Article
Pharmacology & Pharmacy
Fahui Li, Congying Gao, Xueming Li, Jiangyun Wang, Yao Zhao, Yu Ke, Ying Liu, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Summary: The natural compound Jiyuan oridonin A (JOA) has been found to overcome the differentiation blockade in AML cells and leukemic stem-like cells, inhibiting their proliferation and offering a novel therapeutic strategy for AML.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Tony Marchand, Sandra Pinho
Summary: Acute myeloid leukemia (AML) is a common type of leukemia in adults, with complete remission attainable in young and fit patients through intensive chemotherapy, but with frequent relapse and poor prognosis. Leukemic stem cells (LSCs) at the top of the hierarchy are thought to drive relapse due to their specific mutations and metabolic profile, which make them resistant to chemotherapy, as opposed to healthy hematopoietic stem cells (HSCs).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nameeta Shah, Pavan M. Hallur, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Komal Prasad Chandrachari, Ralph B. Puchalski, Aditya Chaubey
Summary: The study demonstrates that the 3D-GMH system effectively mimics the phenotype of treatment-resistant glioma cells that are not represented in neurosphere cultures. Cells cultured in GelMA hydrogels exhibit characteristics similar to cells in specific regions within the glioblastoma core in situ. These findings emphasize the importance of diligence in selecting an appropriate model for designing study objectives.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yong Yang, Xinjing Zhang, Xiaoyan Zhang, Yishu Wang, Xintong Wang, Linda Hu, Yao Zhao, Haihua Wang, Zhanju Wang, Haiying Wang, Lin Wang, Wilhelm G. Dirks, Hans G. Drexler, Xin Xu, Zhenbo Hu
Summary: Leukemic stem cells (LSCs) are a rare cell population that can lead to the development of acute myeloid leukemia. Inhibitors of the histone lysine demethylase JMJD1C, such as JDM-7 and tadalafil, have been identified as potential modulators that selectively inhibit the growth of LSCs.
Article
Oncology
Artem Pilunov, Dmitrii S. Romaniuk, Anton Shmelev, Savely Sheetikov, Anna N. Gabashvili, Alexandra Khmelevskaya, Dmitry Dianov, Ksenia Zornikova, Naina T. Shakirova, Murad Vagida, Apollinariya Bogolyubova, Grigory A. Efimov
Summary: A relapse of malignant disease often occurs after allogeneic hematopoietic stem cell transplantation. Gene-edited MiHA-specific T cells can precisely eliminate malignant cells while sparing donor and non-hematopoietic patient cells. This therapeutic approach could be used to prevent and treat leukemia relapse.
Article
Veterinary Sciences
Harumichi Itoh, Kenji Tani, Hiroshi Sunahara, Munekazu Nakaichi, Toshie Iseri, Hiro Horikirizono, Kazuhito Itamoto
Summary: This study established sphere-forming cells from a canine HCC cell line, showing increased stem cell marker expression, chemoresistance, higher xCT expression, and lower reactive oxygen species levels compared to adherent cells. Treatment with a xCT-specific inhibitor reduced sphere formation efficiency.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Oncology
Igor Valentim Barreto, Flavia Melo Cunha de Pinho Pessoa, Caio Bezerra Machado, Laudreisa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Germison Silva Lopes, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes Filho, Lucas Eduardo Botelho de Souza, Rommel Mario Rodriguez Burbano, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: This article describes the characteristics and differences between hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs), as well as the challenges of LSCs treatment and possible alternative approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sweta B. Patel, Travis Nemkov, Angelo D'Alessandro, Robert S. Welner
Summary: This review discusses the metabolic differences between hematopoietic stem cells and leukemic stem cells in different leukemic models, and sheds light on the advancements and limitations of metabolic techniques in studying stem cell metabolism.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Muneerah A. H. Huwaikem, Gauthaman Kalamegam, Ghadeer Alrefaei, Farid Ahmed, Roaa Kadam, Talal Qadah, Khalid H. W. Sait, Peter N. Pushparaj
Summary: The study found that hWJSCs and their extracts could inhibit the growth of K562 cells by regulating the cell cycle and inducing apoptosis, but further in vivo evaluation is needed to uncover their true potential in CML inhibition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Caigang Liu, Yixiao Zhang, Jiujiao Gao, Qi Zhang, Lisha Sun, Qingtian Ma, Xinbo Qiao, Xinnan Li, Jinchi Liu, Jiawen Bu, Zhan Zhang, Ling Han, Dongyu Zhao, Yongliang Yang
Summary: This study reports the discovery and biological evaluation of a highly potent small-molecule antagonist, LFS-1107, targeting breast cancer stem-like cells (BCSCs) in triple-negative breast cancer (TNBC). LFS-1107 selectively eliminates CD44(+)CD24(-) enriched BCSCs and shows significant inhibitory effects on TNBC tumor cells. These findings provide preclinical evidence that LFS-1107 could be a promising therapeutic agent for the treatment of TNBC.
DRUG RESISTANCE UPDATES
(2023)
Article
Multidisciplinary Sciences
Alena Kalinina, Catherine Gnyra, Vera Tang, Yingben Xue, Diane C. Lagace
Summary: The use of DNA-binding dyes in stem cell research is significant for isolating specific cell populations. In this study, a distinct side population of cells was identified in the mouse brain using a DNA-binding dye, and these cells showed sensitivity to ABC transporter inhibitors. Furthermore, the majority of these cells expressed CD31 and were not adult neural stem cells.
Article
Plant Sciences
Aeyung Kim, Seo-Young Lee, Sun-Ku Chung
Summary: The study found that caffeic acid (CAA) selectively eliminates undifferentiated induced pluripotent stem cells (iPSCs) and suppresses teratoma formation, suggesting its potential in preparing safe iPSC-based therapeutic cells.
Article
Oncology
Ruhui Yang, Bingjin Liu, Mingyue Yang, Feng Xu, Songquan Wu, Shufang Zhao
Summary: Lumiflavin reduces drug resistance and enhances the chemotherapy effect in ovarian cancer stem cells by inducing phenotypic differentiation. Animal experiments also confirmed that lumiflavin enhances the effect of chemotherapy on tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Jacob Stauber, John M. Greally, Ulrich Steidl
Summary: This review discusses the role of clonal evolution in hematological malignancies and emphasizes the contribution of the hematopoietic stem cell population in disease progression and relapse. Recent advances and unanswered questions in this field are highlighted.
Article
Oncology
Jin Wen, Ying Chen, Chenxi Liao, Xiao Ma, Mengyuan Wang, Qian Li, Di Wang, Yingnan Li, Xiaolan Zhang, Lei Li, Hao Zhou, Jing Zou, Lingbo Liu, Danyue Peng
Summary: This study successfully designed an effective delivery system by modifying mesenchymal stem cells (MSCs) and MSC-derived exosomes, promoting the selective clearance of LSCs and impeding AML development. These findings provide new insights into the development of novel therapies with greater cellular targeting specificity.
