Review
Biochemistry & Molecular Biology
Farzad Rahbar Kouibaran, Mario Sabatino, Chiara Barozzi, Igor Diemberger
Summary: ANP is synthesized by the atria and serves the purposes of vasodilation and increasing renal excretion of sodium and water. Understanding ANP's role in cardiac systems has improved in recent decades. This review focuses on analyzing the regulations between the endocrine and mechanical function of the heart and emphasizes the impact of ANP on atrial fibrillation (AF) and related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pascal B. Meyre, Stefanie Aeschbacher, Steffen Blum, Gian Voellmin, Peter M. Kastner, Elisa Hennings, Beat A. Kaufmann, Michael Kuehne, Stefan Osswald, David Conen
Summary: This study investigated the changes in biomarkers and clinical measures in patients with and without atrial fibrillation (AF) recurrence after electrical cardioversion. The results showed significant differences in bone morphogenetic protein 10 (BMP10), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total bilirubin levels between patients with and without AF recurrence. The reductions in BMP10 and NT-proBNP levels were independently associated with the follow-up rhythm status.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas A. Marston, Amanda C. Garfinkel, Frederick K. Kamanu, Giorgio M. Melloni, Carolina Roselli, Petr Jarolim, David D. Berg, Deepak L. Bhatt, Marc P. Bonaca, Christopher P. Cannon, Robert P. Giugliano, Michelle L. O'Donoghue, Itamar Raz, Benjamin M. Scirica, Eugene Braunwald, David A. Morrow, Patrick T. Ellinor, Steven A. Lubitz, Marc S. Sabatine, Christian T. Ruff
Summary: In patients with cardiovascular conditions, AF PRS is a strong independent predictor of incident AF that provides complementary predictive value when added to a validated clinical risk score and NT-proBNP.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Azmil H. Abdul-Rahim, Atefeh Talebi, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Milton Packer, Mark Petrie, Piotr Ponikowski, Jean L. Rouleau, Marc S. Sabatine, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Pardeep S. Jhund, John J. McMurray
Summary: A simple risk model can be used to identify HFrEF patients without AF who have a high risk of stroke, allowing for targeted use of prophylactic anticoagulant therapy.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
K. E. Juhani Airaksinen
Summary: Cardioversion is an important strategy in the treatment of atrial fibrillation, and the timing of the procedure is crucial for its success and safety. Early cardioversion has a higher success rate and lower risk of early recurrences compared to later elective cardioversion. However, cardioversion does increase the risk of thromboembolic complications, which can be reduced with effective anticoagulation. Even with therapeutic anticoagulation, each elective cardioversion still carries a higher risk of stroke compared to acute cardioversion or avoiding cardioversion. For otherwise healthy patients on therapeutic anticoagulation, a short wait-and-see approach may be a reasonable option.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Jan Daniel Niederdoeckl, Alexander Simon, Nina Buchtele, Nikola Schuetz, Filippo Cacioppo, Julia Oppenauer, Sophie Gupta, Sebastian Schnaubelt, Alexander Spiel, Dominik Roth, Fritz Wimbauer, Isabel Fegers-Wustrow, Katrin Esefeld, Martin Halle, Juergen Scharhag, Thomas Laschitz, Harald Herkner, Hans Domanovits, Michael Schwameis
Summary: A predictive model was developed and validated in this study to estimate the success rate of intravenous pharmacological cardioversion using different antiarrhythmic agents in patients with haemodynamically stable atrial fibrillation. The research showed good calibration and clinical usefulness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Rasa Karaliute, Arnoldas Leleika, Ieva Apanaviciute, Tomas Kazakevicius, Vaida Mizariene, Vytautas Zabiela, Ausra Kavoliuniene, Nijole Ragaisyte, Daiva Urboniene, Gintare Sakalyte
Summary: In patients with persistent atrial fibrillation, left atrial strain may be the most accurate predictor of early recurrence of atrial fibrillation after electrical cardioversion, with significant associations with natriuretic peptides and inflammatory markers identified.
MEDICINA-LITHUANIA
(2022)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Karola S. Jering, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Milton Packer, Mark C. Petrie, Marc A. Pfeffer, Margaret M. Redfield, Jean L. Rouleau, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Scott D. Solomon, John J. V. McMurray
Summary: This study validated a simple risk model for predicting stroke risk in heart failure patients with preserved ejection fraction but without atrial fibrillation. The results showed that the risk for stroke increased with increasing risk score, suggesting the use of anticoagulation therapy in high-risk patients.
CIRCULATION-HEART FAILURE
(2023)
Article
Multidisciplinary Sciences
Daniel Enriquez-Vazquez, Jorge G. Quintanilla, Alba Garcia-Escolano, Marinela Couselo-Seijas, Ana Simon-Chica, Peter Lee, Jose Manuel Alfonso-Almazan, Patricia Mahia, Andres Redondo-Rodriguez, Javier Modrego, Adriana Ortega-Hernandez, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Ruben Gomez-Gordo, Ping Yan, Giulio La Rosa, Jose Bustamante-Madrion, Carlos Nicolas Perez-Garcia, F. Javier Martin-Sanchez, David Calvo, Jesus M. de la Hera, Maria Jesus Garcia-Torrent, Alvaro Garcia-Osuna, Jordi Ordonez-Llanos, Jesus Vazquez, Julian Perez-Villacastin, Nicasio Perez-Castellano, Leslie M. Loew, Javier Sanchez-Gonzalez, Dulcenombre Gomez-Garre, David Filgueiras-Rama
Summary: The authors use non-invasive atrial electromechanical assessment during atrial fibrillation to identify early remodeling changes associated with underlying myopathy, which decreases the probability of successful rhythm control. This study provides mechanistic insights into the electromechanical remodeling process associated with AF progression and demonstrates its prognostic value in the clinic.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Arwa Younis, Nofrat Nehoray, Michael Glikson, Christopher Bodurian, Eyal Nof, Nicola Luigi Bragazzi, Michael Berger, Wojciech Zareba, Ilan Goldenberg, Roy Beinart
Summary: This study evaluated the changes in QTc over time following electrical cardioversion (ECV) in patients with persistent atrial fibrillation (AF), and compared the effectiveness of continuous Holter monitoring and conventional ECG follow-up. The results showed that ECV was associated with an increased transient risk of QTc prolongation in nearly half of the patients, and Holter monitoring was superior to conventional monitoring in detecting clinically significant QTc prolongation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Predrag Stojadinovic, Dan Wichterle, Masato Fukunaga, Petr Peichl, Vojtech Melenovsky, Janka Franekova, Josef Kautzner, Marek Sramko
Summary: Plasma natriuretic peptides (NPs) are increased in patients with atrial fibrillation (AF) compared with patients with sinus rhythm, and this phenomenon is intrinsic to heart rhythm irregularity and independent of heart rate and left atrial pressure.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Paritosh Prasai, Dhan Bahadur Shrestha, Eltaib Saad, Angkawipa Trongtorsak, Aarya Adhikari, Suman Gaire, Prakash Raj Oli, Jurgen Shtembari, Pabitra Adhikari, Yub Raj Sedhai, Muhammad Sikander Akbar, Islam Y. Elgendy, Ghanshyam Shantha
Summary: There is no clear consensus on the preference for pharmacological cardioversion (PC) compared to electric cardioversion (EC) for hemodynamically stable new-onset atrial fibrillation (NOAF) patients. This meta-analysis suggests that there is no difference in successful restoration of sinus rhythm with either modality among patients with hemodynamically stable NOAF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lidia Staszewsky, Jennifer M. T. A. Meessen, Deborah Novelli, Ursula-Henrike Wienhues-Thelen, Marcello Disertori, Aldo P. Maggioni, Serge Masson, Gianni Tognoni, Maria Grazia Franzosi, Donata Lucci, Roberto Latini
Summary: Novel circulating biomarkers may help in understanding AF mechanisms. The study found total NT-proBNP, NT-proBNP, Ang2, and BMP10 were strongly associated with ongoing AF and predictive of recurrent AF and CV hospitalization. The association of total NT-proBNP with AF first recurrence was similar to NT-proBNP, suggesting no influence of glycosylation.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Ozan Demirel, Alexander E. Berezin, Moritz Mirna, Elke Boxhammer, Sarah X. Gharibeh, Uta C. Hoppe, Michael Lichtenauer
Summary: Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is an effective urgent treatment strategy for recent-onset AF. However, accurate predictive serum biomarkers for AF relapse after cardioversion are lacking. Many biomarkers have been associated with AF occurrence, but their predictive ability for post-cardioversion outcomes remains controversial. Novel circulating biomarkers are needed to improve the predictive tools for AF treatment.
Article
Cardiac & Cardiovascular Systems
Tetsuma Kawaji, Satoshi Shizuta, Takanori Aizawa, Shushi Nishiwaki, Takashi Yoshizawa, Suguru Nishiuchi, Masashi Kato, Takafumi Yokomatsu, Shinji Miki
Summary: This study assessed the prognostic importance of B-type natriuretic peptide (BNP) concentrations for clinical outcomes after catheter ablation for atrial fibrillation (AF). It found that low BNP concentrations were associated with lower risks of arrhythmia recurrence and heart failure hospitalization or cardiac death. The impact of low BNP concentrations on arrhythmia recurrence was more pronounced in patients with paroxysmal AF.
CIRCULATION JOURNAL
(2023)
