Article
Oncology
Zuhong Tian, Shuhui Liang, Xinmin Zhou, Hui Luo, Miaomiao Tian, Xianghan Zhang, Changcun Guo, Jing Zhang
Summary: This study developed a tumor-specific probe for real-time intraoperative NIR fluorescence imaging guidance in gastric cancer surgery. The probe showed specific binding to tumor vascular endothelial cells and produced strong NIR signals at the tumor site. Using the probe in real-time surgery allowed clear visualization of tumor margins and peritoneal metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Carolina Bobadilla Mendez, Amber Gonda, Jay Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Prabhas Moghe, Vidya Ganapathy, Mark C. Pierce
Summary: The study demonstrated that REANCs as short-wave infrared emitting contrast agents showed better signal-to-background ratio and contrast compared to ICG, with excellent photostability and the ability to perform FGS under ambient lighting.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Biochemical Research Methods
Mebin B. George, Benjamin Lew, Steven Blair, Zhongmin Zhu, Zuodong Liang, Indrajit Srivastava, Austin Chang, Hyungsoo Choi, Kyekyoon Kim, Shuming Nie, Sunil Singhal, Viktor Gruev
Summary: We developed a bioinspired endoscopic system that can image multiple tumor-targeted probes, quantify volumetric ratios, and detect tumors. Our optimized endoscope achieves a 60% improvement in NIR spatial resolution compared to a leading FDA-approved endoscope. The system can help assess multiple tumor-targeted probe concepts during surgical procedures.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Medicine, Research & Experimental
Sorel Kurbegovic, Karina Juhl, Kasper Kildegaard Sorensen, Julie Leth, Gro Linno Willemoe, Anders Christensen, Yvonne Adams, Anja Ramstedt Jensen, Christian von Buchwald, Jane Skjoth-Rasmussen, Michael Ploug, Knud J. Jensen, Andreas Kjaer
Summary: Glioblastoma is a devastating cancer with poor survival rates, and surgery remains a key treatment method. A new uPAR-targeted optical probe has been developed for precise tumor visualization and shows promise for fluorescence guided surgery.
Article
Engineering, Biomedical
Xiaojing Shi, Zhe Zhang, Zeyu Zhang, Caiguang Cao, Zhen Cheng, Zhenhua Hu, Jie Tian, Nan Ji
Summary: This translational study demonstrates that ICG-based NIR-II FGS can significantly improve the complete resection rate and prolong the progression-free survival and overall survival of high-grade glioma patients, indicating its importance in improving patient outcomes.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Madeline T. Olson, Eric N. Aguilar, Cory L. Brooks, Carly C. Isder, Kathryn M. Muilenburg, Geoffrey A. Talmon, Quan P. Ly, Mark A. Carlson, Michael A. Hollingsworth, Aaron M. Mohs
Summary: Surgery is the only potential curative treatment for pancreatic cancer, but various factors make resections difficult. Fluorescence-guided surgery (FGS) has emerged as a method to improve cancer detection during surgery. The imaging agent AR9.6-IRDye800 developed in this study is effective and safe for intraoperative identification of pancreatic cancer.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Zhengjun Li, Mozhu Xia, Chang Liu, Liwei Xie, Tao Wang, Yi Ren
Summary: This study proposes a simple and effective minimally invasive method using indocyanine green to locate pulmonary nodules, which is of great significance for the localization of pulmonary nodules in thoracoscopic surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Yining Zhang, Zijun Luo, Lixiao Guo, Haofeng Zhang, Tongdan Su, Zhenzhen Tan, Qian Ren, Can Zhang, Yan Fu, Ruijuan Xing, Ran Guo, Xiaowei Shi, Huicai Guo, Yi Liu, Lei Wang
Summary: A series of tumor-targeted near-infrared fluorescent probes were designed and synthesized, with novel anti-folates used as targeting ligands. Among them, GT-NIR-4 showed better binding affinity and higher tumor uptake.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Feifei Wang, Liangqiong Qu, Fuqiang Ren, Ani Baghdasaryan, Yingying Jiang, RuSiou Hsu, Peng Liang, Jiachen Li, Guanzhou Zhu, Zhuoran Ma, Hongjie Dai
Summary: This study developed a compact imager capable of simultaneous visible photographic and near-infrared II (NIR-II) fluorescence imaging for preclinical image-guided surgery. Using molecular imaging of angiogenesis markers in a murine breast tumor model, high-resolution noninvasive tumor imaging was achieved with NIR-IIb imaging, enabling clear identification of tumor margin and residual cancer cells during surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Zhongquan Cheng, Yushen Jin, Jiaqian Li, Guangyuan Shi, Leyi Yu, Bing Shao, Jie Tian, Yang Du, Zhu Yuan
Summary: A smart fibronectin-targeting and metalloproteinase-activatable imaging probe CREKA-GK8-QC is developed to detect breast cancer and lung micro-metastatic lesions, improving surgery prognosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biology
Lisanne K. A. Neijenhuis, Lysanne D. A. N. de Myunck, Okker D. Bijlstra, Peter J. K. Kuppen, Denise E. Hilling, Frank J. Borm, Danielle Cohen, J. Sven D. Mieog, Willem H. Steup, Jerry Braun, Jacobus Burggraaf, Alexander L. Vahrmeijer, Merlijn Hutteman
Summary: Lung cancer, particularly non-small cell lung cancer (NSCLC), is prevalent worldwide. Near-infrared (NIR) fluorescence imaging has been tested as an intraoperative technique to localize pulmonary nodules, allowing tumor identification, detection of additional lesions, and prevention of positive resection margins.
Review
Chemistry, Multidisciplinary
Hangqi Luo, Shuai Gao
Summary: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is widely used for cancer treatment, but conventional PTT/PDT lack disease recognition ability, resulting in limited therapeutic effects. Integrating fluorescence imaging with PTT/PDT can reveal tumor locations in real-time, enabling early diagnosis and precision treatment. The use of NIR-II fluorescence imaging with PTT/PDT can significantly improve tumor theranostics accuracy and minimize damage to normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Spectroscopy
Chang Liu, Huimin Yan, Jianhong Wu, Zhiming Wang, Song He, Liancheng Zhao, Xianshun Zeng
Summary: A new near-infrared fluorescent probe Qcy-OH based on an acceptor-donor-acceptor (ADA) pi-electron system with a turn-on mechanism was developed for monitoring pH fluctuations in biological systems. The probe showed a strong pH-sensitive response and high selectivity for intracellular lysosomes, enabling the tracking of lysosomal pH changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Medicine, General & Internal
Nariaki Okamoto, Zaid Al-Difaie, Max H. M. C. Scheepers, Danique J. I. Heuvelings, Maria Rita Rodriguez-Luna, Jacques Marescaux, Michele Diana, Laurents P. S. Stassen, Nicole D. Bouvy, Mahdi Al-Taher
Summary: Near-infrared fluorescence (NIRF) image-guided surgery is a useful tool for reducing complications and improving tissue recognition. Both methylene blue (MB) and indocyanine green (ICG) can be used for lymph node identification, with MB showing better results than ICG.
Article
Chemistry, Multidisciplinary
Lei G. Wang, Antonio R. Montano, Anas M. Masillati, Jocelyn A. Jones, Connor W. Barth, Jason R. Combs, Sashini Udeshika Kumarapeli, Nourhan A. Shams, Nynke S. van den Berg, Alexander L. Antaris, S. N. Galvis, Ian Mcdowall, Syed Zaki Husain Rizvi, Adam W. G. Alani, Jonathan M. Sorger, Summer L. Gibbs
Summary: A library of near-infrared (NIR) fluorophores has been developed for nerve-specific imaging during surgery by combining drug-like molecular design and fluorophore chemistry. These fluorophores are compatible with the clinically available da Vinci Surgical System and can accurately visualize prostatic nerves, paving the way for reducing nerve injury in prostate cancer patients.
ADVANCED MATERIALS
(2023)
Article
Oncology
L. C. Franken, F. A. Vuijk, E. C. Soer, E. Roos, J. Erdmann, G. K. J. Hooijer, A. L. Vahrmeijer, S. S. Gambhir, T. M. van Gulik, A. Farina Sarasqueta, J. Verheij, R. J. Swijnenburg
Summary: The study found that integrin alpha(nu)beta 6 is abundantly expressed in PHC, lower in benign diseases, ICC and HCC, highlighting its potential as a target for tumor-specific molecular imaging.
Review
Biochemistry & Molecular Biology
Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Summary: Traditional tracers aid surgeons in locating affected tissues during surgery, but new "active" tracers can more effectively target tumors and pathological tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Oncology
Cornelis F. M. Sier, Alexander L. Vahrmeijer
CLINICAL CANCER RESEARCH
(2021)
Article
Orthopedics
Peter van Schie, Thies J. N. van der Lelij, Maxime Gerritsen, Ruben P. J. Meijer, Ewoud R. A. van Arkel, Marta Fiocco, Jan-Willem A. Swen, Alexander L. Vahrmeijer, Hans Marten Hazelbag, Stijn Keereweer, Pieter B. A. A. van Driel
Summary: This study demonstrates the potential of NIRF imaging to visualize the vascularization of the meniscus, as vascularization was observed in six out of eight patients with histologically proven meniscal vascularization.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Oncology
J. Sven D. Mieog, Friso B. Achterberg, Aimen Zlitni, Merlijn Hutteman, Jacobus Burggraaf, Rutger-Jan Swijnenburg, Sylvain Gioux, Alexander L. Vahrmeijer
Summary: Fluorescence-guided surgery (FGS) using tumor-targeted imaging agents has emerged as a promising method for intraoperative cancer detection in the past decade, but its clinical implementation is still in the early stages. The key to success lies in the coordination of target selection, imaging agents, and detection systems to achieve real-time intraoperative visualization for the benefit of cancer patients.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
L. J. Lauwerends, H. Abbasi, T. C. Bakker Schut, P. B. A. A. Van Driel, J. A. U. Hardillo, I. P. Santos, E. M. Barroso, S. Koljenovic, A. L. Vahrmeijer, R. J. Baatenburg de Jong, G. J. Puppels, S. Keereweer
Summary: A clear margin is important for the prognosis of solid tumours treated by surgery, and intraoperative fluorescence imaging and Raman spectroscopy can improve the complete resection of tumour tissue. However, the signal processing for fluorescence imaging is complex, and Raman spectroscopy has weak signal intensity. This review discusses the state-of-the-art of these optical techniques and their combined intraoperative application for clinical research.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor M. Baart, Labrinus van Manen, Shadhvi S. Bhairosingh, Floris A. Vuijk, Luisa Iamele, Hugo de Jonge, Claudia Scotti, Massimo Resnati, Robert A. Cordfunke, Peter J. K. Kuppen, Andrew P. Mazar, Jacobus Burggraaf, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Summary: In this study, fluorescence-guided surgery using uPAR-targeting antibody fragments resulted in earlier tumor visualization compared to the parent IgG, but at the expense of peak fluorescence intensity.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Otorhinolaryngology
Maarten C. Dorr, Arta Hoesseini, Aniel Sewnaik, Jose A. Hardillo, Robert J. Baatenburg de Jong, Marinella P. J. Offerman
Summary: The study found that the use of the prognostic model OncologIQ can provide assistance in the decision-making process of head and neck cancer, especially for older patients, patients with a WHO performance score >= 2, or patients with a high tumor stage. This individualized decision-making model plays an important role in facilitating multidisciplinary consultation decisions.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Ajay T. Bakas, Harmke A. Polinder-Bos, Fleur Streng, Francesco U. S. Mattace-Raso, Gijsbertus Ziere, Rob J. Baatenburg de Jong, Aniel Sewnaik
Summary: This study found that the G8 is a valid screening tool to identify frail patients in younger patients with head and neck cancer, and it is associated with mortality.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Hanneke Doremiek van Oorschot, Dominique Valerie Clarence de Jel, Jose Angelito Hardillo, Ludi E. Smeele, Robert Jan Baatenburg de Jong, Dutch Head and Neck Audit Grp
Summary: The study aimed to assess and improve the quality of head and neck cancer care. By analyzing data from DHNA, it was found that waiting times have gradually improved, with four hospitals exceeding the quality standard.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Chemistry, Analytical
Hamed Abbasi, Lorraine J. Lauwerends, Tom Bakker C. Schut, Ines P. Santos, Peter J. Caspers, Jose A. U. Hardillo, Senada Koljenovic, Alexander L. Vahrmeijer, Robert J. Baatenburg de Jong, Stijn Keereweer, Gerwin J. Puppels
Summary: This paper describes a Raman spectroscopy setup capable of recording high-quality Raman spectra from tissue containing near-infrared exogenous fluorescent agents by avoiding spectral overlap. The optimal wavelength interval (900-915 nm) for Raman excitation is identified to avoid both excitation of fluorescent dyes and Raman signal self-absorption by the tissue. This combined novel setup could pave the way for clinical trials benefiting from both fluorescence imaging and Raman spectroscopy to avoid positive margins in cancer surgery.
Article
Health Care Sciences & Services
Anouk M. I. A. van Alphen, Eline M. Krijkamp, Benjamin Y. Gravesteijn, Robert J. Baatenburg de Jong, Jan J. Busschbach
Summary: Physicians value health states higher than citizens, but these differences only result in minor changes in rankings. Therefore, HRQoL values obtained from physicians are sufficient for supporting decision models during crises.
QUALITY OF LIFE RESEARCH
(2023)
Article
Environmental Sciences
Kira S. S. Van Hof, Arta Hoesseini, Maarten C. C. Dorr, Irma M. M. Verdonck-de Leeuw, Femke Jansen, C. Rene Leemans, Robert P. P. Takes, Chris H. J. Terhaard, Robert Jan Baatenburg de Jong, Aniel Sewnaik, Marinella P. J. Offerman
Summary: This prospective cohort study investigates the burden of caregiving for head and neck cancer patients among informal caregivers, and explores its impact on their distress and quality of life, as well as the relationship between caregivers and patients. The study reveals that caring for HNC patients imposes a significant burden on caregivers, which affects their psychological well-being and daily life, and highlights the interaction between caregivers and patients. Healthcare professionals are advised to include caregivers in counseling and support.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Angelina M. M. Santoso, Femke Jansen, Carel F. W. Peeters, Robert J. Baatenburg de Jong, Ruud H. Brakenhoff, Johannes A. Langendijk, C. Rene Leemans, Robert P. Takes, Chris H. J. Terhaard, Annemieke van Straten, Irma M. Verdonck-de Leeuw
Summary: This study analyzed data from newly diagnosed head and neck cancer (HNC) patients and found that poor sleep quality, fatigue, CRP, and IL-6 play an important role in the connections between psychoneurological symptoms and biomarkers of stress and inflammation.
Article
Surgery
Renu R. Bahadoer, Koen C. M. J. Peeters, Geerard L. Beets, Nuno L. Figueiredo, Esther Bastiaannet, Alexander Vahrmeijer, Sofieke J. D. Temmink, W. M. Elma Meershoek-Klein Kranenbarg, Annet G. H. Roodvoets, Angelita Habr-Gama, Rodrigo O. Perez, Cornelis J. H. van de Velde, Denise E. Hilling
Summary: This study compared the oncological outcomes of watch and wait strategy in rectal cancer patients aged less than 50 years with those aged 50 years or more. The study found no additional oncological risk in young patients compared with their older counterparts when following a watch-and-wait strategy after a clinical complete response.
BRITISH JOURNAL OF SURGERY
(2022)