Article
Infectious Diseases
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Barbara Gardella, Ermelinda Monti, Carlo Antonio Liverani, Alessandro Ghelardi, Salvatore Insinga, Michele Montanari, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Elena Roncella, Andrea Ciavattini
Summary: The study found a decreasing trend in HPV 16/18 prevalence in women with CIN3 over the years, indicating the herd effect of the HPV vaccine, but the increase in high-risk HPV genotypes must be closely monitored.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Monica S. Sierra, Sabrina H. Tsang, Shangying Hu, Carolina Porras, Rolando Herrero, Aimee R. Kreimer, John Schussler, Joseph Boland, Sarah Wagner, Bernal Cortes, Ana C. Rodriguez, Wim Quint, Leen-Jan van Doorn, Mark Schiffman, Joshua N. Sampson, Allan Hildesheim
Summary: The study found that age and sexual behavior variables were associated with acquisition of oncogenic non-HPV-16/18 infections among HPV-vaccinated women, while no notable factors were associated with persistence of acquired infections. Factors such as age, parity, and hormonally related exposures were associated with progression to CIN2+ among the same group of women.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Partha Basu, Sylla G. Malvi, Smita Joshi, Neerja Bhatla, Richard Muwonge, Eric Lucas, Yogesh Verma, Pulikkottil O. Esmy, Usha Rani Reddy Poli, Anand Shah, Eric Zomawia, Sharmila Pimple, Kasturi Jayant, Sanjay Hingmire, Aruna Chiwate, Uma Divate, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Maqsood Siddiqi, Subha Sankaran, Priya Ramesh Prabhu, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Surendra S. Shastri, Devasena Anantharaman, Tarik Gheit, Massimo Tommasino, Catherine Sauvaget, M. Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Summary: This study in India compared the efficacy of single dose HPV vaccine with two and three doses in protecting against persistent HPV 16 and 18 infection over a 10-year period. The research found that a single dose of the vaccine provided similar protection against these infections as two or three doses, which are responsible for nearly 70% of cervical cancers.
Article
Biotechnology & Applied Microbiology
Ziwen Zheng, Xiaorong Yang, Xinyu Yao, Ling Li
Summary: The study explored the prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in predicting the progression of low-grade cervical squamous intraepithelial lesion (LSIL). Results showed that HPV 16/18 positivity rate and geminin mRNA levels can differentiate between high-grade and low-grade squamous intraepithelial lesions, suggesting a potential role of geminin in the progression of LSIL. Combining HPV genotyping and geminin mRNA qRT-PCR could improve clinical intervention efficacy for progressive LSIL.
Article
Plant Sciences
Yunhua Liu, Pengfei Zheng, Tingting Jiao, Mengmeng Zhang, Yingjie Wu, Xinjiang Zhang, Shuyue Wang, Zongjiang Zhao
Summary: This study investigated the pharmacological mechanism of paiteling in regulating cervical cancer cell apoptosis. The results showed that paiteling can induce cervical cancer cell apoptosis by inhibiting the E6/E7-Pi3k/Akt signaling pathway, providing an effective alternative strategy of traditional Chinese medicine for the treatment of epithelial neoplasia caused by HPV infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Virology
Daisuke Tamura, Wataru Sako, Rina Watanabe, Akihiro Shitara, Fumiko Saito, Misa Yamauchi, Akihiro Sugita, Akihiro Karube
Summary: In this retrospective cohort study, we found that the quantitatively measured area of CIN2/3 was closely associated with patient age, high-risk HPV status, especially single HPV16 infection, and uterine position.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Elaina Kaufman, Tyler Williamson, Marie-Helene Mayrand, Ann N. Burchell, Marina Klein, Louise Charest, Sophie Rodrigues-Coutlee, Francois Coutlee, Alexandra de Pokomandy
Summary: In this study, multivariable logistic regression analysis was used to analyze the baseline data of anal HPV 16 infection, and it was found that current smoking, nadir CD4 count, prevalent cervical HPV 16 infection, and anogenital herpes in the previous 6 months were associated with prevalent anal HPV 16 infection.
Article
Oncology
Sayaka Ikeda, Yutaka Ueda, Megumi Hara, Asami Yagi, Tetsuhisa Kitamura, Yuri Kitamura, Hiroshi Konishi, Tadao Kakizoe, Masayuki Sekine, Takayuki Enomoto, Tomotaka Sobue
Summary: This nationwide case-control study in Japan demonstrated a substantial risk reduction in abnormal cytology and CIN among women who did versus those who did not receive HPV vaccination.
Article
Immunology
Ayazhan Akhatova, Chee Kai Chan, Azliyati Azizan, Gulzhanat Aimagambetova
Summary: Cervical cancer is a serious public health concern, and despite existing preventative and screening methods, it remains a common and deadly cancer. DNA therapeutic vaccines show promise in treating cervical cancer, with their safety and effectiveness being well-documented.
Article
Multidisciplinary Sciences
Jihoon Kim, Halim Jo, Min Chul Ha, Hyunil Kim, Jung Kuk Lee, Jae Hun Han, San-Hui Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim, Hee Man Kim
Summary: This study investigated the association between ulcerative colitis (UC) and uterine cervical cancer in South Korean women using health insurance claims data. The results showed that UC patients had a higher risk of developing cervical cancer, especially among elderly patients and those with low socioeconomic status. Regular cervical cancer screening is recommended for elderly patients recently diagnosed with UC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Khalid Al-Shibli, Hiba Abdul Latif Mohammed, Ramona Maurseth, Mikkel Fostervold, Sebastian Werner, Sveinung Wergeland Sorbye
Summary: The study aimed to investigate the detection rate of CIN3+ in women aged 25-39 with normal cytology by using a 3-type HPV mRNA test as a targeted quality assurance measure. Results showed that testing women with normal cytology result using a specific 3-type HPV mRNA test can increase the screening program sensitivity without an excessive additional workload. Women with normal cytology and a negative HPV mRNA test have a very low risk of cervical cancer.
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Oncology
Yi Chen, Ying Xu, Zhengrong Zhang, Zhenhong Xiong, Dan Wu
Summary: This study shows that ALA-PDT is effective in treating HPV-infected CIN and promotes HPV clearance. The HPV clearance rate and LSIL reversal rate in the ALA-PDT group are significantly higher compared to the laser therapy group. There are no significant differences in treatment outcomes based on lesion location and different HPV types, but partially visible transformation zones have lower HPV negative conversion rate and LSIL residual/recurrence rate. The control group has a higher incidence of complications compared to the experimental group.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Kosuke Hiramatsu, Yutaka Ueda, Asami Yagi, Akiko Morimoto, Tomomi Egawa-Takata, Satoshi Nakagawa, Eiji Kobayashi, Toshihiro Kimura, Tadashi Kimura, Ryoko Minekawa, Yumiko Hori, Kazuaki Sato, Eiichi Morii, Tomio Nakayama, Yoshimichi Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Masaki Mandai, Jyunko Saito, Yorihiko Horikoshi, Tetsu Takagi, Takayuki Enomoto, Kentaro Shimura
Summary: The study showed that HPV vaccination significantly reduced the infection rate of high-risk HPV and had an impact on the development of CIN2 or worse. Additionally, the HPV vaccine demonstrated cross-protection effects against other high-risk HPV types, such as HPV 31, 45, and 52.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Obstetrics & Gynecology
Maiju Gronvall, Minna Tikkanen, Jorma Paavonen, Mikko Loukovaara, Vedran Stefanovic
Summary: Among women undergoing IRP for PPH, about two-thirds developed psychological sequelae and one-third reported lacking professional support. Factors contributing to psychological sequelae were not associated with volume of bleeding, whether hysterectomy was performed, or whether IRP was done as an emergency procedure or prophylactically.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Immunology
Irene Man, Simopekka Vanska, Matti Lehtinen, Johannes A. Bogaards
Summary: The study indicates that type replacement after HPV vaccination is influenced by the balance between cross-immunity and cross-protection, with the latter being crucial to prevent type replacement. Monitoring of nonvaccine-type prevalence is essential for gauging the population-level impacts of HPV vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Simopekka Vanska, Tapio Luostarinen, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Bengt Andrae, Par Sparen, Karin Sundstrom, Matti Lehtinen, Joakim Dillner
Summary: The study analyzed HPV genotyping data from Sweden between 2002 and 2011 to estimate age-specific cervical cancer incidence by HPV type and the impact of removing different types of HPV. The results showed that after eliminating vaccine-protected HPV types, very few cases of cervical cancer will be left, especially among fertile, reproductive-age women.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
Hanna Kann, Matti Lehtinen, Tiina Eriksson, Helja-Marja Surcel, Joakim Dillner, Helena Faust
Summary: The study demonstrates that cross-reactive antibodies can still be detected 12 years after HPV vaccination. Women with high levels of anti-HPV16 antibodies and recipients of the bivalent vaccine show higher rates of cross-reactive seropositivity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimee R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N. Sampson
Summary: Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection, and although the vaccine does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. However, pooled data from 2 large-scale randomized controlled trials did not show a significant effect in expediting clearance of incident infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Claudia Robles, Laia Bruni, Amelia Acera, Joan Carles Riera, Laia Prats, Mario Poljak, Jana Mlakar, Anja Ostrbenk Valencak, Tiina Eriksson, Matti Lehtinen, Karolina Louvanto, Maria Hortlund, Joakim Dillner, Mette T. Faber, Christian Munk, Susanne K. Kjaer, Karl Ulrich Petry, Agnieszka Denecke, Lan Xu, Marc Arbyn, Louise Cadman, Jack Cuzick, Veronique Dalstein, Christine Clavel, Silvia de Sanjose, F. Xavier Bosch
Summary: The study found that acceptance and completion of the human papillomavirus vaccination program in adult women largely depended on recruitment method, national vaccination program coverage, and personal relationship status. Knowledge of the benefits and safety of the vaccine may be crucial in expanding the target age for vaccination.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Maria Pekkola, Minna Tikkanen, Mika Gissler, Mikko Loukovaara, Jorma Paavonen, Vedran Stefanovic
Summary: This study found that women with stillbirth were more likely to undergo labor induction and less likely to have cesarean sections compared to women with live birth. They also had shorter duration of labor but higher risk for postpartum interventions and bleeding complications.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Tuomas Lehtinen, K. Miriam Elfstrom, Antti Makitie, Mari Nygard, Simopekka Vanska, Michael Pawlita, Joakim Dillner, Tim Waterboer, Matti Lehtinen
Summary: The incidence of HPV-associated OPSCC has tripled among middle-aged males in four high income Nordic countries over the past 30 years. Implementing school-based prophylactic HPV vaccination for early adolescent boys and girls is expected to decrease the incidence and eventually eliminate these types of cancers. However, there are still approximately 50 birth cohorts born in 1995 or earlier that would benefit from screening for HPV-associated OPSCC.
PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ilkka Kalliala, Tiina Eriksson, Karoliina Aro, Mari Hokkanen, Matti Lehtinen, Mika Gissler, Pekka Nieminen
Summary: The study found that the rates of preterm birth, especially early preterm birth, were lower among women who received HPV vaccination, indicating that prophylactic HPV vaccination may help reduce preterm birth rates.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Matti Lehtinen, Camilla Lagheden, Tapio Luostarinen, Tiina Eriksson, Dan Apter, Anne Bly, Penelope Gray, Katja Harjula, Kaisa Heikkila, Mari Hokkanen, Heidi Karttunen, Marjo Kuortti, Pekka Nieminen, Mervi Nummela, J. Paavonen, Johanna Palmroth, Tiina Petaja, Eero Pukkala, Anna Soderlund-Strand, Ulla Veivo, Joakim Dillner
Summary: The study findings suggest that HPV vaccination provides type-specific protection against invasive cancer, with 100% efficacy against all HPV-positive cancers during up to 11 years of follow-up.
Article
Oncology
Matti Lehtinen, Dan Apter, Tiina Eriksson, Katja Harjula, Mari Hokkanen, Kari Natunen, Pekka Nieminen, Jorma Paavonen, Johanna Palmroth, Tiina Petaja, Eero Pukkala, Simopekka Vanska, Brigitte Cheuvart, Maaria Soila, Dan Bi, Frank Struyf
Summary: The study in Finland showed that the overall effectiveness of vaccinating only girls with the HPV vaccine was significantly higher than gender-neutral vaccination. Total effectiveness was over 90% regardless of vaccination strategy, but no herd effect was found. Immune response to the AS04-HPV-16/18 vaccine was high in both sexes.
Article
Psychology, Clinical
Natalie O. Rosen, Marie-Pier Vaillancourt-Morel, Serena Corsini-Munt, Marc Steben, Isabelle Delisle, Mary-Lou Baxter, Sophie Bergeron
Summary: The study found that longer duration of relationship, lower anxiety in women, partner's higher solicitousness, and higher approach sexual goals predicted better pain outcomes for women with provoked vestibulodynia. Cognitive behavioral couple therapy was more effective in improving women's sexual function, especially when women had partners with higher anxiety and lower approach sexual goals; while lidocaine was more effective in improving women's sexual function when partners had higher approach sexual goals.
Article
Obstetrics & Gynecology
Maria Pekkola, Minna Tikkanen, Mikko Loukovaara, Jorma Paavonen, Vedran Stefanovic
Summary: This study aimed to assess parents' satisfaction with the care and support they received during a stillbirth. A questionnaire survey was conducted at Helsinki University Hospital, and the results showed that parents generally felt well supported during delivery and were satisfied with the time holding their newborn. However, there was room for improvement in social worker counseling and support after discharge. Further training of healthcare professionals and other professionals involved in stillbirth aftercare is needed.
JOURNAL OF PERINATAL MEDICINE
(2022)
Review
Immunology
Gilbert Donders, Istvan Oszkar Sziller, Jorma Paavonen, Phillip Hay, Francesco de Seta, Jean Marc Bohbot, Jan Kotarski, Jordi Antoni Vives, Bela Szabo, Ramona Cepuliene, Werner Mendling
Summary: Recurrent vulvovaginal candidosis (RVVC) is a chronic and difficult to treat vaginal infection caused by Candida species. Fluconazole resistance and the rising prevalence of non-albicans Candida species pose challenges in treatment. Innovative strategies and research into new drugs and the impact of RVVC on patients' quality of life and sex life are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Tiina Holster, Elina Urpilainen, Jorma Paavonen, Ulla Puistola, Mirja Puolakkainen
Summary: This study explored the role of C. trachomatis infection in epithelial ovarian cancer (EOC) by analyzing antibody responses to chlamydial TroA, HtrA, and MOMP. The results showed that women with these antibodies were more likely to have a complete response to the first-line treatment.
ANTICANCER RESEARCH
(2023)