Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Massimo Claudio Fantini, Ilaria Guadagni
Summary: Patients with UC and CD have an increased risk of developing CRC, with inflammation playing a crucial role in the pathogenesis of CAC. Control of inflammation is pivotal to the prevention of CAC.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Medicine, General & Internal
Kenneth P. Batts, Mohamed Atwaibi, David I. Weinberg, Robert P. McCabe
Summary: The study suggests that IBD patients with serrated epithelial changes have a higher likelihood of developing dysplasia in affected areas, although the significance was not seen in multivariate analysis. One cancer case was found in each group of patients.
POSTGRADUATE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Medicine, General & Internal
Michael Stuerzl, Meik Kunz, Susanne M. Krug, Elisabeth Naschberger
Summary: Inflammatory bowel disease is a chronic inflammatory disorder with a rising incidence. Disease development involves the breakdown of the epithelial cell barrier, where blood vessels play a significant role in disease progression. The communication between the gut-vascular barrier and the epithelial barrier may contribute to the pathogenesis of IBD.
FRONTIERS IN MEDICINE
(2021)
Review
Surgery
Sara Lauricella, Silvia Fabris, Patricia Sylla
Summary: This study provides a summary of the incidence rate of colorectal cancer and advanced neoplasia in patients with inflammatory bowel disease and flat low-grade dysplasia, as well as identifies the risk factors associated with neoplastic progression.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Jean-Paul Motta, Corinne Rolland, Anissa Edir, Ana-Carolina Florence, David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, Muriel Quaranta-Nicaise, Emmanuel Mas, Delphine Bonnet, Elena F. Verdu, Derek M. McKay, Etienne Buscail, Laurent Alric, Nathalie Vergnolle, Celine Deraison
Summary: Imbalance between proteases and their inhibitors is crucial in the development of Inflammatory Bowel Diseases (IBD). This study identifies a previously unrevealed production of elastase 2A (ELA2A) by colonic epithelial cells in IBD patients, leading to inflammation and loss of barrier function. Targeting ELA2A hyperactivity could be a potential treatment for IBD.
MUCOSAL IMMUNOLOGY
(2021)
Review
Immunology
Lacey R. Lopez, Ju-Hyun Ahn, Tomaz Alves, Janelle C. Arthur
Summary: Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and severe comorbidities. Disease-associated alterations to the intestinal microbiota and microbial metabolites play a crucial role in IBD development. Understanding the microbial function in the context of IBD and characterizing disease-associated microbial metabolites are necessary for targeted treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Thomas Wolf, Ayanna Lewis, Laurent Beaugerie, Magali Svrcek, Julien Kirchgesner, St Antoine IBD Network
Summary: In patients with inflammatory bowel disease, post-inflammatory polyps do not increase the risk of colorectal neoplasia after controlling for histologic activity.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Anouk M. Wijnands, Sjoerd G. Elias, Evelien Dekker, Herma H. Fidder, Frank Hoentjen, Joren R. ten Hove, P. W. Jeroen Maljaars, Andrea E. van der Meulen-de Jong, Erik Mooiweer, Renske J. Ouwehand, Bas B. L. Penning de Vries, Cyriel Y. Ponsioen, Fiona D. M. van Schaik, Bas Oldenburg
Summary: This study aimed to clarify the association between smoking and the development of colorectal neoplasia in patients with inflammatory bowel disease (IBD). The results showed that smoking was not associated with the risk of recurrent colorectal neoplasia, but an increasing number of pack-years was associated with a higher risk of recurrence.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Shailja C. Shah, Steven H. Itzkowitz
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Chronic inflammation plays a key role in the development of neoplastic progression, resulting in dysplastic precursor lesions. Colitis-associated CRC shares molecular similarities with sporadic CRC and the microbiome and host immune system may also play a role. However, further research is needed to understand the specific molecular differences and their role in inflammation-associated cancers.
Article
Gastroenterology & Hepatology
Misha Kabir, Siwan Thomas-Gibson, Ailsa L. Hart, Phil J. Tozer, Omar Faiz, Janindra Warusavitarne, Ana Wilson
Summary: When facing prognostic uncertainty and conflicting choices in managing dysplasia in IBD patients, personalized communication is necessary. The study found that a substantial proportion of dysplasia-experienced patients did not feel well informed about the associated cancer risk and management, indicating a need for enhancing patient involvement in treatment decisions.
COLORECTAL DISEASE
(2021)
Article
Pathology
Aatur D. Singhi, Kevin M. Waters, Elias P. Makhoul, Alyssa Parian, Mark G. Lazarev, Siobhan S. Proksell, Jeffrey M. Dueker, Marc B. Schwartz, Abigail Wald, Marina N. Nikiforova, Elizabeth A. Montgomery
Summary: Serrated epithelial change (SEC) in patients with long-standing inflammatory bowel disease (IBD) is characterized by disorganized crypt architecture, irregular serrations, and goblet cell-rich epithelium. SEC, distinct from sporadic serrated polyps, is associated with colorectal neoplasia and may serve as an early precursor to IBD-associated neoplasia. In SEC, TP53 mutations were most frequently observed, while in SSL-like/SL-NOS specimens, KRAS/BRAF mutations were more common.
Article
Gastroenterology & Hepatology
Annika Bergquist, Tobias J. Weismueller, Cynthia Levy, Christian Rupp, Deepak Joshi, Jeremy Shanika Nayagam, Aldo J. Montano-Loza, Ellina Lytvyak, Ewa Wunsch, Piotr Milkiewicz, Roman Zenouzi, Christoph Schramm, Nora Cazzagon, Annarosa Floreani, Ingalill Friis Liby, Miriam Wiestler, Heiner Wedemeyer, Taotao Zhou, Christian P. Strassburg, Eirini Rigopoulou, George Dalekos, Manasa Narasimman, Xavier Verhelst, Helena Degroote, Mette Vesterhus, Andreas E. Kremer, Bennet Buendgens, Fredrik Rorsman, Emma Nilsson, Kristin Kaasen Jorgensen, Erik von Seth, Martin Cornillet Jeannin, Nils Nyhlin, Harry Martin, Stergios Kechagias, Kristine Wiencke, Marten Werner, Benedetta Terziroli Beretta-Piccoli, Marco Marzioni, Helena Isoniemi, Johanna Arola, Agnes Wefer, Jonas Soderling, Martti Farkkila, Henrike Lenzen
Summary: This study compares different follow-up strategies in patients with PSC and finds that scheduled imaging can improve survival. There are considerable variations in follow-up strategies across centers, but multiple factors may contribute to this result.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Piia Peltoniemi, Pertti Pere, Harri Mustonen, Hanna Seppanen
Summary: Optimizing intraoperative fluid management in pancreaticoduodenectomy can reduce the occurrence of severe complications, while adopting a too-restrictive approach represents an inferior choice.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Nelli Sjoblom, Sonja Boyd, Anniina Manninen, Sami Blom, Anna Knuuttila, Martti Farkkila, Johanna Arola
Summary: A study found that measuring the cytokeratin 7 (K7) load in liver samples using an artificial intelligence (AI) model can serve as an efficient surrogate marker to evaluate disease progression in primary sclerosing cholangitis (PSC). The K7-AI model 2.0 was more accurate in predicting the compound endpoint compared to other serum markers and pathological evaluations, and it also provided additional variables that cannot be measured by human pathologists.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Michael Trauner, Chuhan Chung, Kate Sterling, Xiangyu Liu, Xiaomin Lu, Jun Xu, Clare Tempany-Afdhal, Zachary D. Goodman, Martti Faerkkilae, Atsushi Tanaka, Palak Trivedi, Kris V. Kowdley, Christopher L. Bowlus, Cynthia Levy, Robert P. Myers
Summary: This article presents the background of PSC and the design and implementation of the phase 3 PRIMIS trial, which aims to evaluate the efficacy and safety of cilofexor in noncirrhotic patients with large-duct PSC. The primary objective is to assess whether cilofexor reduces the risk of fibrosis progression compared with placebo.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Sachin Wani, Dag Holmberg, Giola Santoni, Joonas H. Kauppila, Martti Farkkila, My von Euler-Chelpin, Nicholas J. Shaheen, Jesper Lagergren
Summary: A significant number of esophageal adenocarcinoma cases are diagnosed within a year after an ostensibly negative upper endoscopy in patients with newly diagnosed Barrett's esophagus. Interventions to improve detection rates and reduce post-endoscopy esophageal adenocarcinoma and neoplasia are needed.
Article
Biochemistry & Molecular Biology
Kaisa Lehtomaki, Eetu Heerva, Pirkko-Liisa Kellokumpu-Lehtinen, Harri Mustonen, Tapio Salminen, Heikki Joensuu, Kethe Hermunen, Mogens Karsbol Boisen, Julia Sidenius Johansen, Caj Haglund, Pia Osterlund
Summary: Based on the analysis of clinical data from patients with colorectal cancer undergoing adjuvant chemotherapy, it was found that CEA levels transiently increased in about half of the patients during the treatment. Compared to patients with a persistent increase, those with transiently increased CEA had better outcomes in terms of disease-free survival and overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Panu K. Luukkonen, Martti Farkkila, Antti Jula, Veikko Salomaa, Satu Mannisto, Annamari Lundqvist, Markus Perola, Fredrik Aberg
Summary: This study investigates the association between genetic variants, abdominal obesity, alcohol use and incident liver disease (ILD). Variants in genes such as PNPLA3, IFNL4, and TM6SF2 are found to be associated with ILD. Genetic risk scores (GRSs) calculated from these variants are exponentially associated with ILD, while not associated with waist-hip ratio (WHR) or alcohol use. The risk of ILD in individuals with high GRS and high WHR or alcohol use is increased by up to 90-fold.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Piia Peltoniemi, Inkeri Lehto, Pertti Pere, Harri Mustonen, Tiina Lehtimaki, Hanna Seppanen
Summary: This study explores the association between perioperative fluid management and complications in pancreatoduodenectomy patients. It is found that patients who received a goal-directed strategy for fluid management had less fluid collections and a lower frequency of complications compared to those who received conventional treatment.
Article
Oncology
Panu Aaltonen, Harri Mustonen, Katriina Peltola, Olli Carpen, Pauli Puolakkainen, Caj Haglund, Malin Sund, Hanna Seppanen
Summary: "This study analyzed the treatment and overall survival rates of gastric cancer patients in Finland between 2000-2008 and 2009-2016. The study found a decrease in the rate of gastric surgery and an increase in the proportion of patients who received preoperative oncological treatment. Overall survival improved during the study period, and female patients had a better survival rate compared to male patients."
Article
Gastroenterology & Hepatology
Fredrik Aberg, Kustaa Saarinen, Antti Jula, Annamari Lundqvist, Terhi Vihervaara, Iris Erlund, Martti Farkkila
Summary: This study evaluated the predictive performance of a combination of liver fibrosis assessment, phenotype profile, and genetic risk in predicting liver-related outcomes. The combination of the chronic liver disease risk score and the enhanced liver fibrosis test significantly improved the predictive performance compared to the enhanced liver fibrosis test alone. The addition of the polygenic risk score did not significantly increase the predictive performance.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Mira Lanki, Harri Mustonen, Marko Salmi, Sirpa Jalkanen, Caj Haglund, Hanna Seppanen
Summary: This study found that inflammatory cytokines CTACK, GRO-a, and b-NGF, in addition to CA19-9 and CRP, may help distinguish between PDAC and CP.
Article
Medicine, General & Internal
Dag Holmberg, Giola Santoni, My von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren
Summary: Patients with non-erosive gastro-oesophageal reflux disease have a similar incidence of oesophageal adenocarcinoma as the general population.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Heini Nieminen, Pirjo Nummela, Tero Satomaa, Annamari Heiskanen, Jukka O. O. Hiltunen, Tuomas Kaprio, Hanna Seppanen, Jaana Hagstrom, Harri Mustonen, Ari Ristimaki, Caj Haglund
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are potentially malignant cystic tumors of the pancreas. Diagnostic methods are needed to recognize IPMNs with malignant potential. Aberrantly expressed glycans offer interesting new options for diagnostics.
SCIENTIFIC REPORTS
(2023)
Correction
Gastroenterology & Hepatology
Kustaa Saarinen, Martti Faerkkilae, Antti Jula, Iris Erlund, Terhi Vihervaara, Annamari Lundqvist, Fredrik Aberg
Article
Medicine, Research & Experimental
Fredrik Aberg, Martti Farkkila, Veikko Salomaa, Antti Jula, Satu Mannisto, Markus Perola, Annamari Lundqvist, Ville Mannisto
Summary: Öberg et al. evaluated the predictive performance of obesity measures, including waist-hip ratio, waist circumference, and BMI, for liver-related outcomes in participants of Finnish health surveys. They found that waist-hip ratio is a better predictor for liver-related outcomes than other measures and synergizes with harmful alcohol use.
COMMUNICATIONS MEDICINE
(2023)