Article
Oceanography
S. Kraft, A. C. Winkler, D. Abecasis
Summary: This study found that common stingrays in a Portuguese marine protected area exhibit seasonal site fidelity and have higher activity levels during nocturnal and crepuscular periods. Most individuals also seasonally migrate between the marine protected area and a nearby estuary.
OCEAN & COASTAL MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Arnis Kuksis, Waldemar Pruzanski
Summary: This study explores the effects of epoxyeicosatrienoic (EET) and epoxyeicosatetraenoic (EEQ) acids on tumor growth and metastasis, as well as the inhibitory effects of eicosapentaenoic (EPA) and epoxydocosapentaenoic (EDP) acids. It also investigates the conversion of precursor fatty acids to epoxy acids by cytochrome P450 epoxygenases, and the formation of epoxy acids during lipid autoxidation.
Article
Fisheries
Desiree Grancagnolo, Carlo Cattano, Federico Quattrocchi, Marco Milazzo
Summary: Shallow and coastal aggregations of batoids are not well-documented in the Mediterranean Sea, despite the potential threats they face. This study reports the first observations of a potential summer reproductive aggregation of the common stingray in Scilla Bay, Italy. The presence of pregnant females, a mature male, and a female with fresh bite wounds suggests that this area could serve as an important site for parturition and mating, highlighting the significance for conservation efforts of this Vulnerable species.
MEDITERRANEAN MARINE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Arnis Kuksis, Waldemar Pruzanski
Summary: This study investigates the presence of mono-, di-, and trihydroxy PUFA-GPCs in plasma lipoproteins and their hydrolysis by different sPLA(2)s enzymes. It was found that lipoproteins contain varying amounts of polyhydroxy-PUFA-GPC, likely the product of lipid peroxidation and the action of enzymes. Interestingly, the trihydroxy-16:0/PUFA-GPC was largely absent in one type of HDL, while unidentified material was present in the same area. LC/ESI-MS analysis showed agreement between the masses of polyhydroxy PUFA-GPC and the calculated masses for related GPCs.
Article
Parasitology
Susan M. Dippenaar, Kruspkaya Narvaez, Filip Osaer, Tshepo Mangena
Summary: The biology, including accompanying ectoparasitic fauna, remains unstudied for several elasmobranchs off the Canary Islands in spite of concerns over their conservation. This study reports on copepod associations with smooth hammerhead sharks and common stingrays for the first time, as well as the discovery of new geographical records for symbiotic siphonostomatoids. The study also provides a re-examination of the morphology of Pseudocharopinus pillaii and a molecular analysis of its genetic relationship with other Pseudocharopinus species.
PARASITOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aladahalli S. Giresha, Deepadarshan Urs, J. G. Manjunatha, P. Sophiya, B. H. Supreetha, Shankar Jayarama, K. K. Dharmappa
Summary: Elemolic acid from Boswellia serrata was found to inhibit the activity of human group IIA secreted phospholipase A2 (GIIA), and reduce the inflammatory response caused by GIIA.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mona Alonazi, Aida Karray, Raida Jallouli, Abir Ben Bacha
Summary: This study reported the biochemical and enzymatic characteristics of PLA(2)-V from dromedary, as well as its antimicrobial and cytotoxic effects.
Article
Parasitology
Luis F. Rangel, Amira Elloumi, Yann Quilichini, Maria J. Santos, Sihem Bahri
Summary: A new species of Chloromyxum, C. dasyatidisn. sp., was discovered in the gallbladder of the Mediterranean elasmobranch fish Dasyatis pastinaca (Linnaeus) from Tunisia. The species has unique characteristics, including the shape and size of its myxospores, as well as seasonal variation in infection prevalence.
SYSTEMATIC PARASITOLOGY
(2023)
Article
Oncology
Yasuyuki Kinjo, Yusuke Matsuura, Takayuki Ohguri, Yoko Aoyama, Midori Murakami, Kaori Hoshino, Hiroshi Harada, Taeko Ueda, Tomoko Kurita, Seiji Kagami, Kiyoshi Yoshino
Summary: This study aimed to evaluate the validity of the recurrence risk classification using the GOG score for stage IB-IIA node-negative cervical cancer. The results showed that a GOG score <= 70 does not require adjuvant therapy, while a GOG score > 70 requires consideration of adjuvant therapy.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mona Alonazi, Aida Karray, Raida Jallouli, Abir Ben Bacha
Summary: This study reported the biochemical and enzymatic characteristics of PLA(2)-V from dromedary, as well as its antimicrobial and cytotoxic effects.
Article
Multidisciplinary Sciences
Rawan Al-Nemari, Abir Ben Bacha, Abdulrahman Al-Senaidy, Mikhlid H. Almutairi, Maha Arafah, Hadel Al-Saran, Nael Abutaha, Abdelhabib Semlali
Summary: The leaf extract of A. squamosa has shown strong anticancer activity in inhibiting cell proliferation and inducing apoptosis. In vivo experiments have demonstrated its significant therapeutic effect on breast cancer, suggesting its potential as a novel drug for future development.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Nahed N. E. El-Sayed, Norah M. Almaneai, Abir Ben Bacha, Mohamed K. El-Ashrey, Maha Al-Zaben, Zainab M. Almarhoon
Summary: Colorectal carcinogenesis is a complex process involving dysregulation of various enzymes. In this study, new quinazolinone derivatives were synthesized and evaluated for their inhibitory effects on enzymes and cytotoxicity against colorectal cancer cells. Promising cytotoxic effects and enzymatic inhibitory effects were observed in several compounds, which were further analyzed through molecular docking studies and physicochemical predictions. The results suggest the potential of these compounds as lead scaffolds for developing enzyme inhibitors and anti-colorectal agents.
Article
Chemistry, Multidisciplinary
Dharambeer S. Malhi, Harvinder S. Sohal, Kishanpal Singh, Zainab M. Almarhoon, Abir Ben Bacha, Maha I. Al-Zaben
Summary: 1,4-Dihydropyridines are important compounds with various applications in the pharmaceutical industry. This study synthesized novel dicarboxylic derivatives of 1,4-DHPs through electrocarboxylation reaction and demonstrated their excellent antimicrobial activity.
Article
Biochemistry & Molecular Biology
Rafik Saddik, Imad Hammoudan, Said Tighadouini, Othmane Roby, Smaail Radi, Maha Al-Zaben, Abir Ben Bacha, Vijay H. Masand, Zainab M. Almarhoon
Summary: In this study, a highly efficient and selective silica-based adsorbent was developed for the removal of Cu(II) ions from aqueous solutions. The adsorbent showed excellent selectivity and high adsorption capacity, outperforming other similar adsorbents currently published. The adsorption mechanism, thermodynamics, reusability, and the effects of various experimental conditions were investigated. Theoretical studies were also conducted to understand the adsorption mechanism and the nature of the bonds formed.
Article
Engineering, Chemical
Mona Alonazi, Humidah Alanazi, Mona G. Alharbi, Raida Jallouli, Aida Karray
Summary: Traditional wastewater treatments are expensive, so researchers have developed a cost-effective immobilized enzyme technology for wastewater treatment. By immobilizing a thermostable alkaline lipase, they were able to significantly reduce chemical oxygen demand (COD) and lipid content in the wastewater, demonstrating the potential value of immobilized lipase as an effective biocatalyst for wastewater hydrolysis.
Article
Biochemistry & Molecular Biology
Abir Ben Bacha, Mona Alonazi, Mona G. Alharbi, Habib Horchani, Imen Ben Abdelmalek
Summary: This study successfully produced biodiesel with high yield using waste cooking oil through enzymatic transesterification reaction, and employed immobilized lipases as environmentally friendly catalysts, which exhibited superior stability and activity compared to free lipases. The produced biodiesel complied with international specifications and possessed desirable properties.
Article
Chemistry, Physical
Mohamed Moutaouakil, Said Tighadouini, Zainab M. Almarhoon, Maha I. Al-Zabe, Abir Ben Bacha, Vijay H. Masand, Jamal Jamaleddine, Rafik Saddik
Summary: This study focuses on finding new catalysts for the oxidation reaction of catechol to o-quinone. Seven quinoline-based compounds were investigated, and it was found that complexes formed with Cu(OAc)(2) showed higher catalytic activity compared to Cu(NO3)(2) and CuCl2 complexes. The oxidation rate depends on the chemical structure of the ligands and the nature of the coordinated ions.
Article
Agronomy
Mostafa Nafaa, Samah Mohamed Rizk, Tahany Abdel-Ghafar Ahmed Aly, Mohamed Abdel-Salam Rashed, Diaa Abd El-Moneim, Abir Ben Bacha, Mona Alonazi, Mahmoud Magdy
Summary: In this study, fungal diversity in newly reclaimed land in Egypt was investigated. The results showed that these fungi can enhance nutrient availability in the soil and produce the plant growth hormone IAA. The findings suggest the potential of developing fungal biofertilizers for improving agriculture reclamation processes and practices.
Article
Biochemistry & Molecular Biology
Mona Alonazi, Abir Ben Bacha, Mona G. Alharbi, Arwa Ishaq A. Khayyat, Laila AL-Ayadhi, Afaf El-Ansary
Summary: Rodent models are useful for studying the potential connection between autism spectrum disorder (ASD) and gut microbiota, as autistic patients often experience gastrointestinal problems. In this study, 30 young male rats were divided into different groups and treated with bee pollen and probiotics to investigate the effects on gut health and oxidative stress markers. The results showed that the combination treatment significantly improved leaky gut biomarkers and reduced oxidative stress levels in rats exposed to propionic acid, which is associated with the pathogenesis of autism. These findings suggest that bee pollen and probiotics could be a beneficial therapeutic intervention for relieving the neurotoxic effects of propionic acid.
Article
Biochemistry & Molecular Biology
Mona Alonazi, Najeh Krayem, Mona G. Alharbi, Arwa Ishaq A. Khayyat, Humidah Alanazi, Habib Horchani, Abir Ben Bacha
Summary: This study identified and characterized a new type II secreted phospholipase A(2) with unique characteristics. The enzyme showed high activity and stability, and exhibited dose-dependent cytotoxic effects on various human cancer cell lines, while potentially having angiogenic activity as well.
Article
Food Science & Technology
Nouf Aldawood, Sarah Almustafa, Saleh Alwasel, Waleed Aldahmash, Abir Ben Bacha, Abdullah Alamri, Mohammad Alanazi, Abdel Halim Harrath
Summary: This study evaluated the transgenerational effects of Fumonisin B1 (FB1) exposure on the structure and function of kidneys in offspring. The results showed that FB1 exposure caused histopathological changes, decreased antioxidant markers, induced autophagy, and led to DNA hypomethylation. These findings highlight the nephrotoxicity and transgenerational effects of early-life FB1 exposure.
Article
Neurosciences
Mona Alonazi, Abir Ben Bacha, Anwar Al Suhaibani, Ahmad T. Almnaizel, Hisham S. Aloudah, Afaf El-Ansary
Summary: This study evaluated the protective and therapeutic potential of bee pollen and probiotics in brain intoxication caused by propionic acid in juvenile rats. The results demonstrated that the combination of bee pollen and probiotics was effective in alleviating the neurotoxic effects of propionic acid.
TRANSLATIONAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Dharambeer S. Malhi, Harvinder S. Sohal, Kishanpal Singh, Zainab M. Almarhoon, Abir Ben Bacha, Maha I. Al-Zaben
Summary: In this study, a series of novel dicarboxylic derivatives of 1,4-dihydropyridines were synthesized using electrochemical methods. These compounds exhibited excellent antimicrobial activity against various microbes, and the introduction of acid groups significantly enhanced their activity.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
