Article
Biochemistry & Molecular Biology
Akram Ghantous, Alexei Novoloaca, Liacine Bouaoun, Cyrille Cuenin, Marie-Pierre Cros, Ya Xu, Hector Hernandez-Vargas, Momodou K. Darboe, Andrew M. Prentice, Sophie E. Moore, Yun Yun Gong, Zdenko Herceg, Michael N. Routledge
Summary: The study provides further evidence that exposure to aflatoxin in early childhood may impact DNA methylation. Differentially methylated CpG sites and regions associated with aflatoxin exposure were found, affecting gene expression and influencing pathways related to inflammation, signaling, and growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joao Victor Batista da Silva, Carlos Augusto Fernandes de Oliveira, Leandra Naira Zambelli Ramalho
Summary: Aflatoxin B1 (AFB1) is a mycotoxin with mutagenic and carcinogenic potential, causing developmental abnormalities in embryos and fetuses in animals and humans, including skeletal malformations, visceral anomalies, and low birth weight.
Article
Toxicology
Andrea Gerdemann, Benedikt Cramer, Gisela H. Degen, Jannik Veerkamp, Georgia Guenther, Wiebke Albrecht, Matthias Behrens, Melanie Esselen, Ahmed Ghallab, Jan G. Hengstler, Hans-Ulrich Humpf
Summary: This study compared the metabolism of AFB(1) in mouse, rat, and human primary hepatocytes, revealing differences in toxification and detoxification mechanisms. Mouse hepatocytes exhibited the fastest metabolism, mainly forming aflatoxin P-1, while human cells produced higher levels of aflatoxin M-1. In addition to glutathione conjugation, phase I metabolism was found to play an important role in AFB(1) detoxification.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pawel Jaruga, Rachana Tomar, Melis Kant, Vladimir Vartanian, Benjamin Sexton, Carmelo J. Rizzo, Robert J. Turesky, Michael P. Stone, Miral Dizdaroglu, R. Stephen Lloyd
Summary: Exposure to Aflatoxin B-1 (AFB(1)) through contaminated food is a major cause of liver cancer worldwide. Hepatitis B viral infections in the liver enhance the carcinogenic effect of AFB(1) exposure. The formation of AFB(1)-N7-Gua and AFB(1)-FapyGua adducts in DNA, resulting from the reaction between AFB(1) and N7-guanine, is critically important for the development and prevention of AFB1-induced liver cancer. Liquid chromatography-tandem mass spectrometry with stable isotope-labeled analogues of AFB(1)-N7-Gua and AFB(1)-FapyGua as internal standards is the most accurate and sensitive method for the identification and quantification of these biomarkers.
Article
Food Science & Technology
Rouaa Daou, Maha Hoteit, Khlood Bookari, Majid Al-Khalaf, Sahar Nahle, Ayoub Al-Jawaldeh, Mohamad Koubar, Samah Doumiati, Andre El Khoury
Summary: This study investigated the contamination levels of Aflatoxin M1 (AFM1) in infant powdered formula brands and Aflatoxin B-1 (AFB1) in children's food brands, and assessed the estimated daily intake (EDI), hazard quotient (HQ), and margin of exposure (MOE) of AFM1 in Lebanese infants. The results showed that some infant powdered formula samples exceeded the maximum tolerable limit set by the European commission, indicating a high risk of AFM1 exposure for infants in Lebanon.
Article
Biochemical Research Methods
Marie Roser, David Beal, Camille Eldin, Leslie Gudimard, Fanny Caffin, Fanny Gros-Desormeaux, Daniel Leonco, Francois Fenaille, Christophe Junot, Christophe Pierard, Thierry Douki
Summary: This study aimed to identify new biomarkers of exposure to sulfur mustard (SM) and validate their detectability in various models and body fluids. The results demonstrated that N7Gua-CEES, glutathione, and cysteine conjugates of 2-chloroethyl ethyl sulfide (CEES) were easily quantifiable in different models and plasma, showing promising potential for application in toxicological studies related to SM.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Toxicology
Hansruedi Glatt, Wolfram Engst, Simone Florian, Monika Schreiner, Chimgee Baasanjav-Gerber
Summary: Research has found that consuming Brassica vegetables can lead to the formation of DNA adducts in animal models. These adducts can be attributed to specific phytochemicals. Steaming the vegetables may result in higher levels of adducts in the large intestine due to inactivation of the enzyme responsible for activating the phytochemicals.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
William P. Watson, Tony Munter, Bernard T. Golding
Summary: Vitamin B12 acts as a partner for enzymatic reactions in humans and its deficiency may increase the risk of neurological illnesses, heart disease and cancer. This study investigated the effect of vitamin B12 on the genotoxicity caused by styrene oxide, a metabolite of styrene. The results suggest that vitamin B12 can protect DNA from genotoxic effects, potentially reducing the risk of carcinogenesis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Public, Environmental & Occupational Health
Kathy S. Xue, Lili Tang, Chwan Li Shen, Bradley H. Pollock, Fernando Guerra, Timothy D. Phillips, Jia-Sheng Wang
Summary: The study showed a significant increase in serum AFB(1)-lysine adduct levels in populations from East and West Texas over the past decade, indicating a shift in AF contamination pattern in the state and suggesting the need for further research on potential risk assessment.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Plant Sciences
Zixia Hu, Yanjia Zhao, Yi Yang, Wei Li, Rong Tan, Linhua Zhao, Xiaolin Tong, Ying Peng, Jiang Zheng
Summary: In this study, a mechanism-based biomarker based on plasma protein adduction was developed to determine the exposure to Dioscorea bulbifera L. (DBL) and predict DBL-induced hepatotoxicity. The results showed that the adduction of DBL metabolite to plasma proteins correlated well with the exposure of DBL in rats, making it a potential biomarker for diagnosing DBL-induced liver injury and an indicator for DBL medication plans.
Article
Microbiology
Tatiana Ermi, Carmen Vallin, Ana Gabriela Regalado Garcia, Moises Bravo, Ismaray Fernandez Cordero, Holly Anne Martin, Mario Pedraza-Reyes, Eduardo Robleto
Summary: The study examined the impact of non-B DNA on mutagenesis in Bacillus subtilis and found that sequences predicted to form non-B DNA structures promoted mutagenesis in stationary-phase cells. Additionally, the transcription-coupled repair factor Mfd was shown to promote mutagenesis at these predicted structures, providing insights into mechanisms underlying genetic instability in stressed bacterial cells.
Article
Environmental Sciences
Jose F. Herrera-Moreno, Guadalupe Estrada-Gutierrez, Haotian Wu, Tessa R. Bloomquist, Maria Jose Rosa, Allan C. Just, Hector Lamadrid-Figueroa, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: This study aimed to investigate the associations of prenatal lead exposures with telomere length and DNA-methylation-based predictors of age in cord blood, but no significant associations were found.
ENVIRONMENTAL RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Rafael Mora-Medina, Antonio Jesus Lora-Benitez, Ana Maria Molina-Lopez, Nahum Ayala-Soldado, Rosario Moyano-Salvago
Summary: In recent years, there has been a growing concern about milk pollution by aflatoxin M1 due to the increasing prevalence of aflatoxins in animal feeding and dairy product consumption. A study was conducted to determine the transfer of aflatoxin B1 into milk and its effects on production and serological parameters in goats. Goats were exposed to different doses of aflatoxin B1 for 31 days and the concentration of aflatoxin M1 in milk was found to significantly increase with the amount of aflatoxin B1 ingested. However, the ingested amount did not affect the aflatoxin M1 carryover, indicating a certain resistance of goats to the effects of aflatoxin B1.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Environmental Sciences
Yiju Zhang, Qiao Wang, Yaoran Li, Jun Cheng, Xinyu Chen, Yu Zhang
Summary: This study developed a rapid and sensitive method for analyzing two DNA adducts induced by acrylamide exposure, and found that catechins can effectively inhibit the formation of these adducts.
Article
Environmental Sciences
Yingya Zhao, Pengpeng Wang, Yuhan Zhou, Bin Xia, Qingyang Zhu, Wenzhen Ge, Jialin Li, Huijing Shi, Xirong Xiao, Yunhui Zhang
Summary: This study examined the impact of prenatal PM2.5 exposure on fetal growth and placental epigenetic mechanisms in Chinese women. Results showed that increased PM2.5 exposure was associated with reduced fetal growth characteristics and aberrant changes in placental DNA methylation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)