Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 61, Issue -, Pages 487-493Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.07.021
Keywords
Collagen hydrogels; Oxidized alginate; Macromolecular cross-linker; Degradation
Funding
- National Basic Research Program of China [2011CB606201]
- Natural Science Foundation of China [31100684]
- Applied Basic Research Program of Sichuan Province [2012JY0088]
- Ph.D. Programs Foundation of Ministry of Education of China [20090181120080]
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Collagen hydrogels are widely used in cartilage tissue engineering for their mimicked chondrogenic environment. Due to the rapid degradation nature and weak mechanical property, collagen hydrogels are often cross-linked in application. In this work, collagen hydrogels were soaked into oxidized alginate solution which used as macromolecular cross-linker to prepare the cross-linked hydrogels. Soaking method could retain the self-assemble property of collagen and also bring in a cross-linking network. The compressive modulus and degradation properties of collagen hydrogels were ameliorated after crosslinked, and chondrocytes encapsulated in the cross-linked hydrogels proliferated well and maintained the cell phenotype. This study implied that collagen hydrogels cross-linked by oxidized alginate may have a great potential for application in cartilage tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.
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