Review
Infectious Diseases
Samantha B. Shapiro, Cassandra Laurie, Mariam El-Zein, Eduardo L. Franco
Summary: This study synthesized the available evidence on the association between male circumcision and HPV infections in males and females. The results showed that male circumcision was associated with decreased odds of prevalent and incident HPV infections in males, as well as increased risk of clearing HPV infections. Additionally, females with circumcised partners were protected from HPV infection.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Stephanie M. Davis, Melissa A. Habel, Carel Pretorius, Teng Yu, Carlos Toledo, Timothy Farley, Geoffrey Kabuye, Julia Samuelson
Summary: Modeling study suggests that scaling up voluntary medical male circumcision (VMMC) could significantly reduce cervical cancer cases and deaths, particularly in settings with lower HPV vaccination coverage.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Public, Environmental & Occupational Health
Blanchard Mbay Iyemosolo, Tawanda Chivese, Tonya M. Esterhuizen
Summary: This study in a mining town in Rustenburg, South Africa shows that both medical and traditional circumcision can reduce the risk of STIs in high-risk populations, especially after adjusting for other factors.
Article
Immunology
Holly D. Mitchell, Tatiana Garcia Vilaplana, Sema Mandal, Natasha Ratna, Megan Glancy, Ammi Shah, Ruth Simmons, Celia Penman, Freja Kirsebom, Annastella Costella, Alison E. Brown, Hamish Mohammed, Valerie Delpech, Katy Sinka, Gwenda Hughes
Summary: Since the start of the coronavirus pandemic response in March 2020, there has been a decline in tests, vaccinations, diagnoses, and treatment initiations for sexual health, HIV, and viral hepatitis in England. The rapid shift towards online and outreach services during 2020 highlights the importance of evaluating the impact of these strategies on health inequalities.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Samantha B. Shapiro, Michel D. Wissing, Farzin Khosrow-Khavar, Mariam El-Zein, Ann N. Burchell, Pierre-Paul Tellier, Francois Coutlee, Eduardo L. Franco
Summary: In this longitudinal study, there was no strong evidence for a relationship between male circumcision and the prevalence, transmission, or clearance of human papillomavirus infections in males and females.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Mitch Matoga, Mina C. Hosseinipour, Sara Jewett, Irving F. Hoffman, Charles Chasela
Summary: Evidence on the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. Recent findings continue to strongly support the protective effect of male medical circumcision against acquisition and transmission of common sexually transmitted infections (STIs) such as herpes simplex virus type 2 (HSV-2), human papillomavirus (HPV), syphilis in heterosexual men and women, and bacterial vaginosis and trichomoniasis in women. More evidence is needed for men who have sex with men (MSM). This review supports policy recommendations for the protective benefits of VMMC against STIs.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Article
Microbiology
George Valasoulis, Abraham Pouliakis, Georgios Michail, Ioulia Magaliou, Christos Parthenis, Niki Margari, Christine Kottaridi, Aris Spathis, Danai Leventakou, Argyro-Ioanna Ieronimaki, Georgios Androutsopoulos, Periklis Panagopoulos, Alexandros Daponte, Sotirios Tsiodras, Ioannis G. Panayiotides
Summary: This study aimed to investigate the possible association of sexually transmitted bacterial infections (STIs) with cervical HPV infection. The findings suggested a correlation between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology, in a population with a high prevalence for STIs.
Article
Public, Environmental & Occupational Health
Morten Frisch, Jacob Simonsen
Summary: In the first national cohort study in Denmark, it was found that non-therapeutic male circumcision in infancy or childhood did not provide protection against HIV or other STIs in males up to age 36. In fact, circumcised males had a higher overall STI rate, particularly for anogenital warts and syphilis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kirsten Beyer, Simon Kasasa, Ronald Anguzu, Robert Lukande, Sarah Nambooze, Phoebe M. Amulen, Yuhong Zhou, Brendah Nansereko, Courtney Jankowski, Tonny Oyana, Danielle Savino, Kavanya Feustel, Henry Wabinga
Summary: This study geocoded cervical cancer data from Kampala, Uganda to create high-resolution disease maps, which can be used for cervical cancer prevention and control planning, and provide lessons for optimizing efforts in other low-resource settings.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Cell & Tissue Engineering
Kadi Lohmussaar, Rurika Oka, Jose Espejo Valle-Inclan, Milou H. H. Smits, Hila Wardak, Jeroen Korving, Harry Begthel, Natalie Proost, Marieke van de Ven, Onno W. Kranenburg, Trudy G. N. Jonges, Ronald P. Zweemer, Sebastiaan Veersema, Ruben van Boxtel, Hans Clevers
Summary: The study describes a long-term culturing protocol for cervical epithelia that generates 3D organoids recapitulating the two tissues of origin. By establishing a small biobank of tumoroids derived from patients, a potential role of the poorly characterized HPV30 subtype in carcinogenesis was revealed. This serves as an experimental platform for cervical (cancer) research and future personalized medicine approaches.
Article
Multidisciplinary Sciences
Marlieke de Fouw, Yael Stroeken, Ben Niwagaba, Mwalimu Musheshe, John Tusiime, Isingoma F. Sadayo, Ria F. Reis, Alexander Arnold Willem F. Peters, Jogchum Jan F. Beltman
Summary: This qualitative study aimed to understand the perspectives of males on cervical cancer screening and HPV vaccination in Western-Uganda. The study found that there were misconceptions about the causes of cervical cancer and limited knowledge about the preventative aspect of screening and vaccination among men. However, after being informed about cervical cancer, men were willing to support prevention for their wives and daughters. Therefore, active involvement of men in creating awareness is crucial to increase uptake and acceptance of prevention services.
Article
Immunology
Rosalyn E. Plotzker, Akanksha Vaidya, Utsav Pokharel, Elizabeth A. Stier
Summary: HPV is a common, highly transmissible STI. Low-risk strain infections cause most cases of AGWs, while high-risk strains, especially types 16 and 18, are responsible for the majority of cervical cancer and other less common types of cancers. Immunization and screening campaigns have shown promise in prevention, with significant declines in HPV-related diseases. However, efforts are needed to improve cervical screening and vaccine availability in regions with high disease burden, particularly in Sub-Saharan Africa and Melanesia. Additionally, research and advocacy are necessary to develop anal cancer screening strategies for high-risk populations.
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
(2023)
Review
Virology
Ehsan Ghasemian, Emma Harding-Esch, David Mabey, Martin J. Holland
Summary: The global incidence of sexually transmitted infections (STIs) remains high, with co-infections of multiple pathogens being prevalent. Chlamydia trachomatis (CT) is the most reported bacterial STI worldwide, co-infecting with viral and other bacterial STIs. This review provides an overview of the epidemiology of these co-infections and specifically focuses on the underlying mechanisms by which CT influences the transmission and infection dynamics of HIV and HSV. It also explores the complex relationship between CT and HPV infection.
Article
Medicine, General & Internal
Magda Orzechowska, Mateusz Cybulski, Elzbieta Krajewska-Kulak, Marek Sobolewski, Agnieszka Gniadek, Wiaczeslaw Niczyporuk
Summary: This study conducted a comparative analysis of sexually transmitted viral infections in Poland from 2010 to 2015, taking into account the country's administrative division. It found a declining trend in the incidence of genital herpes, with genital warts being the most frequent infection. The incidence of newly detected HIV infections appeared to be stable. The study also observed a correlation between the incidence rates and urbanization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yilu Zhou, Xiaoyu Shi, Jiaxin Liu, Lina Zhang
Summary: This article aims to summarize the role of different genotypes, multiple infections, especially viral load, in cervical precancerous lesions, in order to guide early intervention.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)