Article
Biochemistry & Molecular Biology
Silvia Da Ros, Giulia Nicoletto, Riccardo Rigo, Silvia Ceschi, Eleonora Zorzan, Mauro Dacasto, Mery Giantin, Claudia Sissi
Summary: The regulation of conformational arrangements of gene promoters is a crucial physiological mechanism for fine control of gene expression. By studying the G-quadruplex forming sites in the KIT promoter, it was found that different G4 sites impact SP1 binding and protein expression levels, with kit2 and kit* serving as an on-off system for KIT expression. Using two G4 binders could potentially target kit2-kit* as a reliable pharmacological intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Gisela Orozco, Stefan Schoenfelder, Nicolas Walker, Stephan Eyre, Peter Fraser
Summary: Genome sequencing has identified over 300 million genetic variations in human populations, with the majority being single nucleotide polymorphisms (SNPs). These variations have been linked to specific phenotypic traits and diseases through genome wide association studies. Understanding the 3D organization of the genome can help identify the interactions between gene promoters and distal regulatory elements, allowing for the linking of disease-associated SNPs to their target genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
Jinpeng Chen, Xinshuai Li, Jianling Huang, Qing Wang, Shaowen Wang, Shina Wei, Qiwei Qin, Min Yang
Summary: In this study, the transcriptional regulation of Epinephelus akaara RFX5 (EaRFX5) on EaMHCI and its effect on immune pathways were investigated. The results showed that EaRFX5 plays a differentiated immunomodulatory role in response to various stimuli in different tissues, with the most significant upregulation in the kidney after SGIV challenge. In addition, EaRFX5 appeared to promote the expression of EaMHCIa gene, interferon signaling pathway and inflammatory cytokine.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Krishna Kumar Rai, Shilpi Singh, Ruchi Rai, L. C. Rai
Summary: Alr0671 and All2352 are novel WD40 proteins in Anabaena that function as transcription factors and mediate DNA-protein interaction to regulate biochemical functions and abiotic stress tolerance. These proteins scavenge reactive oxygen species, modulate the functions of other cellular proteins, stabilize protein structure and biophysical functions, and confer tolerance to agriculturally relevant abiotic stresses.
PLANT MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samia Nisar, Magali Torres, Alassane Thiam, Bruno Pouvelle, Florian Rosier, Frederic Gallardo, Oumar Ka, Babacar Mbengue, Rokhaya Ndiaye Diallo, Laura Brosseau, Salvatore Spicuglia, Alioune Dieye, Sandrine Marquet, Pascal Rihet
Summary: This study systematically investigated the regulatory effect of genetic variants associated with severe malaria and identified a regulatory region that affects the risk of severe malaria. The study also demonstrated the functional activity of the identified genetic variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Lei Chen, Xia Qiu, Abigail Dupre, Oscar Pellon-Cardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D. Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O. Perekatt, Wenwei Hu, Scott T. Magness, Jason R. Spence, Michael P. Verzi
Summary: This study identified the role of TGFB signaling in intestinal regeneration following injury. TGFB1 was found to induce fetal-like transcriptional signature and enhance the regenerative response in the epithelium. Additionally, TGFB1 treatment enhanced the ability of primary epithelial cultures to engraft into damaged murine colon, suggesting potential for cellular therapy.
Article
Fisheries
Min Yang, Jinpeng Chen, Xinshuai Li, Jianling Huang, Qing Wang, Shaowen Wang, Shina Wei, Qiwei Qin
Summary: This study characterized NFYC and MHCIa in red-spotted grouper, revealing that EaNFYC can regulate the MHC pathway by activating EaMHCIa as well as interferon signalling molecules and inflammatory cytokines. Additionally, EaNFYC exerts its effect on a specific region of the EaMHCIa promoter and activates MHCIa expression through binding at specific binding sites. These findings contribute to a better understanding of the regulatory mechanisms of NFYC in fish MHC transcription.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chuan Shen, Xia Li
Summary: In this study, the characteristics and functions of the P450 gene family in Camellia sinensis were analyzed using bioinformatics-based methods. A total of 273 putative P450 genes were identified, and they were well-balanced across the genome. Phylogenetic analysis divided the CsP450s into 34 subfamilies, with CYP71 being the most abundant. Subcellular localization analysis showed that P450 was distributed in various organelles. The promoter region of CsP450s contained cis-acting elements related to phytohormones and stress responses. Tissue expression analysis revealed that P450 was highly expressed in roots and stems. Furthermore, qPCR analysis confirmed the expression patterns under drought and cold stress.
Article
Multidisciplinary Sciences
Buze Chen, Xiaojuan Ding, Ailing Wan, Xin Qi, Xiaoman Lin, Haihong Wang, Wenyu Mu, Gang Wang, Junnian Zheng
Summary: TLX2 plays an important role in multiple tumors and its abnormal expression is associated with a poor overall survival rate in several cancer types. The most common type of alteration in TLX2 is amplification, and it co-occurs with alterations in other genes. TLX2 has high methylation levels in various tumors. Its expression is related to immune infiltration, immune checkpoint genes, and chemoresistance.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Psychiatry
Jiayu Chen, Zening Fu, Juan R. Bustillo, Nora Perrone-Bizzozero, Dongdong Lin, Jose Canive, Godfrey D. Pearlson, Julia M. Stephen, Andrew R. Mayer, Steven G. Potkin, Theo G. M. van Erp, Peter Kochunov, L. Elliot Hong, Bhim M. Adhikari, Ole A. Andreassen, Ingrid Agartz, Lars T. Westlye, Jing Sui, Yuhui Du, Fabio Macciardi, Faith M. Hanlon, Rex E. Jung, Jessica A. Turner, Jingyu Liu, Vince D. Calhoun
Summary: This study found that the cognitive differences between schizophrenia and bipolar disorder patients may be related to genetic factors and brain connectivity, providing new clues for more precise patient classification and treatment.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Agronomy
Jiawei Cai, Bohao Zhao, Jiali Li, Zhiyuan Bao, Yang Chen, Yan Liu, Xinsheng Wu
Summary: This study reveals the conservation of the WIF1 gene in three different rabbit breeds, and identifies a key SNP in the WIF1 promoter region associated with rabbit fiber length trait.
Article
Biochemistry & Molecular Biology
Csaba Papp, Vineeth T. Mukundan, Piroon Jenjaroenpun, Fernaldo Richtia Winnerdy, Ghim Siong Ow, Anh Tuan Phan, Vladimir A. Kuznetsov
Summary: The composition of DNA sequences determines the structure and stability of G-quadruplexes (G4s). In this study, a large family of computationally defined and experimentally verified potential G4-B forming sequences (pG4-BS) was introduced. These sequences are preferentially localized in transcription regulatory regions and are associated with brain tissue, immune, and developmental processes. The ability of these sequences to form G4 structures was predicted with 91.5% accuracy in vitro.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shi-Xiao Peng, Jingwen Pei, Berardo Rinaldi, Jiang Chen, Yu-Han Ge, Min Jia, Jun Wang, Andree Delahaye-Duriez, Jia-Hui Sun, Yan-Yu Zang, Yong-Yun Shi, Ning Zhang, Xiang Gao, Donatella Milani, Xijia Xu, Nengyin Sheng, Benedicte Gerard, Chen Zhang, Allan Bayat, Na Liu, Jian-Jun Yang, Yun Stone Shi
Summary: The study identified two rare genetic mutations and a genetic polymorphism associated with aggressive behavior. Knocking out the GluA3 gene revealed that abnormal excitability in the brain cortex leads to aggressive behavior.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Anton Bogomolov, Sergey Filonov, Irina Chadaeva, Dmitry Rasskazov, Bato Khandaev, Karina Zolotareva, Anna Kazachek, Dmitry Oshchepkov, Vladimir A. Ivanisenko, Pavel Demenkov, Nikolay Podkolodnyy, Ekaterina Kondratyuk, Petr Ponomarenko, Olga Podkolodnaya, Zakhar Mustafin, Ludmila Savinkova, Nikolay Kolchanov, Natalya Tverdokhleb, Mikhail Ponomarenko
Summary: Atherosclerosis is a systemic disease characterized by the accumulation of lipoproteins and cholesterol in focal lesions, leading to the narrowing of blood vessels and cardiovascular diseases. Lifestyle factors and genetic predisposition contribute to atherosclerosis, while antioxidant diets and recreational exercises act as protective measures. The search for molecular markers related to atherogenesis and atheroprotection is a promising direction for research. This study analyzed 1068 human genes associated with atherogenesis, atherosclerosis, and atheroprotection, and identified 330 candidate SNP markers that affect the affinity of TATA-binding protein for gene promoters. These findings provide insights into the importance of gene expression regulation in atherosclerosis and cardiovascular health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Maria Plesa, Vincent Gagne, Sanja Glisovic, Melissa Younan, Bahram Sharif-Askari, Caroline Laverdiere, Nathalie Alos, Jean-Marie Leclerc, Stephen E. Sallan, Donna Neuberg, Jeffery L. Kutok, Lewis B. Silverman, Daniel Sinnett, Maja Krajinovic
PHARMACOGENOMICS JOURNAL
(2019)
Article
Nutrition & Dietetics
E. Delvin, N. Alos, F. Rauch, V. Marcil, S. Morel, M. Boisvert, M. -A. Lecours, C. Laverdiere, D. Sinnett, M. Krajinovic, J. Dubois, S. Drouin, G. Lefebvre, M. Samoilenko, C. Nyalendo, E. Cavalier, E. Levy
CLINICAL NUTRITION
(2019)
Article
Cardiac & Cardiovascular Systems
Maxime Caru, Denis Corbin, Delphine Perie, Valerie Lemay, Jacques Delfrate, Simon Drouin, Laurence Bertout, Maja Krajinovic, Caroline Laverdiere, Gregor Andelfinger, Daniel Sinnett, Daniel Curnier
CLINICAL RESEARCH IN CARDIOLOGY
(2019)
Article
Genetics & Heredity
Yosr Hamdi, Martin Leclerc, Martine Dumont, Stephane Dubois, Martine Tranchant, Guy Reimnitz, Penny Soucy, Pauline Cassart, Manon Ouimet, Daniel Sinnett, M'Hamed Lajmi Lakhal Chaieb, Jacques Simard
Article
Oncology
Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Valerie Lemay, Laurence Bertout, Caroline Laverdiere, Gregor Andelfinger, Maja Krajinoyic, Daniel Sinnett, Daniel Curnier
Article
Health Care Sciences & Services
Miguel Caubet Fernandez, Simon Drouin, Mariia Samoilenko, Sophia Morel, Maja Krajinovic, Caroline Laverdiere, Daniel Sinnett, Emile Levy, Valerie Marcil, Genevieve Lefebvre
BMC MEDICAL RESEARCH METHODOLOGY
(2019)
Meeting Abstract
Sport Sciences
Gabrielle E. Duhamel, Maxime Caru, Valerie Lemay, Simon Drouin, Nathalie Alos, Laurence Bertout, Maja Krajinovic, Caroline Laverdiere, Marie-Josee Raboisson, Daniel Sinnett, Gregoir Andelfinger, Daniel Curnier
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Multidisciplinary Sciences
Kateryna Petrykey, Sarah Lippe, Philippe Robaey, Serge Sultan, Julie Laniel, Simon Drouin, Laurence Bertout, Patrick Beaulieu, Pascal St-Onge, Aubree Boulet-Craig, Aziz Rezgui, Yutaka Yasui, Yadav Sapkota, Kevin R. Krull, Melissa M. Hudson, Caroline Laverdiere, Daniel Sinnett, Maja Krajinovic
Article
Oncology
Maxime Caru, Mariia Samoilenko, Simon Drouin, Valerie Lemay, Laurence Kern, Lucia Romo, Laurence Bertout, Genevieve Lefebvre, Gregor Andelfinger, Maja Krajinovic, Caroline Laverdiere, Daniel Sinnett, Daniel Curnier
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2019)
Article
Nutrition & Dietetics
Sophie Berard, Sophia Morel, Emma Teasdale, Nitin Shivappa, James R. Hebert, Caroline Laverdiere, Daniel Sinnett, Emile Levy, Valerie Marcil
Article
Pediatrics
Johanne Kerba, Catherine Demers, Veronique Belanger, Melanie Napartuk, Isabelle Bouchard, Caroline Meloche, Sophia Morel, Nicolas Prud'homme, Isabelle Gelinas, Johanne Higgins, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study aims to assess the needs, barriers and facilitators to healthy lifestyle promotion interventions for adolescents with cancer. The findings suggest that adolescents with cancer need activities adapted to their age, peer support, and support to maintain their education and friendships. Lack of motivation, fatigue, and treatment side effects are reported as barriers to intervention.
Article
Pediatrics
Melanie Napartuk, Veronique Belanger, Isabelle Bouchard, Caroline Meloche, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study examined the changes in diet and anthropometric and cardiometabolic profiles of children and adolescents undergoing cancer treatments after a one-year nutritional intervention. It found that the intervention improved diet quality and adherence, as well as weight, BMI, HDL-C levels, and vitamin D levels.
Article
Nutrition & Dietetics
E. Delvin, V Marcil, N. Alos, C. Laverdiere, D. Sinnett, M. Krajinovic, V Belanger, S. Drouin, C. Nyalendo, E. Levy
CLINICAL NUTRITION ESPEN
(2019)
Article
Pharmacology & Pharmacy
Genevieve Nadeau, Erika Ouimet-Grennan, Michelle Aaron, Simon Drouin, Laurence Bertout, Albert Shalmiev, Patrick Beaulieu, Pascal St-Onge, Louis-Nicolas Veilleux, Frank Rauch, Kateryna Petrykey, Caroline Laverdiere, Daniel Sinnett, Nathalie Alos, Maja Krajinovic
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2019)
Article
Multidisciplinary Sciences
Maryse Fournier, Eric Bonneil, Carole Garofalo, Guy Grimard, Caroline Laverdiere, Maja Krajinovic, Simon Drouin, Daniel Sinnett, Valerie Marcil, Emile Levy
SCIENTIFIC REPORTS
(2019)