Article
Food Science & Technology
Yizhong Bao, Xihao Wang, Wei Mao, Xinyao Li, Jiangjie Lou, Weihua Jin, Genxiang Mao, Lijiang Tang, Yingzheng Weng
Summary: Atherosclerosis is the leading cause of cardiovascular diseases worldwide. This study investigated the anti-atherosclerosis activities of two types of oligosaccharides and found that sulfated glucuronomannan hexamer exhibited the best activity. It down-regulated the expression of LOX-1 and regulated multiple signaling pathways to reduce plaque progression and promote plaque stabilization.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Gozde Erturk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlita, Halef Okan Dogan, Gokmen Zararsiz
Summary: Multiple studies have shown a high prevalence of dyslipidemia in children, emphasizing the importance of early recognition to prevent future coronary heart disease. Among the various equations for estimating LDL-C, the extended Martin-Hopkins formula was found to provide the most reliable results in a large pediatric population.
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Cell Biology
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Eduardo Araujo, Steven Nusinowitz, Srinivasa T. Reddy, Ram Kannan
Summary: Lipid peroxidation caused by oxidative stress is a major factor in age-related macular degeneration (AMD). This study aims to investigate the role of LDLR in the NaIO3-induced model of dry AMD. The results indicate that LDLR loss leads to lipid accumulation and impaired retinal function, which may contribute to the development of AMD.
Article
Chemistry, Multidisciplinary
Xiyang Wei, Shicheng Yu, Tinghong Zhang, Liansheng Liu, Xu Wang, Xiaodan Wang, Yun-Shen Chan, Yangming Wang, Shu Meng, Ye-Guang Chen
Summary: This study reveals the crucial role of intestinal epithelial microRNAs, particularly the miR-200 family, in regulating intestinal stem cells and epithelial regeneration. The downregulation of miR-200 family and hyperactivation of the p53 pathway are verified in patients with active ulcerative colitis. Importantly, the oral delivery of lipid nanoparticles carrying miR-200 can restore intestinal stem cells and promote intestinal regeneration, providing a promising therapeutic approach for active ulcerative colitis patients.
Article
Cardiac & Cardiovascular Systems
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri-Sverdlov, David S. Leake
Summary: The study shows that cysteamine can induce regression of atherosclerotic lesions in LDL receptor-deficient mice, improve lesion stability, reduce oxidized phospholipids, decrease liver lipid levels and expression of specific proteins and cytokines, as well as enhance skeletal muscle function. No changes were observed in plasma lipid concentrations. This suggests that lysosomal oxidation inhibition with antioxidants targeted at lysosomes may be a promising therapy for atherosclerosis in patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Shun Yu Sun, Wei Yi Yang, Zhuo Tan, Xing Yu Zhang, Yi Lin Shen, Qi Wei Guo, Guo Ming Su, Xu Chen, Jia Lin, Ding Zhi Fang
Summary: The study investigated the serum levels of FFAs and their associations with routine serum lipids in diet-induced obese mice. The findings suggest that obesity may influence the serum FFAs profiles and the relationship of individual FFAs and their relative levels to other FFAs with routine serum lipids. Individual FFAs may interact with others and obesity on levels of routine serum lipids, providing potential novel perspectives for improving hyperlipidemia in subjects with obesity.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Medicine, General & Internal
Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani
Summary: Eradication of Helicobacter pylori increases HDL-C levels and triglyceride levels, but does not significantly affect low-density lipoprotein-cholesterol levels. Further studies are needed to clarify the effects of lipid changes following H. pylori eradication on cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Benjamin N. Wadstrom, Kasper M. Pedersen, Anders B. Wulff, Borge G. Nordestgaard
Summary: This study found that elevated remnant cholesterol and plasma triglycerides were associated with an increased mortality rate from cardiovascular and other causes, but not from cancer, according to data from the Copenhagen General Population Study. This novel finding should be confirmed in other cohorts.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Honglin Han, Yuexuan Wang, Suifeng Xu, Chengzong Han, Qiwei Qin, Shina Wei
Summary: Lipid metabolism, particularly high-density lipoprotein (HDL), plays a crucial role in viral infections. This study investigates the role of Epinephelus coioides SR-B1 (Ec-SR-B1) in red-spotted grouper nervous necrosis virus (RGNNV) infection and reveals that Ec-SR-B1 can promote RGNNV infection. The study also demonstrates the involvement of HDL in facilitating RGNNV entry and the interaction between Ec-SR-B1 and RGNNV's capsid protein (CP).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Toxicology
Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai
Summary: Lipidomics analysis revealed that the decreased levels of phosphatidylcholine (PC) (18:0/20:4) in plasma and liver, as well as the decreased levels of serum TG-rich VLDL, may be involved in the pathogenesis of ETH-induced hepatic steatosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Mingxi Shao, Yingzhu Li, Jisen Teng, Shengjie Li, Wenjun Cao
Summary: The study found that serum lipid levels were significantly higher in patients with primary angle-closure glaucoma compared to the control group. High serum HDL-C, LDL-C, APOA, APOB, LPa, and CHOL levels were significantly associated with PACG.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jessica G. G. Woo, John T. T. Melchior, Debi K. K. Swertfeger, Alan T. T. Remaley, Ebrima A. A. Sise, Fatou Sosseh, Jeffrey A. A. Welge, Andrew M. M. Prentice, W. Sean Davidson, Sophie E. E. Moore, Laura A. A. Woollett
Summary: The study evaluated the impact of pregnancy on lipoprotein particle concentrations and compositions. It found that lipoprotein subfraction concentrations changed during gestation but were not associated with infant birth weights. Changes in the proteome of HDL were observed to support gestation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Tatjana Josefs, Debapriya Basu, Tomas Vaisar, Britt Arets, Jenny E. Kanter, Lesley-Ann Huggins, Yunying Hu, Jianhua Liu, Noemie Clouet-Foraison, Jay W. Heinecke, Karin E. Bornfeldt, Ira J. Goldberg, Edward A. Fisher
Summary: The study found that hypertriglyceridemia and reduced HDL-C did not affect atherosclerosis lesion size or macrophage content, suggesting that atherosclerosis regression in mice is primarily driven by LDL-C reduction and not impacted by hypertriglyceridemia and plasma HDL-C levels.
CIRCULATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Haruhisa Nakao, Kenji Wakai, Norimitsu Ishii, Yuji Kobayashi, Kiyoaki Ito, Masashi Yoneda, Mitsuru Mori, Masanori Nojima, Yasutoshi Kimura, Takao Endo, Masato Matsuyama, Hiroshi Ishii, Makoto Ueno, Sawako Kuruma, Naoto Egawa, Keitaro Matsuo, Satoyo Hosono, Shinichi Ohkawa, Kozue Nakamura, Akiko Tamakoshi, Mami Takahashi, Kazuaki Shimada, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin
BMC GASTROENTEROLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Hori, Hiroaki Onaya, Nobuyoshi Hiraoka, Taiki Yamaji, Hideaki Kobayashi, Mami Takahashi, Michihiro Mutoh, Kazuaki Shimada, Hitoshi Nakagama
JAPANESE JOURNAL OF RADIOLOGY
(2016)
Article
Cell Biology
Marimu Sakumoto, Rieko Oyama, Mami Takahashi, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Makoto Endo, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Biochemistry & Molecular Biology
Rikako Ishigamori, Masami Komiya, Shinji Takasu, Michihiro Mutoh, Toshio Imai, Mami Takahashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Oncology
Marimu Sakumoto, Mami Takahashi, Rieko Oyama, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Akihiko Yoshida, Makoto Endo, Akira Kawai, Tadashi Kondo
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Cell Biology
Fusako Kito, Rieko Oyama, Marimu Sakumoto, Mami Takahashi, Kumiko Shiozawa, Zhiwei Qiao, Hiromi Sakamoto, Takeshi Hirose, Nokitaka Setsu, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Cell Biology
Rieko Oyama, Mami Takahashi, Fusako Kito, Marimu Sakumoto, Kumiko Shiozawa, Zhiwei Qiao, Akihiko Yoshida, Makoto Endo, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Review
Oncology
Mami Takahashi, Mika Hori, Rikako Ishigamori, Michihiro Mutoh, Toshio Imai, Hitoshi Nakagama
Article
Multidisciplinary Sciences
Rieko Oyama, Mami Takahashi, Akihiko Yoshida, Marimu Sakumoto, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Yasuhito Arai, Tatsuhiro Shibata, Yoshihiro Araki, Makoto Endo, Akira Kawai, Tadashi Kondo
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Rieko Oyama, Fusako Kito, Zhiwei Qiao, Marimu Sakumoto, Rei Noguchi, Mami Takahashi, Shunichi Toki, Yoshikazu Tanzawa, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Cell Biology
Rieko Oyama, Fusako Kito, Mami Takahashi, Marimu Sakumoto, Kumiko Shiozawa, Zhiwei Qiao, Rei Noguchi, Takashi Kubo, Shunichi Toki, Fumihiko Nakatani, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
Article
Biochemical Research Methods
Kumiko Shiozawa, Rieko Oyama, Mami Takahashi, Fusako Kito, Emi Hattori, Akihiko Yoshida, Akira Kawai, Masaya Ono, Tadashi Kondo
PROTEOMICS CLINICAL APPLICATIONS
(2019)
Article
Oncology
Shigehiro Yagishita, Ken Kato, Mami Takahashi, Toshio Imai, Yasushi Yatabe, Takeshi Kuwata, Mikiko Suzuki, Atsushi Ochiai, Atsushi Ohtsu, Kazuaki Shimada, Toshirou Nishida, Akinobu Hamada, Hiroyuki Mano
Summary: The establishment of a Japanese PDX library from cancer specimens of Japanese patients has been successful in providing a platform for drug discovery and development. When conducting coclinical trials, it is important to consider the target cancer type, stage, and engraftment rate based on the findings of this report.
Article
Biochemistry & Molecular Biology
Wataru Murase, Yukino Kamakura, Serina Kawakami, Ayaka Yasuda, Momoka Wagatsuma, Atsuhito Kubota, Hiroyuki Kojima, Tohru Ohta, Mami Takahashi, Michihiro Mutoh, Takuji Tanaka, Hayato Maeda, Kazuo Miyashita, Masaru Terasaki
Summary: Fucoxanthin shows chemopreventive effects in a pancreatic cancer mouse model, suppressing key cancer-related genes and protein expressions to slow down tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mika Hori, Michihiro Mutoh, Rikako Ishigamori, Toshio Imai, Mami Takahashi
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)