Article
Oncology
Shoukai Zhang, Hulai Wei, Xiaoqin Ha, Yueyu Zhang, Yufen Guo
Summary: The overexpression of NK4 gene inhibits cell proliferation and migration, promotes cell apoptosis, and induces cell cycle arrest in S phase in laryngeal carcinoma AMC-HN-8 cells. NK4 overexpression also inhibits the tumorigenic ability of AMC-HN-8 cells, possibly through the regulation of the DKK1/Wnt1/beta-Catenin signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jun Liang, Jingang Liu, Zhaoming Deng, Zhigang Liu, Lizhong Liang
Summary: DLX6 is overexpressed in oral cancer tissues and is associated with advanced tumor stage and poor prognosis. DLX6 promotes proliferation and inhibits cell apoptosis in oral cancer cells. The EGFR-CCND1 pathway may be a potential mechanism involved in the regulatory axis.
Review
Biochemistry & Molecular Biology
Anna Maria Luciano, Ana B. Perez-Oliva, Victoriano Mulero, Donatella Del Bufalo
Summary: Apoptosis is crucial for eliminating damaged cells in multicellular organisms. Bcl-xL, an anti-apoptotic protein, plays significant roles in cancer, including melanoma, by regulating cell survival, migration, invasion, and angiogenesis. Targeting Bcl-xL may offer potential benefits for cancer patients, but further studies are needed to develop safe and effective inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lin Liu, Cheng Peng, Yan Ruan, Qian Zhang
Summary: The natural compound lapiferin was found to promote the expression of P21 and inhibit proliferation while enhancing apoptosis of GSCC cells. This suggests lapiferin may have potent antitumor effects on GSCC and could be a potential therapeutic agent.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Dermatology
Jesse Veenstra, David Ozog, Ian Loveless, Indra Adrianto, Peter Dimitrion, Kalpana Subedi, Ben J. Friedman, Li Zhou, Qing-Sheng Mi
Summary: Differentiating between keratoacanthoma (KA) and well-differentiated cutaneous squamous cell carcinoma (cSCC) is challenging due to overlapping clinical and histological features. This study used RNA sequencing and imaging mass cytometry to identify key differences in transcriptomes and cellular characteristics between KA and cSCC, revealing distinct keratinocyte populations and immunosuppressive environments.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Paula Hoffmeister-Wittmann, Andreas Mock, Federico Nichetti, Felix Korell, Christop E. Heilig, Anna-Lena Scherr, Michael Gunther, Thomas Albrecht, Eblina Kelmendi, Kaiyu Xu, Luisa Nader, Annika Kessler, Nathalie Schmitt, Sarah Fritzsche, Sofia Weiler, Benjamin Sobol, Albrecht Stenzinger, Stefan Boeck, Christoph B. Westphalen, Klaus Schulze-Osthoff, Jorg Trojan, Thomas Kindler, Wilko Weichert, Karsten Spiekermann, Michael Bitzer, Gunnar Folprecht, Anna-Lena Illert, Melanie Boerries, Frederick Klauschen, Sebastian Ochsenreiter, Jens Siveke, Sebastian Bauer, Hanno Glimm, Benedikt Brors, Jennifer Huellein, Daniel Huebschmann, Sebastian Uhrig, Peter Horak, Simon Kreutzfeld, Jesus M. Banales, Christoph Springfeld, Dirk Jaeger, Peter Schirmacher, Stephanie Roessler, Steffen Ormanns, Benjamin Goeppert, Stefan Froehling, Bruno C. Koehler
Summary: The study identified Bcl-x(L) as a key protein in cell death resistance of CCA and suggested its potential prognostic value, serving as a potential therapeutic target.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chang
Summary: Sertindole has been found to have antiproliferative effects on bladder cancer cells by inhibiting the STAT3/BCL-xL signaling pathway, suggesting its potential as a therapeutic strategy for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Mas-Bargues, Consuelo Borras, Jose Vina
Summary: Cellular senescence is related to the inability of cells to adapt to stress conditions, a specific level of senescence can promote development, remodeling and healing, while chronicity of senescence can result from constant stresses and a weakening immune system. Centenarians overexpress Bcl-xL, which helps them avoid the deleterious effects of accumulated senescent cells and maintain a fully functional immune system. There is a paradox in the fact that Bcl-xL inhibitors have been shown to protect from aging in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hiresh Ayoubian, Joana Heinzelmann, Sebastian Hoelters, Oybek Khalmurzaev, Alexey Pryalukhin, Philine Loertzer, Julia Heinzelbecker, Stefan Lohse, Carol Geppert, Hagen Loertzer, Heiko Wunderlich, Rainer M. Bohle, Michael Stoeckle, Vsevolod Borisovich Matveev, Arndt Hartmann, Kerstin Junker
Summary: Specific miRNAs were identified as potential diagnostic and prognostic markers in different histological subtypes of penile squamous cell carcinoma (PSCC) and were associated with HPV infection. Microarray analyses revealed significant differences in expression patterns between distinct histological subtypes and metastatic PSCC.
Article
Pathology
Haiming Tang, John T. Seykora, Christine J. Ko
Summary: This paper reviews recent genetic studies, emphasizing on potential truncal mutations in actinic keratosis, squamous cell carcinoma in situ, cutaneous squamous cell carcinoma, keratoacanthoma, and keratoacanthoma-like squamous proliferation.
Article
Genetics & Heredity
Wenfeng Lu, Yun Dong, Qing Cui, Yuhan Wang, Xiwen Yang, Xiaoyue Cai, Ming Zhang
Summary: This study found that citron kinase (CIT) is highly expressed in esophageal squamous cell carcinoma (ESCC) tissues and knockdown of CIT can inhibit cell proliferation and promote apoptosis, as well as reduce tumorigenicity in vivo. Microarray and IPA analysis revealed that CIT interacts with PRKAA1, SQSTM1, and IL6, and upregulation of PRKAA1 and SQSTM1 and downregulation of IL6 can contribute to ESCC development. This suggests that CIT may serve as a promising therapeutic target for ESCC.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Ge Wu, Fangfang Yang, Xuecheng Cheng, Zihao Mai, Xiaoping Wang, Tongsheng Chen
Summary: The transmembrane carboxyl terminal domain (TMD) of Bcl-2 family proteins, specifically Bcl-xL, plays a crucial role in modulating apoptosis by preventing the apoptotic functions of Bad and Bax. Also, this domain is necessary for the anti-apoptotic capacity and mitochondrial localization of Bcl-xL.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Chunguang Zhao, Zhiyun Liu
Summary: It has been discovered that SERPINE1 is highly expressed in oral squamous cell carcinoma (OSCC) and exerts oncogenic effects through a mechanism mediated by miR-617. The miR-617/SERPINE1 axis may serve as a potential therapeutic target for OSCC.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Honghe Luo, Weize Lv, Huayong Zhang, Chunxia Lin, Fei Li, Fangfang Zheng, Beilong Zhong
Summary: This study revealed that miR-204-5p regulates cell proliferation and apoptosis in ESCC through targeting Nestin, providing potential therapeutic targets for ESCC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)