Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Sayra Dilmac, Nilay Kuscu, Ayse Caner, Sendegul Yildirim, Burcak Yoldas, Ammad Ahmad Farooqi, Gamze Tanriover
Summary: This study investigated the roles of SIRT and FoxO proteins in breast cancer metastasis and found that SIRT1 co-operates with FoxO proteins and plays a critical role in metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ai Sato, Kiyoshi Takagi, Ayano Yoshimura, Wakana Tsukamoto, Mio Yamaguchi-Tanaka, Yasuhiro Miki, Akiko Ebata, Minoru Miyashita, Takashi Suzuki
Summary: This study explores the clinical significance of KLK12 in breast cancer. The results show that KLK12 is strongly associated with low-grade malignancy and has favorable prognostic effects. Knockdown of KLK12 enhances proliferation and migration of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mio Yamaguchi, Kiyoshi Takagi, Koki Narita, Yasuhiro Miki, Yoshiaki Onodera, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki
Summary: Chemokines, particularly CCL5, secreted from stromal cells play crucial roles in interaction with carcinoma cells and regulating tumor progression. In human breast carcinoma tissues, the expression of CCL5 and CCR3 is significantly correlated with aggressive phenotype, and patients with positive CCL5 and CCR3 but negative CCR1 and CCR5 have a higher risk of recurrence. These findings suggest that the CCL5-CCR3 axis may contribute to a worse prognosis in breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Syazalina Zahari, Saiful Effendi Syafruddin, M. Aiman Mohtar
Summary: Breast cancer is a complex and challenging disease. The secretome, which includes proteins, lipids, and nucleic acids secreted by breast cancer cells, plays a crucial role in the development, progression, and drug resistance of breast cancer. Understanding the role of the secretome is essential for developing innovative therapies. This review explores the impact of the secretome on breast cancer progression and its interactions with the tumor microenvironment, and identifies potential therapeutic opportunities.
Article
Biochemistry & Molecular Biology
Meicen Zhou, Wenbao Lu, Bingwei Li, Xiaochen Yuan, Mingming Liu, Jianqun Han, Xueting Liu, Ailing Li
Summary: Roquin2 is identified as a novel breast cancer suppressor that inhibits tumor angiogenesis by selectively downregulating the expression of proangiogenic genes. Overexpression of Roquin2 can inhibit breast tumor-induced angiogenesis, while silencing Roquin2 enhances tumor angiogenesis. In vivo induction of Roquin2 significantly suppresses breast tumor growth, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eduardo Duran-Jara, Tamara Vera-Tobar, Lorena De Lourdes Lobos-Gonzalez
Summary: Lactadherin is associated with cancer development and progression, and can serve as a biomarker and therapeutic target for cancer. It plays important roles in cell adhesion, angiogenesis, and tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yang Li, Jun Cao, Jianfeng Wang, Weidong Wu, Liren Jiang, Xing Sun
Summary: This study found that IGF2BP3 plays an important role in the progression and distant metastasis of breast cancer and is closely associated with brain metastasis. Positive IGF2BP3 expression is related to decreased distant metastasis-free survival and the occurrence of brain metastasis in breast cancer patients. High IGF2BP3 expression is associated with the PD-1 checkpoint pathway, HER2-HER3 signaling, and epithelial-mesenchymal transition.
Review
Cell Biology
Menglu Dong, Quan Liu, Yi Xu, Qi Zhang
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer known for its diverse biological behavior, high aggressiveness, and poor prognosis. Extracellular vesicles (EVs) play a crucial role in long-distance cell-to-cell communication in shaping the tumor microenvironment. EVs released by TNBC cells have potential as valuable biomarkers for diagnosis, monitoring, and treatment evaluation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Shao-Ying Yang, Yi-Fan Xie, Tai-Mei Zhang, Ling Deng, Li Liao, Shu-Yuan Hu, Yin-Ling Zhang, Fang-Lin Zhang, Da-Qiang Li
Summary: This study reports the upregulation of IMPA1 in TNBC and its role in proliferation, metastasis and tumor formation in TNBC cells. Transcriptome sequencing analysis reveals that IMPA1 induces mTOR activity and epithelial-mesenchymal transition (EMT) process, thus promoting TNBC progression.
Article
Cell Biology
Yu Zhang, Wanyu Wang, Jiali Min, Suosi Liu, Qianrong Wang, Yu Wang, Yang Xiao, Xia Li, Zhiguang Zhou, Shanshan Liu
Summary: The expression of ZNF451 is upregulated in triple-negative breast cancer (TNBC) and is associated with a poor prognosis. ZNF451 enhances TNBC progression by interacting with and enhancing the activity of the transcriptional activator SLUG. Disturbing the ZNF451-SLUG interaction can suppress TNBC progression by reducing CCL5 expression and counteracting the migration and activation of tumor-associated macrophages.
Article
Biochemistry & Molecular Biology
Shiro Uchida, Takashi Sugino
Summary: This study identified genes associated with breast cancer progression mechanisms and potential therapeutic targets using bioinformatic tools. It found several genes involved in breast cancer progression and identified potential novel therapeutic targets.
Article
Chemistry, Multidisciplinary
Qi Shang, Shiyao Zhou, Zijia Zhou, Yue Jiang, Yuxia Luan
Summary: Targeting breast cancer stem cells (BCSCs) therapy is a promising strategy to eliminate tumors by remolding the disequilibrium state and blocking the EMT process, demonstrating a potential photodynamic platform against tumor progression and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Vikrant Mehta, Prabhat Suman, Harish Chander
Summary: This study aimed to analyze the expression of CHAC1 protein in malignant breast cancer tissues. The results showed significant up-regulation of CHAC1 in breast cancer tissues, and it was associated with high proliferation and positive lymph node metastasis. High CHAC1 expression was associated with poor overall survival in breast cancer patients, suggesting that CHAC1 may have a prognostic significance in breast cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)