Article
Medicine, General & Internal
Paavo V. H. Raittinen, Heimo Syvala, Teuvo L. J. Tammela, Merja R. Hakkinen, Pauliina Ilmonen, Seppo Auriola, Teemu J. Murtola
Summary: The study investigated the impact of atorvastatin on steroid profiles in the serum and prostatic tissue of men with prostate cancer. The findings suggest that atorvastatin may influence adrenal androgen levels in the serum and possibly in the prostate, indicating a potential for improving androgen deprivation therapy efficacy.
Review
Biochemistry & Molecular Biology
Chiara Chiodo, Catia Morelli, Fabiola Cavaliere, Diego Sisci, Marilena Lanzino
Summary: This article reviews the challenges of breast cancer prevention and highlights the role of steroid hormones and their receptors in the development of the disease. It specifically focuses on the impact of androgens and their receptor on breast tissue and their correlation to breast cancer risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bhrugesh Pravinchandra Joshi, Vishwambhar Vishnu Bhandare, Mahima Vankawala, Prittesh Patel, Rajesh Patel, Bhavin Vyas, Ramar Krishnamurty
Summary: Potential phytochemical inhibitors against CYP17A1, including Friedelin and CT extract, have been identified through virtual screening. These inhibitors have shown anticancer activity in prostate cancer, as confirmed by in vitro and in vivo studies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Medicine, Research & Experimental
Joanna Dulinska-Litewka, Dominik Felkle, Kacper Dykas, Zuzanna Handziuk, Marta Krzysztofik, Bartosz Gasiorkiewicz
Summary: The role of cyclins in hormone-dependent neoplasms, especially breast cancer, is crucial. However, cyclins in prostate cancer are less studied, particularly the role of other cyclins that requires further investigation. Recent studies have shown that cyclins not only regulate the cell cycle but also interact with other signaling pathways. The androgen signaling axis plays a significant role in prostate cancer progression and interferes with cyclin pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Takahiro Sawada, Yoshiaki Kanemoto, Tomohiro Kurokawa, Shigeaki Kato
Summary: Androgen and androgen deprivation therapies are used to treat prostate cancer patients, but many patients eventually develop castration-resistant prostate cancer. This review discusses the role of androgen receptor in the epigenetic transition to castration-resistant prostate cancer and the clinical applications of AR ligands, co-regulators, and enhancer RNA in chromatin reorganization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mehdi Baratchian, Ritika Tiwari, Sirvan Khalighi, Ankur Chakravarthy, Wei Yuan, Michael Berk, Jianneng Li, Amy Guerinot, Johann de Bono, Vladimir Makarov, Timothy A. Chan, Robert H. Silverman, George R. Stark, Vinay Varadan, Daniel D. De Carvalho, Abhishek A. Chakraborty, Nima Sharifi
Summary: Antiandrogen strategies are commonly used in prostate cancer treatment, but they often lead to drug resistance. This study reveals that antiandrogen treatment activates retroelements (REs), which triggers an interferon response and inhibits tumor growth. Furthermore, the study identifies H3K9 trimethylation as an essential epigenetic adaptation to antiandrogens, as it suppresses REs and prevents the activation of interferon signaling and glucocorticoid receptor. The expression of terminal H3K9me3 writers is associated with poor patient outcomes in hormonal therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin Horkeby, Marie K. Lagerquist, Henrik Ryberg, Matti Poutanen, Liesbeth Vandenput, Claes Ohlsson
Summary: In this study, it was found that DHEA treatment can restore the levels of testosterone and dihydrotestosterone in male reproductive organs, but not in skeletal muscle or brain. Additionally, supraphysiological levels of androgens were observed in the liver after DHEA treatment, which raises concerns regarding the uncontrolled use of DHEA.
Review
Endocrinology & Metabolism
Kunal Desai, Jeffrey M. McManus, Nima Sharifi
Summary: Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone deprivation in the 1940s, leading to the concept of prostate cancer being highly androgen-dependent. Since then, hormonal therapy has evolved from gonadal testosterone deprivation to inhibiting extragonadal androgens, to directly binding and inhibiting the androgen receptor. Today's standard of care for advanced prostate cancer includes gonadotropin-releasing hormone agonists and androgen receptor antagonists.
Article
Biochemical Research Methods
Patrick Caron, Veronique Turcotte, Chantal Guillemette
Summary: Bioactive 11-oxygenated C 19 adrenal-derived steroids have potential significance in endocrine and metabolic contexts. A LC-ESI-MS/MS method for quantifying seven 11-oxy C 19 was developed and validated, demonstrating applicability in adult men and women with sex differences. However, detection of one steroid, 11KDHT, remained undetectable possibly due to interfering endogenous molecules.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Cell Biology
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young Um
Summary: In this study, the therapeutic efficacy of ellagic acid (EA) for benign prostate hyperplasia (BPH) was investigated. EA was found to improve BPH by inhibiting the AR signaling axis and STAT3 pathway. EA reduced prostate weight, epithelial thickness, and serum DHT levels in BPH rats. It also improved testicular injury and induced apoptosis in prostate cells.
CELL DEATH & DISEASE
(2022)
Article
Urology & Nephrology
Samuel Tremblay, Lily Summers-Trasiewicz, Frederic Pouliot, Juanita M. Crook, Keyue Ding, Laurence Klotz, Paul Toren
Summary: This study aimed to evaluate the relationship between testosterone levels and PSA levels during ADT and its impact on clinical outcomes. The results showed that testosterone levels had a smaller prognostic effect compared to PSA levels on outcomes. Specifically, there was no significant association between the cumulative testosterone exposure and outcomes.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz M. Wrobel, Oksana Rogova, Katyayani Sharma, Maria Natalia Rojas Velazquez, Amit V. Pandey, Flemming Steen Jorgensen, Frederic S. Arendrup, Kasper L. Andersen, Fredrik Bjorkling
Summary: In this study, twenty new compounds targeting CYP17A1 were synthesized and evaluated for their biological activity. One compound showed comparable potency and selectivity to existing drugs.
Article
Chemistry, Medicinal
Alexis Paquin, Yassine Oufqir, Irina F. Sevrioukova, Carlos Reyes-Moreno, Gervais Berube
Summary: The study reports the synthesis of two isomeric testosterone dimers and an androstenedione dimer, utilizing an efficient transformation leading to the formation of key diene. The most active dimer was found to be composed of natural testosterone, exhibiting significant inhibitory effects on androgen-dependent prostate cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Bourcin Serifoglou, Evangelia Konstantinou, George Notas, Elias Castanas, Marilena Kampa
Summary: Calcium homeostasis plays a significant role in the development and progression of prostate cancer, with androgens regulating cell processes through calcium changes. The study found that testosterone can rapidly increase intracellular calcium levels through OXER1 receptor and specific signaling cascade. These findings reveal the receptor involved in rapid calcium changes induced by androgens in prostate cancer cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Andrea Delbarba, Deborah Cosentini, Paolo Facondo, Marta Lagana, Letizia Chiara Pezzaioli, Valentina Cremaschi, Andrea Alberti, Salvatore Grisanti, Carlo Cappelli, Alberto Ferlin, Alfredo Berruti
Summary: Hypogonadism is common in male patients with adrenocortical carcinoma (ACC) who undergo mitotane treatment, and this should be promptly detected and counteracted to minimize the negative impact on quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Organic
Mykhaylo S. Frasinyuk, Galyna P. Mrug, Svitlana P. Bondarenko, Vitaliy M. Sviripa, Wen Zhang, Xianfeng Cai, Michael V. Fiandalo, James L. Mohler, Chunming Liu, David S. Watt
ORGANIC & BIOMOLECULAR CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Mykhaylo S. Frasinyuk, Galyna P. Mrug, Svitlana P. Bondarenko, Volodymyr P. Khilya, Vitaliy M. Sviripa, Oleksandr A. Syrotchuk, Wen Zhang, Xianfeng Cai, Michael V. Fiandalo, James L. Mohler, Chunming Liu, David S. Watt
Article
Oncology
John J. Stocking, Michael V. Fiandalo, Elena A. Pop, John H. Wilton, Gissou Azabdaftari, James L. Mohler
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2016)
Article
Mathematical & Computational Biology
Adam D. DePriest, Michael V. Fiandalo, Simon Schlanger, Frederike Heemers, James L. Mohler, Song Liu, Hannelore V. Heemers
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2016)
Article
Chemistry, Organic
Mykhaylo S. Frasinyuk, Wen Zhang, Przemyslaw Wyrebek, Tianxin Yu, Xuehe Xu, Vitaliy M. Sviripa, Svitlana P. Bondarenko, Yanqi Xie, Huy X. Ngo, Andrew J. Morris, James L. Mohler, Michael V. Fiandalo, David S. Watt, Chunming Liu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Endocrinology & Metabolism
Michael V. Fiandalo, John H. Wilton, Krystin M. Mantione, Carol Wrzosek, Kristopher M. Attwood, Yue Wu, James L. Mohler
Article
Biochemical Research Methods
Chengjian Tu, Michael V. Fiandalo, Elena Pop, John J. Stocking, Gissou Azabdaftari, Jun Li, Hua Wei, Danjun Ma, Jun Qu, James L. Mohler, Li Tang, Yue Wu
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Endocrinology & Metabolism
Sarah F. Cook, Michael V. Fiandalo, David S. Watt, Yue Wu, James L. Mohler, Robert R. Bies
Article
Biochemistry & Molecular Biology
Michael V. Fiandalo, Steven R. Schwarze, Natasha Kyprianou
Editorial Material
Endocrinology & Metabolism
Michael V. Fiandalo, Natasha Kyprianou
Article
Biochemistry & Molecular Biology
Perry A. Christian, Michael V. Fiandalo, Steven R. Schwarze
Article
Multidisciplinary Sciences
Nelson T. Gross, Jianmin Wang, Michael V. Fiandalo, Eduardo Cortes Gomez, Anica Watts, Alejandro S. Godoy, Gary J. Smith, Yue Wu
Review
Urology & Nephrology
Michael V. Fiandalo, Daniel T. Gewirth, James L. Mohler
ASIAN JOURNAL OF UROLOGY
(2019)
Article
Pharmacology & Pharmacy
Michael V. Fiandalo, Wenjie Wu, James L. Mohler
CURRENT DRUG TARGETS
(2013)
