Article
Biology
Juan P. Zanin, Wilma J. Friedman
Summary: Neuronal migration is a crucial process for brain development, and p75NTR serves as an anti-migratory factor by maintaining elevated levels of active RhoA to prevent granule cell migration.
Article
Biology
Anna Perri, Vittoria Rago, Rocco Malivindi, Lorenza Maltese, Danilo Lofaro, Emanuela Alessandra Greco, Luigi Tucci, Renzo Bonofiglio, Margherita Vergine, Sandro La Vignera, Eusebio Chiefari, Antonio Brunetti, Antonio Aversa
Summary: Studies have shown that p75(NTR) is overexpressed in several human cancer types, and in TGCTs, it may serve as a specific marker for seminoma and staging progression.
Article
Biochemistry & Molecular Biology
Tomas Barrio, Enric Vidal, Marina Betancor, Alicia Otero, Inmaculada Martin-Burriel, Marta Monzon, Eva Monleon, Marti Pumarola, Juan Jose Badiola, Rosa Bolea
Summary: Neurotrophins and their receptors, including p75(NTR), were studied in the brains of scrapie-affected sheep and infected mice, showing p75(NTR) overexpression in early stages in sheep and higher abundance of p75(NTR) immunostained cells in infected mice. These findings suggest a potential role of p75(NTR) in the neurodegeneration associated with prion diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
C. H. H. Hor, J. C. W. Lo, A. L. S. Cham, W. Y. Leong, E. L. K. Goh
Summary: The study showed that conditional knock-out of the Shh pathway repressor Rab23 in mice resulted in mis-patterning of the cerebellum and increased GCP proliferation. Despite no prevalent occurrence of medulloblastoma in adulthood, Rab23-depleted GCPs exhibited upregulated Shh pathway activities and abnormal ciliogenesis.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Danielle A. Simmons, Brian D. Mills, Robert R. Butler III, Jason Kuan, Tyne L. M. McHugh, Carolyn Akers, James Zhou, Wassim Syriani, Maged Grouban, Michael Zeineh, Frank M. Longo
Summary: This study investigates the use of multimodal MRI and plasma cytokines as potential pharmacodynamic biomarkers for Huntington's disease treatment. Results show that the small molecule p75(NTR) ligand LM11A-31 can alleviate volume reductions in brain regions, normalize DTI metrics, and diminish plasma cytokine levels in an HD mouse model. These findings suggest that a combination of MRI and plasma cytokine levels could be effective biomarkers for assessing treatment efficacy in clinical trials.
Article
Developmental Biology
Biren M. Dave, Xin Chen, Fraser McCready, Connor S. Charton, Rachel M. Morley, Jignesh K. Tailor, James Ellis, Xi Huang, Peter B. Dirks
Summary: This study differentiated human hindbrain neuroepithelial stem cells into cerebellar granule neurons (CGNs) in vitro, mimicking their development process and identifying human specific sub-ventricular cell identities. The study also found that sonic hedgehog promotes GABAergic lineage specification and CGN progenitor proliferation. This work provides a new model for studying the development and diseases of the CGN lineage in a human context.
Article
Neurosciences
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead
Summary: Despite similarities with other TNFR superfamily members, p75 neurotrophin receptor (p75(NTR)) exhibits distinct characteristics in terms of expression, ligand interaction, and co-receptor utilization. Recent evolutionary adaptation allows B7-1 to engage with p75(NTR) in primates, triggering synaptic elimination in the brain. These findings suggest a shared response to immunoregulatory cues and highlight the immune-driven modulation of synaptic actions during injury or inflammation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The perimetastatic capsule is a strong positive prognostic factor in liver metastases. This study reveals that survival is associated with the extent of encapsulation and tumor-hepatocyte contact. The capsule exhibits a gradual zonation, with different cellular composition in different regions. Capsule formation is correlated with decreased tumor viability and preoperative chemotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The presence of a perimetastatic capsule is a positive prognostic factor in liver metastases, and its origin is linked to tumor invasion and reparative processes.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Fengjiao Liu, Jingyuan Shao, Haihong Yang, Guochao Yang, Qian Zhu, Yan Wu, Lingling Zhu, Haitao Wu
Summary: Our study found that Rack1 was significantly upregulated in the majority of human cerebellar MB tumors. Genetic ablation of Rack1 expression in SHH-MB tumor mice could significantly inhibit MB proliferation, reduce the tumor size, and prolong the survival of tumor rescue mice. Further studies showed that in rescue mice, while apoptosis and autophagy levels were unaffected, the expression of Gli1 and HDAC2 was significantly decreased suggesting the inactivation of the SHH signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Christopher Lawson, Thowaiba Babikr Ahmed Alta, Georgia Moschou, Vasiliki Skamnaki, Theodora G. A. Solovou, Caroline Topham, Joseph Hayes, Timothy J. Snape
Summary: Medulloblastoma is a highly aggressive and heterogeneous tumor that accounts for 15-20% of childhood brain tumors. In this study, potent in vitro anticancer activity against medulloblastoma cell lines was achieved using first-generation compounds, leading to the development of second-generation compounds with up to sixty times the activity, providing promising new leads for further research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Erika Kropf, Margaret Fahnestock
Summary: Nerve growth factor (NGF) and its precursor, proNGF, play critical roles in neuronal survival and cognitive function. Dysregulation of proNGF may contribute to age-related memory loss and Alzheimer's disease. Increased reactive oxygen and nitrogen species (ROS/RNS) in the brain may impair proNGF transport and signalling, leading to vulnerability of the basal forebrain in AD. Antioxidant treatments may help restore proNGF signalling and reduce neurodegeneration and cognitive deficits in the basal forebrain.
Article
Neurosciences
Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Summary: This study found that the Sonic Hedgehog (SHH) subtype of medulloblastoma (MB) has a unique tumor microenvironment compared to other subtypes. The SHH MB cells were found to produce elevated levels of IGFBP2, which is required for SHH MB cell proliferation, colony formation, and cell migration. These findings suggest that targeting the IGFBP2-STAT3 axis could be a novel therapeutic approach for SHH medulloblastoma.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudiere-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raul A. Suarez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Berube, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, Francois Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fevre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklos Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique Lopez-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Lolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguia, Mario Perezpena, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Juri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor
Summary: Medulloblastoma (MB) is a pediatric embryonal neoplasm of the hindbrain with subtypes including Sonic hedgehog MB, WNT MB and G4 MB. Somatic mutations in G4 MB converge on the core binding factor alpha (CBFA) complex, and knocking down OTX2 can relieve differentiation blockage.
Article
Oncology
Jiaqing Yi, BongWoo Kim, Xuanming Shi, Xiaoming Zhan, Q. Richard Lu, Zhenyu Xuan, Jiang Wu
Summary: This study reveals that PRC2 heterogeneity plays an oncogenic role in SHH medulloblastoma, promoting tumor growth. Deletion of PRC2 core subunit EED inhibits tumor growth, while mosaic deletion of EED enhances tumor growth. The presence of EED is essential for maintaining cerebellum granule neuron precursors.
Article
Oncology
L. Angenendt, S. Reuter, D. Kentrup, A. S. Benk, F. Neumann, J. Hueve, A. C. Martens, C. Schwoeppe, T. Kessler, L. H. Schmidt, T. Sauer, C. Brand, J-H Mikesch, G. Lenz, R. M. Mesters, C. Mueller-Tidow, W. Hartmann, E. Wardelmann, D. Neri, W. E. Berdel, C. Roesli, C. Schliemann
Article
Oncology
Christian Spurny, Sareetha Kailayangiri, Silke Jamitzky, Bianca Altvater, Eva Wardelmann, Uta Dirksen, Jendrik Hardes, Wolfgang Hartmann, Claudia Rossig
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Michaela C. Baldauf, Martin F. Orth, Marlene Dallmayer, Aruna Marchetto, Julia S. Gerke, Rebeca Alba Rubio, Merve M. Kiran, Julian Musa, Maximilian M. L. Knott, Shunya Ohmura, Jing Li, Nusret Akpolat, Ayse N. Akatli, Ozlem Ozen, Uta Dirksen, Wolfgang Hartmann, Enrique de Alava, Daniel Baumhoer, Giuseppina Sannino, Thomas Kirchner, Thomas G. P. Gruenewald
Article
Multidisciplinary Sciences
Mitchell J. Machiela, Thomas G. P. Grunewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valerie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna Gonzalez-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadege Corradini, Perrine Marec Berard, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Andreas E. Kulozik, Jennifer Kriebel, Thomas Meitinger, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Ilka Isfort, Magdalene Cyra, Sandra Elges, Sareetha Kailayangiri, Bianca Altvater, Claudia Rossig, Konrad Steinestel, Inga Gruenewald, Sebastian Huss, Eva Esseling, Jan-Henrik Mikesch, Susanne Hafner, Thomas Simmet, Agnieszka Wozniak, Patrick Schoffski, Olle Larsson, Eva Wardelmann, Marcel Trautmann, Wolfgang Hartmann
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemical Research Methods
Malte Bayer, Linus Angenendt, Christoph Schliemann, Wolfgang Hartmann, Simone Konig
JOURNAL OF MASS SPECTROMETRY
(2020)
Article
Oncology
Marcel Trautmann, Magdalene Cyra, Ilka Isfort, Birte Jeiler, Arne Krueger, Inga Gruenewald, Konrad Steinestel, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Jessica Becker, Pierre Amana, Eva Wardelmann, Sebastian Huss, Wolfgang Hartmann
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Emergency Medicine
Jan Kuechler, Stephan Klaus, Ludger Bahlmann, Nils Onken, Alexander Keck, Emma Smith, Jan Gliemroth, Claudia Ditz
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2020)
Article
Clinical Neurology
Jan Kuechler, Jann F. Wojak, Emma Smith, Jan Brocke, Abdulkareem Abusamha, Volker M. Tronnier, Claudia Ditz
CLINICAL NEUROLOGY AND NEUROSURGERY
(2019)
Article
Clinical Neurology
Alexander Neumann, Claudia Ditz, Hannes Schacht, Linda Aulmann, Volker Martin Tronnier, Peter Schramm, Jan Nils Kuechler
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2020)
Article
Clinical Neurology
Hannes Schacht, Jan Kuechler, Tobias Boppel, Jan Leppert, Claudia Ditz, Peter Schramm, Alexander Neumann
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Article
Neurosciences
Julia Thranitz, Martin Knauth, Marcus Heldmann, Jan Kuechler, Thomas F. Muente, Georg Royl
HUMAN BRAIN MAPPING
(2020)
Article
Clinical Neurology
Claudia Ditz, Jan Leppert, Alexander Neumann, Kara L. Krajewski, Jan Gliemroth, Volker M. Tronnier, Jan Kuechler
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Alexander Neumann, Jan Kuechler, Claudia Ditz, Kara Krajewski, Jan Leppert, Peter Schramm, Hannes Schacht
Summary: In the study, patients with CVS due to sSAH were treated with either NCB or CB. Follow-up assessment showed that there were no significant delayed arterial narrowing detected in arteries treated with either NCB or CB, supporting the use of TBA as a low-risk treatment option for CVS after sSAH.
STROKE AND VASCULAR NEUROLOGY
(2021)
Article
Respiratory System
A. B. Schulze, L. H. Schmidt, L. Baie, B. Heitkoetter, A. Kuemmel, M. Mohr, R. Buhl, H. Hillmann, G. Geissler, R. Kelsch, D. Goerlich, W. E. Berdel, W. Hartmann, R. Wiewrodt
CLINICAL RESPIRATORY JOURNAL
(2018)
