γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

(2011) K Pandya et al.   BRITISH JOURNAL OF CANCER

GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia

(2011) X Meng et al.   LEUKEMIA

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress

(2011) L Dong et al.   ONCOGENE

Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma

(2010) M. R. Kamstrup et al.   BLOOD

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL

(2010) E. Rosati et al.   BLOOD

Targeting Multiple Kinase Pathways: A Change In Paradigm

(2010) L. Gossage et al.   CLINICAL CANCER RESEARCH

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

(2010) M. Baou et al.   HAEMATOLOGICA

New Agents in Chronic Lymphocytic Leukemia

(2010) Thomas S. Lin   Current Hematologic Malignancy Reports

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

(2009) S Rasul et al.   BRITISH JOURNAL OF CANCER

A new genetic lesion in B-CLL: aNOTCH1PEST domain mutation

(2009) Mauro Di Ianni et al.   BRITISH JOURNAL OF HAEMATOLOGY

z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor-Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response

(2009) M. Monticone et al.   MOLECULAR CANCER RESEARCH

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

(2008) C. Pepper et al.   BLOOD

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage

(2008) S. Giordano et al.   CURRENT MEDICINAL CHEMISTRY

Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies

(2008) Yulia Nefedova et al.   DRUG RESISTANCE UPDATES

Mechanisms of proteasome inhibitor action and resistance in cancer

(2008) David J. McConkey et al.   DRUG RESISTANCE UPDATES

In vitro validation of  -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

(2008) K. De Keersmaecker et al.   HAEMATOLOGICA

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD