Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation

Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment

(2012) Caroline Nunes-Xavier et al.   Anti-Cancer Agents in Medicinal Chemistry

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

(2012) S Cagnol et al.   ONCOGENE

Deletion of the Dual Specific Phosphatase-4 (DUSP-4) Gene Reveals an Essential Non-redundant Role for MAP Kinase Phosphatase-2 (MKP-2) in Proliferation and Cell Survival

(2011) Ahmed Lawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up and downregulation of p16Ink4a expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer

(2011) Lydia Kriegl et al.   MODERN PATHOLOGY

Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications

(2011) Aziz Zaanan et al.   CELLULAR ONCOLOGY

Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins

(2010) Janka Teutschbein et al.   BMC CANCER

Epigenetic Downregulation of Mitogen-Activated Protein Kinase Phosphatase MKP-2 Relieves Its Growth Suppressive Activity in Glioma Cells

(2010) A. Waha et al.   CANCER RESEARCH

Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK

(2010) Peng Dong et al.   CELL CYCLE

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

(2010) Jochen Gaedcke et al.   GENES CHROMOSOMES & CANCER

Mitogen-Activated Protein Kinase Phosphatase 2 Regulates the Inflammatory Response in Sepsis

(2010) T. T. Cornell et al.   INFECTION AND IMMUNITY

Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling

(2009) Joel S. Britson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2

(2009) Laurence C. Cadalbert et al.   CELLULAR SIGNALLING

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

(2009) D Chitale et al.   ONCOGENE

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples

(2008) Marcus Bettstetter et al.   LABORATORY INVESTIGATION

Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice

(2008) T Hasegawa et al.   ONCOGENE