Article
Biochemistry & Molecular Biology
Ya Han, Hengmin Wang
Summary: This study explored the role and mechanism of miR-3918 in glioma malignancy. The findings showed that miR-3918 overexpression impaired the proliferative and migratory capacities of glioma cells by inactivating PI3K/AKT and ERK pathways. Additionally, it was confirmed that miR-3918 targeted EGFR and EGFR overexpression can restore the inactivated PI3K/AKT and ERK pathways caused by miR-3918 and influence glioma cell proliferation and migration.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biology
Yu Liu, Sen Li, Ruoping Chen, Juxiang Chen, Bo Xiao, Yicheng Lu, Jiangang Liu
Summary: This study found that BTBD10 is downregulated in human glioma tissue and its expression negatively correlates with the pathological grade of the tumor. BTBD10 overexpression inhibits cell proliferation, induces G0/G1 arrest, and promotes cell apoptosis.
OPEN LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yu-Long Lan, Jianmin Zhang
Summary: RNA modification is a crucial form of regulation in cancer biology, with untranslated region-alternative polyadenylation (UTR-APA) potentially playing a key role in the pathogenesis of glioma. Less targeted strategies, such as inhibitors of UTR-APA regulators, may have superior therapeutic effects in glioma treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Kouminin Kanwore, Konimpo Kanwore, Gabriel Komla Adzika, Ayanlaja Abdulrahman Abiola, Xiaoxiao Guo, Piniel Alphayo Kambey, Ying Xia, Dianshuai Gao
Summary: This review examines the underlying mechanisms of glioma initiation and metabolism activation, as well as the tumor microenvironment changes that affect epigenetic modifications in immune cells, from an oncological and immunological perspective. The potential for therapeutic intervention is also highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Feng Yan, Jianfeng Zhuang, Qian Yu, Zhangqi Dou, Xuefeng Jiang, Shuyu Tan, Yifeng Han, Xinyan Wu, Yi Zang, Cong Li, Jia Li, Huaijun Chen, Libin Hu, Xin Li, Gao Chen
Summary: Novel fluorescent probe design strategy targeting PDGFR beta successfully developed PDGFP 1 probe for accurate glioma imaging and grading. Experimental results demonstrated high selectivity and positive correlation with tumor grades in mouse models and patient samples, showing potential for clinical translation.
Article
Multidisciplinary Sciences
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen, Michael C. Ostrowski, Wenjian Gan
Summary: AKT is involved in key cellular processes, and arginine methylation by PRMT5 promotes AKT activity and tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Bo Liu, Zhaoqi Liu, Sisi Chen, Michelle Ki, Caroline Erickson, Jorge S. Reis-Filho, Benjamin H. Durham, Qing Chang, Elisa de Stanchina, Yiwei Sun, Raul Rabadan, Omar Abdel-Wahab, Sarat Chandarlapaty
Summary: Hotspot mutations in SF3B1 play a significant role in promoting abnormal splicing in breast cancer, leading to activation of AKT and NF-kappa B signaling pathways, enhanced cell migration, and accelerated tumor development.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Ganesh Kumar Barik, Osheen Sahay, Anindya Mukhopadhyay, Rajesh Kumar Manne, Sehbanul Islam, Anup Roy, Somsubhra Nath, Manas Kumar Santra
Summary: This study reveals that FBXW2 functions as a tumor suppressor and AKT kinase plays a key role in the oncogenic function of Moesin in breast cancer. AKT phosphorylates Moesin at a specific site, preventing its degradation by FBXW2 and thus contributing to the role of Moesin in breast cancer progression. Additionally, Moesin also acts as an upstream regulator of the oncogene SKP2, stabilizing it by preventing its degradation.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ragini Yeeravalli, Komal Kaushik, Amitava Das
Summary: The study demonstrates the crucial role of PDGFR beta in regulating EMT in breast CSCs, leading to increased physiological and molecular properties in breast cancer cells and CSCs with PDGFR beta overexpression. Mechanistically, PDGFR beta overexpression induces FAK and Src activation, promoting cell migration and invasion. Stable silencing of PDGFR beta disrupts these biological phenomena and could be a potential therapeutic target for treating TNBC patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Gerardo Caruso, Aristide Nanni, Antonello Curcio, Giuseppe Lombardi, Teresa Somma, Letteria Minutoli, Maria Caffo
Summary: An increase in brain tumor incidence has been observed in industrialized countries, leading to interest in the study of heavy metals and their presence in the environment. Accumulation of heavy metals in the body could increase the risk of various pathologies, including brain tumors, through the generation of reactive oxygen species. Iron, cadmium, lead, nickel, chromium, and mercury levels are significantly elevated in patients with gliomas. This study aims to explore the correlation between heavy metals, their presence in the environment, and glioma tumorigenesis, and provides a literature review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zicheng Sun, Qiwei Jiang, Bing Gao, Xiaomei Zhang, Lang Bu, Lei Wang, Ying Lin, Wei Xie, Jie Li, Jianping Guo
Summary: The PI3K-AKT signaling pathway is frequently dysregulated and hyperactivated in breast cancer. Mass spectrometry-based analyses revealed that AKT binds and phosphorylates SIK1, leading to the activation of STAT3 and breast tumor growth. Targeting the JAK2-STAT3 axis could be a potential therapeutic strategy in AKT-driven breast cancer.
Article
Biochemistry & Molecular Biology
Jia Mai, Xiao-Dan Peng, Jun Tang, Tian Du, Yu-Hong Chen, Zi-Feng Wang, Hai-Liang Zhang, Jun-Hao Huang, Zhuo-Yan Zhong, Dong Yang, Zhi-Ling Li, Yun Huang, Gong-Kan Feng, Xiao-Feng Zhu, Rong Deng
Summary: The study reveals that the protein kinase AKT phosphorylates Mel18 to disrupt PRC1 complex formation, leading to the upregulation of oncogenes and promoting malignant behaviors. Prognostic models based on p-AKT and pT334-Mel18 are established for breast cancer patients, highlighting the potential of the AKT-Mel18-H2AK119ub axis as a novel prognostic biomarker and therapeutic target.
Article
Medicine, Research & Experimental
Jianhua Li, Jiamin Ma, Mengyu Li, Jing Tao, Jiayi Chen, Chengye Yao, Shanglong Yao
Summary: The study demonstrates that GYY4137 inhibits the activation of the NLRP3 inflammasome by blocking the PDGFR beta/Akt/NF-kappa B pathway, which contributes to the treatment of CLP-induced ALI in mice.
Article
Oncology
Qun Zhao, Jian Guo, Guizhen Wang, Yun Bi, Xinran Cheng, Yingying Liao, Shu Jin, Lian Li, Yang Guo, Longrui Pan, Xudong Zhang, Yan Tan, Guangbiao Zhou, Xianjun Yu
Summary: This study revealed that the inhibition of CXCL13 in colorectal cancer has a mitigating effect on disease progression by promoting intestinal tumorigenesis through the activation of the AKT signaling pathway. Intestinal microbiota translocation drives CXCL13 production in dendritic cells through the activation of NF-kappa B signaling. Inhibition of microbiota translocation reduces CXCL13 production and ameliorates intestinal tumorigenesis.
Article
Pathology
Fangning Pang, Wei He, Xuantong Liu, Zheng Zou, Weidong Wu, Yu Wang, Peng Yang, Bin Wen, Jinquan Jiang, Yunpeng Teng, Xinyu Yang, Ligang Chen, Qingge Jia, Mingyang Li, Jin Xu
Summary: This study found that PRKCH expression in glioma tissues was higher than in adjacent tissues and it is an independent prognostic factor, promoting poor prognosis and shorter survival in glioma patients. In addition, overexpression of PRKCH significantly increased stem cell properties and enhanced cell viability in glioma stem cells.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Jiang Zhu, Shiping He, Jie Du, Zhulin Wang, Wang Li, Xianxiong Chen, Wenqi Jiang, Duo Zheng, Guangyi Jin
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2015)
Article
Biochemistry & Molecular Biology
T. Xiao, J. J. Zhu, S. Huang, C. Peng, S. He, J. Du, R. Hong, X. Chen, A. M. Bode, W. Jiang, Z. Dong, D. Zheng
Article
Oncology
Duo Zheng, Ann M. Bode, Qing Zhao, Yong-Yeon Cho, Feng Zhu, Wei-Ya Ma, Zigang Dong
Article
Oncology
Duo Zheng, Yong-Yeon Cho, Andy T. Y. Lau, Jishuai Zhang, Wei-Ya Ma, Ann M. Bode, Zigang Dong
Article
Oncology
Ann M. Bode, Yong-Yeon Cho, Duo Zheng, Feng Zhu, Marna E. Ericson, Wei-Ya Ma, Ke Yao, Zigang Dong
Article
Biotechnology & Applied Microbiology
Lei Xie, Li-Yan Li, Duo Zheng, Yang-Min Xie, Xiu-E Xu, Li-Hua Tao, Lian-Di Liao, Ying-Hua Xie, Yin-Wei Cheng, Li-Yan Xu, En-Min Li
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Pharmacology & Pharmacy
Chenyang Xue, Wei Chen, Aiwu Yuan, Cheng Chen, Shuaihu Li, Kai Chen, Yang Zhao, Tian Xiao, Genze Shao, Yongdong Zou, Duo Zheng
Summary: Dezocine has been shown to inhibit proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, as well as induce apoptosis. The drug targets NAMPT, inhibiting its enzyme activity and leading to cellular NAD depletion, ultimately inhibiting cell proliferation. These findings suggest that Dezocine and NAMPT may serve as novel therapeutic targets for TNBC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chi Hin Wong, Chi Han Li, Joanna Hung Man Tong, Duo Zheng, Qifang He, Zhiyuan Luo, Ut Kei Lou, Jiatong Wang, Ka-Fai To, Yangchao Chen
Summary: Long non-coding RNA HOTAIR is overexpressed in multiple cancers and promotes tumor growth and metastasis. This study reveals that hypermethylation of intragenic exon CpG islands is correlated with HOTAIR expression, and methylation enhances the transcription elongation process of HOTAIR. Furthermore, targeting the oncogenic CDK7-CDK9-H3K4me3 axis downregulates HOTAIR expression and inhibits cell growth in many cancers.
Article
Cell Biology
Yongjie Xu, Yumeng Hu, Tao Xu, Kaowen Yan, Ting Zhang, Qin Li, Fen Chang, Xueyuan Guo, Jingyu Peng, Mo Li, Min Zhao, Hongying Zhen, Luzheng Xu, Duo Zheng, Li Li, Genze Shao
Summary: The study reveals that RNF8 is overexpressed in lung cancer and promotes cancer cell proliferation and resistance to chemotherapy. Therefore, RNF8 could be a very promising target in precision medicine for lung cancer.
Article
Oncology
Wenhan Yang, Kaiping Gao, Youhui Qian, Yongyi Huang, Qin Xiang, Cheng Chen, Qianqian Chen, Yiling Wang, Fuyuan Fang, Qihan He, Siqi Chen, Juan Xiong, Yangchao Chen, Ni Xie, Duo Zheng, Rihong Zhai
Summary: This study identifies a new oncogenic tRF, AS-tDR-007333, and uncovers a novel mechanism by which AS-tDR-007333 promotes the malignancy of NSCLC cells through the HSPB1-MED29 and ELK4-MED29 axes. AS-tDR-007333 has the potential to serve as a diagnostic or prognostic marker and therapeutic target for NSCLC.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Li Li, Cheng Chen, Qin Xiang, Songqing Fan, Tian Xiao, Yangchao Chen, Duo Zheng
Summary: TRPV1 is overexpressed in non-small-cell lung cancer, and its overexpression leads to increased resistance to DDP and 5-FU. TRPV1 mediates chemoresistance by increasing drug efflux, enhancing DNA repair pathways, and promoting cell survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li Li, Cheng Chen, Chengyao Chiang, Tian Xiao, Yangchao Chen, Yongxiang Zhao, Duo Zheng
Summary: TRPV1, a transmembrane protein activated by various stimuli, is associated with pain transmission and has been found to play crucial roles in cancer tumorigenesis and development. Studies have shown direct links between TRPV1 and cancer cell proliferation, death, and metastasis, with TRPV1 being a potential target for treating diseases. Research is focusing on the effects of TRPV1 agonists/antagonists on cancer, with both types of drugs potentially having anti-cancer effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Chengyao Chiang, Min Zhang, Dian Wang, Tian Xiao, Lizhi Zhu, Kai Chen, Junrong Huang, Jingying Huang, Jiang Zhu, Li Li, Cheng Chen, Yangchao Chen, Hongyi Hu, Wenqi Jiang, Yongdong Zou, Ting Wang, Duo Zheng
Review
Oncology
Guanqun Huang, Shuaihu Li, Nuo Yang, Yongdong Zou, Duo Zheng, Tian Xiao