Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 59, Issue -, Pages 72-83Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2013.04.024
Keywords
Chitosan; Elevated plus maze; Maximum tolerated dose; Morris water maze; Optimization; Rivastigmine tartrate
Funding
- Haryana State Counseling society
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The study aims at formulation and optimization brain targeted nanoparticles (NP) of Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP were optimized using a two factor three level (3(2)) central composite design aiming to minimize particle size; maximize zeta potential and drug entrapment efficiency of NP. The optimized formulation (cRTNP) was evaluated using in vitro drug release study; in vivo behavioral, and biochemical and maximum tolerated dose (MTD) study. The optimized formulation evidenced a significant reversal of scopolamine-induced amnesia by Tween 80 (R) coated nanoparticles as compared to both pure RT as well as uncoated nanoparticles. The MTD of RT was increased by 10% by formulating them as cRTNP. Thus, formulation of RT as cRTNP improved the therapeutic and safety profile of RT. (C) 2013 Elsevier B.V. All rights reserved.
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