Article
Public, Environmental & Occupational Health
Marion Pineros, Mona Saraiya, Iacopo Baussano, Maxime Bonjour, Ann Chao, Freddie Bray
Summary: Population-based cancer registries are crucial for assessing cancer burden and monitoring national progress in cervical cancer surveillance. However, in countries with high cervical cancer incidence rates, their level of development is suboptimal and requires significant investment to document the impact of WHO initiatives to eliminate cervical cancer as a public health problem.
PREVENTIVE MEDICINE
(2021)
Article
Surgery
Shao-Hua Xie, Giola Santoni, Matteo Bottai, Eivind Gottlieb-Vedi, Pernilla Lagergren, Jesper Lagergren
Summary: This study aimed to develop a prediction model for survival after surgery for esophageal cancer, based on joint density functions. The model was validated in two Swedish population-based cohorts and showed good performance and accuracy in predicting all-cause and disease-specific mortality.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
S. M. Evans, K. Ivanova, R. Rome, D. Cossio, Chc Pilgrim, J. Zalcberg, Y. Antill, L. Blake, A. Du Guesclin, A. Garrett, D. Giffard, N. Golobic, D. Moir, S. Parikh, A. Parisi, K. Sanday, C. Shadbolt, M. Smith, L. Te Marvelde, K. Williams
Summary: In this paper, the completeness of stage information for endometrial cancer in Australian cancer registries is described, and a set of rules for calculating stage using available data is developed and validated.
Article
Medicine, General & Internal
Hunter K. Holt, Caryn E. Peterson, Shannon MacLaughlan David, Abdullah Abdelaziz, George F. Sawaya, Jenny S. Guadamuz, Gregory S. Calip
Summary: Black and Hispanic or Latina women are at higher risk of being diagnosed with and dying from cervical cancer compared to White women. Health insurance coverage could help diagnose cervical cancer at an earlier stage. This study found that insurance status played a role in explaining the differences in advanced-stage cervical cancer diagnoses among different racial and ethnic groups.
Article
Oncology
Vicki B. Benard, J. Elizabeth Jackson, April Greek, Virginia Senkomago, Warner K. Huh, Cheryll C. Thomas, Lisa C. Richardson
Summary: This study examined screening and diagnostic practices of women in the United States five years prior to an invasive cervical cancer diagnosis. The results showed that 60% of women had not been screened, and among those with abnormal screening results, 67% had adequate follow-up care. Predictors of being screened included younger age, higher income, and having insurance, while predictors of adequate follow-up care included higher income. Women with stage 1 cervical cancer were more likely to have been screened and were younger in age.
Article
Medicine, Research & Experimental
Yelda A. Leal, Javier Torres, Ricardo Gamboa, Alejandra Mantilla-Morales, Patricia Pina-Sanchez, Oscar Arrieta, Laura Bonifaz, Abelardo Meneses, Celida Duque, Marion Pineros
Summary: This article presents the first results of the Merida population-based cancer registry in Mexico over a four-year period. The main incident cancers were prostate and breast cancer, while cervical cancer had high incidence rates among women. Further exploration is needed for lymphomas and liver cancer data.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Oncology
Walter Mazzucco, Francesco Vitale, Sergio Mazzola, Rosalba Amodio, Maurizio Zarcone, Davide Alba, Claudia Marotta, Rosanna Cusimano, Claudia Allemani
Summary: The study examined survival rates of HCC patients based on their level of access to care and age, finding that patients with easier access to care had higher 5-year survival rates during 2006-2015. The results suggest a correlation between access to care and improved survival outcomes for HCC patients.
Article
Oncology
Cathrine Fonnesbech Hjorth, Per Damkier, Tore Bjerregaard Stage, Soren Feddersen, Stephen Hamilton-Dutoit, Mikael Rorth, Bent Ejlertsen, Timothy Lee Lash, Thomas Patrick Ahern, Henrik Toft Sorensen, Deirdre Cronin-Fenton
Summary: SNPs in GSTP1, CYP3A, and SLCO1B1 were found to be associated with breast cancer recurrence and mortality in premenopausal women. These SNPs likely influence the pharmacokinetics of docetaxel, affecting its effectiveness in treating non-distant metastatic breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Emanuele Crocetti, Veronica Mattioli, Carlotta Buzzoni, Silvia Franceschi, Diego Serraino, Salvatore Vaccarella, Stefano Ferretti, Susanna Busco, Ugo Fedeli, Massimo Varvara, Fabio Falcini, Manuel Zorzi, Giuliano Carrozzi, Walter Mazzucco, Cinzia Gasparotti, Silvia Iacovacci, Federica Toffolutti, Rossella Cavallo, Fabrizio Stracci, Antonio G. Russo, Adele Caldarella, Stefano Rosso, Antonino Musolino, Lucia Mangone, Claudia Casella, Mario Fusco, Giovanna Tagliabue, Daniela Piras, Rosario Tumino, Linda Guarda, Ylenia M. Dinaro, Silvano Piffer, Pasquala Pinna, Guido Mazzoleni, Anna C. Fanetti, Luigino Dal Maso
Summary: The study found that thyroid cancer patients have a certain risk of developing a second primary cancer, with significantly increased SIRs for bone/soft tissue, breast, prostate, kidney, and hemolymphopoietic cancers. Conversely, patients with other primary cancers also have a risk of developing thyroid cancer. Therefore, caution is needed in the follow-up of cancer patients to avoid overdiagnosis and overtreatment.
Article
Public, Environmental & Occupational Health
J. Smith Torres-Roman, Luz Ronceros-Cardenas, Bryan Valcarcel, Janina Bazalar-Palacios, Jorge Ybaseta-Medina, Greta Carioli, Carlo La Vecchia, Christian S. Alvarez
Summary: There is significant variability in cervical cancer mortality rates among young women in Latin America and the Caribbean. Cervical cancer screening programs should be a high priority in the region. Primary and secondary prevention measures in the community are necessary to accelerate the reduction of cervical cancer mortality by 2030.
Article
Oncology
Ariana Znaor, Heba Fouad, Fosca Majnoni d'Intignano, Asmus Hammerich, Slim Slama, Nasim Pourghazian, Sultan Eser, Marion Pineros Petersen, Freddie Bray
Summary: The study revealed high involvement of population-based cancer registries in cancer control planning and screening evaluation in the Eastern Mediterranean region, with lower participation in palliative care and rehabilitation activities. Identified barriers included poor governance, lack of awareness by policymakers, insufficient resources, and limited availability of data electronically, including mortality data. Proposed solutions included appropriate planning for sustainability, increased training, research capacity building, and efficient data provision to policymakers.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Medicine, General & Internal
Julie Chor, Andrew M. Davis, Jennifer M. Rusiecki
Summary: This article summarizes guidance from the American Cancer Society on cervical cancer screening, including recommendations for when to start screening, how often to test, and which modality to use.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Ana Paula de Souza Franco, Eric Renato Lima Figueiredo, Giovana Salomao Melo, Josiel de Souza e Souza, Nelson Veiga Goncalves, Fabiana de Campos Gomes, Joao Simao de Melo Neto
Summary: This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Data revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15-40 age group.
Article
Multidisciplinary Sciences
Mohamed Aseafan, Edward Devol, Mahmoud AlAhwal, Riad Souissi, Reham Sindi, Haya AlEid, Shouki Bazarbashi
Summary: This article reports the survival rates of the most common cancer sites in Saudi Arabia from 1994 to 2009, and finds that the survival rates have improved for most cancers. The findings of this study are of significant importance for improving cancer care in Saudi Arabia.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Tadeusz Dyba, Giorgia Randi, Freddie Bray, Carmen Martos, Francesco Giusti, Nicholas Nicholson, Anna Gavin, Manuela Flego, Luciana Neamtiu, Nadya Dimitrova, Raquel Negrao Carvalho, Jacques Ferlay, Manola Bettio
Summary: This article presents the incidence and mortality estimates for 25 major cancers across 40 individual countries within European areas and the EU-27 for the year 2020. The most common cancers are breast, colorectal, lung, and prostate cancers, which account for half the overall cancer burden in Europe. The estimates provide a basis for setting priorities in cancer-control measures across Europe.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Lucia Iglesias-Vazquez, Victoria Arija, Nuria Aranda, Elom K. Aglago, Amanda J. Cross, Matthias B. Schulze, Daniel Quintana Pacheco, Tilman Kuhn, Elisabete Weiderpass, Rosario Tumino, Daniel Redondo-Sanchez, Maria Santucci de Magistris, Domenico Palli, Eva Ardanaz, Nasser Laouali, Emily Sonestedt, Isabel Drake, Lucia Rizzolo, Carmen Santiuste, Carlotta Sacerdote, Ramon Quiros, Pilar Amiano, Antonio Agudo, Paula Jakszyn
Summary: The study revealed that the prevalence of excess iron in European adults increases with latitude, with obesity, age, alcohol consumption, and heme iron intake being independent determinants for iron status.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Health Care Sciences & Services
Massimo Gion, Giulia Cardinali, Stefano Guzzinati, Paolo Morandi, Chiara Trevisiol, Aline S. C. Fabricio, Massimo Rugge, Manuel Zorzi
Summary: This study assessed the adherence to clinical practice guidelines (CPGs) regarding diagnostic tests ordering during breast cancer (BC) follow-up. The study found that there was a substantial overordering of tests in asymptomatic BC patients, contrary to the recommendations of CPGs.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2022)
Article
Oncology
Fabio Girardi, Veronica Di Carlo, Charles Stiller, Gemma Gatta, Ryan R. Woods, Otto Visser, Brigitte Lacour, Thomas C. Tucker, Michel P. Coleman, Claudia Allemani
Summary: This study provides comprehensive data on global trends in population-based survival for childhood brain tumors. The researchers used a revised version of the International Classification of Childhood Cancer and estimated survival rates for different histology groups. The findings have important implications for public health.
Article
Oncology
Alberto Fantin, Mario Gruppo, Ottavia De Simoni, Sara Lonardi, Chiara Cristofori, Tiziana Morbin, Giulia Peserico, Sabina Grillo, Annalisa Masier, Monica Franco, Pierluigi Pilati, Stefano Guzzinati, Manuel Zorzi, Massimo Rugge
Summary: This study analyzed the impact of microscopic diagnosis of pancreatic cancer (MiDPC) on diagnostic-therapeutic management and outcome. The results showed that the percentage of MiDPC in pancreatic cancer patients has been increasing, especially among younger patients. The study also reported a significant increase in biopsy on the primary neoplasm. Patients with MiDPC had a higher survival rate compared to those without MiDPC.
Article
Multidisciplinary Sciences
Stefano Guzzinati, Jessica Battagello, Emanuela Bovo, Maddalena Baracco, Susanna Baracco, Eva Carpin, Antonella Dal Cin, Anna Rita Fiore, Alessandra Greco, Giancarla Martin, Laura Memo, Daniele Monetti, Silvia Rizzato, Carmen Stocco, Sara Zamberlan, Manuel Zorzi, Massimo Rugge
Summary: Population-based cancer registration methods follow international rules and often adopt digital processing methods for efficient case recording. This study examines the performance of digital processing (DP) at the Veneto Tumor Registry, comparing it with registrars' assessments (RAs). The results show a high level of concordance between DP and RAs in cancer status, topography, and morphology. The study highlights the importance of good-quality clinical information and regular interdisciplinary monitoring for the efficiency and reliability of digital cancer registration.
Article
Oncology
Viviana Perotti, Sabrina Fabiano, Paolo Contiero, Maria Michiara, Antonio Musolino, Lorenza Boschetti, Giuseppe Cascone, Maurizio Castelli, Giovanna Tagliabue, Cancer Registries Working Group
Summary: This study found that sex and age can influence various aspects of colorectal cancer, including tumor characteristics and patient survival. Understanding the underlying biological mechanisms can lead to earlier diagnosis and improved prognosis. Therefore, considering sex and age in screening and treatment strategies is important.
Article
Biotechnology & Applied Microbiology
Massimo Gion, Roberto De Gobbi, Manuel Zorzi, Giovanni Carretta, Luca Leonardi, Stefano Guzzinati, Chiara Trevisiol, Maurizio Cancian, Giulia Cardinali, Federica Michieletto, Ruggero Dittadi, Aline S. C. Fabricio, Massimo Rugge, Francesca Russo
Summary: This study used administrative datasets to assess the overordering of tumor markers and the impact of interventions to improve appropriateness. The results showed that over 55.9% of tumor marker orders were made without appropriate disease codes. Despite a significant reduction in orders after the implementation of a national decree-law, there still remained a high rate of inappropriate requests (44.4%), with orders of tumor markers exceeding the expected prevalence and incidence figures of specific malignancies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2023)
Article
Oncology
Xiaoshuang Feng, Wendy Yi-Ying Wu, Justina Ucheojor Onwuka, Zahra Haider, Karine Alcala, Karl Smith-Byrne, Hana Zahed, Florence Guida, Renwei Wang, Julie K. Bassett, Victoria Stevens, Ying Wang, Stephanie Weinstein, Neal D. Freedman, Chu Chen, Lesley Tinker, Therese Haugdahl Nost, Woon-Puay Koh, David Muller, Sandra M. Colorado-Yohar, Rosario Tumino, Rayjean J. Hung, Christopher Amos, Xihong Lin, Xuehong Zhang, Alan A. Arslan, Maria-Jose Sanchez, Elin Pettersen Sorgjerd, Gianluca Severi, Kristian Hveem, Paul Brennan, Arnulf Langhammer, Roger L. Milne, Jian-Min Yuan, Beatrice Melin, Mikael Johansson, Hilary A. Robbins, Mattias Johansson
Summary: This study aimed to develop a proteomics-based risk model for lung cancer and compare its performance with a smoking-based risk model and a commercially available autoantibody biomarker test. We conducted a case-control study in 6 prospective cohorts, involving 624 lung cancer participants and 624 smoking-matched cancer free participants. The protein-based risk model showed promise in predicting incident lung cancer and outperformed the standard risk prediction model and the commercialized EarlyCDT-Lung.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Medicine, General & Internal
Silvia Mancini, Lauro Bucchi, Federica Zamagni, Flavia Baldacchini, Emanuele Crocetti, Orietta Giuliani, Alessandra Ravaioli, Rosa Vattiato, Mario Preti, Rosario Tumino, Stefano Ferretti, Annibale Biggeri, Paola Ballotari, Lorenza Boschetti, Angelita Brustolin, Adele Caldarella, Rossella Cavallo, Claudia Cirilli, Annarita Citarella, Maria L. Contrino, Luigino Dal Maso, Rosa A. Filiberti, Mario Fusco, Rocco Galasso, Fernanda L. Lotti, Michele Magoni, Lucia Mangone, Giuseppe Masanotti, Guido Mazzoleni, Walter Mazzucco, Anna Melcarne, Maria Michiara, Paola Pesce, Angela Pinto, Daniela Piras, Roberto V. Rizzello, Magda Rognoni, Stefano Rosso, Massimo Rugge, Giuseppe Sampietro, Santo Scalzi, Tiziana Scuderi, Giovanna Tagliabue, Federica Toffolutti, Susanna Vitarelli, Fabio Falcini
Summary: Survival rates for vulvar squamous cell carcinoma in Italy have shown no significant improvement from 1990 to 2015. It is necessary to reassess strategies for controlling vulvar squamous cell carcinoma in Italy and globally.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis
Summary: Comparable indicators on complete cancer prevalence are needed in Europe. Two alternative approaches, empirical indices derived from European registries and pre-calculated indices derived from US-SEER cancer registries, were compared to standard estimates using data from 62 registries in 27 countries. Empirical estimates differ little from standard estimates for elderly-diagnosed tumors, but may underestimate complete prevalence for early-onset cancers. SEER estimates are comparable to standard ones for most cancers, even derived from short time series, but longer observations are needed for certain cancers with remarkable differences in incidence and prognosis between European and US populations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Federica Toffolutti, Stefano Guzzinati, Angela De Paoli, Silvia Francisci, Roberta De Angelis, Emanuele Crocetti, Laura Botta, Silvia Rossi, Sandra Mallone, Manuel Zorzi, Gianfranco Manneschi, Ettore Bidoli, Alessandra Ravaioli, Francesco Cuccaro, Enrica Migliore, Antonella Puppo, Margherita Ferrante, Cinzia Gasparotti, Maria Gambino, Giuliano Carrozzi, Fabrizio Stracci, Maria Michiara, Rossella Cavallo, Walter Mazzucco, Mario Fusco, Paola Ballotari, Giuseppe Sampietro, Stefano Ferretti, Lucia Mangone, Roberto Vito Rizzello, Michael Mian, Giuseppe Cascone, Lorenza Boschetti, Rocco Galasso, Daniela Piras, Maria Teresa Pesce, Francesca Bella, Pietro Seghini, Anna Clara Fanetti, Pasquala Pinna, Diego Serraino, Luigino Dal Maso
Summary: This study utilized national cancer registry data to calculate limited duration prevalence and estimate indicators of cancer cure. The results showed disparities in the cure rates and prevalence between male and female patients, with relatively high cure rates for certain common types of cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Enrique Almanza-Aguilera, Estefania Davila-Cordova, Daniel Guinon-Fort, Marta Farras, Giovanna Masala, Maria Santucci de Magistris, Ivan Baldassari, Rosario Tumino, Lisa Padroni, Verena A. Katzke, Matthias B. Schulze, Augustin Scalbert, Raul Zamora-Ros
Summary: This study analyzed the correlations between the acute and habitual intake of dietary tyrosols and their main food sources with urinary excretions of tyrosol and hydroxytyrosol. The results showed that urinary excretions correlated more strongly with acute intake than habitual intake. They also found correlations between urinary excretions and other tyrosol precursors as well as major food sources. Based on these findings, urinary excretions could be proposed as biomarkers of total tyrosol intake, especially for acute intakes.
Article
Microbiology
Patrizia Spigaglia, Fabrizio Barbanti, Elena Angela Pia Germinario, Enrico Maria Criscuolo, Giovanni Bruno, Lupe Sanchez-Mete, Barbara Porowska, Vittoria Stigliano, Fabio Accarpio, Andrea Oddi, Ilaria Zingale, Silvia Rossi, Roberta De Angelis, Alessia Fabbri
Summary: This study analyzed enterotoxigenic Bacteroides fragilis (ETBF) isolates from colorectal biopsies of individuals with colorectal cancer (CRC), pre-cancerous lesions (pre-CRC), or healthy intestines, and evaluated environmental factors that could contribute to CRC development and affect gut microbiota composition. The study found that a particular ETBF type, denominated C, was prevalent in pre-CRC patients, while a different type, denominated F, was detected in a CRC patient. ETBF isolates from pre-CRC or CRC patients exhibited a specific pattern of the B. fragilis pathogenicity island (BFPAI) region and showed higher antibiotic resistance compared to isolates from healthy individuals.
Article
Oncology
Hasmik Grigoryan, Partow Imani, Carlotta Sacerdote, Giovanna Masala, Sara Grioni, Rosario Tumino, Paolo Chiodini, Sandrine Dudoit, Paolo Vineis, Stephen M. Rappaport
Summary: Using untargeted adductomics, researchers identified features associated with non-Hodgkin lymphoma (NHL) by studying stable reactive oxygen species (ROS) adducts in human serum albumin. The results suggest that altered ROS homeostasis may contribute to NHL incidence, with differences observed between males and females.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
