Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Zeltzin Ceja-Galicia, Diana Calderon-DuPont, Alberto Daniel, Luz Maria Chiu, Andrea Diaz-Villasenor
Summary: This study evaluated the expression of leptin and adiponectin in mature 3T3-L1 adipocytes exposed to palmitate, arsenite, or both. The results showed that the secretion of leptin and adiponectin was decreased, which could result in reduced satiety and decreased insulin sensitivity.
Review
Oncology
Xi Pu, Deyu Chen
Summary: Obesity is a global epidemic and closely related to the occurrence and development of various tumors, adipokines secreted by adipocytes and insulin/IGF play important roles in tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Absalon D. Gutierrez, Carlos A. Flores, Sapna Naik, MinJae Lee, Parisa Asgarisabet, Masha Resman, Miryoung Lee, Joseph B. McCormick, Susan P. Fisher-Hoch
Summary: Resistin decreased as glucose tolerance deteriorated, positively associated with IL-1 beta and IL-8, inversely associated with TNF-alpha, and not significantly associated with IL-6. There are complex relationships between resistin, adipokines, and demographic variables.
Article
Biochemistry & Molecular Biology
Vicente Barrios, Santiago Guerra-Cantera, Alvaro Martin-Rivada, Sandra Canelles, Ana Campillo-Calatayud, Eduardo Arilla-Ferreiro, Laura M. Frago, Julie A. Chowen, Jesus Argente
Summary: Leptin is involved in regulating insulin signaling and lipid metabolism in peripheral tissues. This study found that leptin activates insulin signaling and reduces muscle inflammation parameters, while decreasing the levels of non-esterified fatty acids.
Review
Cell Biology
Alin Garcia-Miranda, Alejandra Garcia-Hernandez, Eduardo Castaneda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
Summary: Excess body weight and obesity have been identified as significant risk factors for cancer development, with adipokines playing a crucial role in promoting an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Autophagy, a process implicated in both tumor suppression and cancer progression, has been suggested as a therapeutic target in cancer treatment, with its effectiveness potentially influenced by tumor type and microenvironmental conditions influenced by circulating adipokines.
Article
Endocrinology & Metabolism
Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G. William Wong, Nibaldo C. Inestrosa
Summary: The link between metabolic syndrome and brain function is not well understood, but adipokines, including adiponectin and resistin, may play a role. A high-fat diet-induced model revealed that adiponectin treatment improved cognitive functions and reduced AD pathology, while resistin exacerbated pathology.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Lucelia Scarabeli Silva Barroso, Marcelo Henrique Salviano Faria, Antonio Felipe Souza-Gomes, Joao Luis Vieira Monteiro Barros, Adriana Maria Kakehasi, Erica Leandro Marciano Vieira, Ana Cristina Simoes e Silva, Albena Nunes-Silva
Summary: Adipose tissue produces and releases adipokines, and exercise can modulate adipokine production in adipocytes. The aim of this longitudinal study was to evaluate the acute and chronic effects of strength training on plasma levels of adiponectin, leptin, and resistin. The results showed that strength training acutely and chronically affected the levels of adipokines in the blood.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrea Marcinno, Erica Gallo, Fausto Roveta, Silvia Boschi, Alberto Grassini, Innocenzo Rainero, Elisa Rubino
Summary: This study investigated the expression of adiponectin, leptin, and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). The results showed that lower resistin concentrations were associated with an increased risk of dementia, particularly in AD. The study suggests that the resistin-linked metabolic profile should be further investigated in AD.
Article
Biochemistry & Molecular Biology
Fabio Perrotta, Filippo Scialo, Marta Mallardo, Giuseppe Signoriello, Vito D'Agnano, Andrea Bianco, Aurora Daniele, Ersilia Nigro
Summary: This study investigated the relationship between obesity and COVID-19, specifically analyzing the levels of adiponectin, HMW oligomers, leptin, and resistin in severe COVID-19 patients. The results showed that total adiponectin levels were lower, while leptin and resistin levels were higher in severe COVID-19 patients compared to healthy individuals. HMW adiponectin oligomers were negatively correlated with leptin and positively associated with lung injury scores. Resistin showed a positive association with IL-6, IL-2R, and KL-6. These findings suggest that adipose tissue plays a functional role in COVID-19, and HMW adiponectin oligomers may serve as a laboratory resource for predicting disease severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O'haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Summary: The study found significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, in the T2DM patient group compared to the controls, with more pronounced alterations in the obese and highly obese patients. This suggests that these four adipokines play a significant role in the onset, progression, and associated complications of T2DM. More research on a larger sample size is needed to further explore the relationship between adipokines and T2DM.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Physiology
Lubica Cibickova, Michal Grega, Roman Dohnal, Jan Schovanek
Summary: Bariatric procedures, particularly laparoscopic sleeve gastrectomy (LSG), are highly effective in treating obesity. LSG leads to weight loss and metabolic improvement, as well as changes in adipokine levels. Adipokines, including leptin, resistin, visfatin, chemerin, adiponectin, and omentin, play a crucial role in regulating insulin resistance and chronic inflammation, and are significantly altered after LSG.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Psychiatry
Petros Petrikis, Andreas Karampas, George Leondaritis, Georgios Markozannes, Dimitra T. Archimandriti, Polyxeni Spyrou, Georgios Georgiou, Petros Skapinakis, Paraskevi V. Voulgari
Summary: This study compared serum levels of adiponectin, resistin, and leptin between drug-naive first-episode patients with psychosis and healthy controls, as well as the changes after six weeks of antipsychotic treatment. The results showed significantly higher levels of these adipokines in the patient group before treatment, and a significant reduction in leptin levels after six weeks of treatment.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Biochemistry & Molecular Biology
Jan Milanowski, Kamil Kozerawski, Weronika Falecka, Dominik Dudek, Beata Lisewska, Pawel Lisewski, Jaroslaw Nuszkiewicz, Roland Wesolowski, Jakub Wojtasik, Celestyna Mila-Kierzenkowska, Karolina Szewczyk-Golec
Summary: In this study, we found changes in melatonin and adipokine levels in Parkinson's disease patients at different stages of the disease. Melatonin levels were lower in the early stage and higher in the advanced stage, while leptin levels were increased in both stages compared to the control group. Resistin levels were only increased in patients with dyskinesia. These findings have important implications for the treatment and further research of Parkinson's disease.