Article
Pharmacology & Pharmacy
Yanting Yang, Xiuhong Zhu, Guohua Yu, Jinbo Ma
Summary: This study demonstrates that Pyxinol can mitigate cisplatin-induced renal injury by attenuating DNA damage response and tubular cell apoptosis. Furthermore, Pyxinol can enhance the in vivo anti-tumor efficacy of cisplatin against xenograft tumors in nude mice. The combination of Pyxinol with cisplatin may represent a beneficial adjunct therapy for cisplatin-based chemotherapeutic regimens in the clinic.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan
Summary: This study investigated the toxic effects of deoxynivalenol (DON) on gastric mucosal epithelial cells and found that DON can inhibit cell activity, induce DNA damage, apoptosis, and cell cycle arrest. These findings are important for understanding the cytotoxicity and gastric diseases caused by DON.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Songwang Xie, Zhen Hong, Yan Li, Junyong Wang, Jian Wang, Shaoquan Li, Yongchang Liu
Summary: The study found that RNF216 is overexpressed in GBM and is associated with a poor prognosis. Overexpression of RNF216 promotes GBM cell growth and inhibits apoptosis, while knockdown of RNF216 has the opposite effects. RNF216 overexpression also degrades the p53 protein and negatively regulates the p53 pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Lei Sang, Rui Dong, Rui Liu, Qinggang Hao, Weiyu Bai, Jianwei Sun
Summary: Our study reveals that NHR-14/HNF4 alpha cooperates with CEP-1/p53 to regulate DNA damage-induced apoptosis.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Simona Ferracchiato, Nicola Di-Iacovo, Damiano Scopetti, Danilo Piobbico, Marilena Castelli, Stefania Pieroni, Marco Gargaro, Giorgia Manni, Stefano Brancorsini, Maria Agnese Della-Fazia, Giuseppe Servillo
Summary: The study demonstrated impaired DNA-damage response in Hops heterozygous mice and mouse embryonic fibroblasts, showing reduced levels of p53 protein and apoptotic cells. Additionally, reduced HOPS levels caused deregulation in the transcript profiles of p53-dependent genes. Overall, the results suggest a novel role for Hops as a tumor-suppressor gene in DNA damage repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sumiran Kumar Gurung, Sangeeta Kumari, Srikanta Dana, Kalyanashis Mandal, Sobhan Sen, Pritam Mukhopadhyay, Neelima Mondal
Summary: Naphthalene diimide (NDI) derivative 1a shows potent anticancer activity against gastric cancer cells through inducing DNA damage, inhibiting cell migration and apoptosis, and suppressing the β-catenin/c-Myc pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Conor T. Ronayne, Sravan K. Jonnalagadda, Shirisha Jonnalagadda, Grady L. Nelson, Lucas N. Solano, Hithardha Palle, Chinnadurai Mani, Jon Rumbley, Jon Holy, Venkatram R. Mereddy
Summary: CBISC, a novel nitrogen mustard, demonstrates enhanced inhibition of cell proliferation against certain cancer cell lines, and shows potential tumor growth inhibitory properties in both in vitro and in vivo studies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Xinxin Rao, Peiyuan Tang, Yuanchuang Li, Guoxiang Fu, Shengzhi Chen, Xiaoya Xu, Yi Zhou, Xiaomeng Li, Long Zhang, Shaobo Mo, Sanjun Cai, Junjie Peng, Zhen Zhang, Jianjun Gao, Guoqiang Hua
Summary: CBP/P300 inhibitors have been found to effectively mitigate radiation-induced gastrointestinal syndrome (RIGS) by promoting organ and crypt regeneration, and delaying intestinal epithelial cell cycle progression, leading to improved mouse survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Yucheng Liu, Xinyan Wang, Wucheng Zhu, Zhongheng Sui, Xiangqing Wei, Yang Zhang, Jiansong Qi, Yanhong Xing, Wuyang Wang
Summary: This study reveals the mechanism by which TRPML1 inhibits autophagy to regulate apoptosis, involving disrupted mitochondrial turnover, elevated ROS, DNA damage, and p53 activation. These findings have potential clinical implications for treating melanoma and glioblastoma.
Article
Oncology
Apisada Jiso, Philipp Demuth, Madeleine Bachowsky, Manuel Haas, Nina Seiwert, Daniel Heylmann, Birgit Rasenberger, Markus Christmann, Lea Dietrich, Thomas Brunner, Riyanti, Till F. Schaeberle, Anuchit Plubrukarn, Joerg Fahrer
Summary: Merosesquiterpenes show promise as potential therapeutic agents for colorectal cancer, as they induce DNA damage, trigger apoptosis, and exhibit cytotoxic activity against CRC cell lines and tumor organoids. Their efficacy is observed in both wild-type and mutant p53 CRC cells, making them a potential candidate for CRC chemotherapy.
Article
Cell Biology
Yuli Thamires Magalhaes, Viktor Kalbermatter Boell, Giovanna Duo Cardella, Fabio Luis Forti
Summary: This study aimed to investigate the effects of Rho GTPases on DNA damage repair and therapeutic sensitivity. The results showed that inhibiting the Rho pathway increased the sensitivity of glioblastoma cells to radiation therapy and delayed DNA repair. Additionally, the study found that there is an interdependence between p53 and Rho, with G-actin mediating nuclear translocation of p53 enhanced by IR. Overall, the findings suggest that Rho and actin cytoskeleton dynamics are sensitive targets for reversing acquired resistance in GBM tumors with wild-type p53.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Sirong Song, Dongbin Ma, Lixia Xu, Qiong Wang, Lanxiang Liu, Xiaoguang Tong, Hua Yan
Summary: Low-intensity pulsed ultrasound (LIPUS) can wake up glioma stem cells (GSCs) and enhance their sensitivity to chemotherapy. LIPUS weakens the Wnt and Hh signaling pathways, allowing GSCs to escape from quiescence, and triggers telomere crisis by converting oxygen molecules into singlet oxygen.
Article
Chemistry, Medicinal
Perihan A. Elzahhar, Hisham A. Nematalla, Houssam Al-Koussa, Carla Abrahamian, Amira F. El-Yazbi, Larry Bodgi, Jolie Bou-Gharios, Joyce Azzi, Joelle Al Choboq, Hala F. Labib, Wassim Abou Kheir, Marwa M. Abu-Serie, Mohamed A. Elrewiny, Ahmed F. El-Yazbi, Ahmed S. F. Belal
Summary: Structural modifications of nitrofurantoin were explored for potential anticancer activity. Eleven compounds showed safety in non-cancerous cells and demonstrated antitumor efficacy on various cancer cell lines. Three compounds induced oxidative DNA damage and triggered cellular apoptosis by regulating Bax, Bcl-2, and caspase 3/7. The compounds showed similar DNA damage in both p53 wild-type and mutant cell lines. Mechanistic studies revealed their dependence on p53-mediated pathways by suppressing p53-MDM2 interaction. In vivo antitumor activity was confirmed in an MCF7-xenograft model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Peng Wang, Chun Wang, Chunying Liu
Summary: Dioscin inhibits skin cancer cell proliferation by adjusting ATM/p53-mediated cell apoptosis, migration, and DNA damage.
Article
Oncology
Yuta Imaizumi, Saishu Yoshida, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida
Summary: In colorectal cancer, the expression of DYRK2 is decreased, affecting clinical prognosis. Overexpression of DYRK2 through adenovirus-mediated gene transfer can inhibit cell proliferation and induce apoptosis, providing a potential therapy for colorectal cancer.
Review
Gastroenterology & Hepatology
Kohji Yamada, Kiyotsugu Yoshida
Summary: Protein kinase C delta (PKC delta) is a member of the PKC family and plays important roles in various biological and cancerous processes. Its function is regulated by factors such as phosphorylation and subcellular localization. Recent studies have found its unique extracellular localization and growth factor-like function in liver cancer cells, contributing to our understanding of its involvement in liver cancer progression.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, Kiyotsugu Yoshida
Summary: PKC delta is secreted from liver cancer cells and binds to the epidermal growth factor receptor (EGFR), activating the EGFR signaling pathway and promoting cell proliferation and tumor growth in liver cancer.
Article
Cell Biology
Akira Kawamura, Saishu Yoshida, Katsuhiko Aoki, Yuya Shimoyama, Kohji Yamada, Kiyotsugu Yoshida
Summary: This study reveals that dual-specificity tyrosine-regulated kinase 2 (DYRK2) is a novel regulator of neddylation, promoting neddylation through forming a complex with NEDD8-activating enzyme E1 component NAE1, and thus maintaining genome stability.
JOURNAL OF CELL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Kohji Yamada, Saya Motohashi, Tsunekazu Oikawa, Naoko Tago, Rei Koizumi, Masaya Ono, Toshiaki Tachibana, Ayano Yoshida, Saishu Yoshida, Masayuki Shimoda, Masahiro Oka, Yoshihiro Yoneda, Kiyotsugu Yoshida
Summary: The study reveals the role of E-Syt1 in mediating cytosolic protein secretion at the ER-PM contact sites in liver cancer cells. SEC22B vesicles tethered to the PM via Q-SNAREs for their secretion, while PKC delta secretion and tumorigenicity were regulated by the interaction with E-Syt1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto, Kiyotsugu Yoshida
Summary: This study investigates the role of PKC delta in colorectal cancer (CRC) and finds that PKC delta acts as a negative regulator of cellular senescence in p53 wild-type CRC. The activation of p21 via a p53-independent pathway by PKC delta is shown to be essential for its activity. The study also proposes a novel therapeutic strategy for CRC targeting wt-p53.
Article
Biochemistry & Molecular Biology
Kohji Yamada, Kiyotsugu Yoshida
Summary: Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. This article provides an overview of UPS mechanisms and categorizes cancer-specific UPS as CUPS due to their distinct features in cancer cells.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kohji Yamada, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura, Yuta Mochimaru, Ken Eto, Kiyotsugu Yoshida
Summary: This study demonstrates that E-Syt1 plays a critical role in the tumorigenic potential of liver cancer cells. E-Syt1 depletion inhibits cell proliferation and is associated with a poorer prognosis in hepatocellular carcinoma. Furthermore, E-Syt1 is required for the unconventional secretion of PKCd and the activation of IGF1R and Erk1/2 signaling pathways, which are implicated in liver cancer tumorigenesis.
Review
Biochemistry & Molecular Biology
Saishu Yoshida, Kiyotsugu Yoshida
Summary: The DYRK family, from invertebrates to mammals, plays a crucial role in regulating cell processes such as proliferation, apoptosis, survival, and differentiation. However, limited evidence exists regarding their in vivo roles in mammalian development. This review provides an overview of in vivo studies on Dyrks, shedding light on their roles in mammalian tissue development and congenital diseases.
Article
Oncology
Yasuhiro Takano, Satomi Yogosawa, Yuta Imaizumi, Hiroshi Kamioka, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida
Summary: DYRK2 expression is associated with chemosensitivity to 5-fluorouracil and oxaliplatin in p53 wild-type colorectal cancer, suggesting its importance as a new marker in therapeutic strategies.
Article
Gastroenterology & Hepatology
Hiroshi Kamioka, Satomi Yogosawa, Tsunekazu Oikawa, Daisuke Aizawa, Kaoru Ueda, Chisato Saeki, Koichiro Haruki, Masayuki Shimoda, Toru Ikegami, Yuji Nishikawa, Masayuki Saruta, Kiyotsugu Yoshida
Summary: DYRK2 has been found to play an anti-tumor role in hepatocellular carcinoma (HCC) by promoting the degradation of Myc and Hras. This study provides new insights into the potential therapeutic approach of using DYRK2 gene transfer for HCC treatment.
Meeting Abstract
Oncology
Yoshimi Imawari, Rei Mimoto, Kiyotsugu Yoshida
Review
Biochemistry & Molecular Biology
Yuta Mochimaru, Kiyotsugu Yoshida
Summary: DYRK2 plays diverse roles in cancer, with controversy regarding its functional conservation. Although studies have been conducted in different types of cancer, the current methods used are not sufficient to fully comprehend the role of DYRK2 in cancer.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Oncology
Kohji Yamada, Tsunekazu Oikawa, Saya Motohashi, Ayano Yoshida, Rei Koizumi, Saishu Yoshida, Kiyotsugu Yoshida
Meeting Abstract
Oncology
Saya Motohashi, Kohji Yamada, Ayano Yoshida, Rei Koizumi, Kiyotsugu Yoshida
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)