IL-1β inhibits self-renewal capacity of dormant CD34+/CD38−acute myelogenous leukemia cellsin vitroandin vivo

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

(2012) J. J. Trowbridge et al.   GENES & DEVELOPMENT

CD34+/CD38−acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells

(2012) Chie Nishioka et al.   INTERNATIONAL JOURNAL OF CANCER

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells

(2011) Lena Vockentanz et al.   CELL CYCLE

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

(2011) Luisa Cimmino et al.   Cell Stem Cell

Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia

(2011) Takayuki Ikezoe et al.   INTERNATIONAL JOURNAL OF CANCER

Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein

(2011) A S M Yong et al.   LEUKEMIA

Self-Renewal of Leukemia Stem Cells in Friend Virus-Induced Erythroleukemia Requires Proviral Insertional Activation of Spi1 and Hedgehog Signaling but Not Mutation of p53

(2011) Shailaja Hegde et al.   STEM CELLS

The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity

(2010) C. J. V. Campbell et al.   BLOOD

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+/CD38− cells and sensitizes them to antileukemia agents

(2010) Takayuki Ikezoe et al.   INTERNATIONAL JOURNAL OF CANCER

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

(2010) Simone Radtke et al.   JOURNAL OF CELL SCIENCE

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene

(2010) C Nishioka et al.   LEUKEMIA

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Anthracycline Dose Intensification in Acute Myeloid Leukemia

(2009) Hugo F. Fernandez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

(2008) D. C. Taussig et al.   BLOOD

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

(2008) Richard F. Schlenk et al.   NEW ENGLAND JOURNAL OF MEDICINE