Terol Espinosa de Los Monteros, Evangeline G. Warmerdam, Tim Leiner, Heynric B. Grotenhuis, Monique R. M. Jongbloed, Mark G. Hazekamp, Arno A. W. Roest, Hildo J. Lamb
Summary: This study explores the relationship between blood flow dynamics in the TCPC and exercise capacity and liver fibrosis/congestion. The results show that adverse blood flow dynamics in the TCPC are associated with decreased exercise capacity and increased levels of liver fibrosis/congestion.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Marieke Nederend, Anastasia D. Egorova, Hubert W. Vliegen, Arno A. W. Roest, Bastian N. Ruijter, Tijmen Korteweg, Maarten K. Ninaber, Katja Zeppenfeld, Mark G. Hazekamp, Philippine Kies, Monique R. M. Jongbloed
Summary: This article discusses the clinical care and complications of patients with univentricular physiology, highlighting the need for a multidisciplinary team approach.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
