Steps in prostate cancer progression that lead to bone metastasis

Prostate Cancer Cell-Derived Urokinase-Type Plasminogen Activator Contributes to Intraosseous Tumor Growth and Bone Turnover

(2015) Zhong Dong et al.   NEOPLASIA

Type I Collagen Receptor (α2β1) Signaling Promotes Prostate Cancer Invasion through RhoC GTPase

(2015) Christopher L. Hall et al.   NEOPLASIA

Matrix Metalloproteinases and Angiogenic Factors

(2010) Silvan Boxler et al.   AMERICAN JOURNAL OF PATHOLOGY

Treatment and prevention of bone complications from prostate cancer

(2010) Richard J. Lee et al.   BONE

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pathogenesis of osteoblastic bone metastases from prostate cancer

(2010) Toni Ibrahim et al.   CANCER

Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling

(2010) R. S. Wahdan-Alaswad et al.   CANCER RESEARCH

Cadherin-11 Increases Migration and Invasion of Prostate Cancer Cells and Enhances their Interaction with Osteoblasts

(2010) Chih-Fen Huang et al.   CANCER RESEARCH

Matrix Metalloproteinases Contribute Distinct Roles in Neuroendocrine Prostate Carcinogenesis, Metastasis, and Angiogenesis Progression

(2010) L. E. Littlepage et al.   CANCER RESEARCH

Dasatinib: A potent SRC inhibitor in clinical development for the treatment of solid tumors

(2010) John Araujo et al.   CANCER TREATMENT REVIEWS

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

A New Therapy Paradigm for Prostate Cancer Founded on Clinical Observations

(2010) E. Efstathiou et al.   CLINICAL CANCER RESEARCH

Bone complications of androgen deprivation therapy: screening, prevention, and treatment

(2010) Jean-Baptiste Lattouf et al.   CURRENT OPINION IN UROLOGY

The CXCR4/SDF-1 Chemokine Axis: A Potential Therapeutic Target for Bone Metastases?

(2010) A.C. Hirbe et al.   CURRENT PHARMACEUTICAL DESIGN

Anti-endothelin drugs in solid tumors

(2010) Antonio Russo et al.   EXPERT OPINION ON EMERGING DRUGS

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts

(2010) Y-C Lee et al.   ONCOGENE

Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases

(2010) Nanda K. Thudi et al.   PROSTATE

Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells

(2010) Hui He et al.   PROSTATE

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

(2010) Karen E. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma

(2009) Ravi Vij et al.   AMERICAN JOURNAL OF HEMATOLOGY

Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis

(2009) T. Tsuji et al.   CANCER RESEARCH

SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancer

(2009) Fred Saad et al.   CANCER TREATMENT REVIEWS

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway

(2009) Begoña Mellado et al.   Clinical & Translational Oncology

Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer

(2009) E. Y. Yu et al.   CLINICAL CANCER RESEARCH

Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes

(2009) R. M. Attar et al.   CLINICAL CANCER RESEARCH

Src Family Kinase Activity Is Up-Regulated in Hormone-Refractory Prostate Cancer

(2009) O. Tatarov et al.   CLINICAL CANCER RESEARCH

Role of denosumab in breast cancer

(2009) Rupert Bartsch et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Molecular mechanisms of castration-resistant prostate cancer progression

(2009) Smitha S Dutt et al.   Future Oncology

Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

(2009) Rosemary A Hannon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Randomized Phase II Trial of Denosumab in Patients With Bone Metastases From Prostate Cancer, Breast Cancer, or Other Neoplasms After Intravenous Bisphosphonates

(2009) Karim Fizazi et al.   JOURNAL OF CLINICAL ONCOLOGY

The critical role of the bone microenvironment in cancer metastases

(2009) Sandra Casimiro et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer

(2009) Matthew R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

From pathogenesis to prevention of castration resistant prostate cancer

(2009) Helmut Bonkhoff et al.   PROSTATE

Tumor–stroma co-evolution in prostate cancer progression and metastasis

(2009) Sajni Josson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effect of bisphosphonates on pain and quality of life in patients with bone metastases

(2009) Luis Costa et al.   Nature clinical practice. Oncology

Molecular mechanisms of metastasis in prostate cancer

(2008) Noel W. Clarke et al.   ASIAN JOURNAL OF ANDROLOGY

Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in bone

(2008) Mandeep S. Virk et al.   BONE

Prostate Cancer Induces Bone Metastasis through Wnt-Induced Bone Morphogenetic Protein-Dependent and Independent Mechanisms

(2008) J. Dai et al.   CANCER RESEARCH

Targeting Src Family Kinases Inhibits Growth and Lymph Node Metastases of Prostate Cancer in an Orthotopic Nude Mouse Model

(2008) S. I. Park et al.   CANCER RESEARCH

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

(2008) M. P. Kim et al.   CELL AND TISSUE RESEARCH

The cell-cell adhesion molecule E-cadherin

(2008) F. van Roy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions

(2008) Jinhui Liao et al.   INTERNATIONAL JOURNAL OF CANCER

Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner

(2008) Sanaa M. Nabha et al.   INTERNATIONAL JOURNAL OF CANCER

Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone

(2008) K. Chu et al.   MOLECULAR CANCER RESEARCH

RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis

(2008) R. E. Miller et al.   MOLECULAR CANCER THERAPEUTICS

CD147, MMP-1, MMP-2 and MMP-9 Protein Expression as Significant Prognostic Factors in Human Prostate Cancer

(2008) Wei-de Zhong et al.   ONCOLOGY

Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis

(2008) Christopher L. Hall et al.   PROSTATE

Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins

(2008) Tzu-Hsiu Lai et al.   PROSTATE

Expression of urokinase-type plasminogen activator system in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy

(2008) Masafumi Kumano et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

(2006) Etsuko Abe et al.   JOURNAL OF BONE AND MINERAL RESEARCH