Article
Nutrition & Dietetics
Claudia Fancony, Ania Soares, Joao Lavinha, Miguel Brito
Summary: This study found that zinc deficiency may impair immune response to infections, and it is associated with an increased risk of anemia, especially in children with iron deficiency anemia.
Article
Fisheries
Jie Cui, Tianchao Xu, Hongli Lv, Meng-yao Guo
Summary: A lack of zinc in freshwater environments causes slow growth, malnutrition, and abnormal biological functions in organisms. In this study, a zinc deficiency model of grass carp hepatocytes was established using TPEN. The results showed increased LDH, AST, ALT, and AKP activities, as well as ROS levels and decreased antioxidant enzyme activities in a zinc-deficient environment. RT-PCR and ELISA demonstrated increased expression levels of genes related to endoplasmic reticulum stress, apoptosis, and inflammation. These findings suggest that zinc deficiency induces inflammation and apoptosis in grass carp hepatocytes in the presence of calcium, highlighting the adverse effects of zinc deficiency in freshwater environments.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Sajad Nazari, Mohammad Pourkazemi, Hamed Paknejad, Esmaeil Kazemi, Mostafa Ghaderi, Khalil Eslamloo
Summary: This study investigated the effects of different sources of zinc supplements on the transcriptome profiling of male rainbow trout broodstocks. The results revealed a strong inhibitory effect of mineral zinc supplement on the gene expression of O. mykiss.
Review
Medicine, Research & Experimental
Yuting Zhang, Yuyang Tian, Haowen Zhang, Baohua Xu, Hongping Chen
Summary: Zinc is the second most abundant necessary trace element in the human body, and zinc deficiency has been reported to promote the progression of various cancers through multiple signaling pathways. Factors such as oxidative stress, DNA damage, cell cycle, and inflammation level are closely related to cancer development.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Xiaoqi Wang, Xiaobin Wu, Pei Zhang, Yuan Zhou, Jun Cai, Ling Jin
Summary: The adaptive immune response mediated by T cells plays a vital role in blood pressure elevation. This study identified four subsets of memory T cells in hypertensive patients and found that CD8 effector memory T cells have more biological functions. Subpopulation 1 of CD8 TEM cells was shown to contribute to blood pressure elevation, and marker genes CKS2, PLIN2, and CNBP were identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinglei Wu, Kai Li, Jian Li, Henk Schat, Yanbang Li
Summary: Excess copper has significant impacts on plants, especially in flower responses. Genes related to Fe deficiency response are affected by excess copper, leading to reduced photosynthesis parameters and chlorophyll content.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Yanping Zhao, Ruxia Qiao, Siyuan Zhang, Guoxiang Wang
Summary: The study found that microplastic fibers can cause intestinal damage and toxicity in zebrafish, with longer fibers producing more serious effects. Metabolomics analysis revealed that microplastic fibers can up-regulate glycerophospholipids metabolism, exacerbating oxidative damage and inflammation, while down-regulating fatty acyls metabolism related to nutritional deficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Genmei Lin, Dong Gao, Jianguo Lu, Xiaowen Sun
Summary: This study investigated the gene expression patterns during gonad differentiation in the half-smooth tongue sole, revealing differentially expressed genes associated with sex differentiation and gonad development. Trend analysis showed that gene expression patterns varied over time, with either common features or significant sexual dimorphism. Transcript structure analyses identified both sex and time differences among samples, clarifying the significant sexual differences during early development and providing insight into sex differentiation and development mechanisms.
MARINE BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Zhenghang Lv, Fei Liu, Ping Zhang, Weimin Li, Qianqian Song, Jin Xu
Summary: Zinc deficiency is a serious issue for crop growth and development, but the molecular mechanisms underlying zinc uptake and deficiency response in quinoa plants are unclear. This study investigated the responses of hydroponically-grown quinoa seedlings to zinc deficiency through physiological, biochemical, and transcriptomic analyses. Zinc depletion resulted in oxidative damage and increased enzyme activities in quinoa roots. Genome-wide transcriptome analysis revealed upregulated expression of genes involved in zinc sensing and metal transport in zinc-depleted plants. Interestingly, some iron-responsive genes were not induced by zinc deficiency, suggesting direct regulation by zinc in maintaining micronutrient balance. Zinc deficiency also affected phytohormone pathways in quinoa roots. These findings provide insights into the mechanisms of zinc uptake and deficiency response in quinoa and offer a theoretical basis for breeding zinc-efficient crops.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Genetics & Heredity
Komudi Singh, Yun-Ching Chen, Shahin Hassanzadeh, Kim Han, Jennifer T. Judy, Fayaz Seifuddin, Ilker Tunc, Michael N. Sack, Mehdi Pirooznia
Summary: SARS-CoV-2 infection leads to specific dysregulation of inflammatory, mitochondrial, and autophagy-related gene expression in lung cells, affecting autophagic flux and mitochondrial function. Drugs targeting lysosome acidification or autophagic flux may be potential intervention strategies. Analysis of human data also shows impaired antiviral signaling pathways and dysregulated gene expression due to SARS-CoV-2 infection.
FRONTIERS IN GENETICS
(2021)
Article
Forestry
Conghui Wang, Fuhua Fan, Xianwen Shang, Zijing Zhou, Guijie Ding
Summary: This study identified ten SPX domain-containing genes in Pinus massoniana in response to phosphorus deprivation, revealing differential expression patterns of PmSPX genes and specific promoter elements related to phosphorus stress response. The results highlight the foundational functions of PmSPXs in maintaining plant phosphorus homeostasis.
Article
Biochemistry & Molecular Biology
Marian L. Kruzel, Paulina Olszewska, Barbara Pazdrak, Anna M. Krupinska, Jeffrey K. Actor
Summary: The study evaluated the systemic effects of orally and intravenously administered lactoferrin on blood cell transcriptome profiling, finding similarities in the gene responses between oral and IV administration, particularly involving oxidative stress and inflammatory responses.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Briana C. Bywaters, Gladys Pedraza, Andreea Trache, Gonzalo M. Rivera
Summary: A better understanding of endothelial dysfunction has the potential to improve interventions for preventing and treating atherosclerosis. This study reveals stage- and sex-dependent effects of endothelial NCK2 signaling on arterial wall inflammation and atherosclerosis development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yu Pan, Shirong Cao, Jiaqi Tang, Juan P. Arroyo, Andrew S. Terker, Yinqiu Wang, Aolei Niu, Xiaofeng Fan, Suwan Wang, Yahua Zhang, Ming Jiang, David H. Wasserman, Ming-Zhi Zhang, Raymond C. Harris
Summary: Obesity-related complications are causing increasing morbidity and mortality worldwide, mainly due to inflammation and dysregulated metabolism in adipose tissue leading to insulin resistance and metabolic syndrome. Studies have shown that the ATM COX-2/PGE2/EP4 axis in adipose tissue plays a critical role in inhibiting adipose tissue dysfunction during obesity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Kai Zhang, Shuang Li, Qingyu Zhao, Jing Li, Yunsheng Han, Yuchang Qin, Junmin Zhang, Chaohua Tang
Summary: This study investigated the interaction among redox status, energy metabolism, and inflammation in nutritional muscle dystrophy induced by dietary selenium (Se) deficiency. Results showed that Se deficiency led to redox imbalance, reprogramming of muscle central carbon and lipid metabolism, enhanced glycolysis pathway, and decreased phospholipid synthesis. Inflammation and apoptosis were observed in response to Se deficiency-induced muscle oxidative stress, possibly associated with extracellular matrix remodeling, suppressed focal adhesion and PI3K/AKT signaling, and activation of the NF-kappa B signaling pathway.
JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Francesca Lovat, Pierluigi Gasparini, Giovanni Nigita, Karilyn Larkin, John C. Byrd, Mark D. Minden, Michael Andreeff, Bing Z. Carter, Carlo M. Croce
Summary: The study found that the loss of both miR-15/16 clusters may act as a potential oncogenic driver in the transition from chronic phase to blast crisis in CML patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Chao Jin, Xiaonan Liu, Wenyuan Zheng, Liping Su, Yang Liu, Xu Guo, Xiaoming Gu, Hongping Li, Bo Xu, Gang Wang, Jiyan Yu, Qiong Zhang, Dengke Bao, Shaogui Wan, Fei Xu, Xiaohuan Lai, Jiayun Liu, Jinliang Xing
Summary: The study identified five typical CNV markers in cfDNA of HCC samples, with size selection enhancing TF and CNV signals significantly. Additionally, three preferred 4-mer end motifs were found in HCC samples. The association between fragment size and end motifs suggests a potential for effective detection of patients with HCC using cfDNA.
MOLECULAR ONCOLOGY
(2021)
Editorial Material
Genetics & Heredity
Gerd A. Blobel, Douglas R. Higgs, Jennifer A. Mitchell, Dimple Notani, Richard A. Young
Summary: In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.
NATURE REVIEWS GENETICS
(2021)
Article
Genetics & Heredity
Guanlin Zhou, Ying Li, Shicheng Li, Hongxia Liu, Fei Xu, Xiaohuan Lai, Qiong Zhang, Jingxiang Xu, Shaogui Wan
Summary: The study found that high ccf-mtDNA content may increase the risk of death in HBV-HCC patients receiving TACE and TCM treatment, but no significant association was found in univariate analysis.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Felice Pepe, Laura Z. Rassenti, Yuri Pekarsky, Jadwiga Labanowska, Tatsuya Nakamura, Giovanni Nigita, Thomas J. Kipps, Veronica Balatti, Carlo M. Croce
Summary: Chronic lymphocytic leukemia (CLL) is a common adult leukemia characterized by chromosomal aberrations. This study found that some CLL patients have undetected microdeletions, which are closely associated with chromosomal alterations in cancer. These findings may have clinical relevance for successful stratification of patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Computer Science, Artificial Intelligence
Chiara Vischioni, Fabio Bove, Federica Mandreoli, Riccardo Martoglia, Valentino Pisi, Cristian Taccioli
Summary: The study of Copy Number Variations (CNVs) is a hot topic in biomedical cancer research. VarNuCopy is a novel platform that allows visual, interactive exploration and analysis of CNV data across multiple species, providing a comprehensive and efficient solution for researchers to identify complex trends and patterns in a large amount of data.
Article
Genetics & Heredity
Chiara Vischioni, Fabio Bove, Matteo De Chiara, Federica Mandreoli, Riccardo Martoglia, Valentino Pisi, Gianni Liti, Cristian Taccioli
Summary: This study identified novel gene targets linked to tumor predisposition and found that miRNA copy number patterns are associated with cancer progression and susceptibility.
Article
Biochemistry & Molecular Biology
Nicoletta Bianchi, Luisa Doneda, Luca Elli, Cristian Taccioli, Valentina Vaira, Alice Scricciolo, Vincenza Lombardo, Anna Terrazzan, Patrizia Colapietro, Leonardo Terranova, Carlo Bergamini, Maurizio Vecchi, Lucia Scaramella, Nicoletta Nandi, Leda Roncoroni
Summary: This study identified a set of microRNAs in serum that can differentiate between different types of refractory diseases and aid in monitoring disease progression. The study also revealed the functions of these microRNAs, including cell signaling, epigenetic regulation, and inflammatory profiles.
Article
Biology
Carlo M. Bergamini, Nicoletta Bianchi, Valerio Giaccone, Paolo Catellani, Leonardo Alberghini, Alessandra Stella, Stefano Biffani, Sachithra Kalhari Yaddehige, Tania Bobbo, Cristian Taccioli
Summary: This study demonstrates for the first time that machine learning algorithms can identify and discriminate probiotic bacteria from pathogenic organisms in the human gut. The information content within tRNA sequences was found to be the key genomic feature in characterizing probiotics.
Biographical-Item
Oncology
Gary S. Stein, Carlo M. Croce
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Yazavinder Singh, Marco Cullere, Davide Bertelli, Severino Segato, Giovanni Franzo, Antonio Frangipane di Regalbono, Paolo Catellani, Cristian Taccioli, Silvia Cappellozza, Antonella Dalle Zotte
Summary: Insects, such as silkworm chrysalis, can be a sustainable and alternative feed ingredient due to their rich nutritional profile. This research aimed to understand the potential of silkworm chrysalis as a feedstuff for laying quails, finding that it can be included up to 12% in the feed formulation for optimal performance and egg quality.
Article
Biochemistry & Molecular Biology
Henry R. Kilgore, Peter G. Mikhael, Kalon J. Overholt, Ann Boija, Nancy M. Hannett, Catherine Van Dongen, Tong Ihn Lee, Young-Tae Chang, Regina Barzilay, Richard A. Young
Summary: This research reveals that different types of intracellular condensates have distinct chemical environments that affect molecular distribution. Machine learning approaches can predict the selective partitioning of molecules in condensates, providing insights for the development of small molecule therapeutics with optimal subcellular distribution and therapeutic benefits.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carlo M. Bergamini, Chiara Vischioni, Gianluca Aguiari, Carmen Grandi, Anna Terrazzan, Stefano Volinia, Nicoletta Bianchi, Cristian Taccioli
Summary: The long non-coding RNA TG2-lncRNA plays a role in breast cancer cells by influencing multiple biological networks relevant to tumorigenesis, and has the potential to directly interact with key transcription factors.
Meeting Abstract
Oncology
Lucia Casadei, Patricia Sarchet, Luciano Cascione, Giovanni Nigita, Fernanda Costas Casal de Faria, Carlo Maria Croce, Valerie Grignol, Raphael E. Pollock