Article
Health Care Sciences & Services
Edem Allado, Mathias Poussel, Eliane Albuisson, Jean Paysant, Margaux Temperelli, Oriane Hily, Anthony Moussu, Noura Benhajji, Gerome C. Gauchard, Bruno Chenuel
Summary: This study evaluated the efficacy of the Six-Minute Walk Test (6MWT) in determining the physical activity capacities of patients with chronic disease. The results showed a moderate relationship between 6MWT and physical activity capacity for these patients.
Article
Cardiac & Cardiovascular Systems
Jaruwat Bumrungkittikul, Wilawan Thirapatarapong
Summary: This study aimed to identify the factors independently associated with the six-minute walk test (6MWT) at the 4-6-week follow-up after cardiac surgery and develop an equation to predict the 6MWT during this period. Retrospective analysis of patient data showed that 6MWT at discharge was correlated with 6MWT at the 4-6-week follow-up, as well as regular exercise, age, gender, and preoperative New York Heart Association (NYHA) classification. An equation was generated based on these factors to predict 6MWT at 4-6 weeks after hospital discharge.
Article
Chemistry, Analytical
Ivan Miguel Pires, Hanna Vitaliyivna Denysyuk, Maria Vanessa Villasana, Juliana Sa, Diogo Luis Marques, Jose Francisco Morgado, Carlos Albuquerque, Eftim Zdravevski
Summary: This paper presents a systematic review of the use of sensors to measure different physical parameters during the performance of 6MWT, focusing on various diseases, sensors, and implemented methodologies. The analysis discovered that the measurements of 6MWT are primarily performed with inertial and magnetic sensors, and most research studies related to this test focus on multiple sclerosis and pulmonary diseases.
Article
Physiology
Jiachen Wang, Yaning Zang, Qian Wu, Yingjia She, Haoran Xu, Jian Zhang, Shan Cai, Yuzhu Li, Zhengbo Zhang
Summary: This study aimed to predict adverse events during 6MWT using continuous physiological parameters and demographic variables. The results showed that features related to blood oxygen were the most important and those related to heart rate were the most numerous. The LightGBM model had the highest AUC, with Logistic Regression following closely behind. The mMRC and Borg scales had the lowest performance in predicting adverse events.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Basuni Radi, Ade Meidian Ambari, Bambang Dwiputra, Ryan Enast Intan, Kevin Triangto, Anwar Santoso, Budhi Setianto
Summary: This study identified the determinants that influence the 6-MWD in patients after CABG and valve surgery, and generated prediction equations for these two groups respectively.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Clinical Neurology
Alice Macchiavelli, Antonella Giffone, Francesco Ferrarello, Matteo Paci
Summary: The six-minute walking test (6MWT) has high test-retest reliability when used to assess individuals with stroke. However, other types of reliability, as well as SEM and MDC, require further investigation in populations with stroke.
NEUROLOGICAL SCIENCES
(2021)
Article
Oncology
Nicole Tubiana-Mathieu, Thibault Cornette, Stephane Mandigout, Sophie Leobon, Francois Vincent, Laurence Venat, Elise Deluche
Summary: Physical activity is effective for breast cancer patients, with the use of adapted target heart rate for exercise intensity. The 6MWT-HR and CPET provide useful information for prescribing exercise programs before and after treatment. This method is beneficial for patients' recovery and physical health post-treatment.
Article
Chemistry, Analytical
Martijn Scherrenberg, Cindel Bonneux, Deeman Yousif Mahmood, Dominique Hansen, Paul Dendale, Karin Coninx
Summary: A smartphone application was developed for cardiac patients to conduct a six-minute walk test at home. Through a prospective study of 102 cardiovascular disease patients, the optimal conditions were identified, and it was demonstrated that random walk and standardized walk tests have the same accuracy.
Article
Physiology
Helena Lenasi, Ana Novak, Borut Jug, Edvin Dervisevic, Damir Karpljuk, Mateja Videmsek, Maroje Soric, Vedran Hadzic
Summary: The study emphasizes the importance of regular and actual walking ability testing in patients with stable CAD to obtain their cardiorespiratory fitness, rather than simply predicting it from regression equations obtained from non-representative or non-comparable samples.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Rehabilitation
Alen Palackic, Stephanie Abazie, Ingrid Parry, Soman Sen, Ronald P. Mlcak, Jong O. Lee, David N. Herndon, Ludwik K. Branski, Steven E. Wolf, Heidi Spratt, Oscar E. Suman
Summary: This study compares the performance of pediatric patients with severe burns in the six-minute walk test and the Modified Bruce treadmill test. The results show that the Modified Bruce treadmill test challenges the cardiorespiratory system more, while the six-minute walk test is more clinically feasible for assessing submaximal functional exercise capacity.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Pediatrics
Jiangbo Qu, Hui Shi, Yugong Guo, Xinxin Chen, Xuwen Xiao, Xiaojuan Zheng, Yanqin Cui
Summary: This study aimed to assess the validity of the 6MWT in reflecting the functional capacity of children with CHD, evaluate the correlation between 6MWT distance and CPET variables, and find a cutoff value for stratifying physical fitness in this population.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Jose Oliveros, Pamela Seron, Claudia Roman, Manuel Galvez, Rocio Navarro, Gonzalo Latin, Tania Marileo, Juan Pablo Molina, Pablo Sepulveda, Gabriel Nasri Marzuca-Nassr, Sergio Munoz
Summary: This study investigated the relationship between 6MWT and 2MST in patients with treated coronary artery disease, finding a weak positive correlation between the two tests in this population and varying degrees of correlation with biodemographic factors. Results showed that in this population, age, weight, height, lower limb strength, and grip strength better explained performance in the 6MWT, indicating that 2MST may not be effectively substituted for 6MWT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jae Ha Lee, Ji Hoon Jang, Hang-Jea Jang, Song Yee Kim, Man Pyo Chung, Hongseok Yoo, Sung Hwan Jeong, Jin Woo Song, Hong Lyeol Lee, Sun Mi Choi, Young Whan Kim, Yong Hyun Kim, Sung Woo Park, Jong Sun Park, Yangin Jegal, Jongmin Lee, Soo-Taek Uh, Tae-Hyung Kim, Yee Hyung Kim, Beomsu Shin, Hyun-kyung Lee, Sei-Hoon Yang, Hyun Lee, Sang-Heon Kim, Eun-Joo Lee, Hye Sook Choi, Hyung Koo Kang, Eun Young Heo, Won-Yeon Lee, Moo Suk Park
Summary: In this study, a new prognostic scoring system called GAP6 was developed and compared with the existing GAP model using the Korea IPF Cohort (KICO) registry. The GAP6 model, which includes nadir SpO(2) during the six-minute walk test, showed significant prognostic value for mortality and outperformed the GAP model in terms of prediction ability. The study concludes that the GAP6 model improves prediction ability and further multinational studies are needed to validate its applicability and accuracy.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Amna Omar, Arthur de Sa Ferreira, Fatma A. Hegazy, Gopala Krishna Alaparthi
Summary: This study investigates the cardiorespiratory response induced by the six-minute step test (6MST) in post-COVID-19 patients and compares it with the response of the six-minute walk test (6MWT). The results show that post-COVID-19 patients performed worse than the healthy group in both tests. Therefore, the 6MST can be used as an assessment tool for COVID-19 patients to evaluate their functional capacity and activities of daily living (ADL).
Article
Respiratory System
Lucy Robertson, Rachel Lowry, Karl Sylvester, Helen Parfrey, Beverley Moseley, Karen Sheares, Katrina Oates
Summary: The study found that forehead sensors recorded higher values for SpO2 and HR compared to finger sensors during the 6MWT. The variance in bias between the sensors suggests that pulse oximetry may not accurately reflect capillary oxygen saturation measurements, particularly in subjects who experience desaturation during the test.
CHRONIC RESPIRATORY DISEASE
(2022)
Article
Veterinary Sciences
Bruna Carvalho Silveira, Alexandre Pinto Ribeiro, Fabio Dumit Pizzinatto, Paloma Moraes Lobo, Hanna Rodrigues Miranda, Nathalia de Assis Pereira
Summary: This study found that the instillation of a commercial amniotic membrane extract did not accelerate corneal wound healing or suppress the early expression of MMP-9 in the tears of cats with experimentally induced superficial ulcerative keratitis.
VETERINARY OPHTHALMOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Marcelo Martins Pinto-Filho, Carla P. M. Soares, Gabriela Miana Paixao, Antonio Luiz Pinho Ribeiro
Article
Neurosciences
Eliana C. B. Toscano, Erica L. M. Vieira, Lea T. Grinberg, Natalia P. Rocha, Joseane A. S. Brant, Regina S. Paradela, Alexandre V. Giannetti, Claudia K. Suemoto, Renata E. P. Leite, Ricardo Nitrini, Milene A. Rachid, Antonio L. Teixeira
Summary: Temporal lobe epilepsy (TLE) is associated with cognitive deficits, and this study investigates the underlying neuronal basis. The researchers found that an increase in p-tau burden is potentially involved in cognitive deficits in mesial TLE, particularly attention impairment and seizure frequency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Letter
Dermatology
Maria Cecilia Campos Canesso, Puebla Cassini-Vieira, Camila Francisco Moreira, Suzanne Luong, Milene Alvarenga Rachid, Flaviano Santos Martins, Mauro Martins Teixeira, Angelica Thomas Vieira, Charles Reay Mackay, Luciola Silva Barcelos
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Article
Biophysics
Jermana L. de Moraes, Gabriela M. M. Paixao, Paulo R. Gomes, Eduardo M. A. M. Mendes, Antonio Luiz P. Ribeiro, Alessandro Beda
Summary: Automatic detection of ECG quality is important to minimize costs and risks related to delayed diagnosis. A new algorithm called Noise Automatic Classification Algorithm (NACA) was introduced to assess 12-lead ECG quality, which showed better performance compared to previous algorithms.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Immunology
Andrew Bacon, Mauro Teixeira, Vivian Costa, Peter Bone, Jennifer Simmons, Jeffrey Drew
Summary: Here we developed a thermally stable, orally administered Zika vaccine using engineered AdHu5. This vaccine, formulated with a mix of sugars and modified amino acids and protected by an enteric coated capsule, induced immune responses and reduced viral counts in mice and non-human primates. It has advantages over current vaccines that require cold storage and parenteral administration.
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Review
Rheumatology
Parnian Shobeiri, Saba Maleki, Mobina Amanollahi, Amirhossein Habibzadeh, Antonio L. Teixeira, Nima Rezaei
Summary: This study aimed to investigate the blood BDNF levels in patients with SLE. The meta-analysis of 8 studies showed no significant differences in blood BDNF concentrations between SLE patients and healthy controls. Further high-quality studies are needed to explore the potential role and relevance of BDNF in SLE.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Bruno Azevedo Chagas, Adriana Silvina Pagano, Raquel Oliveira Prates, Elisa Cordeiro Praes, Kicila Ferreguetti, Helena Vaz, Zilma Silveira Nogueira Reis, Leonardo Bonisson Ribeiro, Antonio Luiz Pinho Ribeiro, Thais Marques Pedroso, Alline Beleigoli, Clara Rodrigues Alves Oliveira, Milena Soriano Marcolino
Summary: This study evaluated the user experience quality of a COVID-19 chatbot in Brazil and found that overall, users had a positive experience with the chatbot. However, there are still areas for improvement.
JMIR HUMAN FACTORS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto, Philip D. Adamson, Isabelle van Gelder, Ganesan Karthikeyan, David E. Newby, Kazem Rahimi, Antonio Luiz Pinho Ribeiro, Jae-Kwan Song
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Geriatrics & Gerontology
Natalia P. Rocha, Antonio L. Teixeira, Gabriela D. Colpo, Michelle A. Babicz, Jennifer L. Thompson, Steven Paul Woods
Summary: This study found a significant association between plasma levels of neurofilament light chain (NfL) and HIV-associated neurocognitive disorders (HANDs), suggesting that NfL may serve as a promising biomarker for assessing cognitive function in people living with HIV.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
