Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Eunbyeol Go, Su-Jin Yoo, Suyoung Choi, Pureum Sun, Min Kyung Jung, Somin Kwon, Bu Yeon Heo, Yeeun Kim, Ju-Gyeong Kang, Jinhyun Kim, Eui-Cheol Shin, Seong Wook Kang, Jaeyul Kwon
Summary: In patients with Rheumatoid arthritis (RA), there is a significant decrease in the frequency of effector T-reg cells and a reduction in overall CD25 expression in T-reg cells in peripheral blood. These findings suggest altered T-reg homeostasis associated with RA pathogenesis.
Article
Cell Biology
Ling Wang, Wei Chen, Fu-Biao Kang, Ya-Hui Zhang, Li-Li Qi, Ying-Ze Zhang
Summary: Hip fracture patients experience immunological changes, with blood transfusion potentially helping to rebalance the immune response and improve prognosis.
Article
Cardiac & Cardiovascular Systems
Jessica Handke, Laura Kummer, Markus A. Weigand, Jan Larmann
Summary: The study found that preoperative expansion of Tregs can mitigate the destabilization of atherosclerotic plaques induced by surgical stress. This suggests that therapeutic expansion of Tregs prior to major surgery may help prevent cardiovascular events associated with non-cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Biochemistry & Molecular Biology
Yan Zhang, Shuang Song, Haitao Li, Xinyan Wang, Lianlian Song, Jianfei Xue
Summary: Ganoderma lucidum polysaccharide-1 (GLP-1) has been found to alleviate cognitive impairment in mice with chronic cerebral hypoperfusion (CCH) by increasing regulatory T cell levels and regulating cytokine levels as well as abnormal energy metabolism.
Article
Oncology
Tokuhiro Matsubara, Tsutomu Nishida, Akiyoshi Shimoda, Hiromi Shimakoshi, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Masashi Yamamoto, Shiro Hayashi, Sachiko Nakajima, Koji Fukui, Masami Inada
Article
Medicine, General & Internal
Tokuhiro Matsubara, Tsutomu Nishida, Yu Higaki, Ryo Tomita, Hiromi Shimakoshi, Akiyoshi Shimoda, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Dai Nakamatsu, Kaori Mukai, Masashi Yamamoto, Koji Fukui, Shiro Adachi, Masami Inada
Article
Gastroenterology & Hepatology
Takahiro Amano, Tokuhiro Matsubara, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Masashi Yamamoto, Shiro Hayashi, Sachiko Nakajima, Koji Fukui, Masami Inada
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Gastroenterology & Hepatology
Makiko Urabe, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Shiro Hayashi, Sachiko Nakajima, Koji Fukui, Tsukasa Tanida, Takamichi Komori, Shunji Morita, Masami Inada
Correction
Multidisciplinary Sciences
Shiro Hayashi, Tsutomu Nishida, Tokuhiro Matsubara, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Masashi Yamamoto, Koji Fukui, Masami Inada
Article
Multidisciplinary Sciences
Shiro Hayash, Tsutomu Nishida, Tokuhiro Matsubara, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Masashi Yamamoto, Koji Fukui, Masami Inada
Article
Oncology
Tsutomu Nishida, Aya Sugimoto, Ryo Tomita, Yu Higaki, Naoto Osugi, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Dai Nakamatsu, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2019)
Review
Gastroenterology & Hepatology
Li-sa Chang, Yoshito Tomimaru, Tsutomu Nishida, Hiromi Tamura, Ryo Yoshioka, Kozo Noguchi, Shingo Noura, Hiroshi Imamura, Tokuhiro Matsubara, Shiro Adachi, Keizo Dono
HEPATOLOGY RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Tsutomu Nishida, Yuri Tsujii, Akino Okamoto, Ryo Tomita, Yu Higaki, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Tokuhiro Matsubara, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada
Review
Gastroenterology & Hepatology
Tsutomu Nishida, Tokuhiro Matsubara, Takayuki Yakushijin, Masami Inada
HEPATOLOGY INTERNATIONAL
(2019)
Article
Oncology
Aya Sugimoto, Tsutomu Nishida, Naoto Osugi, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Tokuhiro Matsubara, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada
MOLECULAR AND CLINICAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Takahiro Amano, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Tokuhiro Matsubara, Masashi Yamamoto, Shiro Hayashi, Sachiko Nakajima, Koji Fukui, Masami Inada
ENDOSCOPY INTERNATIONAL OPEN
(2018)
Letter
Pharmacology & Pharmacy
Shiro Hayashi, Dai Nakamatsu, Tokuhiro Matsubara, Masashi Yamamoto, Tsutomu Nishida
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2017)
Article
Gastroenterology & Hepatology
Shiro Hayashi, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada
WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY
(2016)
Article
Gastroenterology & Hepatology
Hirotsugu Saiki, Tsutomu Nishida, Masashi Yamamoto, Shiro Hayashi, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aisa Sakamoto, Yuriko Otake, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Sachiko Nakajima, Koji Fukui, Masami Inada, Katsumi Yamamoto, Ryozo Tokuda, Shiro Adachi
ENDOSCOPY INTERNATIONAL OPEN
(2016)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)