Article
Clinical Neurology
Ian M. Greenlund, Jeremy A. Bigalke, Anne L. Tikkanen, John J. Durocher, Carl A. Smoot, Jason R. Carter
Summary: The study found that evening binge alcohol consumption can reduce cardiac vagal tone and baroreflex sensitivity in different sleep stages.
Article
Clinical Neurology
Ian M. Greenlund, Jeremy A. Bigalke, Anne L. Tikkanen, John J. Durocher, Carl A. Smoot, Jason R. Carter
Summary: The study showed that evening binge alcohol consumption negatively affects cardiac vagal tone and baroreflex sensitivity during sleep, providing insights into the potential cardiovascular risks associated with binge drinking.
Article
Cardiac & Cardiovascular Systems
Hui Gong, Xing Lyu, Lini Dong, Shengyu Tan, Shizhen Li, Jieting Peng, Yang Liu, Xiangyu Zhang
Summary: The severity of OSA is significantly associated with cardiac injury and remodeling in patients with DCM, potentially through altering autophagy levels. This study provides new clues for the treatment of heart failure caused by OSA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Rachel J. Skow, Nicole A. Garza, Damsara Nandadeva, Brandi Y. Stephens, Alexis N. Wright, Ann-Katrin Grotle, Benjamin E. Young, Paul J. Fadel
Summary: Emerging evidence suggests that COVID-19 may affect cardiac autonomic function, but the limited findings in young adults have been inconclusive. This study found no significant differences in heart rate variability and cardiac baroreflex sensitivity between young adults with persistent symptoms following COVID-19, those who were asymptomatic, and controls who never had COVID-19. However, there were significant relationships between measures of cardiac autonomic function and time since diagnosis, suggesting that COVID-19-related changes in cardiac autonomic function are transient in young, otherwise healthy adults.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Giannoni, Francesco Gentile, Francesco Buoncristiani, Chiara Borrelli, Paolo Sciarrone, Jens Spiesshoefer, Francesca Bramanti, Giovanni Iudice, Shahrokh Javaheri, Michele Emdin, Claudio Passino
Summary: This study assessed the clinical and prognostic significance of baroreflex sensitivity (BRS) and chemoreflex sensitivity (CRS) in patients with chronic heart failure (HF) on modern treatments. The results showed that decreased BRS and increased CRS were associated with adverse outcomes in HF patients.
JACC-HEART FAILURE
(2022)
Article
Biology
C. E. L. Araujo, R. Ferreira-Silva, E. M. Gara, T. T. Goya, R. S. Guerra, L. Matheus, E. Toschi-Dias, A. G. Rodrigues, E. R. F. Barbosa, R. Fazan, G. Lorenzi-Filho, C. E. Negrao, L. M. Ueno-Pardi
Summary: Exercise training has positive effects on heart rate variability, BRS, fatigue, and sleep parameters in patients with OSA. These effects are associated with improved sleep parameters, fatigue, and cardiac autonomic modulation.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mauro Contini, Antonio Sarmento, Paola Gugliandolo, Alessandra Leonardi, Gianluigi Longinotti-Buitoni, Camilla Minella, Carlo Vignati, Massimo Mapelli, Andrea Aliverti, Piergiuseppe Agostoni
Summary: This study evaluated the ability of an innovative wearable system, X10X and X10Y, to detect and classify sleep apnea events without the use of a flowmeter. The results showed that these devices performed well in terms of respiratory signal quality, duration and classification of apneas, and identification of hypopneas. The devices were able to provide accurate grading of sleep respiratory disorders and can be considered as a type 3 sleep test device for screening tests.
Article
Critical Care Medicine
Jeremy E. Orr, Indu Ayappa, Danny J. Eckert, Jack L. Feldman, Chandra L. Jackson, Shahrokh Javaheri, Rami N. Khayat, Jennifer L. Martin, Reena Mehra, Matthew T. Naughton, Winfried J. Randerath, Scott A. Sands, Virend K. Somers, M. Safwan Badr
Summary: The international multidisciplinary group identified 11 specific research priorities regarding central sleep apnea (CSA) in heart failure patients, focusing on areas such as control of breathing, variability across individuals, examination techniques, treatment impact, and implementation strategies. Advancing care for patients with CSA in the context of heart failure will require progress in translational, epidemiological, and patient-centered outcome research. Priority should be given to targeted research to improve knowledge of CSA pathogenesis and treatment, given the increasing prevalence of heart failure and its substantial burden.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Shengnan Li, Liyue Xu, Xiaosong Dong, Xueli Zhang, Brendan T. Keenan, Fang Han, Taoran Bi, Yuan Chang, Yongbo Yu, Bing Zhou, Allan Pack, Samuel T. Kuna
Summary: HSAT with a type 3 portable monitor is effective in diagnosing sleep-disordered breathing and identifying respiratory events in adults with chronic heart failure.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Sunil Sharma, Robert Stansbury, Benjamin Hackett, Henrik Fox
Summary: Obstructive sleep apnea (OSA) and pulmonary hypertension (PH) are known to be associated, with limited understanding of the relationship which appears to be bidirectional. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. Further research on the mechanisms of this relationship is important.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Clinical Neurology
Bruce D. Nearing, Imad Libbus, Gerrard M. Carlson, Badri Amurthur, Bruce H. KenKnight, Richard L. Verrier
Summary: This study shows that chronic high-intensity vagus nerve stimulation improves intrinsic heart rate recovery, heart rate turbulence slope, and left ventricular ejection fraction over a period of 3 years. The correlated favorable effects on heart rate turbulence slope suggest enhanced baroreceptor function in response to vagus nerve stimulation.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Physiology
Shiyue Pan, Emma Karey, Madeline Nieves-Cintron, Yi-Je Chen, Sung Hee Hwang, Bruce D. Hammock, Kent E. Pinkerton, Chao-Yin Chen
Summary: Secondhand smoke exposure significantly affects cardiac autonomic function and blood pressure regulation. The adverse cardiovascular effects of secondhand smoke can be reversed by discontinuing exposure, and inhibiting soluble epoxide hydrolase can prevent these effects.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Monika Zawadka-Kunikowska, Lukasz Rzepinski, Malgorzata Tafil-Klawe, Jacek J. Klawe, Pawel Zalewski, Joanna Slomko
Summary: This study aimed to evaluate the cardiac and autonomic function in patients with myasthenia gravis (MG) and investigate its relationship with disease outcomes. The results showed that MG patients exhibited altered systolic blood pressure variability, reduced heart rate response to deep breathing test, increased sympathovagal balance after tilt, lower baroreflex sensitivity, and decreased hemodynamic parameters compared to controls. Disease severity was found to be associated with diminished vagal tone and increased sympathetic response. Age and sex were the main predictors of hemodynamic parameters. These findings highlight the importance of evaluating autonomic balance in MG patients, especially those at risk for cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Michael Wester, Michael Arzt, Frederick Sinha, Lars Siegfried Maier, Simon Lebek
Summary: Heart failure with preserved ejection fraction (HFpEF) is a widespread disease with high morbidity and mortality, and sleep-disordered breathing (SDB) has been found to be closely associated with the development and progression of the obese HFpEF phenotype. Individualized therapeutic strategies and novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing are needed to improve treatment outcomes.
Article
Clinical Neurology
Weijun Huang, Xiaoman Zhang, Xiaoting Wang, Tianjiao Zhou, Xiaolong Zhao, Huajun Xu, Xinyi Li, Jian Guan, Hongliang Yi, Shankai Yin
Summary: In our large-scale study, we found that obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is correlated with cardiac autonomic dysfunction. This correlation was assessed using standard polysomnography (PSG) to measure OSA and heart rate variability (HRV) to evaluate cardiac autonomic dysfunction. Our study also found that a higher apnea-hypopnea index during REM sleep (AHIREM) is associated with increased cardiovascular disease (CVD) risk. Mediation analysis showed that this association is mediated by the ratio of low-frequency and high-frequency (LF/HF) and low frequency in normalized units (LF (n.u.)). These findings suggest that OSA during REM sleep may be a marker for increased CVD risk due to its impact on cardiac autonomic dysfunction.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Critical Care Medicine
Sara Q. C. Giampa, Sofia F. Furlan, Lunara S. Freitas, Thiago A. Macedo, Adriana Lebkuchen, Karina H. M. Cardozo, Valdemir M. Carvalho, Franco C. Martins, Indira F. B. Azam, Valeria Costa-Hong, Heno F. Lopes, Mariana L. Baptista, Carlos E. Rochitte, Luiz A. Bortolotto, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: Despite an improved reversibility rate, most patients still retained the diagnosis of metabolic syndrome after CPAP treatment. CPAP treatment did not significantly affect adiposity biomarkers and deposits, indicating a modest role of OSA in modulating metabolic syndrome.
Article
Clinical Neurology
Claudia K. Suemoto, Ronaldo B. Santos, Soraya Giatti, Aline N. Aielo, Wagner A. Silva, Barbara K. Parise, Lorenna F. Cunha, Silvana P. Souza, Rosane H. Griep, Andre R. Brunoni, Paulo A. Lotufo, Isabela M. Bensenor, Luciano F. Drager
Summary: Sleep disturbances have a potential impact on cognitive performance, and the association between insomnia and cognitive function is modified by OSA and oxygen saturation.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Andre A. F. Mello, Giovanna D'Angelo, Ronaldo B. Santos, Isabela Bensenor, Paulo A. Lotufo, Geraldo Lorenzi-Filho, Luciano F. Drager, Pedro R. Genta
Summary: This study compared the influence of in-lab polysomnography (PSG) and ambulatory Portable Monitor (PM) sleep study on body position, and found that patients undergoing PSG spent more time in the supine position and may overestimate the severity of obstructive sleep apnea (OSA) compared to PM. The diagnosis of OSA was also associated with increased time spent in the supine position.
SLEEP AND BREATHING
(2023)
Article
Multidisciplinary Sciences
Linda M. Ueno-Pardi, Fabio L. Souza-Duran, Larissa Matheus, Amanda G. Rodrigues, Eline R. F. Barbosa, Paulo J. Cunha, Camila G. Carneiro, Naomi A. Costa, Carla R. Ono, Carlos A. Buchpiguel, Carlos E. Negrao, Geraldo Lorenzi-Filho, Geraldo Busatto-Filho
Summary: Exercise training can improve exercise capacity, decrease apnea-hypopnea index, increase attention/executive functioning, and increase CMRgl in the frontal lobe of OSA patients, potentially leading to improvements in cognitive functioning.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Leonardo Barbosa Almeida, Mateus Camaroti Laterza, Maria Urbana Pinto Brandao Rondon, Luciana Diniz Nagem Janot de Matos, Catherine L. Granger, Linda Denehy, Cristino Carneiro Oliveira, Patricia Fernandes Trevizan, Daniel Godoy Martinez
Summary: This study aimed to investigate the effect of inspiratory muscle training (IMT) in addition to conventional physical rehabilitation on hospitalized patients undergoing hematopoietic stem cell transplantation (HSCT). The results support the effectiveness of IMT in improving inspiratory muscle strength, reducing fatigue, and blood pressure.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Multidisciplinary Sciences
Rosa Hasan, Pedro Rodrigues Genta, George do Lago Pinheiro, Michelle Louvaes Garcia, Paula Gobi Scudeller, Carlos Roberto Ribeiro de Carvalho, Geraldo Lorenzi-Filho
Summary: Obstructive sleep apnea (OSA) is a common condition with many undiagnosed cases. This study validated the use of Biologix, a wireless oximeter with built-in accelerometer and smartphone integration, as a simple and reliable method for diagnosing OSA at home.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Leonardo Barbosa de Almeida, Mateus Camaroti Laterza, Maria Urbana Pinto Brandao Rondon, Edgar Toschi-Dias, Luciana Diniz Nagem Janot de Matos, Cristino Carneiro Oliveira, Patricia Fernandes Trevizan, Daniel Godoy Martinez
Summary: This study investigates the correlation between cardiac autonomic control, cardiac troponin I, and clinical cardiotoxicity in patients undergoing autologous hematopoietic stem cell transplantation. The results show that cardiac autonomic control worsens after high-dose chemotherapy and is associated with troponin I and clinical cardiotoxicity.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Article
Peripheral Vascular Disease
Diego Faria, Renata J. Moll-Bernardes, Laura Testa, Camila M. V. Moniz, Erika C. Rodrigues, Amanda G. Rodrigues, Amanda Araujo, Maria J. N. N. Alves, Bruna E. Ono, Joao E. Izaias, Vera M. C. Salemi, Camila P. Jordao, Graziela Amaro-Vicente, Maria U. P. B. Rondon, Katelyn R. Ludwig, Daniel H. Craighead, Matthew J. Rossman, Fernanda M. Consolim-Colombo, Katia De Angelis, Maria C. C. Irigoyen, Douglas R. Seals, Carlos E. Negrao, Allan R. K. Sales
Summary: COVID-19 survivors exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, and reduced exercise capacity compared to controls. Further investigation is needed to determine whether these manifestations are persistent longer-term and their impact on the cardiovascular health of COVID-19 survivors.
Editorial Material
Acoustics
Thiago Andrade Macedo, Luciano F. F. Drager, Marcelo Luiz Campos Vieira
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Editorial Material
Respiratory System
G. Lorenzi-Filho, L. F. Drager, T. D. Bradley
Article
Peripheral Vascular Disease
Rafael Y. Fecchio, Julio C. S. de Sousa, Laura Oliveira-Silva, Natan D. da Silva Junior, Andrea Pio-Abreu, Giovanio V. da Silva, Luciano F. Drager, David A. Low, Claudia L. M. Forjaz
Summary: This study compared the effects of dynamic resistance training (DRT), isometric handgrip training (IHT), and combined training (CRT) on blood pressure, systemic hemodynamics, vascular function, and cardiovascular autonomic modulation in hypertensive men. The results showed that DRT and CRT significantly decreased systolic blood pressure and improved microvascular function, while IHT had no significant effect on these variables. Therefore, DRT was beneficial for blood pressure and microvascular function in treated hypertensive men, and CRT did not provide additional improvements compared to DRT alone.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Beatriz R. Goes-Santos, Eduardo Rondon, Guilherme W. P. Fonseca, Allan R. K. Sales, Marcelo R. Santos, Ligia M. Antunes-Correa, Linda M. Ueno-Pardi, Patricia Oliveira, Patricia F. Trevizan, Fabio G. Mello Franco, Raffael Fraga, Maria Janieire N. N. Alves, Maria Urbana P. B. Rondon, Ludhmila A. Hajjar, Roberto Kalil Filho, Carlos E. Negrao
Summary: This study aimed to determine if exercise training is associated with reductions in muscle sympathetic nerve activity (MSNA) and increases in muscle blood flow (MBF) in patients with heart failure with reduced ejection fraction (HFrEF). The results showed that exercise training increased peak oxygen consumption (VO2), LVEF, MBF, and MVC, while significantly decreasing MSNA. Logistic regression analyses demonstrated that MSNA was independently associated with peak VO2.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Teresa Cristina D. C. Nascimento, Livia do Valle Costa, Amanda Danieletto Ruiz, Carla B. Ledo, Valeria Paes Lima Fernandes, Luiz Francisco Cardoso, Jose Mauro Vieira Jr, Roberta Saretta, Roberto Kalil-Filho, Luciano F. Drager
Summary: Effective vaccination against coronavirus reduces the risk of hospitalization and death, but it's unclear if vaccination status affects long COVID symptoms in hospitalized patients. This study evaluated 412 COVID-19 patients admitted to hospitals in Brazil and found that those with no or incomplete vaccination had higher rates of ICU admissions, corticosteroid use, and pulmonary embolism or deep vein thrombosis compared to fully vaccinated patients. After discharge, patients with no or incomplete vaccination had a higher frequency of symptoms than fully vaccinated patients. Overall, vaccination mitigates the likelihood of long COVID symptoms even in severe cases.
SCIENTIFIC REPORTS
(2023)
Article
Respiratory System
Daniela Pachito, Beny Finkelstein, Claudia Albertini, Antonio Gaspar, Carolina Pereira, Paulo Vaz, Alan Luiz Eckeli, Luciano F. Drager
Summary: This study aimed to present data on the volume of legal proceedings regarding access to diagnosis and treatment of OSA in Brazil. The results showed that legal action as a strategy for accessing OSA diagnostic and therapeutic resources is a common practice, but it lacks efficiency and equity.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2023)
