Article
Chemistry, Physical
Adrian Ges Naranjo, Herlys Viltres Cobas, Nishesh Kumar Gupta, Katy Rodriguez Lopez, Aldo Martinez Pena, Daniel Sacasas, Ruben Alvarez Brito
Summary: Nanogels offer a promising approach for enhancing cancer therapy by increasing the concentration of anti-tumor agents at tumor sites and prolonging their effects on cancer cells without significantly impacting normal tissues.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Mechanics
Juan Shi, Peichan Wu, Yannan Zhou, Zhenqian Chen
Summary: This paper examines the effects of interventional stent treatment on the cerebral hemodynamics of elastic aneurysms. It finds that higher blood flow rates and greater wall compliance provide a more stable flow environment, while the stent attenuates the impact of wall compliance and acts as a flow diverter to reduce the risk of aneurysm rupture.
Article
Engineering, Environmental
Xiyan Guo, Wei Tan, Liyan Liu, Cenfan Liu, Guorui Zhu
Summary: The experimental results show that despite the variation of length-diameter ratio of the leakage holes, the expansion angles and jet velocities behave similarly and maintain stable values. An empirical two-phase mass outflow rate model has been developed based on the experimental data, which can be supported in mass flow rate evaluation, especially for specific release cases.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2021)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Article
Pharmacology & Pharmacy
Jihane Mzoughi, Thierry Vandamme, Valeriy Luchnikov
Summary: Biphasic drug delivery systems are used to quickly release a specific amount of drug for immediate relief, followed by sustained release to avoid repeated dosing. This study presents a novel architecture for biphasic release media without the need for a rapidly disintegrating layer and with adjustable sustained release rate capabilities.
Article
Pharmacology & Pharmacy
Tadej Ojstersek, Grega Hudovornik, Franc Vrecer
Summary: This study investigated the influence of selected excipients on the release performance of carvedilol from HPMC-based matrix tablets. Compression mixtures were directly compressed using different grades of excipients. LOESS modelling was used to compare the release profiles by estimating burst release, lag time, and times at which a certain % of carvedilol was released. The similarity between the release profiles was evaluated using the bootstrapped similarity factor (f(2)). The best control of carvedilol release was achieved with POLYOX® WSR N-80 and Polyglykol® 8000 P in water-soluble excipients, and AVICEL® PH-102 and AVICEL® PH-200 in water-insoluble excipients.
Article
Clinical Neurology
Zi-Ai Zhao, Nan-Nan Zhang, Yu Cui, Hui-Sheng Chen
Summary: The study suggests that head-down tilt treatment at certain degrees may provide neuroprotective effects after MCAO/R by improving cerebral blood flow velocity and protecting pericytes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Materials Science, Multidisciplinary
Chitrangda Singh, Chandan Bhogendra Jha, Navneet Kumar, Ragini Singh, Himanshu Ojha, Sreedevi Upadhyayula, Raunak Varshney, Rashi Mathur
Summary: This study synthesized ZIF-8 and conducted simulation studies to gain a comprehensive understanding of the drug's interactions with ZIF-8. Experimental and computational results revealed the adsorption mechanism and energy interactions between the drug and the MOF framework, providing guidance for the design of new metal-organic ligand drug carriers.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Thermodynamics
C-H Kim, N-H Kim
Summary: This study investigated two-phase flow distribution in a parallel flow condenser using R-134a flow distribution tests. The results showed relatively uniform flow distribution within the channels, with variations at the top and bottom channels. Thermal degradation due to flow mal-distribution was found to be insignificant.
APPLIED THERMAL ENGINEERING
(2021)
Article
Engineering, Environmental
Toon Van Dael, Lei Xia, Kobe Van Dijck, Sid Potemans, Erik Smolders
Summary: High phosphorus peaks in lowland rivers during the summer months are mainly caused by the reductive dissolution of ferric iron minerals in sediments. Lowering water flow velocity enhances the release of phosphorus from sediment into the water, while amending sediment with iron-rich glauconite sand can reduce dissolved phosphorus concentrations.
Article
Chemistry, Multidisciplinary
Deval Patel, Ying Zhang, Yixuan Dong, Haiou Qu, Darby Kozak, Muhammad Ashraf, Xiaoming Xu
Summary: This study developed an adaptive perfusion method for size-based separation of particles and simultaneous analysis of drug release rate and extent, achieving faster and higher release profiles compared to conventional dialysis methods. The method has potential for further extension to explore manufacturing process impacts on drug distribution and release characteristics of complex drug products.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Mechanics
A. Podoprosvetova, J. Zayko, V Yushutin, V. Vedeneev
Summary: Experimental studies were conducted on the stability of collapsible tubes conveying fluid in the context of cardiovascular mechanics. This paper investigated the turbulent and laminar regimes with equal flow rates and pressure drops to identify the stability boundary and self-exciting oscillation modes of Penrose tubes in the Starling resistor. Four oscillation modes were observed visually and through pressure measurements for laminar and turbulent regimes. Comparisons were made between amplitudes, frequencies, and boundaries of different oscillation modes for equivalent laminar and turbulent flow regimes.
Article
Chemistry, Applied
Huazhong Ma, Juan Yu, Liang Liu, Yimin Fan
Summary: This study prepared TEMPO-oxidized nanocellulose and nanochitin-based hydrogels, demonstrating the diversity of release capacity of the hydrogels in different pH environments, with potential applications in specific areas such as drug delivery, wound dressing, and food packaging.
CARBOHYDRATE POLYMERS
(2021)
Article
Geochemistry & Geophysics
L. Spina, A. Cannata, D. Morgavi, E. Privitera, D. Perugini
Summary: This study investigates the gliding phenomenon of acoustic and seismic tremors observed in analogue degassing experiments. It finds that the gliding episodes are mostly related to the volume variation of shallow interconnected gas pockets. The findings have implications for the churn dynamics in volcanic environments and call for further research.
EARTH AND PLANETARY SCIENCE LETTERS
(2022)
Article
Thermodynamics
Ranjana Rathaur, Sumana Ghosh
Summary: Oil-water stratification is studied during drainage from a tank, with the viscosity ratio of oil to water affecting the flow behavior. Different flow patterns and the movement of air and oil in the drain pipe are observed. Optical probes are successfully used to detect various air-oil-water regimes in the drainpipe.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2022)
Article
Engineering, Biomedical
P. R. Umashankar, A. Sabareeswaran, Sachin J. Shenoy
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Engineering, Biomedical
Yingying Huang, Subbu S. Venkatraman, Freddy Y. C. Boey, Eeva M. Lahti, P. R. Umashankar, Mira Mohanty, Sabareeswaran Arumugam, Laxmikant Khanolkar, Sudhir Vaishnav
Article
Engineering, Biomedical
P. R. Umashankar, T. Arun, T. V. Kumari
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2011)
Article
Engineering, Biomedical
P. R. Umashankar, T. Arun, T. V. Kumary
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2013)
Article
Cardiac & Cardiovascular Systems
Yingying Huang, Subbu S. Venkatraman, Freddy Y. C. Boey, P. R. Umashankar, Mira Mohanty, Sabareeswaran Arumugam
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2009)
Article
Immunology
Madathipat Unnikrishnan, P. R. Umashankar, Sidharth Viswanathan, Ajay Savlania, Roy Joseph, C. V. Muraleedharan, Vivek Agrawal, Sachin J. Shenoy, Lissy K. Krishnan, P. V. Mohanan, A. Sabareeswaran
INDIAN JOURNAL OF MEDICAL RESEARCH
(2017)
Article
Engineering, Biomedical
B Balakrishnan, M Mohanty, PR Umashankar, A Jayakrishnan
Article
Engineering, Biomedical
LK Krishnan, M Mohanty, PR Umashankar, AV Lal
Article
Engineering, Biomedical
S Abiraman, HK Varma, PR Umashankar, A John
Article
Biochemical Research Methods
CM Devi, MV Bai, AV Lal, PR Umashankar, LK Krishnan
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS
(2002)
Article
Biochemistry & Molecular Biology
Leena Kuruvilla, Renuka R. Nair, P. R. Umashankar, Arthur Vijayan Lal, Chandrasekharan Cheranellore Kartha
CELL BIOCHEMISTRY AND BIOPHYSICS
(2007)
Article
Medicine, Research & Experimental
S Rajasree, PR Umashankar, AV Lal, PS Sarma, CC Kartha
