Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Genetics & Heredity
Ziqi Jia, Yansong Huang, Jiaqi Liu, Gang Liu, Jiayi Li, Hengyi Xu, Yiwen Jiang, Song Zhang, Yidan Wang, Gang Chen, Guangdong Qiao, Yalun Li
Summary: Through a study on genetic polymorphisms, we found significant associations between breast cancer risk and SNPs rs12493607 (TGFBR2), rs4784227 (CASC16), and rs2046210 (ESR1) in the Chinese female population. Further analysis revealed associations between different subtypes of breast cancer and different SNPs. These findings provide important insights into breast cancer susceptibility and personalized treatment.
Article
Oncology
Chiara Corradi, Manuel Gentiluomo, Laszlo Gajdan, Giulia Martina Cavestro, Edita Kreivenaite, Gregorio Di Franco, Cosimo Sperti, Matteo Giaccherini, Maria Chiara Petrone, Francesca Tavano, Domenica Gioffreda, Luca Morelli, Pavel Soucek, Angelo Andriulli, Jakob R. Izbicki, Niccolo Napoli, Ewa Malecka-Panas, Peter Hegyi, John P. Neoptolemos, Stefano Landi, Yogesh Vashist, Claudio Pasquali, Ye Lu, Klara Cervena, George E. Theodoropoulos, Stefania Moz, Gabriele Capurso, Oliver Strobel, Silvia Carrara, Thilo Hackert, Viktor Hlavac, Livia Archibugi, Martin Oliverius, Giuseppe Vanella, Pavel Vodicka, Paolo Giorgio Arcidiacono, Raffaele Pezzilli, Anna Caterina Milanetto, Rita T. Lawlor, Audrius Ivanauskas, Andrea Szentesi, Juozas Kupcinskas, Sabrina G. G. Testoni, Martin Lovecek, Michael Nentwich, Maria Gazouli, Claudio Luchini, Raffaella Alessia Zuppardo, Erika Darvasi, Hermann Brenner, Cristian Gheorghe, Krzysztof Jamroziak, Federico Canzian, Daniele Campa
Summary: A new PDAC risk locus was identified, with genetic variation disrupting the binding between lncRNA and miRNA possibly affecting the development of PDAC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaoying Li, Qijun Wu, Baosen Zhou, Yashu Liu, Jiale Lv, Qing Chang, Yuhong Zhao
Summary: This study found that only 13 SNPs were strongly correlated with lung cancer risk based on systematic reviews and meta-analyses, providing valuable insights for further genetic studies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, General & Internal
Yaheng Li, Chuanyin Li, Shuyuan Liu, Jia Yang, Li Shi, Yufeng Yao
Summary: SNPs in miRNA genes play critical roles in the development of cervical cancer, potentially altering miRNA expression and maturation, and impacting the development of various cancers.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
G. Vigneshwaran, Qurratulain Annie Hasan, Rahul Kumar, Avinash Eranki
Summary: This study constructed a framework to identify genes associated with triple-negative breast cancer (TNBC) and screen the single nucleotide polymorphisms (SNPs) reported in these genes. The study found the association of genes such as BRCA1, BRCA2, EGFR, PIK3CA, PTEN, and TP53 with TNBC. The framework was demonstrated to have high accuracy in identifying pathogenic alterations in breast cancer samples.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Armin Mooranian, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov, Hani Al-Salami
Summary: Recent studies have shown the potential applications of bile acid-Eudragit NM30D(R) capsules in drug encapsulation and viable-cell encapsulation. These capsules can improve cell viability, insulin levels, inflammatory profile, and bioenergetics, and the stability of the capsules is associated with cellular biological activities. Changes in ratios of bile acids to Eudragit NM30D(R) can alter the microenvironment of the capsules and subsequent cellular activities.
Article
Cell Biology
Ivo Bozovic, Vladimir Perovic, Ivana Basta, Stojan Peric, Zorica Stevic, Dusan Popadic, Irena Vukovic, Aleksandar Stojanov, Emina Milosevic
Summary: The role of innate and adaptive immune responses in CIDP pathogenesis is mediated by cytokine production. Single-nucleotide polymorphisms (SNPs) in cytokine genes may affect the pathogenesis of autoimmune diseases. However, the impact of cytokine gene SNPs in CIDP patients has not been assessed yet.
Article
Pharmacology & Pharmacy
Yasmin Cura, Almudena Sanchez-Martin, Noelia Marquez-Pete, Encarnacion Gonzalez-Flores, Fernando Martinez-Martinez, Cristina Perez-Ramirez, Alberto Jimenez-Morales
Summary: This study evaluated the association of SNPs with severe toxicity and treatment suspension in colorectal cancer patients treated with Capecitabine-based therapy. SNPs CES1 rs71647871 and CDA rs1048977 were identified as potential predictive biomarkers of treatment safety.
Article
Biochemistry & Molecular Biology
Allison Duncan, Darryl Nousome, Randy Ricks, Huai-Ching Kuo, Lakshmi Ravindranath, Albert Dobi, Jennifer Cullen, Shiv Srivastava, Gregory T. Chesnut, Gyorgy Petrovics, Indu Kohaar
Summary: Growing evidence suggests that genetics plays a role in prostate cancer susceptibility and severity. This study investigated the association between TP53 gene SNPs and clinico-pathological features of prostate cancer in African American (AA) and Caucasian (CA) men. The results showed ancestral differences in allele frequencies, with the TP53 Arg72Pro SNP associated with a shorter time to biochemical recurrence.
Article
Cell Biology
Concetta Scimone, Luigi Donato, Simona Alibrandi, Concetta Alafaci, Angela D'Ascola, Sergio Vinci, Rosalia D'Angelo, Antonina Sidoti
Summary: This study reveals the importance of epitranscriptomic modifications in gene expression regulation and suggests the involvement of altered epitranscriptome profile in the development of CCM. These findings provide new insights for further investigation into the pathogenesis of CCM.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Carmen Perez-Duran, Noelia Marquez-Pete, Jose Maria Galvez-Navas, Yasmin Cura, Susana Rojo-Tolosa, Laura Elena Pineda-Lancheros, Mcarmen Ramirez-Tortosa, Carlos Garcia-Collado, Maria del Mar Maldonado-Montoro, Jesus Maria Villar-del-Moral, Cristina Perez-Ramirez, Alberto Jimenez-Morales
Summary: Recent studies have suggested that vitamin D might influence the development and prognosis of colorectal cancer, and its activity might be influenced by single nucleotide polymorphisms in the genes involved in its metabolism. This study evaluated the influence of 13 SNPs in the vitamin D metabolic pathway on colorectal cancer survival. The results showed that variants in VDR, CYP24A1, and GC genes are associated with a lower survival rate.
Article
Oncology
Dan Liu, Ya Gao, Lingling Li, He Chen, Lu Bai, Yanli Qu, Baosen Zhou, Ying Yan, Yuxia Zhao
Summary: The T allele of the rs799917 SNP in the BRCA1 gene is associated with a lower risk of lung cancer in the Han Chinese population in Liaoning Province, suggesting a potential protective factor against lung cancer.
Article
Multidisciplinary Sciences
Catherine G. Derington, Jordana B. Cohen, April F. Mohanty, Tom H. Greene, James Cook, Jian Ying, Guo Wei, Jennifer S. Herrick, Vanessa W. Stevens, Barbara E. Jones, Libo Wang, Alexander R. Zheutlin, Andrew M. South, Thomas C. Hanff, Steven M. Smith, Rhonda M. Cooper-DeHoff, Jordan B. King, G. Caleb Alexander, Dan R. Berlowitz, Faraz S. Ahmad, M. Jason Penrod, Rachel Hess, Molly B. Conroy, James C. Fang, Michael A. Rubin, Srinivasan Beddhu, Alfred K. Cheung, Weiming Xian, William S. Weintraub, Adam P. Bress
Summary: This study suggests that continued use of ARB or ACEI medications may be beneficial for patients already using these drugs before SARS-CoV-2 infection. The observed beneficial association between ARBs and ACEIs on hospitalization or mortality among outpatients should be confirmed through randomized trials.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jordan B. King, Ransmond O. Berchie, Jennifer S. Herrick, Dave L. Dixon, Jordana B. Cohen, Daichi Shimbo, Ian M. Kronish, Joseph J. Saseen, Paul Muntner, Andrew E. Moran, Adam P. Bress
Summary: Combination antihypertensive therapy is underused, especially in certain race/ethnic groups, in the treatment of hypertension in the United States. Factors associated with monotherapy use despite uncontrolled blood pressure include higher systolic blood pressure, younger age, recent healthcare visits, higher body mass index, and the presence of heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Aubrey E. Jones, Madeleine M. McCarty, Juan P. Brito, Peter A. Noseworthy, Kerri L. Cavanaugh, Kenzie A. Cameron, Geoffrey D. Barnes, Benjamin A. Steinberg, Daniel M. Witt, George H. Crossley, Rod Passman, Preeti Kansal, Ian Hargraves, Monika Schmidt, Elizabeth Jackson, Adriana Guzman, Anthony Ariotti, Mandy L. Pershing, Jennifer Herrick, Victor M. Montori, Angela Fagerlin, Elissa M. Ozanne
Summary: This study aims to compare the effectiveness of patient decision aid (PDA) and encounter decision aid (EDA) in shared decision making. The study will recruit atrial fibrillation (AF) patients and their managing clinicians for stroke prevention strategies in a randomized controlled trial. The results will contribute to improving AF outcomes and patient experiences with stroke prevention strategies.
AMERICAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Review
Medicine, General & Internal
Chase Paulson, Samuel C. Thomas, Orlando Gonzalez, Samuel Taylor, Cole Swiston, Jennifer S. Herrick, Lori McCoy, Karen Curtin, Craig J. Chaya, Brian C. Stagg, Barbara M. Wirostko
Summary: This study is the largest epidemiological study of exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Baja Verapaz region of Guatemala among individuals seeking eye exams and interventions. The study found a high prevalence of XFS/XFG, particularly among individuals in rural areas and those who speak the Mayan language.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jordana B. Cohen, Zachary A. Marcum, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Daniel Scharfstein, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: This observational cohort study aimed to evaluate the cognitive outcomes of individuals at risk for mild cognitive impairment and probable dementia after initiating an ARB- vs ACEI-based antihypertensive regimen. The study found no significant difference in the rate of amnestic MCI or PD among new users of ARB compared with ACEI.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jennifer S. Herrick, Robert S. Rosenson, Bharat Poudel, Monika M. Safford, Todd M. Brown, Elizabeth A. Jackson, Mark Woodward, Stephanie Reading, Kate Orroth, Jason Exter, Salim S. Virani, Paul Muntner, Adam P. Bress
Summary: This study investigated lipid-lowering therapy (LLT) among US veterans after myocardial infarction or elective coronary revascularization. The results showed that less than half of the patients received LLT intensification within one year, indicating a missed opportunity to reduce cardiovascular disease risk.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Article
Peripheral Vascular Disease
Byron C. Jaeger, Ligong Chen, Kathryn Foti, Shakia T. Hardy, Adam P. Bress, Sean P. Kane, Lei Huang, Jennifer S. Herrick, Catherine G. Derington, Bharat Poudel, Ashley Christenson, Lisandro D. Colantonio, Paul Muntner
Summary: A web-based application was developed to provide hypertension statistics for US adults using data from the US National Health and Nutrition Examination Survey. The study found that the mean systolic blood pressure decreased from 123 mm Hg in 1999-2000 to 120 mm Hg in 2009-2010 and then increased to 123 mm Hg in 2017-2020. The age-adjusted prevalence of hypertension was 47.9% in 1999-2000, 43.0% in 2009-2010, and 44.7% in 2017-2020. The study also estimated that 115.3 million US adults had hypertension in 2017-2020.
Article
Cardiac & Cardiovascular Systems
Catherine G. G. Derington, Adam P. P. Bress, Jennifer S. S. Herrick, Joshua A. A. Jacobs, Alexander R. R. Zheutlin, Ransmond O. O. Berchie, Molly B. B. Conroy, William C. C. Cushman, Jordan B. B. King
Summary: It is found that only one-third of hypertensive patients in the US market can be satisfied with the currently available fixed-dose combination antihypertensive products, indicating the need for further improvement in the pharmaceutical product landscape.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Alexander R. Zheutlin, Daniel K. Addo, Joshua A. Jacobs, Catherine G. Derington, Jennifer S. Herrick, Tom Greene, Eric L. Stulberg, Dan R. Berlowitz, Jeff D. Williamson, Nicholas M. Pajewski, Mark A. Supiano, Adam P. Bress
Summary: Despite evidence supporting the benefits of intensive blood pressure management, older adults have the lowest rates of blood pressure control. The association between age and therapeutic inertia was determined in the SPRINT study, with older age found to be associated with greater therapeutic inertia independent of physical or cognitive function. This suggests age bias in hypertension management.
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine G. Derington, Adam P. Bress, Jennifer S. Herrick, Wenjun Fan, Nathan D. Wong, Katherine E. Andrade, Jonathan Johnson, Sephy Philip, David Abrahamson, Lixia Jiao, Deepak L. Bhatt, William S. Weintraub
Summary: Treating all eligible adults with icosapent ethyl as part of the REDUCE-IT trial can prevent a substantial number of ASCVD events, although there are significant medication costs involved. The indirect cost savings from event prevention may outweigh the incurred direct costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
