Article
Endocrinology & Metabolism
Susan L. Samson, Lisa B. Nachtigall, Maria Fleseriu, Mojca Jensterle, Patrick J. Manning, Atanaska Elenkova, Mark E. Molitch, William H. Ludlam, Gary Patou, Asi Haviv, Nienke R. Biermasz, Andrea Giustina, Christian J. Strasburger, Laurence Kennedy, Shlomo Melmed
Summary: This study reports the long-term durability of therapeutic response in adults with acromegaly receiving oral octreotide capsules (OOC). The results show that patients maintained a biochemical response while receiving OOC and no new adverse events were observed with prolonged OOC exposure.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Eva C. Coopmans, Aart J. van der Lely, Sebastian J. C. M. M. Neggers
Summary: Acromegaly is a chronic disorder caused by GH-producing pituitary adenoma. While surgery and medical therapy are standard treatments, some tumors behave aggressively and are resistant to these therapies. In such cases, multimodal therapeutic strategies should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Araceli Garcia-Martinez, Guillermo Serra, Cristina Hostalot, Carmen Fajardo-Montanana, Cristina Carrato, Ignacio Bernabeu, Monica Marazuela, Helena Rodriguez-Lloveras, Rosa Camara, Isabel Salinas, Cristina Lamas, Betina Biagetti, Andreu Simo-Servat, Susan M. Webb, Antonio Pico, Mireia Jorda, Manel Puig-Domingo
Summary: Acromegaly is a condition caused by excessive growth hormone production due to a pituitary tumor. This study examines the relationship between epithelial-mesenchymal transition (EMT) and resistance to somatostatin receptor ligands (SRLs) in GH-producing tumors. The findings suggest that EMT-related gene expression patterns are heterogeneous, which may explain the varying responses to SRLs.
Review
Endocrinology & Metabolism
Manel Puig-Domingo, Ignacio Bernabeu, Antonio Pico, Betina Biagetti, Joan Gil, Cristina Alvarez-Escola, Mireia Jorda, Montserrat Marques-Pamies, Berta Soldevila, Maria-Angeles Galvez, Rosa Camara, Javier Aller, Cristina Lamas, Monica Marazuela
Summary: This paper proposes including the clinico-pathologic phenotype in the therapeutic algorithm for acromegaly, utilizing biomarkers for personalized medicine to accelerate the implementation of precision medicine. Additionally, the development, validation, and clinical use of a pasireotide acute test is suggested to identify patients responsive to pasireotide LAR.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Monica R. Gadelha, Luiz Eduardo Wildemberg, Leandro Kasuki
Summary: This article discusses the future perspectives of currently available SRLs, including the use of biomarkers of response and precision medicine, new formulations of these SRLs, and new drugs under development. Precision medicine based on biomarkers of response can help improve treatment decision-making and response rates. New formulations may improve patients' adherence to treatment and quality of life. New drugs may present higher efficacy than currently available drugs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Jacobo Kerbel, Amayrani Cano-Zaragoza, Rodrigo Espinosa-Dorado, Keren-Enid Garcia de la Torre, Moises Mercado
Summary: National registries are valuable tools to investigate rare conditions like acromegaly, providing insights into epidemiology, clinical presentation, diagnosis, treatment outcomes, and mortality. While single-center studies are more homogeneous, they are often limited by small sample sizes and lack statistical power.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
K. B. Daniel, A. de Oliveira Santos, R. A. de Andrade, M. B. F. Trentin, H. M. Garmes
Summary: The study on the application of GaDOTATATE PET/CT in acromegalic patients under SSA treatment found that evaluating the SUV max at the pituitary region through Ga-68-DOTATATE PET/CT may be useful in assessing drug response predictors without the need of tumoral tissue.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Joan Gil, Montserrat Marques-Pamies, Miguel Sampedro, Susan M. Webb, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Cristina Carrato, Antonio Pico, Araceli Garcia-Martinez, Luciana Martel-Duguech, Teresa Sardon, Andreu Simo-Servat, Betina Biagetti, Carles Villabona, Rosa Camara, Carmen Fajardo-Montanana, Cristina Alvarez-Escola, Cristina Lamas, Clara V. Alvarez, Ignacio Bernabeu, Monica Marazuela, Mireia Jorda, Manel Puig-Domingo
Summary: This study aimed to predict the response of acromegaly patients to somatostatin receptor ligands (SRL) using mathematical modeling and clinical information. Accuracy of patient stratification was significantly improved when the cohort was fragmented based on relevant clinical characteristics. The proposed stratification method based on tumor characteristics, sex, age, and multiple biomarkers achieved accuracies ranging from 71% to 95%. The use of data mining offers a promising approach for personalized medicine in acromegaly.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, Research & Experimental
David Cella, Jennifer Evans, Marion Feuilly, Sebastian Neggers, Dirk Van Genechten, Jackie Herman, Mohid S. Khan
Summary: Based on a systematic literature review, LAN was favored over OCT in the treatment of acromegaly and NETs, with technical problems and pain during injections being the most influential factors in treatment experience.
ADVANCES IN THERAPY
(2021)
Review
Medicine, General & Internal
Nazanin Ershadinia, Nicholas A. Tritos
Summary: Acromegaly is a condition caused by a pituitary adenoma that secretes growth hormone, resulting in various complications. Early diagnosis and appropriate treatment are crucial. Diagnosis is confirmed through biochemical tests and MRI. Pituitary surgery is usually the first-line treatment, while medical therapy and radiation therapy can be used as adjunct options.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Medicine, General & Internal
Robert Pichler, Ognian Kalev, Berndt Tomancok, Michael Sonnberger, Daniela Ehrlich, Marina Hodolic
Summary: Somatostatin analogues, including first-generation analogues and pasireotide, are considered the first-line treatment for acromegaly, targeting different SSTR subtypes to improve therapeutic outcomes. Immunohistochemical analysis of SSTR subtypes may have predictive value for treatment response in patients with acromegaly, especially those with clinical relapse and complex clinical courses.
Review
Endocrinology & Metabolism
Artak Labadzhyan, Shlomo Melmed
Summary: Molecular therapeutic targets in growth hormone-secreting adenomas have potential for drug development, including surface receptors recognized by approved drugs and markers for new drug candidates. Current medical therapies control the disease in most patients but the degree of control varies and is related to disease aggressiveness and tumor factors. Understanding the mechanisms behind these molecular markers and their relationship to outcomes holds promise for expanding treatment options and personalized approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryan P. Reddy, C. Ross Schmidtlein, Romina G. Giancipoli, Audrey Mauguen, Daniel LaFontaine, Heiko Schoder, Lisa Bodei
Summary: Ga-68-labeled somatostatin analog PET/CT is a standard component in the management of neuroendocrine tumors. However, the assessment of treatment response for these tumors still relies on morphologic size measurements, which may not accurately reflect the disease burden. This study aimed to test the accuracy of different methods for measuring functional tumor volume (FTV) using PET/CT and identify a reliable method for assessing tumor burden. The results showed that FTV determined with a thresholding approach had the strongest correlation with traditional morphologic volume measurements, indicating its potential use in determining disease extent and prognosis in patients with neuroendocrine tumors.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Artak Labadzhyan, L. B. Nachtigall, M. Fleseriu, M. B. Gordon, M. Molitch, L. Kennedy, S. L. Samson, Y. Greenman, N. Biermasz, M. Bolanowski, A. Haviv, W. Ludlam, G. Patou, C. J. Strasburger
Summary: Results from trials investigating oral octreotide capsules as an alternative treatment for acromegaly showed consistent biochemical response, durability of response, and patient preference for oral treatment, despite differences in trial design.
Article
Endocrinology & Metabolism
C. Hage, E. Sabini, H. Alsharhan, J. A. Fahrner, A. Beckers, A. Daly, R. Salvatori
Review
Cell Biology
Sophie Vanhunsel, An Beckers, Lieve Moons
AGEING RESEARCH REVIEWS
(2020)
Article
Developmental Biology
Anja Beckers, Christian Adis, Karin Schuster-Gossler, Lena Tveriakhina, Tim Ott, Franziska Fuhl, Jan Hegermann, Karsten Boldt, Katrin Serth, Ev Rachev, Leonie Alten, Elisabeth Kremmer, Marius Ueffing, Martin Blum, Achim Gossler
Article
Endocrinology & Metabolism
Adriana Albani, Marily Theodoropoulou
Summary: Transsphenoidal surgery is the main treatment for Cushing's disease, yet incomplete tumor resection and misdiagnosis can lead to persistent disease. A multidisciplinary approach is necessary to minimize potential pitfalls and provide optimal care for patients who have undergone unsuccessful surgery.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Editorial Material
Endocrinology & Metabolism
Adrian F. Daly, Albert Beckers
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Martin Franke, Adrian F. Daly, Leonor Palmeira, Amit Tirosh, Antonio Stigliano, Eszter Trifan, Fabio R. Faucz, Dayana Abboud, Patrick Petrossians, Juan J. Tena, Eleonora Vitali, Andrea G. Lania, Jose L. Gomez-Skarmeta, Albert Beckers, Constantine A. Stratakis, Giampaolo Trivellin
Summary: X-linked acrogigantism (X-LAG) is a TADopathy of the endocrine system, in which Xq26.3 duplications disrupt the local chromatin architecture, causing aberrant expression of GPR101 in pituitary tumors.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Endocrinology & Metabolism
Debra M. Gordon, Pablo Beckers, Emilie Castermans, Sebastian J. C. M. M. Neggers, Liliya Rostomyan, Vincent Bours, Patrick Petrossians, Vinciane Dideberg, Albert Beckers, Adrian F. Daly
Summary: This study identified the Dutch founder effect for PPGL in South Africa for the first time. Awareness of the presence of the exon 3 SDHB deletion could promote targeted screening at a local level. Insights into PPGL genetics in South Africa could be achieved by studying existing patient databases for Dutch founder mutations in SDHx genes.
ENDOCRINE CONNECTIONS
(2022)
Article
Medicine, General & Internal
A. Beckers, P. Beckers, L. Rostomyan, A. F. Daly
Summary: Pituitary gigantism is a rare condition caused by excessive secretion of growth hormone from a pituitary adenoma. Recent genetic studies have identified various gene mutations associated with this condition, such as X-Linked AcroGigantism. Understanding the physiology and pathology of growth in these cases has been advanced through these studies.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2022)
Article
Endocrinology & Metabolism
Iulia Potorac, Jean-Francois Bonneville, Adrian F. Daly, Wouter de Herder, Patricia Fainstein-Day, Philippe Chanson, Marta Korbonits, Fernando Cordido, Elisa Baranski Lamback, Mohamed Abid, Veronique Raverot, Gerald Raverot, Emma Anda Apinaniz, Philippe Caron, Helene Du Boullay, Martin Bildingmaier, Marek Bolanowski, Marie Laloi-Michelin, Francoise Borson-Chazot, Olivier Chabre, Sophie Christin-Maitre, Claire Briet, Gonzalo Diaz-Soto, Fabrice Bonneville, Frederic Castinetti, Monica R. Gadelha, Nathalie Oliveira Santana, Maria Stelmachowska-Banas, Tomas Gudbjartsson, Rocio Villar-Taibo, Taiba Zornitzki, Luaba Tshibanda, Patrick Petrossians, Albert Beckers
Summary: This study provides a comprehensive analysis of pituitary MRI characteristics in patients with ectopic acromegaly, highlighting the utility of T2-weighted sequences as an additional tool for establishing the correct diagnosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Pharmacology & Pharmacy
Adrian F. Daly
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Iulia Potorac, Marie Laterre, Olivier Malaise, Vlad Nechifor, Corinne Fasquelle, Orphal Colleye, Nancy Detrembleur, Hannah Verdin, Sofie Symoens, Elfride De Baere, Adrian F. Daly, Vincent Bours, Patrick Petrossians, Axelle Pintiaux
Summary: Infertility is a common problem in couples, with both female and male factors playing a similar role. Rare congenital disorders can affect both female and male gametogenesis. Mutations in the MCM9 gene have been found to cause premature ovarian insufficiency in females and are also associated with an increased risk of cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Endocrinology & Metabolism
Aleksandra Antosz, Kamila Szeliga, Karolia Skrzynska, Agnieszka Pietrusik, Zofia Kolesinska, Adrian F. Daly, Albert Beckers, Aneta Gawlik
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Claudia Hernandez, Magdalena Rodriguez Saa, Ivana Fernandez, Silvina Figurelli, Adrian Daly, Mirta Guitelman
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Marta Sarquis, Stephen J. Marx, Albert Beckers, Arthur R. Bradwell, William F. Simonds, Maria Aparecida C. Bicalho, Adrian F. Daly, Daniela Betea, Eitan Friedman, Luiz De Marco