Article
Medical Laboratory Technology
Jianrong Shi, Lin He, Ran Tao, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Shiqiang Shang
Summary: This study found that TLR4 gene polymorphisms are associated with the susceptibility and severity of AD in Chinese Han children.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Volodymyr Dvornyk, Irina Ponomarenko, Tatyana Belyaeva, Evgeny Reshetnikov, Mikhail Churnosov
Summary: The study found significant associations between FLG gene polymorphisms and AD in females, but not in males, in the Caucasian population of Central Russia. Bioinformatic analysis predicted the involvement of SNPs of the FLG gene in gene expression control and alternative splicing related to AD pathophysiology.
Article
Pediatrics
Yong Zhou, Sheng Li
Summary: This systematic review investigated the potential relationship between vitamin D receptor (VDR) gene polymorphisms and childhood asthma. The study found that FokI and TaqI polymorphisms were significantly associated with childhood asthma susceptibility, while ApaI and BsmI polymorphisms were not.
FRONTIERS IN PEDIATRICS
(2022)
Article
Sport Sciences
Rikhard Maki-Heikkila, Jussi Karjalainen, Jari Parkkari, Heini Huhtala, Maarit Valtonen, Lauri Lehtimaki
Summary: This comparative study found that the prevalence of asthma is approximately 2.5 times higher in cross-country skiers compared to the control group, with a later onset of asthma. Most skiers with asthma have well-controlled symptoms and are on regular maintenance treatment.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ivan Sammir Aranda-Uribe, Juan Carlos Lopez-Vazquez, Rosa Elda Barbosa-Cobos, Julian Ramirez-Bello
Summary: The study investigated the association between TLR4 and TLR9 gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Mexican patients, and found that these variants are not risk factors for RA or SLE in this population.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Hematology
Julia Hoglund, Torgny Karlsson, Therese Johansson, Weronica E. Ek, Asa Johansson
Summary: The study confirmed a strong association between the ABO gene and cardiovascular diseases, identified associations with various diseases including diabetes, and provided new evidence on thrombotic disorders and von Willebrand factor levels. The results indicated an additive effect between genotypes and significant contributions to plasma proteins.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Immunology
Marc Y. Fink, Xiulan Qi, Kari Ann Shirey, Rachel Fanaroff, Svetlana Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. Keegan
Summary: Asthma is a chronic respiratory disease associated with airway inflammation and hyperreactivity. The TLR4 gene polymorphisms have been shown to be associated with a decreased risk for asthma, but the interaction with environmental factors is still unclear.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Javier Martinez-Sanz, Daniel Jimenez, Laura Martinez-Campelo, Raquel Cruz, Pilar Vizcarra, Matilde Sanchez-Conde, Raquel Ron, Mario Rodriguez, Sabina Herrera, Santiago Moreno, Maria Rosa Lopez-Huertas, Sergio Serrano-Villar
Summary: The study found two genetic variants that may increase the risk of individuals being susceptible to SARS-CoV-2, aiding in identifying vulnerable populations and suggesting treatment targets for COVID-19 patients.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Medicine, General & Internal
Fengzhen Wang, Xianming Wen, Ting Wen, Ziyou Liu
Summary: This study assessed the association between TLR4 gene polymorphisms (rs1927914, rs4986790, and rs4986791) and cancer susceptibility. The results showed that individuals with the A allele of rs1927914, the G allele of rs4986790, or the T allele of rs4986791 had a higher risk of cancer.
Article
Cell Biology
Isela Montufar-Robles, Maria Elena Soto, Silvia Jimenez-Morales, Ricardo Gamboa, Claudia Huesca-Gomez, Julian Ramirez-Bello
Summary: This study is the first to demonstrate an association between TNFAIP3 rs2230926T/G and rs5029924C/T with Takayasu arteritis, providing new insights into the genetic foundation of the disease. Other polymorphisms in STAT4, BANK1, BLK, and TNFSF4 were not found to be associated with Takayasu arteritis in this study.
CELLULAR IMMUNOLOGY
(2021)
Article
Psychology, Experimental
Elsa Ivett Ortega-Mora, Ulises Caballero-Sanchez, Talia V. Roman-Lopez, Cintia B. Rosas-Escobar, Juan Antonio Gonzalez-Barrios, Sandra Romero-Hidalgo, Monica Mendez-Diaz, Oscar E. Prospero-Garcia, Alejandra E. Ruiz-Contreras
Summary: The study evaluated the associations between three SNPs of the CNR1 gene and attention and working memory performance, showing individual associations with attention performance and a greater contribution of the composite genotype. The additive-dosage model revealed that adding G-alleles increased the percentage of correct responses, indicating an additive effect on attention performance. The number of risk alleles did not predict efficiency in attention systems or working memory performance.
Article
Biochemistry & Molecular Biology
Nicholette D. Palmer, Bratati Kahali, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F. Feitosa, Lawrence F. Bielak, Jeffrey R. O'Connell, Solomon K. Musani, Xiuqing Guo, Albert Smith, Kathleen A. Ryan, Gudny Eirksdottir, Matthew A. Allison, Donald W. Bowden, Matthew J. Budoff, J. Jeffrey Carr, Yii-Der Chen, Kent D. Taylor, Adolfo Correa, Breland F. Crudup, Brian Halligan, Jian Yang, Sharon L. R. Kardia, Lenore J. Launer, Yi-Ping Fu, Thomas H. Mosley, Jill M. Norris, James G. Terry, Christopher J. O'Donnell, Jerome Rotter, Lynne E. Wagenknecht, Vilmundur Gudnason, Michael A. Province, Patricia A. Peyser, Elizabeth K. Speliotes
Summary: The study identified an association between the APOE gene and the imaging-based identification of NAFLD, as well as its potential link to liver disease and cirrhosis. These findings demonstrate allelic heterogeneity at the APOE locus and indicate an inverse relationship between NAFLD and AD at the exome level.
HUMAN MOLECULAR GENETICS
(2021)
Article
Endocrinology & Metabolism
Frauke Beyer, Rui Zhang, Markus Scholz, Kerstin Wirkner, Markus Loeffler, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the association between obesity, genetic variants, and structural connectivity of the dopaminergic reward network. Higher BMI was found to be correlated with lower reward network structural connectivity, while genetic variants were not associated with reward network connectivity in this population-based cohort.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Allergy
N. G. Santos Jr, R. M. Lima, R. A. Athanazio, R. M. Carvalho Pinto, K. Rabe, A. Cukier, R. Stelmach
Summary: The study showed that over 12 years of follow-up, severe asthmatic patients experienced a significant decline in lung function, with no improvement in disease control. However, exacerbations decreased, daily oral corticosteroid use decreased, and there was a reduction in eosinophils and neutrophils in induced sputum, as well as lower serum IgE levels. Quality of life showed improvement for 62% of patients.