Article
Endocrinology & Metabolism
Shiwei Li, Yuhong Fu, Yue Liu, Xinxin Zhang, Haijun Li, Lei Tian, Lin Zhuo, Ming Liu, Jingqiu Cui
Summary: This study used Mendelian randomization analysis to investigate the causal relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). The results showed that NAFLD is associated with elevated SUA levels, but elevated SUA levels do not have a causal association with the risk of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
Summary: Serum ferritin and uric acid levels are closely associated with the risk of NAFLD. The AUC value of serum ferritin and uric acid in the NAFLD group was 0.771.
Article
Medicine, General & Internal
Haifeng Yu, Ling Zhao, Lijuan Liu, Yanfang Li, Jing Sun, Youde Liu
Summary: The study found a positive correlation between serum uric acid levels and nonalcoholic fatty liver disease in patients with type 2 diabetes. Elevated uric acid levels were significantly associated with an increased prevalence of NAFLD and were identified as an independent risk factor for the occurrence of NAFLD in T2DM patients.
Article
Endocrinology & Metabolism
Qian Zhang, Xiaoqian Ma, Jie Xing, Haiyun Shi, Runkuan Yang, Yue Jiao, Shuohua Chen, Shouling Wu, Shutian Zhang, Xiujing Sun
Summary: This study investigated the association between obesity, serum uric acid, and incident NAFLD, finding that serum uric acid and obesity mediate the development of NAFLD, which is clinically significant.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Seoung-Woo Lee, Young-Jin Lee, Su-Min Baek, Kyung-Ku Kang, Tae-Un Kim, Jae-Hyuk Yim, Hee-Yeon Kim, Se-Hyeon Han, Seong-Kyoon Choi, Sang-Joon Park, Tae-Hwan Kim, Jin-Kyu Park
Summary: Vitamin C treatment plays an important role in nonalcoholic fatty liver disease by suppressing disease progression through decreased diet ingestion and increased water intake.
Article
Medicine, General & Internal
Jun Myong Lee, Hye Won Kim, So Young Heo, Kyung Yi Do, Jun Deok Lee, Seul Ki Han, Soon Koo Baik, Moon Young Kim, Sei-Jin Chang
Summary: This study aimed to investigate the association between serum uric acid (SUA) levels and liver damage in the adult Korean population. The results showed that high SUA levels were associated with elevated liver enzymes and nonalcoholic fatty liver disease (NAFLD), particularly in women. Elevated SUA levels may predict the presence of NAFLD, even in women with normal liver enzyme levels. Hyperuricemia may also predict advanced liver fibrosis in both men and women with NAFLD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Sisi Yang, Ziliang Ye, Mengyi Liu, Yanjun Zhang, Qimeng Wu, Chun Zhou, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin
Summary: This study found that higher serum uric acid (SUA) levels were significantly associated with an increased risk of cardiovascular disease (CVD) mortality in patients with nonalcoholic fatty liver disease (NAFLD), but not in those without NAFLD.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuliang Cui, Jing Liu, Haiyan Shi, Wenmei Hu, Li Song, Qing Zhao
Summary: This study found that uric acid levels are independently associated with non-alcoholic fatty liver disease (NAFLD) in non-obese type 2 diabetic patients in a Chinese population. Uric acid levels were positively associated with risk factors for NAFLD and may serve as a useful predictor for stratifying NAFLD risk in these patients.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Environmental Sciences
Zhao Hui, Qiu Xia, Li Hua Zi, Cui Jia Jia, Sun Yong Ye
Summary: The objective of this case-control study was to examine the association between the serum uric acid to high density lipoprotein cholesterol ratio (UHR) and the risk of nonalcoholic fatty liver disease (NAFLD) in Chinese adults. The study found a positive association between UHR and the risk of NAFLD, and suggested that UHR could be used as an innovative and noninvasive marker to identify individuals at risk of NAFLD.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jun Zheng, Xuerui Li, Yuan Zhang, Yuyang Miao, Qiang Zhang
Summary: In this study, researchers examined the association between different metabolic phenotypes and NAFLD. They found that metabolically unhealthy phenotypes were associated with a higher prevalence of NAFLD, and this association was modified by serum uric acid levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Jie He, Junzhao Ye, Yanhong Sun, Shiting Feng, Youpeng Chen, Bihui Zhong
Summary: Serum uric acid plays an important role in the diagnosis of metabolic-associated fatty liver disease, with high uric acid levels associated with an increased risk of severe steatosis. In lean/normal-weight NAFLD patients, higher uric acid levels still contribute to a higher risk of severe steatosis.
Article
Pediatrics
Luting Peng, Su Wu, Nan Zhou, Shanliang Zhu, Qianqi Liu, Xiaonan Li
Summary: The study investigated possible risk factors of NAFLD in obese children, finding that NASH is closely associated with high BMI-SDS, gender, insulin resistance, and hyperuricemia, providing evidence for developing early prevention strategies.
Article
Endocrinology & Metabolism
Luc Heerkens, Anniek C. van Westing, Trudy Voortman, Isabella Kardys, Eric Boersma, Johanna M. Geleijnse
Summary: NAFLD and CKD are strongly associated in patients with post-myocardial infarction (MI), which is reflected by higher serum uric acid (SUA) concentrations. SUA is a strong predictor of 12-year mortality risk after MI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Sean Felix, Thomas Jeffers, Elena Younossi, Brian Lam, Fatema Nader, Henry A. Tran, Ingrid Schneider, Maria Stepanova
Summary: Cardiovascular disease is common in patients with nonalcoholic fatty liver disease (NAFLD), and high-sensitivity cardiac troponin I (hs-cTnI) is associated with increased risk of coronary artery disease (CAD) in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasow, Malgorzata Wojtkowska, Adrian Chabowski, Dariusz M. Lebensztejn
Summary: This study aimed to evaluate the serum FA concentration in children with obesity and NAFLD. The results showed that the total FA concentration was significantly higher in obese children and in obese children with NAFLD compared to controls. There was a significant positive correlation between total FA concentration and cholesterol, triacylglycerols, and insulin in children with NAFLD.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)