Runx2-smad signaling impacts the progression of tumor-induced bone disease

Integrin  v 6 Promotes an Osteolytic Program in Cancer Cells by Upregulating MMP2

(2014) A. Dutta et al.   CANCER RESEARCH

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells

(2013) Erin M McCoy et al.   BMC CANCER

Extracellular matrix protein fibronectin induces matrix metalloproteinases in human prostate adenocarcinoma cells PC-3

(2013) Sekhar Pal et al.   CELL COMMUNICATION AND ADHESION

Understanding and Targeting Osteoclastic Activity in Prostate Cancer Bone Metastases

(2013) J.L. Sottnik et al.   CURRENT MOLECULAR MEDICINE

Activation of the Wnt Pathway through AR79, a GSK3  Inhibitor, Promotes Prostate Cancer Growth in Soft Tissue and Bone

(2013) Y. Jiang et al.   MOLECULAR CANCER RESEARCH

Cancer-associated bone disease

(2013) R. Rizzoli et al.   OSTEOPOROSIS INTERNATIONAL

Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells

(2012) Dongxuan Jia et al.   BMC CANCER

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

(2012) Tara Karnezis et al.   CANCER CELL

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis

(2012) Aditi Gupta et al.   Molecular Cancer

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells

(2012) K E Luker et al.   ONCOGENE

Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells

(2012) Tatiana M. Tilli et al.   PROSTATE

Transcriptional repression of RUNX2 is associated with aggressive clinicopathological outcomes, whereas nuclear location of the protein is related to metastasis in prostate cancer

(2012) S J Yun et al.   PROSTATE CANCER AND PROSTATIC DISEASES

FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

(2011) H. Zhang et al.   CANCER RESEARCH

MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

(2011) Giuditta Viticchiè et al.   CELL CYCLE

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target

(2011) Jiarong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Metastatic bone disease: Role of transcription factors and future targets

(2010) Jitesh Pratap et al.   BONE

Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis

(2010) Conor C. Lynch   BONE

Effects of Anti-VEGF Treatment Duration on Tumor Growth, Tumor Regrowth, and Treatment Efficacy

(2010) A. Bagri et al.   CLINICAL CANCER RESEARCH

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

(2010) Sanjeev K Baniwal et al.   Molecular Cancer

Bone sialoprotein stimulates focal adhesion-related signaling pathways: Role in migration and survival of breast and prostate cancer cells

(2009) Jonathan A.R. Gordon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Runx2 regulates survivin expression in prostate cancer cells

(2009) Minyoung Lim et al.   LABORATORY INVESTIGATION

Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions

(2009) J Akech et al.   ONCOGENE

Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

(2008) J. Pratap et al.   CANCER RESEARCH

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal

(2008) Amjad Javed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY