Article
Geriatrics & Gerontology
Adeline Dolly, Sarah A. Potgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. de Castro, Chloe Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Goncalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marilia Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels
Summary: This study explores the potential role of the aryl hydrocarbon receptor (AHR) in cancer cachexia and finds that impaired AHR signaling contributes to hepatic inflammatory and metabolic disorders, exacerbating cachectic features. These findings provide innovative therapeutic strategies for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Cell Biology
Xiuqin Jia, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Yuhan Jiao, Lulin Wang, Jingjing Jiang, Feng Pang, Xianzhen Zhang, Jian Zhang
Summary: In this study, the FGFRs inhibitor FIIN-2 was found to inhibit the proliferation, colony formation, and migration of platinum-resistant LUAD cells while inducing mitochondria-mediated apoptosis. Furthermore, FIIN-2 was shown to enhance autophagy flux in these cells, suggesting its potential as a treatment strategy for LUAD, especially in combination with autophagy inhibitors.
CELL DEATH & DISEASE
(2022)
Article
Toxicology
Shunsuke Tomita, Kazuho Inaba, Masashi Sekimoto
Summary: In this study, the researchers identified tyrphostin AG1024 as a potent inhibitor of 3-methylcholanthrene-mediated AhR activation. They found that AG1024 suppressed AhR activation by downregulating AhR protein expression. The molecular target of AG1024 remains unclear but may be an important target for regulating AhR-dependent toxicity.
TOXICOLOGY LETTERS
(2022)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Takeshi Masaki, Makoto Okazawa, Ryotaro Asano, Tadakatsu Inagaki, Tomohiko Ishibashi, Akiko Yamagishi, Saori Umeki-Mizushima, Manami Nishimura, Yusuke Manabe, Hatsue Ishibashi-Ueda, Manabu Shirai, Hirotsugu Tsuchimochi, James T. Pearson, Atsushi Kumanogoh, Yasushi Sakata, Takeshi Ogo, Tadamitsu Kishimoto, Yoshikazu Nakaoka
Summary: This study investigates the role of the aryl hydrocarbon receptor (AHR) in the pathogenesis of pulmonary arterial hypertension (PAH), revealing that AHR agonistic activity is associated with poor prognosis in PAH patients. The findings suggest that AHR plays crucial roles in the development and progression of PAH, highlighting the AHR-signaling pathway as a potential therapeutic target for PAH.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Elizabeth Goya-Jorge, Maria Elisa Jorge Rodriguez, Maite Sylla-Iyarreta Veitia, Rosa M. Giner
Summary: The aryl hydrocarbon receptor (AhR) is a crucial transcription factor in health and disease, particularly in cancer, immunology, inflammatory conditions, and aging. Flavonoids, the largest group of natural AhR ligands in the human diet, have complex modulatory effects on AhR that need further investigation to understand their potentially harmful and beneficial effects. Flavonoids exhibit tissue, organ, and species-specific activities on AhR, suggesting potential benefits in pharmacotherapy.
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Immunology
Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich M. Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht
Summary: The study shows that the environmental sensor AhR and its downstream target CYP1B1 play an important role in preventing exacerbation of allergic airway inflammation by regulating the expression and signaling in lung epithelial cells. Differential expression and signaling of CYP1 family members via AhR in epithelial cells represent an immunoregulatory layer protecting the lung from exacerbation of allergic airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Carolien Eggermont, Philippe Giron, Maxim Noeparast, Hugo Vandenplas, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Greve
Summary: In this study, a high-throughput siRNA kinome screen was performed to identify targets involved in functional drug tolerance against EGFR TKI in NSCLC. STYK1 was identified as a potential target that, when downregulated, enhances the effects of EGFR inhibition. The study also found that STYK1 selectively interacts with mutant EGFR and that its downregulation counteracts the upregulation of FGF1 induced by EGFR TKI. Co-targeting EGFR and STYK1 could lead to a better overall outcome for NSCLC patients.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Wen-Jane Lee, Keng-Hung Lin, Jun-Sing Wang, Wayne Huey-Herng Sheu, Chin-Chang Shen, Cheng-Ning Yang, Sheng-Mao Wu, Li-Wei Shen, Shu-Hua Lee, De-Wei Lai, Keng-Li Lan, Chun-Wei Tung, Shing-Hwa Liu, Meei-Ling Sheu
Summary: This study investigated the role of aryl hydrocarbon receptor (AhR) in diabetic retinopathy (DR) and found that the downregulation of AhR is associated with the progression of DR. The use of AhR agonists could reverse this downregulation and potentially maintain retinal vascular homeostasis, delaying the development of DR.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ziyue Kou, Wei Dai
Summary: Aryl hydrocarbon receptor (AHR) is a cellular protein involved in detoxification of xenobiotic compounds. Research has shown that AHR plays important roles in normal development and homeostasis, and its deficiency can lead to various developmental abnormalities.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Ran Na, Jin Young Kim, Chang Ho Song, Mikyung Kim, Yen Thi Do, Tam Thuy Lu Vo, Eunsom Choi, Eunyoung Ha, Ji Hae Seo, So-Jin Shin
Summary: This study demonstrated the promising antitumor effects of AZD4547 in ovarian cancer cells, including inhibition of proliferation, induction of apoptosis, suppression of migration and invasion, reduction of stem cell activity and angiogenesis, as well as inhibition of in vivo tumor growth in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Chalothon Amporn, Pin-Chi Tang, Chien-Kai Wang
Summary: The conservation of Taiwan Country chicken plays a crucial role in maintaining the adaptability and disease resistance of the local breed. This study successfully isolated and characterized embryonic stem cells (ESCs) of Taiwan Country chicken, providing a foundation for further species conservation and breeding research.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Chung-Yu Wu, Hsuan-Hung Liu, Po-Hung Chen, Chuan-Chin Chiao, Fang-Liang Chu, Yueh-Chun Tsai, Po-Chun Chen, Wen-Yuan Tsai, Ying-Hsuen Wu, Chi-Kuan Tseng
Summary: This study presents the design and verification of a CMOS 256-pixel photovoltaic-powered subretinal prosthetic chip with three key advances. The chip can automatically adapt to changing background illuminance levels, increase injection charges while reducing crosstalk leakage charges, and maintain a stable stimulation voltage for safety. Ex vivo tests have demonstrated the functionality and potential of the chip for subretinal prostheses.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Environmental Sciences
Yuan-Ting Yang, Chung-Hao Hsu, Yu-Fen Wang, Yu-Jun Chang, Hui-Ju Yang, Jiunn-Liang Ko, Kuo-Chia Yang
Summary: This study investigated the quality of life (QoL) and factors influencing QoL in Taiwanese vitiligo patients. The results showed no significant difference in QoL between vitiligo patients and controls. Among vitiligo patients, adults, married females, those with higher education, shorter disease history, and generalized type of vitiligo experienced poorer QoL. This highlights the importance of tailored psychological counseling and treatment for vitiligo patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Engineering, Electrical & Electronic
Sivaneswaran Sankar, Po-Hung Chen, Maryam Shojaei Baghini
Summary: This article proposes a new efficient method for extracting power from piezoelectric transducers using inductive rectifiers. The proposed method ensures maximum output power extraction and avoids negative voltage swing across the transducer. The operational steps are self-timed.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2022)
Article
Environmental Sciences
Po-Hung Chen, Ta-Kang Liu
Summary: Global warming has opened up new shipping routes in the Arctic, and research has focused on the economic costs and CO2 emissions of these routes. A study comparing two routes from Taipei Port to Rotterdam found that the Northeast Passage was shorter but costlier, while the Northwest Passage was shorter and reduced both costs and CO2 emissions.
Article
Transplantation
Amanda Su, Erik Almazan, Vorada Sakulsaengprapha, Jessica Shay, Ilan Wittstein, Muhammad Hammami, Aliaksei Pustavoitau, Nicole Rizkalla, Saleh Alqahtani, Tinsay Woreta, James P. Hamilton, Ruhail Kohli, Shane E. Ottmann, Ahmet Gurakar, Po-Hung Chen
Summary: This study examines the association between coronary artery calcium (CAC) scores and cardiovascular outcomes in liver transplant (LT) candidates. The results show that CAC scores >400 are associated with an increased risk of major adverse cardiovascular events (MACEs) within the 5-year post-LT follow-up period, but not with all-cause mortality.
TRANSPLANTATION DIRECT
(2023)
Article
Chemistry, Analytical
Congo Tak Shing Ching, Chien-Kai Wang, Pin-Chi Tang, Minh-Khue Ha, Chin Li, Hsuan-Ni Chiu, Fiona Yan-Dong Yao, Nguyen Chi Nhan, Nguyen Van Hieu, Thien-Luan Phan
Summary: Day-old male chick culling is a cruel practice in the poultry industry where seven billion male chicks are slaughtered annually. This study introduces a novel non-invasive method using four electrodes and impedance data to determine the gender of chicken eggs. By applying a PCR-based protocol on the eggs at the end of the incubation period, a reliable connection was established between the collected data and the egg's gender, offering a groundbreaking solution to relieve the ethical burden of the poultry industry.
Article
Environmental Sciences
Salim Arrokhman, Yueh-Hsia Luo, Pinpin Lin
Summary: Bisphenol A (BPA) and its analogs, such as bisphenol F (BPF), bisphenol AF (BPAF), and bisphenol B (BPB), were found to increase the mortality of zebrafish embryos (ZFEs) and induce bradycardia. BPAF was the most potent, followed by BPB, BPA, and BPF.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Summary: The currently used air quality index (AQI) is criticized for its inability to capture the additive effects of air pollution on health risks and reflect non-threshold concentration-response relationships. In this study, we propose the air quality health index (AQHI) based on daily air pollution-mortality associations and compare its validity in predicting daily mortality and morbidity risks with the existing AQI.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Shan -Shan Wang, Pinpin Lin, Chia-Chi Wang, Ying-Chi Lin, Chun-Wei Tung
Summary: This study developed a nonlinear machine learning method to predict the migration of chemicals from packaging materials to food, taking into account chemical properties, material type, food type, and temperature. The ensemble model leveraging multiple algorithms provides better performance compared to previous linear regression models. These prediction models can accelerate the assessment of migration of food contact chemicals from package to foods.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Editorial Material
Rheumatology
Mei-Chia Chou, Wei-Kai Lee, Po-Hung Chen, Li-Fei Pan, Su-Boon Yong, Chia-Jung Li
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Environmental Sciences
Pinpin Lin, Pei- Lee, Min-Pei Ling
Summary: This study quantifies the benefit-risk analysis of omega-3 polyunsaturated fatty acid and methylmercury for people consuming mercury-contaminated fish in Taiwan using a probabilistic approach. The results suggest that Taiwan residents do not need to reduce intake rate based on benefit considerations, despite the higher risks associated with cod and scad.
MARINE POLLUTION BULLETIN
(2023)
Meeting Abstract
Surgery
Jonathan Mitchell, Jennifer Motter, Mayan Teles, Kayleigh Herrick-Reynolds, Hannah Sung, Po-Hung Chen, Elizabeth King, Andrew Cameron
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Correction
Construction & Building Technology
Ryan Jasper, Po-Hung Chen, Reeha Patel, Shelly Joseph, Steven Miller, Susan Hutfless
LIGHTING RESEARCH & TECHNOLOGY
(2023)
Article
Environmental Sciences
Kuan-Yu Kuo, Yu Chen, Yi Chuang, Pinpin Lin, Yi-Jun Lin
Summary: This study investigated the health risks of perfluoroalkyl substances (PFASs) on pregnant women, infants, and children, with a focus on the mixture risks of the four main PFASs. The findings revealed that PFOS was the most dominant PFAS in the serum of pregnant women and children globally, with potential immune effects exceeding 1. The cumulative hazard quotients (HQs) for developmental and immune effects in infants could also be greater than 1, suggesting concerns for infant development and immunity. The national and global serum database and risk assessment provide additional insights into PFAS exposure and mixture risks in vulnerable populations, serving as a reference for evaluating regulatory mitigation measures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)