Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 140, Issue 1, Pages 24-33Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2008.10.044
Keywords
Atorvastatin; Cytokine; Lovastatin; Monocytes; T cells
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Funding
- Tri-Service General Hospital [TSGH-C96-5-S05]
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Statins are applied clinically to treat hypercholesterolemia and proposed to have some kinds of anti-inflammatory properties for reducing the incidence of atherosclerosis-related cardiovascular events. However, it was rarely known about statins on the signal transduction on human primary T cells. To gain insight into the mechanism of statins on human T cells, we investigated the effects of both lovastatin and atorvastatin on activated human primary T cells. The human primary T cells from the blood of normal human beings were isolated. We found that lovastatin, but not atorvastatin, can dose-dependently inhibit cytokine production such as interleukin-2, interleukin-4, and interferon-gamma from activated human T cells. Neither lovastatin nor atorvastatin can regulate the TNF-alpha production on both activated human T cells and monocytes. Molecular investigation was performed that lovastatin, but not atorvastatin, could down-regulate both activator protein-1 and NF-kappa B DNA binding activities, assessed by electrophoretic mobility shift assay. Our observations may extend potential and differential therapeutic mechanisms of lovastatin with cell-mediated capacity to prevent or treat some of inflammation related diseases. (C) 2010 Published by Elsevier Ireland Ltd.
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