Article
Immunology
Tanuja Chitnis, Belinda J. Kaskow, Junning Case, Katherine Hanus, Zhenhua Li, Johnna F. Varghese, Brian C. Healy, Christian Gauthier, Taylor J. Saraceno, Shrishti Saxena, Hrishikesh Lokhande, Thais G. Moreira, Jonathan Zurawski, Rachel E. Roditi, Regan W. Bergmark, Federico Giovannoni, Maria F. Torti, Zhaorong Li, Francisco Quintana, William A. Clementi, Kunwar Shailubhai, Howard L. Weiner, Clare M. Baecher-Allan
Summary: The study found that Foralumab can preferentially induce CD8+ T cell stimulation in vitro and have positive effects on the immune system in vivo, reducing CD8+ effector memory cells, increasing naive CD8+ and CD4+ T cells, and decreasing expression of granzyme B and perforin in CD8+ T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marco Fraga, Milly Yanez, Macarena Sherman, Faryd Llerena, Mauricio Hernandez, Guillermo Nourdin, Francisco Alvarez, Joaquin Urrizola, Cesar Rivera, Liliana Lamperti, Lorena Nova, Silvia Castro, Omar Zambrano, Alejandro Cifuentes, Leon Campos, Sergio Moya, Juan Pastor, Marcelo Nunez, Jorge Gatica, Jorge Figueroa, Felipe Zuniga, Carlos Salomon, Gustavo Cerda, Ricardo Puentes, Gonzalo Labarca, Mabel Vidal, Reuben McGregor, Estefania Nova-Lamperti
Summary: The immune system's role in oral cancer is affected by the tumor microenvironment, leading to impairment of T cell responses. Regulatory T cells and Th2 effector cells are associated with poor prognosis in oral squamous cell carcinoma, providing insight into the immunomodulatory mechanisms associated with these cell subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Jing-Han Song, Jun-Ting Gu, Gao-Peng Dang, Zhi-Ting Li, Chen Lei, Ling Li, Zhao Mu, Franklin R. Tay, Kai Jiao, Li-na Niu
Summary: Unmodified collagen scaffolds are limited in bone tissue engineering due to their mechanical and osteoinductive properties. A DNA-crosslinked collagen scaffold (DNA-Col) is fabricated to enhance bone healing. The improved osteogenic performance of DNA-Col is attributed to its interaction with T cells, specifically regulatory T cells (Tregs). Mechanistic experiments show that DNA-Col triggers recruitment of Tregs in vivo, and depletion of Tregs reverses DNA-Col-induced bone regeneration. Further investigations reveal that DNA-Col promotes Treg differentiation through metabolic reprogramming. These findings establish the role of DNA-Col as a bioactive bone regeneration scaffold via its interaction with Tregs.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Microbiology
Catherine S. Nation, Akram A. Da'dara, Manal Elzoheiry, Patrick J. Skelly
Summary: Schistosomes promote Treg survival by cleaving NAD and ATP, creating a less hostile immune environment for the parasites.
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Elena Muraro, Lorenzo Vinante, Elisabetta Fratta, Alessandra Bearz, Daniela Hoefler, Agostino Steffan, Lorena Baboci
Summary: Metronomic chemotherapy is an alternative approach for cancer treatment, which involves continuous administration of low-dose drugs to overcome drug resistance and toxic side effects. It can control tumor growth by inhibiting angiogenesis, suppressing tumor cell growth, and enhancing immune response. Combining metronomic chemotherapy with immune checkpoint inhibitors has shown synergistic therapeutic effects in preclinical and clinical studies. However, optimal drug combinations, sequence, and concentration-time factors still need to be evaluated in representative preclinical models.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jelena Levi, Samuel Goth, Lyna Huynh, Tina Lam, Tony L. Huynh, Brailee Schulte, Juliet A. Packiasamy
Summary: This study aimed to evaluate the potential of F-18-arabinosyl guanine (F-18-AraG) PET as a noninvasive tool for profiling tumors based on CD8+ cells and assessing the immunomodulatory effects of chemotherapy. The results showed significant correlations between F-18-AraG signal intensity and immunological markers, suggesting its utility for patient selection and therapy evaluation. Further research is needed to explore its application in determining optimal timing for immunotherapies and assessing combinatorial treatments.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Silvia Galvan-Pena, Juliette Leon, Kaitavjeet Chowdhary, Daniel A. Michelson, Brinda Vijaykumar, Liang Yang, Angela Magnuson, Zachary Manickas-Hill, Alicja Piechocka-Trocha, Daniel P. Worrall, Kathryn E. Hall, Musie Ghebremichael, Bruce D. Walker, Jonathan Z. Li, Xu G. Yu, Diane Mathis, Christophe Benoist
Summary: Severe COVID-19 is characterized by an uncontrolled inflammatory response, potentially linked to dysregulation in T regulatory cells (Treg) which may suppress antiviral T cell responses and have a direct proinflammatory role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Parasitology
Nilanjana Majumder, Antara Banerjee, Samiran Saha
Summary: Leishmaniases are neglected but dangerous parasitic diseases worldwide, with Indian subcontinent and Eastern Mediterranean region being the hotspots. Conventional drugs for leishmaniases are toxic and expensive, leading to drug resistance. Recent research focuses on finding new drugs through drug design and targeting cellular pathways, with potential for combinatorial therapy.
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Heverton Mendes Araujo, Gabriel Acacio de Moura, Yasmim Mendes Rocha, Joao Pedro Viana Rodrigues, Roberto Nicolete
Summary: This review evaluated the activity of oxadiazole compounds against tumor cell lines and their possible immune-mediated mechanisms. The results showed that oxadiazole derivatives inhibited tumor cell growth and proliferation, blocked cell cycle, modulated mitochondrial membrane potential, and reduced proinflammatory cytokines levels. In addition, oxadiazole derivatives acted as selective inhibitors of the COX enzyme. The increase in oxadiazole patent publications in recent years suggests their potential as promising therapeutic molecules for cancer therapies.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Laisa Macedo Tavares, Luis Claudio Lima de Jesus, Viviane Lima Batista, Fernanda Alvarenga Lima Barroso, Andria dos Santos Freitas, Gabriela Munis Campos, Monique Ferrary Americo, Tales Fernando da Silva, Nina Dias Coelho-Rocha, Giovanna Angeli Belo, Mariana Martins Drumond, Pamela Mancha-Agresti, Katia Duarte Vital, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Alexander Birbrair, Enio Ferreira, Flaviano Santos Martins, Juliana Guimaraes Laguna, Vasco Azevedo
Summary: Intestinal mucositis is frequently observed in cancer patients undergoing chemotherapy and radiotherapy. Probiotics, prebiotics, and synbiotics have been investigated as alternative treatments for intestinal mucositis due to their anti-inflammatory properties. This study evaluated the anti-inflammatory effects of a synbiotic formulation containing L. delbrueckii CIDCA 133 and FOS in mice with 5-FU-induced intestinal mucosa inflammation. The results showed that the synbiotic formulation could modulate inflammatory parameters, protect the intestinal mucosa from damage, and improve the epithelial barrier function.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Immunology
Gabriela Rodrigues Leite, Denise da Gama Jaen Batista, Ana Lia Mazzeti, Rosemeire Aparecida Silva, Ademar Benevolo Lugao, Maria de Nazare Correia Soeiro
Summary: The synthetic peptides PepA and PepB were found to reduce the intracellular parasitism of T. cruzi in macrophages (PMM), but were ineffective against cardiac cells. However, they did not exhibit trypanocidal effects on bloodstream trypomastigotes, nor showed in vivo efficacy when administered after parasite inoculation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tim Tian Y. Han, John T. Walker, Aaron Grant, Gregory A. Dekaban, Lauren E. Flynn
Summary: The study shows that bioreactor preconditioning enhances the regenerative potential of human ASCs by altering the expression characteristics of ASCs on DAT scaffolds through in vitro culture, and also promotes the infiltration of host cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)