Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 131, Issue 4, Pages E348-E361Publisher
WILEY
DOI: 10.1002/ijc.26423
Keywords
c-Myc; germinal center B cells; gene expression; index
Categories
Funding
- Deutsche Krebshilfe (Network Molecular mechanisms of malignant lymphoma)
- BMBF network HamatoSys [0315452H]
- Deutsche Forschungsgemeinschaft [GRK1034, FOR942]
- Leukaemia and Lymphoma Research Fund
- Kubeschka-Stricker-Wirth-Stiftung at the Georg-August-Universitat
- UICC INCRET International Cancer Study Grant
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Gene expression profiling has recently enabled the reclassification of aggressive non-Hodgkin lymphomas (aNHL) into distinct subgroups. In Burkitt lymphoma (BL) aberrant c-Myc activity results from IG-MYC translocations. However, MYC aberrations are not limited to BLs and then have a negative prognostic impact. In this study, we investigated to which extent aberrant c-Myc activity plays a functional role in other aNHL and whether it is independent from MYC translocations. Based on a combined microarray analysis of human germinal center (GC) B cells transfected with c-Myc and 220 aNHLs cases, we developed a c-Myc index. This index measures the extent to which lymphomas express c-Myc responsive genes. It comprises genes that are affected in a variety of tumors compared to normal tissue. This supports the view that aberrant c-Myc expression in GC B cells triggers a tumor-like expression pattern. As expected, the c-Myc index is very high in molecular Burkitt lymphoma (mBL), but more importantly also high within other aNHL. It constitutes a negative prognostic marker independent of established risk factors and of the presence of a MYC translocation. Our data provide new insights into the role of c-Myc activity in different lymphomas and raises the question of treatment changes for those patients under risk.
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