Article
Biochemistry & Molecular Biology
Kyeongsoon Park, Jae Won Ahn, Jin Hyuk Kim, Jin Won Kim
Summary: In this study, researchers fabricated a dextran sulfate-based nano-photosensitizer (DS-Ce6) to specifically target M2-like tumor-associated macrophages (TAMs) for enhanced photodynamic therapy (PDT). The nano-photosensitizer showed selective uptake by M2 macrophages and induced tumor cell apoptosis under laser irradiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Peter Bitsch, Eva S. Baum, Irati Beltran Hernandez, Sebastian Bitsch, Jakob Harwood, Sabrina Oliveira, Harald Kolmar
Summary: In this study, nanobody dextran polymer conjugates (dextraknobs) loaded with small molecules were developed for cancer diagnostics and therapy. It was found that using smaller sized dextrans improved the homogeneous penetration of the conjugates into tumor spheroids. Additionally, the dextraknobs showed potent cell killing effects in photodynamic therapy. The monovalent nanobody conjugates exhibited deeper and more homogeneous penetration compared to the bivalent conjugates. These findings encourage further development of dextraknobs.
Article
Biochemistry & Molecular Biology
Yuting Zhao, Peiyong Guo, Dan Li, Mengjie Liu, Junhao Zhang, Kai Yuan, Hua Zheng, Liang Liu
Summary: This study developed an innovative antibacterial hydrogel loaded with photosensitizer and antibiotics that can release antibiotics on demand in an inflammatory environment and has broad-spectrum antibacterial effects. Additionally, the hydrogel showed good biocompatibility and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Mi Zhang, Xiaoguang Liu, Yinghua Mao, Yuhang He, Juan Xu, Feng Zheng, Weilong Tan, Shu Rong, Yonghong Chen, Xuemei Jia, Hong Li
Summary: A sustained oxygen supply system based on cerium nanoparticles and hydrogel was developed for enhanced synergistic photodynamic therapy (PDT) and gas therapy. The system could alleviate tumor hypoxia and generate nitric oxide for synergistic gas therapy, improving the efficacy of PDT.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Yuanyuan Zhong, Li Zhang, Shian Sun, Zhenghao Zhou, Yunsu Ma, Hao Hong, Dongzhi Yang
Summary: The study developed a sequential drug delivery system using two different materials to load drugs, achieving the sequential release of Combretastatin A4 phosphate and Doxorubicin. Results showed the initial release of the anti-angiogenic drug followed by the release of the anti-cell proliferative drug in the tumor microenvironment, demonstrating a significant sequential drug release behavior.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinyan He, Jun Hong, Shengping Liu, Defeng Xu, Hang Hu
Summary: Hydroxyethyl starch-new indocyanine green (HES-IR-820) conjugates were developed for enhanced cancer photodynamic therapy, exhibiting excellent stability, limited drug release, reduced cytotoxicity, and enhanced antitumor effects.
CARBOHYDRATE RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Qianru Li, Qianqian Liu, Heli Li, Liyun Dong, Yajie Zhou, Jintao Zhu, Liu Yang, Juan Tao
Summary: Nanomedicine has shown great potential in cancer immunotherapy, but there are still limitations in nanoparticle-based immunotherapy. In this study, researchers discovered that encapsulating a photosensitizer in nanoparticles can achieve synergy between photodynamic therapy and immunotherapy. Through experiments, they demonstrated the significant effectiveness of this nanotherapeutic system in inducing antitumor immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ningning Song, Bo Li, Dandan Li, Yunwen Yan
Summary: In this study, a Zr-based metal-organic framework (MOF) modified with hyaluronic acid (HA) was developed for two-photon activated photodynamic therapy (PDT) in triple negative breast cancer (TNBC). The composite ZrTc@HA exhibited significant two-photon activity and excellent light-triggered reactive oxygen species generation ability. It can serve as a diagnostic probe for fluorescence imaging and a therapeutic agent for PDT, showing great potential for monotherapy and synergistic phototherapy in TNBC.
Article
Biotechnology & Applied Microbiology
Tong Ge, Wenshu Ge, Ludan Zhang, Guohui Yu, Yi Li, Lisha Sun, Fan Dong, Zhi Yao, Lei Shi, Yuguang Wang
Summary: This study aimed to combine STING agonist-mediated immunotherapy with photodynamic therapy to treat breast cancer. STING agonist (ADU-S100)-functionalized porphyrin-based nanoparticles (NP-AS) were prepared and their antitumor properties in terms of cell apoptosis/necrosis and immune activation in triple-negative breast cancer were evaluated.
Article
Engineering, Biomedical
Can Wu, Qishu Jiao, Chunlu Wang, Yaxin Zheng, Xiaohui Pan, Wenying Zhong, Keming Xu
Summary: This study designs and synthesizes a self-assembling peptide molecule (LND-K) that targets both integrin receptors and mitochondria of cancer cells, leading to enhanced ablation of mitochondrial function in melanoma cells. By co-assembling LND-K with an anionic photosensitizer TPPS4, a nanofibrillar hydrogel system is developed for slow release and prolonged retention of TPPS4, achieving synergistic killing of cancer cells in vitro and in vivo.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Cristina Stanciu, Marieta Nichifor, Gabriela Liliana Ailiesei
Summary: The study investigated the adsorption performance of two different alkyl chain length gels on bile salts, finding that the hydrogel with 25% pendant dodecyl groups exhibited the best adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
T. Sagir, M. Huysal, M. Senel, S. Isik, N. Burgucu, O. Tabakoglu, M. Zaim
Summary: Novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery in photodynamic therapy. The nanoparticles showed efficient photodynamic therapy effect on MCF-7 cells, causing apoptosis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin, Jinhao Gao
Summary: The photosensitizer-conjugated camptothecin-based prodrug effectively targets cancer cell mitochondria, triggers ROS-responsive release of CPT, and induces mitochondrial damage, achieving high therapeutic efficacy for solid tumors.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiuyan Wan, Tong Wu, Liqun Song, Wei Pan, Na Li, Bo Tang
Summary: A novel porphyrin-containing covalent organic framework (COF) was synthesized for decorating selenium nanoparticles (Se NPs) via in situ reduction. Selenium nanoparticle-mediated therapy (SeT) was combined with photodynamic therapy (PDT) to enhance anticancer effects and address the limitations of PDT.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
M. A. Ramazanov, F. Hajiyeva, Y. A. Babayev, G. V. Valadova, S. G. Nuriyeva, H. A. Shirinova
JOURNAL OF ELASTOMERS AND PLASTICS
(2020)
Article
Materials Science, Multidisciplinary
M. A. Ramazanov, F. Hajiyeva, H. A. Shirinova
Summary: This study prepared optically transparent polymeric nanocomposites based on PP/YSZ using a combination of ex-situ and hot pressing methods. The structure and properties of the synthesized nanocomposites were analyzed, showing that the concentration of YSZ nanoparticles and annealing temperature can affect the photoluminescent intensity of the nanocomposites.
JOURNAL OF ELASTOMERS AND PLASTICS
(2021)
Article
Polymer Science
M. A. Ramazanov, H. A. Shirinova, F. V. Hajiyeva, Dzmitry Bychanok
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Ibrahim Mamedov, Farid Naghiyev, Abel Maharramov, Owens Uwangue, Anne Farewell, Per Sunnerhagen, Mate Erdelyi
MENDELEEV COMMUNICATIONS
(2020)
Article
Physics, Applied
M. A. Ramazanov, A. M. Rahimli, F. Hajiyeva
MODERN PHYSICS LETTERS B
(2020)
Article
Chemistry, Multidisciplinary
A. I. Ismiyev, M. Shoaib, V. V. Dotsenko, K. G. Ganbarov, A. A. Israilova, A. M. Magerramov
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2020)
Article
Physics, Applied
M. A. Ramazanov, S. G. Nuriyeva, H. A. Shirinova, A. H. Karimova, M. A. Nuriyev
Summary: Ag2S/ZnS nanocomposites were synthesized using a novel method, and their structural features and optical properties were investigated using X-ray powder diffraction and scanning electron microscopy. The bandgap of the nanocomposites was found to be approximately 2.4 eV, with lower emission intensity compared to ZnS.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2021)
Article
Materials Science, Multidisciplinary
S. J. Mammadyarova, M. B. Muradov, A. M. Maharramov, G. M. Eyvazova, Z. A. Aghamaliyev, O. O. Balayeva, I. Hasanova
Summary: Ni/NiO nanochains were successfully synthesized through a chemical reduction method and characterized for their structure and properties. The study also investigated the effects of factors such as magnetic field intensity and oxidation temperature on the size and morphology of nanoparticles.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Namiq G. Shikhaliyev, Abel M. Maharramov, Khanim N. Bagirova, Gulnar T. Suleymanova, Biligma D. Tsyrenova, Valentine G. Nenajdenko, Alexander S. Novikov, Victor N. Khrustalev, Alexander G. Tskhovrebov
Summary: Aryl-3-(4-bromophenyl)-4,4-dichloro-1,2-diazabuta-1,3dienes were synthesized through copper-catalyzed reaction, revealing non-covalent Cl???Br interactions and 3D supramolecular framework. Both X-ray diffraction analysis and theoretical calculations confirmed the presence of highly polarizable dichlorodiazadiene unit as a strong halogen bond donor within the framework.
MENDELEEV COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
A. J. Ragimova, V. Mardanova, G. R. Mugalova, A. M. Magerramov, H. D. Nagiev, F. M. Chyragov
Summary: The study focused on the complexation of titanium(IV) with R in the presence of cationic surfactants, forming mixed-ligand complexes. Optimal pH values and ratios were identified, along with the effects of time, temperature, and concentrations on complex formation. The Beer law was observed in the concentration range studied, and the impact of foreign ions on the determination of titanium(IV) was investigated. A spectrophotometric determination method for trace amounts of titanium in sea sand was developed.
JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Chemical
Leyla Veliyeva, Arzu Sadiqova, Zubeyda Israfilova, Irada Rzaeva, Malahat Kurbanova, Vagif Farzaliyev, Abel Maharramov, Afsun Sujayev
Summary: Recently synthesized compounds show potential as inhibitors of oxidation reactions, assisting in antioxidation and decomposition of hydroperoxides. Some compounds demonstrate combined antioxidative action, breaking the chain of oxidative reactions.
APPLIED PETROCHEMICAL RESEARCH
(2021)
Article
Chemistry, Organic
Parham Taslimi, Fidan Akhundova, Malahat Kurbanova, Fikret Turkan, Burak Tuzun, Afsun Sujayev, Nastaran Sadeghian, Abel Maharramov, Vagif Farzaliyev, Ilhami Gulcin
Summary: Bicyclic structures were synthesized using (S)-BINOL as a chiral inductor via LACASA-DA cycloaddition reaction. The study identified different structural features that affect the inhibition of AChE and BChE enzymes, as well as the inhibitory activity of some bicyclic structures against the alpha-glucosidase enzyme.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
G. Sh. Duruskari, A. M. Maharramov
Summary: The biological activity of compounds based on 3-amino-5-phenylthiazolidin-2-iminium bromide was studied, and their structures were confirmed through H-1 and C-13 NMR spectroscopy and X-ray diffraction analysis.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Namiq G. Shikhaliyev, Abel M. Maharramov, Gulnar T. Suleymanova, Gulnara Babayeva, Gunay Z. Mammadova, Irada M. Shikhaliyeva, Aliyar A. Babazade, Valentine G. Nenajdenko
Summary: A series of 4,4-dichloro-1,2-diazabutadienes derived from 3-nitrobenzaldehyde were synthesized through copper-catalyzed reaction, with their structures confirmed by various spectroscopic techniques. The X-ray diffraction analysis revealed halogen binding in the crystal form for some compounds. Azo dyes derived from these compounds exhibited absorption in UV-Vis region, with absorption intensity and λ(max) dependent on solvent polarity and para-substituents on the aromatic moiety.
Article
Biochemistry & Molecular Biology
Valentine G. Nenajdenko, Namiq G. Shikhaliyev, Abel M. Maharramov, Khanim N. Bagirova, Gulnar T. Suleymanova, Alexander S. Novikov, Victor N. Khrustalev, Alexander G. Tskhovrebov
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
