Article
Environmental Sciences
Rasit Asiloglu
Summary: Biochar applications have significant impacts on the soil microbial community and functionality, but studies on protists, which are an important component of eukaryotic diversity, are currently lacking.
Article
Ecology
Rassim Khelifa, Hayat Mahdjoub
Summary: Equity, diversity, and inclusion have become important considerations in various academic fields. The KLOB framework helps to understand the cumulative effect of multiple barriers individuals from different backgrounds face in academic activities, such as scientific publishing. It highlights local and global disparities in socioeconomic, linguistic, and discriminatory factors that determine researchers' opportunities for success in academia.
Article
Psychology, Biological
Aisling Rayne, Hitaua Arahanga-Doyle, Bethany Cox, Murray P. Cox, Catherine M. Febria, Stephanie J. Galla, Shaun C. Hendy, Kirsten Locke, Anna Matheson, Aleksandra Pawlik, Tom Roa, Emma L. Sharp, Leilani A. Walker, Krushil Watene, Priscilla M. Wehi, Tammy E. Steeves
Summary: The current science system is unfair in its memberships, outputs, and outcomes. We advocate for collective action to establish a more just science system that shows care for all participants. To achieve this, we urge the science community to harness complexity processes with intention.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Multidisciplinary Sciences
Dianna M. Smith, Christina Vogel, Monique Campbell, Nisreen Alwan, Graham Moon
Summary: This study aims to model aspects of adult diet consumption in English neighborhoods and identify areas where reported consumption levels deviate significantly from recommended levels. The results highlight specific regions in England where interventions to improve fruit and vegetable consumption or reduce SSB intake should be prioritized. The estimates provide valuable information for targeted interventions at a finer spatial scale to improve diet and health outcomes.
Article
Anesthesiology
Karissa M. Johnston, Lauren Powell, Evan Popoff, Linda Harris, Robert Croop, Vladimir Coric, Gilbert L'Italien
Summary: A network meta-analysis was conducted to compare the benefit-risk profiles of rimegepant, ubrogepant, and lasmiditan. The results provide valuable information for clinical decision-making.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Agronomy
Matteo Serena, Bernhard Leinauer, Ciro Velasco-Cruz, Elena Sevostianova
Summary: Limited information is available on the optimal frequency and amounts of irrigation water needed to establish cool-season turfgrasses from seed in arid environments. Digital image analysis was used to estimate the days needed for establishing turfgrasses. The study suggests that water conserving measures can be used to establish cool-season turfgrasses in arid regions, and further research is needed to determine the lowest irrigation levels or frequency required.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingyu Zhong, Junjie Lu, Guangcheng Zhang, Shiqi Mao, Haoda Chen, Qian Yin, Yangfan Hu, Yue Xing, Defang Ding, Xiang Ge, Huan Zhang, Weiwu Yao
Summary: This study provides an overview of the meta-analyses of radiomics studies, evaluating their quality and evidence level. The systematic reviews on radiomics were found to have suboptimal quality, and only a limited number of radiomics approaches were supported by convincing level of evidence.
INSIGHTS INTO IMAGING
(2023)
Review
Endocrinology & Metabolism
Andre J. Scheen, Fabrice Bonnet
Summary: Type 2 diabetes mellitus is a common health condition in elderly population and is associated with increased risks of cardiovascular disease and heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have shown to improve cardiovascular prognosis and reduce the risk of hospitalization for heart failure. This comprehensive review analyzed the benefit-risk ratio of SGLT2i therapy in older patients with type 2 diabetes by reviewing large studies and observational cohort studies. The results showed that SGLT2is had similar benefits in reducing cardiovascular mortality and heart failure in all age groups, with potentially greater risk reduction in elderly patients.
DIABETES & METABOLISM
(2023)
Article
Environmental Sciences
Craig Poku, Andrew N. Ross, Adrian A. Hill, Alan M. Blyth, Ben Shipway
Summary: Aerosols play a crucial role in the fog life cycle by controlling the droplet number concentration and size. While detailed aerosol-microphysics schemes are unsuitable for forecasting and climate models, a more physically based aerosol activation scheme has been developed to accurately represent droplet formation. This new scheme has shown promising results in improving the calculation of cloud droplet number in fog modeling.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2021)
Article
Geochemistry & Geophysics
Morgan T. Page
Summary: The concern over multifault ruptures in the third edition of UCERF3 model has been raised, but the author argues that the rupture-length distribution matches empirical data and suggests improvements by adding more connectivity to the fault system. This improvement would enhance model fit with data, make the model less characteristic on the faults, potentially improve aftershock forecasts, and reduce sensitivity to inadequacies and unknowns in the modeled fault system.
BULLETIN OF THE SEISMOLOGICAL SOCIETY OF AMERICA
(2021)
Editorial Material
Biochemistry & Molecular Biology
Ann E. Russell, T. Mitchell Aide, Elizabeth Braker, Carissa N. Ganong, Rebecca D. Hardin, Karen D. Holl, Sara C. Hotchkiss, Jeffrey A. Klemens, Erin K. Kuprewicz, Deedra McClearn, George Middendorf, Rebecca Ostertag, Jennifer S. Powers, Sabrina E. Russo, Jennifer L. Stynoski, Ursula Valdez, Charles G. Willis
Summary: Understanding tropical biology is crucial for addressing complex issues like climate change, biodiversity loss, and zoonotic pandemics. However, current biology education primarily focuses on the temperate zone perspective, highlighting the urgent need to integrate tropical research into the curriculum.
Article
Orthopedics
Yuxuan Jiang, Yangjun Zhu, Binfei Zhang, Dongxu Feng
Summary: This study analyzed the characteristics of individuals with subsequent contralateral proximal femoral fracture (PFF) following surgical therapy for first PFF and investigated whether these patients received examination or treatment for osteoporosis, as well as explored the reasons for lack of examination or treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nursing
Olga Yakusheva, Megan A. Czerwinski, Peter I. Buerhaus
Summary: The article highlights the importance of nurses in improving environmental outcomes and reducing environmental waste, as well as proposing changes in nursing education to prepare the next generation of nurses to effectively address environmental problems.
Article
Multidisciplinary Sciences
Lu Huang, Zhou Songyang, Zhiming Dai, Yuanyan Xiong
Summary: This study established and validated two prognostic markers (gene expression score and immune score) based on field cancerization profiles for the diagnosis, treatment, and prognostic evaluation of hepatocellular carcinoma (HCC). The results showed that field cancerization profile-based models outperformed conventional models in risk evaluation, providing insights for further research on prognostic model construction. The findings regarding immune cells and immunotherapy may explain the diverse prognosis and clinical benefit of HCC, and contribute to molecular mechanism studies and therapeutic target development.
Editorial Material
Behavioral Sciences
Laurent Mottron
Summary: The evolution of autism diagnosis has led to a vague diagnosis that makes it difficult to specify the type of support needed, both in clinical settings and research. Focusing on individuals with expert judged prototypicality rather than over-inclusive criteria may help advance the theoretical and practical issues concerning autism diagnosis.
Article
Chemistry, Medicinal
Rocio Recio, Patricia Lerena, Esther Pozo, Jose Manuel Calderon-Montano, Estefania Burgos-Moron, Miguel Lopez-Lazaro, Victoria Valdivia, Manuel Pernia Leal, Bernard Mouillac, Juan Angel Organero, Noureddine Khiar, Inmaculada Fernandez
Summary: NK1R antagonists derived from carbohydrate-based compounds have shown promising results in the treatment of several cancers. Among them, a galactosyl derivative exhibited significant NK1R antagonist effect and selective cytotoxic activity against a variety of cancer cell lines.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Monica C. Garcia, Nabila Naitlho, Jose Manuel Calderon-Montano, Estrella Drago, Manuela Rueda, Marcela Longhi, Antonio M. Rabasco, Miguel Lopez-Lazaro, Francisco Prieto-Dapena, Maria Luisa Gonzalez-Rodriguez
Summary: Stimulus-responsive liposomes were evaluated for controlled drug release in cancer therapy, with findings showing that cholesterol levels and temperature play crucial roles in drug release profiles.
Article
Plant Sciences
Jose Manuel Calderon-Montano, Sara Maria Martinez-Sanchez, Victor Jimenez-Gonzalez, Estefania Burgos-Moron, Emilio Guillen-Mancina, Julio Jose Jimenez-Alonso, Patricia Diaz-Ortega, Felipe Garcia, Abelardo Aparicio, Miguel Lopez-Lazaro
Summary: This study screened plant extracts from Western Andalusia, Spain, and identified potential sources of natural compounds with selective toxicity towards cancer cells, highlighting the importance of finding cytotoxic drugs with high selectivity to improve survival rates in patients with metastatic cancers.
Article
Biochemistry & Molecular Biology
Estefania Burgos-Moron, Nuria Pastor, Manuel Luis Orta, Julio Jose Jimenez-Alonso, Carlos Palo-Nieto, Margarita Vega-Holm, Jose Manuel Vega-Perez, Fernando Iglesias-Guerra, Santiago Mateos, Miguel Lopez-Lazaro, Jose Manuel Calderon-Montano
Summary: AzGalp, a promising compound for anticancer treatment, induces DNA damage to exert cytotoxicity, especially towards cancer cells deficient in the nucleotide excision repair pathway. Combination with oxaliplatin or 5-fluorouracil slightly enhances its selective cytotoxicity, with the highest selectivity observed against acute promyelocytic leukemia cells. Further preclinical studies are needed to evaluate the anticancer potential of AzGalp.
Article
Pharmacology & Pharmacy
Monica C. Garcia, Jose Manuel Calderon-Montano, Manuela Rueda, Marcela Longhi, Antonio M. Rabasco, Miguel Lopez-Lazaro, Francisco Prieto-Dapena, Maria Luisa Gonzalez-Rodriguez
Summary: This study reports the development of pH/thermo-sensitive liposomes using nucleolipids and modified with gold nanoparticles. The results demonstrate that these liposomes can efficiently release anticancer drugs and exhibit significant toxicity against cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nutrition & Dietetics
Julio Jose Jimenez-Alonso, Emilio Guillen-Mancina, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: The study evaluated the therapeutic potential of selective amino acid restriction in colon cancer and found that artificial diets based on this restriction can improve survival rates.
Article
Biochemistry & Molecular Biology
Jose Manuel Calderon-Montano, Emilio Guillen-Mancina, Julio Jose Jimenez-Alonso, Victor Jimenez-Gonzalez, Estefania Burgos-Moron, Alfonso Mate, Maria Concepcion Perez-Guerrero, Miguel Lopez-Lazaro
Summary: This study demonstrates that artificial diets manipulating specific amino acids can selectively inhibit renal cell carcinoma in vitro and in vivo. Replacing normal diet with an artificial diet lacking six amino acids significantly improves mice survival. This simple and inexpensive anticancer strategy shows better efficacy compared to current standard therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sofia Henriksson, Jose Manuel Calderon-Montano, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday
Summary: MTH1 inhibitors TH588 and TH1579 selectively kill cancer cells, and the selectivity may be explained by oncogene-induced replication stress. The mechanisms involve MTH1-independent proteasomal degradation of c-Myc, c-Myc-driven transcription, and CDK activation.
Article
Biochemistry & Molecular Biology
Julio Jose Jimenez-Alonso, Emilio Guillen-Mancina, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: Sulfur-containing amino acids methionine (Met), cysteine (Cys), and taurine (Tau) play important roles in cellular functions and metabolism. This study investigates the role of Cys and Tau in the anticancer activity of Met-restricted diets. The results show that diets supplemented with Cys or Tau exhibit marked anticancer activity in animal models of colon cancer, ovarian cancer, and renal cell carcinoma. These findings suggest the potential use of these diets in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Emilio Guillen-Mancina, Julio Jose Jimenez-Alonso, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: Dietary manipulation can significantly increase the survival of mice with metastatic TNBC, and this non-pharmacological anticancer strategy is more effective than current drugs for treating metastatic TNBC. It also has potential efficacy for other types of metastatic cancers.
Article
Plant Sciences
Victor Jimenez-Gonzalez, Guillermo Benitez, Julio Enrique Pastor, Miguel Lopez-Lazaro, Jose Manuel Calderon-Montano
Summary: Cancer kills millions of people worldwide every year. Finding more selective anticancer agents is crucial for improving the survival rates of patients with metastatic cancers. Research has discovered potential sources of new anticancer drugs in plants from the Iberian Peninsula.
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)
