Article
Biotechnology & Applied Microbiology
Yixiu Zhong, Junxiao Wei, Weicheng Song, Qi Wang, Zhiwen Zhang, Hui Liu, Xi Chen, Xiaowen Huang, Kang Zeng
Summary: In this study, we aimed to explore the immune landscape and biomarkers of Condyloma acuminata (CA) for prevention and treatment. We identified differentially expressed genes (DEGs) and hub genes associated with CA and investigated the microRNA (miRNA) involved. The over-expression of miR-146a-5p was found to reduce cell proliferation and migration in CA, induce apoptosis, and affect immune cell infiltration levels.
Review
Oncology
Haigang Ding, Juan Zhang, Feng Zhang, Yan Xu, Yijun Yu, Wenqing Liang, Qingping Li
Summary: Cervical cancer is a common tumor in women, and traditional treatments can cure early-stage cancer. However, advanced and metastatic stages of cervical cancer are more challenging to treat. With the emergence of novel treatments, the survival rate of patients with advanced cervical cancer has significantly increased. Monotherapy with anti-HPV vaccine ISA101 does not affect tumor growth and progression in HPV-induced cervical cancer patients, therefore combining ISA101 with immune checkpoint blockers or other immunotherapeutic approaches may be more effective.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Csaba Szabo
Summary: H2S, previously known as a toxic gas and environmental hazard, has been found to play multiple biological regulatory roles in mammalian cells as an endogenously produced gaseous transmitter. Its effects in mitochondria serve as an electron transport stimulator in physiological concentrations, particularly significant in cancer cells where it helps maintain mitochondrial organization and DNA repair.
Article
Multidisciplinary Sciences
Ralph T. H. Leijenaar, Sean Walsh, Akshayaa Vaidyanathan, Lorenzo Aliboni, Victoria Lopez Sanchez, Michelle Leech, Ronan Joyce, Charles Gillham, Frederic Kridelka, Roland Hustinx, Denis Danthine, Mariaelena Occhipinti, Wim Vos, Julien Guiot, Philippe Lambin, Pierre Lovinfosse
Summary: The paper validates a previously validated CT-based radiomic signature developed for predicting HPV status in oropharyngeal cancer in the context of anal cancer. A dataset of 59 patients from two different centers was collected for validation in anal cancer. The results show that the AUC in anal cancer is 0.68 [95% CI (0.32-1.00)] with an F1 score of 0.78. This study demonstrates that the radiomic signature has the potential to identify HPV status across multiple cancers and could serve as a CT imaging biomarker of p16 status.
SCIENTIFIC REPORTS
(2023)
Article
Optics
Benjamin Lochocki, Max V. Verweg, Jeroen J. M. Hoozemans, Johannes F. de Boer, Lyubov V. Amitonova
Summary: This study demonstrates high-resolution imaging of subcellular structures in the living brain using a single multimode fiber probe and advanced wavefront engineering techniques. The application of raster-scan imaging and speckle-based compressive imaging significantly reduces acquisition time while maintaining high spatial resolution. The accumulation of age-related pigment lipofuscin in Alzheimer's disease human brain has been successfully visualized with improved speed.
Article
Oncology
William Chu, Amandeep Taggar, Yee Ung, Kelvin K. W. Chan, Craig C. C. Earle, Aliaksandr Karotki, Mark Pasetka, Joe Presutti, John Wong, Liying Zhang, C. Shun Wong
Summary: This study reports a planned interim analysis of a prospective registry study that tailors chemoradiation for anal cancer according to HPV status. De-escalation of CRT for HPV+ anal cancer may result in decreased acute toxicities and similar cancer outcomes compared to standard CRT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Camila Cimadamore-Werthein, Stephany Jaiquel Baron, Martin S. King, Roger Springett, Edmund R. S. Kunji
Summary: The mitochondrial ADP/ATP carrier plays a crucial role in oxidative phosphorylation by importing ADP into the mitochondrial matrix and exporting ATP. Recent studies have revealed that the carrier functions as a monomer with a single substrate binding site and operates with a ping-pong kinetic mechanism. These findings reconcile the discrepancy between the previous assumptions and provide insights into the alternating access mechanism of the carrier.
Article
Medicine, Research & Experimental
Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite, Vitali Moiseenko
Summary: This study evaluated if HPV status serves as an independent predictor of dysphagia outcomes for head and neck cancer patients undergoing radiotherapy. The results indicated that cancer type, smoking history, and mean dose were consistently selected as covariates for predicting early dysphagia outcomes. HPV status was seldom selected and oropharyngeal cancer patients were found to have an increased risk of high-grade dysphagia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Annalisa Palmieri, Dorina Lauritano, Agnese Pellati, Luca Scapoli, Claudio Arcuri, Luigi Baggi, Roberto Gatto, Francesco Carinci
Summary: Oral cavity and oropharynx cancer associated with human papilloma virus infection is a serious public health problem, especially in young people continuously exposed to the virus. Studies showed newly acquired oral oncogenic HPV infections in healthy population are rare, but more research is needed to clarify HPV infection prevalence and guide prevention efforts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Summary: This review explores the use of molecular and viral biomarkers for early detection and prediction of HPV-induced cervical lesions that may progress to CC. The study found an association between high-risk HPV-induced cervical lesions and overexpression of markers of oxidative DNA damage and other proteins, as well as dysregulation of certain markers and high methylation levels in advanced cervical lesions, indicating a higher risk of progression to CC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Dorian Culie, Quentin Lisan, Charlotte Leroy, Anouchka Modesto, Renaud Schiappa, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Bruno Guelfucci, Alain Bizeau, Sebastien Vergez, Agnes Dupret-Bories, Renaud Garrel, Nicolas Fakhry, Laure Santini, Benjamin Lallemant, Guillaume Chambon, Anne Sudaka, Frederic Peyrade, Esma Saada-Bouzid, Karen Benezery, Florence Jourdan-Soulier, Francoise Chapel, Anne Sophie Ramay, Pascal Roger, Thibault Galissier, Valerie Coste, Aicha B. Lakdar, Stephane Temam, Phillipe Gorphe, Joanne Guerlain, Alexandre Bozec, Haitham Mirghani
Summary: The treatment outcomes and patterns of disease recurrence in oropharyngeal cancer patients do not differ significantly between p16-positive and p16-negative patients, except for the initial site of recurrence.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Rosa Vona, Anna Maria Mileo, Paola Matarrese
Summary: Mitochondria are constantly rearranging dynamic networks that play key roles in cellular functions like metabolism regulation, energy production, calcium homeostasis, reactive oxygen species production, and programmed cell death. Their dynamics, including fusion, fragmentation, trafficking, biogenesis, and mitophagy, are actively involved in tumorigenesis and metabolic plasticity, contributing to tumor progression. Understanding the molecular mechanisms regulating mitochondrial dynamics can potentially lead to new molecular targets in cancer therapy.
Article
Pharmacology & Pharmacy
Ali Mokhtar Mahmoud, Magdalena Kostrzewa, Viviana Marolda, Marianna Cerasuolo, Federica Maccarinelli, Daniela Coltrini, Sara Rezzola, Arianna Giacomini, Maria Pina Mollica, Andrea Motta, Debora Paris, Antonio Zorzano, Vincenzo Di Marzo, Roberto Ronca, Alessia Ligresti
Summary: Despite advancements in diagnosis and interventions, hormone refractory prostate cancer (HRPC) remains a challenge in prostate cancer. Metabolic reprogramming plays a crucial role in PCa oncogenesis and resistance. Cannabidiol (CBD) and cannabigerol (CBG) can suppress HRPC development and show anti-tumor effects in TRAMP mice, even when resistant to enzalutamide.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Irena Audzeyenka, Patrycja Rachubik, Marlena Typiak, Tomasz Kulesza, Anna Topolewska, Dorota Rogacka, Stefan Angielski, Moin A. Saleem, Agnieszka Piwkowska
Summary: High glucose impairs mitochondrial dynamics and turnover in glomeruli and podocytes, leading to decreased energy metabolism and potential development of diabetic kidney disease.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai
Summary: This study identified three mitochondrial genes as potential prognostic biomarkers for colorectal cancer, revealing their association with poor prognosis and involvement in carcinogenesis. The integrated analyses of transcriptomic and proteomic data shed light on the down-regulation of mitochondrial genes and their potential role in CRC progression, suggesting HIGD1A, SUCLG2, and SLC25A24 as promising biomarkers for patient stratification and treatment selection.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Virology
Surendra Sharma, Karl Munger
JOURNAL OF VIROLOGY
(2020)
Review
Microbiology
Surendra Sharma, Karl Munger
Article
Virology
Joshua Hatterschide, Alexis C. Brantly, Miranda Grace, Karl Munger, Elizabeth A. White
JOURNAL OF VIROLOGY
(2020)
Article
Microbiology
Surendra Sharma, Karl Munger
Article
Microbiology
Tao Wei, Miranda Grace, Aayushi Uberoi, James C. Romero-Masters, Denis Lee, Paul F. Lambert, Karl Munger
Summary: The E7 protein of papillomavirus interacts with the host cell's RB1 protein to play a critical role in papilloma formation. Experimental infection with a mutant MmuPV1 virus expressing an RB1 binding-defective E7 mutant resulted in smaller and fewer papillomas with delayed onset.
Article
Virology
Dayna Sais, Karl Munger, Nham Tran
Summary: Human Papillomavirus type 16 plays a significant role in the development of Head and Neck cancers by targeting protein coding genes and miRNAs. Recent studies have used interactomes to investigate the impact of HPV16 on miRNAs, providing insights into its global regulation of the disease.
CURRENT OPINION IN VIROLOGY
(2021)
Review
Oncology
Sharon Changshan Wu, Karl Munger
Summary: Cancer/testis antigens show potential as therapeutic targets and prognostic biomarkers in head and neck squamous cell carcinoma, warranting further study to elucidate their role in the pathogenesis of these cancers. Their differential expression in HPV-positive HNSCC may mechanistically contribute to the genesis and clinical characteristics of these cancers, making them attractive targets for immunotherapies. These antigens, historically linked to diverse cancers, are increasingly implicated in various hallmarks of cancer, suggesting potential as cancer drivers.
Review
Virology
James C. Romero-Masters, Paul F. Lambert, Karl Munger
Summary: HPVs cause a wide range of human diseases, from benign warts to malignant cancers. The discovery of a murine papillomavirus that infects laboratory mice provides an opportunity to study HPV-induced malignant diseases. The E6 and E7 proteins encoded by high-risk HPVs contribute to HPV-induced cancers in multiple ways.
Editorial Material
Virology
Felicia Goodrum, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, Lawrence Banks, Sumita Bhaduri-McIntosh, Deepta Bhattacharya, Daniel Blanco-Melo, David Bloom, Adrianus Boon, Steeve Boulant, Curtis Brandt, Andrew Broadbent, Christopher Brooke, Craig Cameron, Samuel Campos, Patrizia Caposio, Gary Chan, Anna Cliffe, John Coffin, Kathleen Collins, Blossom Damania, Michael Daugherty, Kari Debbink, James DeCaprio, Terence Dermody, Jimmy Dikeakos, Daniel DiMaio, Rhoel Dinglasan, W. Paul Duprex, Rebecca Dutch, Nels Elde, Michael Emerman, Lynn Enquist, Bentley Fane, Ana Fernandez-Sesma, Michelle Flenniken, Lori Frappier, Matthew Frieman, Klaus Frueh, Michaela Gack, Marta Gaglia, Tom Gallagher, Denise Galloway, Adolfo Garcia-Sastre, Adam Geballe, Britt Glaunsinger, Stephen Goff, Alexander Greninger, Meaghan Hancock, Eva Harris, Nicholas Heaton, Mark Heise, Ekaterina Heldwein, Brenda Hogue, Stacy Horner, Edward Hutchinson, Joseph Hyser, William Jackson, Robert Kalejta, Jeremy Kamil, Stephanie Karst, Frank Kirchhoff, David Knipe, Timothy Kowalik, Michael Lagunoff, Laimonis Laimins, Ryan Langlois, Adam Lauring, Benhur Lee, David Leib, Shan-Lu Liu, Richard Longnecker, Carolina Lopez, Micah Luftig, Jennifer Lund, Balaji Manicassamy, Grant McFadden, Michael McIntosh, Andrew Mehle, W. Allen Miller, Ian Mohr, Cary Moody, Nathaniel Moorman, Anne Moscona, Bryan Mounce, Joshua Munger, Karl Muenger, Eain Murphy, Mojgan Naghavi, Jay Nelson, Christopher Neufeldt, Janko Nikolich, Christine O'Connor, Akira Ono, Walter Orenstein, David Ornelles, Jing-hsiung Ou, John Parker, Colin Parrish, Andrew Pekosz, Philip Pellett, Julie Pfeiffer, Richard Plemper, Stephen Polyak, John Purdy, Dohun Pyeon, Miguel Quinones-Mateu, Rolf Renne, Charles Rice, John Schoggins, Richard Roller, Charles Russell, Rozanne Sandri-Goldin, Martin Sapp, Luis Schang, Scott Schmid, Stacey Schultz-Cherry, Bert Semler, Thomas Shenk, Guido Silvestri, Viviana Simon, Gregory Smith, Jason Smith, Katherine Spindler, Megan Stanifer, Kanta Subbarao, Wesley Sundquist, Mehul Suthar, Troy Sutton, Andrew Tai, Vera Tarakanova, Benjamin tenOever, Scott Tibbetts, Stephen Tompkins, Zsolt Toth, Koenraad van Doorslaer, Marco Vignuzzi, Nicholas Wallace, Derek Walsh, Michael Weekes, Jason Weinberg, Matthew Weitzman, Sandra Weller, Sean Whelan, Elizabeth White, Bryan Williams, Christiane Wobus, Scott Wong, Andrew Yurochko
Summary: Viruses have posed various challenges for humanity, but virology research has played a crucial role in reducing disease burden. The COVID-19 pandemic has brought unprecedented attention to the field, with concerns about conducting research on human pathogens and uncertainties regarding the origin of SARS-CoV-2. This has led to public confusion and misguided criticism of virology. This article aims to promote rational discourse by explaining gain-of-function approaches, discussing the possible origins of SARS-CoV-2, and outlining the regulatory structures in the United States that oversee virological research. The intention is to provide guidance to policymakers and maintain evidence-based discourse to address public concern and support vital virology research.
JOURNAL OF VIROLOGY
(2023)
Review
Virology
Warda Arman, Karl Munger
Summary: Papillomaviruses are ubiquitous epitheliotropic viruses that can establish persistent infections in mitotically active basal epithelial cells. To enable persistent infections, these viruses need to retain the basal cell identity and hold the cells in a replication-competent state. They achieve this by targeting the DNA damage and repair machinery for viral genome synthesis. Understanding the cellular factors targeted by papillomaviruses may aid in the development of antivirals.
Editorial Material
Microbiology
Felicia Goodrum, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, Lawrence Banks, Sumita Bhaduri-McIntosh, Deepta Bhattacharya, Daniel Blanco-Melo, David Bloom, Adrianus Boon, Steeve Boulant, Curtis Brandt, Andrew Broadbent, Christopher Brooke, Craig Cameron, Samuel Campos, Patrizia Caposio, Gary Chan, Anna Cliffe, John Coffin, Kathleen Collins, Blossom Damania, Michael Daugherty, Kari Debbink, James DeCaprio, Terence Dermody, Jimmy Dikeakos, Daniel DiMaio, Rhoel Dinglasan, W. Paul Duprex, Rebecca Dutch, Nels Elde, Michael Emerman, Lynn Enquist, Bentley Fane, Ana Fernandez-Sesma, Michelle Flenniken, Lori Frappier, Matthew Frieman, Klaus Frueh, Michaela Gack, Marta Gaglia, Tom Gallagher, Denise Galloway, Adolfo Garcia-Sastre, Adam Geballe, Britt Glaunsinger, Stephen Goff, Alexander Greninger, Meaghan Hancock, Eva Harris, Nicholas Heaton, Mark Heise, Ekaterina Heldwein, Brenda Hogue, Stacy Horner, Edward Hutchinson, Joseph Hyser, William Jackson, Robert Kalejta, Jeremy Kamil, Stephanie Karst, Frank Kirchhoff, David Knipe, Timothy Kowalik, Michael Lagunoff, Laimonis Laimins, Ryan Langlois, Adam Lauring, Benhur Lee, David Leib, Shan-Lu Liu, Richard Longnecker, Carolina Lopez, Micah Luftig, Jennifer Lund, Balaji Manicassamy, Grant McFadden, Michael McIntosh, Andrew Mehle, W. Allen Miller, Ian Mohr, Cary Moody, Nathaniel Moorman, Anne Moscona, Bryan Mounce, Joshua Munger, Karl Muenger, Eain Murphy, Mojgan Naghavi, Jay Nelson, Christopher Neufeldt, Janko Nikolich, Christine O'Connor, Akira Ono, Walter Orenstein, David Ornelles, Jing-hsiung Ou, John Parker, Colin Parrish, Andrew Pekosz, Philip Pellett, Julie Pfeiffer, Richard Plemper, Stephen Polyak, John Purdy, Dohun Pyeon, Miguel Quinones-Mateu, Rolf Renne, Charles Rice, John Schoggins, Richard Roller, Charles Russell, Rozanne Sandri-Goldin, Martin Sapp, Luis Schang, Scott Schmid, Stacey Schultz-Cherry, Bert Semler, Thomas Shenk, Guido Silvestri, Viviana Simon, Gregory Smith, Jason Smith, Katherine Spindler, Megan Stanifer, Kanta Subbarao, Wesley Sundquist, Mehul Suthar, Troy Sutton, Andrew Tai, Vera Tarakanova, Benjamin tenOever, Scott Tibbetts, Stephen Tompkins, Zsolt Toth, Koenraad van Doorslaer, Marco Vignuzzi, Nicholas Wallace, Derek Walsh, Michael Weekes, Jason Weinberg, Matthew Weitzman, Sandra Weller, Sean Whelan, Elizabeth White, Bryan Williams, Christiane Wobus, Scott Wong, Andrew Yurochko
Summary: Viruses have posed numerous challenges to humanity, including respiratory infection, cancer, neurological impairment, and immunosuppression. Although virology research has made significant progress in combating these diseases through vaccines and antivirals, the COVID-19 pandemic has brought unprecedented attention to the field, with concerns regarding the safe conduct of research on human pathogens and uncertainties over the origins of SARS-CoV-2. This article aims to promote rational discourse by explaining gain-of-function approaches in science, discussing the possible origins of SARS-CoV-2, and outlining the current regulatory structures in place for virological research in the United States. The goal is to aid policymakers in navigating these controversial issues and ensure balanced, evidence-based discussions that support vital virology research.
Article
Microbiology
James C. Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A. White, Karl Munger, Paul F. Lambert
Summary: Human papillomaviruses (HPVs) contribute to 5% of human cancers. Murine papillomavirus (MmuPV1) provides a powerful tool to study the roles of papillomavirus genes in pathogenesis arising from a natural infection. In this study, we confirmed the interaction between MmuPV1 E7 and PTPN14, and found that the intact PTPN14 binding site is essential for MmuPV1 E7 to promote virus-induced pathogenesis and delay epithelial differentiation.
Article
Microbiology
James C. Romero-Masters, Laura K. Muehlbauer, Mitchell Hayes, Miranda Grace, Evgenia Shishkova, Joshua J. Coon, Karl Munger, Paul F. Lambert
Summary: The E6 protein encoded by MmuPV1 has potent oncogenic activities in mouse keratinocytes, including inhibition of differentiation, promotion of proliferation, and decreased dependence on growth factors. Proteomic and transcriptomic analyses revealed that MmuPV1 E6 upregulates the expression of proteins related to cellular proliferation and other cancer hallmarks. These findings indicate that MmuPV1 E6 is a major driver of MmuPV1-induced pathogenesis.
Article
Microbiology
Sharon C. Wu, Miranda Grace, Karl Munger
Summary: Infections with ss-genus human papillomaviruses can cause skin lesions and potentially contribute to the development of squamous cell carcinomas. These viruses use various mechanisms to inhibit epithelial cell differentiation, allowing them to establish and maintain long-term infections in the basal-like epithelial cells.
Article
Cell Biology
Dimitra Pouli, Hong-Thao Thieu, Elizabeth M. Genega, Laura Baecher-Lind, Michael House, Brian Bond, Danielle M. Roncari, Megan L. Evans, Francisca Rius-Diaz, Karl Munger, Irene Georgakoudi
CELL REPORTS MEDICINE
(2020)