Review
Allergy
Romain Vallion, Saadia Kerdine-Romer
Summary: The skin is often exposed to chemical stress, which may result in delayed hypersensitivity reactions mediated by T-cells. Exposure to contact sensitizers disrupts the homeostasis of the skin, triggering an inflammatory immune response and leading to eczema and allergic contact dermatitis. The Nrf2/Keap1 pathway in the skin plays a crucial role in regulating the immune response to contact sensitizers.
CONTACT DERMATITIS
(2022)
Article
Biology
Tahel Ronel, Matthew Harries, Kate Wicks, Theres Oakes, Helen Singleton, Rebecca Dearman, Gavin Maxwell, Benny Chain
Summary: DPC induces allergic contact dermatitis and is used in the treatment of warts, melanoma, and alopecia areata. Response to DPC is mediated by a polyclonal population of T cells recognizing a small number of dominant antigens.
Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Hiroshi Kuwata, Yoshihito Nakatani, Chieko Yokoyama, Shuntaro Hara
Summary: The study investigated the roles of mPGES-1 and PGIS in cutaneous immune responses using a contact hypersensitivity (CHS) model. The results indicated that these PG terminal synthases play critical roles in acquired cutaneous immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Article
Health Care Sciences & Services
Ghadah F. Alotaibi, Hanan H. Alsalman, Rama A. Alhallaf, Rayan A. Ahmad, Hashem A. Alshareef, Jumanah Meshari Muammar, Fahad M. Alsaif, Felwah F. Alotaibi, Mohamed F. Balaha, Nehad J. Ahmed, El-Sayed Khafagy, Hadil F. Alotaibi, Rahaf Alshammari, Sarah Fatani
Summary: This study investigated the association between smoking and contact dermatitis in the Saudi population. The results suggest that the prevalence of allergic contact dermatitis may be lower in smokers compared to non-smokers, while the prevalence of irritant contact dermatitis may be higher. Further epidemiologic studies are needed to explore the role of smoking in the occurrence of contact dermatitis and its possible mechanisms.
Article
Dermatology
Erin M. Warshaw, Lindsey M. Voller, Howard Maibach, Kathryn A. Zug, Joel G. DeKoven, Amber R. Atwater, Margo J. Reeder, Denis Sasseville, James S. Taylor, Joseph F. Fowler, Melanie D. Pratt, Jonathan Silverberg, Anthony F. Fransway, Matthew J. Zirwas, Donald Belsito, James G. Marks, Vincent A. DeLeo
Summary: A retrospective analysis of North American Contact Dermatitis Group data from 1994-2016 revealed that patients with eyelid dermatitis were more likely to be female, white, and over 40 years old, with a higher prevalence of hay fever, atopic dermatitis, or both. Allergic contact dermatitis was a common primary diagnosis among these patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
D. Linn Holness, Pilar Gomez, Irena Kudla, Sandy Skotnicki, Joel G. DeKoven
Summary: Occupational contact dermatitis often leads to work disruption, but successful return-to-work outcomes can be achieved with good communication, availability of modified work, and worker adherence to the plan. Barriers to successful return-to-work include lack of modified work, unresponsive employers, and ongoing skin problems.
CONTACT DERMATITIS
(2021)
Article
Allergy
Linda Ljungberg Silic, Marine-Alexia Lefevre, Ola Bergendorff, Simon De Bernard, Julien Nourikyan, Laurent Buffat, Audrey Nosbaum, Magnus Bruze, Jean-Francois Nicolas, Cecilia Svedman, Marc Vocanson
Summary: This study provides further insight into the allergic or irritant nature of skin reactions induced by AL-101 patch test. It confirms that AL-101 is an allergen that can cause both contact allergy and contact irritation. Molecular profiling might help to strengthen clinical diagnosis in these cases.
CONTACT DERMATITIS
(2022)
Article
Allergy
Jojo B. Dietz, Torkil Menne, Harald W. Meyer, Sven Viskum, Mari-Ann Flyvholm, Ulrik Ahrensboll-Friis, Swen M. John, Jeanne D. Johansen
Summary: This study found a high prevalence of previously diagnosed AD among young workers with recognized OCD, and AD significantly impacts the severity and long-term consequences of OCD.
CONTACT DERMATITIS
(2023)
Article
Neurosciences
K. Curzytek, M. Maes, M. Kubera
Summary: Allergic contact dermatitis (ACD) is a skin inflammation mediated by T cells and caused by contact hypersensitivity (CHS) to antigens, with a strong comorbidity with major depression. Keratinocytes release immunomodulatory mediators that play a critical role in skin inflammation, and antidepressant drugs have been shown to suppress CHS response and modulate adhesion molecule expression.
NEUROTOXICITY RESEARCH
(2021)
Article
Biology
Dominik Nemeth, Gyorgyi Ponyai
Summary: The clinical characteristics of contact hypersensitivity in the elderly patient population were analyzed in this study. Contact dermatitis was the most common diagnosis, followed by psoriasis. The most common contact allergens identified were preservatives, balsam of Peru, and nickel. It is important to conduct patch testing to verify contact hypersensitivity in older individuals, even for conditions such as contact dermatitis, venous stasis dermatitis, rosacea, and atopic dermatitis.
Article
Immunology
Matin Dokht Ashoori, Kensuke Suzuki, Yosuke Tokumaru, Naoko Ikuta, Masaki Tajima, Tasuku Honjo, Akio Ohta
Summary: Blocking PD-1 can enhance skin inflammation by promoting infiltration of CD8(+) T cells and development of reactive T cells, which may lead to the emergence of dermatitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Review
Biochemistry & Molecular Biology
Yu Sawada
Summary: The skin, as the outermost layer of the human body, is constantly exposed to external stimuli, which can lead to skin irritation. Occupational skin diseases, especially in the healthcare sector, are the most common work-related illnesses. During the COVID-19 pandemic, healthcare professionals experienced a range of occupational skin diseases associated with their work. This review focuses on the characteristics of these skin disorders in COVID-19-engaged healthcare professionals and explores potential pathogenesis and preventive methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Hiromi Mizutani, Risa Tamagawa-Mineoka, Risa Yasuike, Yoichi Minami, Kazuhiro Yagita, Norito Katoh
Summary: The study found that constant exposure to light may exacerbate allergic and non-allergic skin inflammation, including increased ear swelling response and local leukocyte infiltration.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Physiology
Helen G. Hanstock, Andrew D. Govus, Thomas B. Stenqvist, Anna K. Melin, Oystein Sylta, Monica K. Torstveit
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2020)
Article
Immunology
Helen G. Hanstock, Jason P. Edwards, Neil P. Walsh
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Physiology
E. K. Ahokas, H. Kyrolainen, A. A. Mero, S. Walker, H. G. Hanstock, J. K. Ihalainen
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Engineering, Mechanical
Mats Ainegren, Helen Hanstock, Nikolai Stenfors
Summary: This study investigated the resistance to breathing in heat and moisture exchanging devices (HME) used during physical activity in the cold. The results showed significant differences in resistance between HMEs from different manufacturers and also demonstrated the influence of different ventilations and headwind conditions on resistance.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART P-JOURNAL OF SPORTS ENGINEERING AND TECHNOLOGY
(2022)
Article
Physiology
Alasdair S. Tutt, Hampus Persson, Erik P. Andersson, Mats Ainegren, Nikolai Stenfors, Helen G. Hanstock
Summary: The study found that using HME impairs maximal running performance and increases the physiological demands of submaximal exercise, with a greater impact on individuals with higher body mass.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Haris Pojski, Helen G. Hanstock, Tsz-Hin Tang, Lara Rodriguez-Zamora
Summary: Acute exposure to normobaric hypoxia detrimentally affected the balance performance in sub-elite but not elite basketball players.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Nikolai Stenfors, Hampus Persson, Alasdair Tutt, Ellen Tufvesson, Erik P. Andersson, Mats Ainegren, Helen G. Hanstock
Summary: This study examined whether a heat- and moisture-exchanging breathing device (HME) could attenuate airway responses to high-intensity exercise in sub-zero temperatures among healthy subjects. The results showed that the use of HME reduced the decrease in forced expiratory volume and alleviated airway and general symptoms intensity in response to exercise.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Linda M. Eklund, Asa Skondal, Ellen Tufvesson, Rita Sjostrom, Lars Soderstrom, Helen G. Hanstock, Thomas Sandstrom, Nikolai Stenfors
Summary: Heavy exercise during exposure to cold air at -15 degrees Celsius can induce airway constriction, epithelial stress, cytokine responses, and symptoms from the lower airways. These effects are more pronounced compared to rest in the same environment.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Editorial Material
Respiratory System
Helen G. Hanstock, Theodore S. Kapellos, Holly R. Keir, P. Padmini S. J. Khedoe, Merete B. Long, Elza Evren, Niki D. Ubags, Joana Cruz
Article
Respiratory System
Angelos Gavrielatos, Iluta Ratkevica, Nikolai Stenfors, Helen G. Hanstock
Summary: A 90-minute bout of moderate-intensity exercise at -15 degrees Celsius does not cause significant lung function decrements, airway epithelial damage, or respiratory symptoms compared to 30 minutes of running in the same environment, despite an increase in white blood cell redistribution. However, exercise at -15 degrees Celsius may cause airway injury and evoke respiratory symptoms, even at moderate intensity. Atopic status may lead to greater peripheral bronchodilation and a higher frequency of respiratory symptoms after long-duration exercise in the cold.
RESPIRATORY RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Magdalene C. Blakeson, Scott P. Jerome, Neil P. Walsh, Erika Schagatay, Helen G. Hanstock
Summary: This study found that recent illness, rest periods, and higher sleep requirements may be potential risk factors for upper respiratory symptoms onset during a multiday endurance challenge, while psychological factors were not associated with illness incidence.
WILDERNESS & ENVIRONMENTAL MEDICINE
(2022)
Article
Sport Sciences
Nikolai Stenfors, Helen Hanstock, Mats Ainegren, Anne Lindberg
Summary: This study investigated the usage and attitudes toward heat- and moisture-exchanging breathing devices (HME) among elite Swedish skiers, revealing that they commonly use HMEs and have positive attitudes towards increasing their usage in cold environments.
TRANSLATIONAL SPORTS MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Linda Eklund, Filip Schagatay, Ellen Tufvesson, Rita Sjostrom, Lars Soderstrom, Helen G. Hanstock, Thomas Sandstrom, Nikolai Stenfors
Summary: Short-duration moderate-intensity exercise in -10 degrees Celsius induces mild symptoms from the lower airways, with no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury. Compared to exercise in +10 degrees Celsius, exercise in -10 degrees Celsius elicits more intense symptoms from the upper airways.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2021)
Review
Sport Sciences
Helen G. Hanstock, Mats Ainegren, Nikolai Stenfors
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2020)
Article
Public, Environmental & Occupational Health
Rita Sjostrom, Lars Soderstrom, Carolina Klockmo, Alexander Patrician, Thomas Sandstrom, Glenn Bjorklund, Helen Hanstock, Nikolai Stenfors
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2019)