Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 51, Issue 5, Pages 788-793Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.07.019
Keywords
Codonopsis pilosula; Polysaccharide; Antitumor; Metastasis; Ovarian cancer
Funding
- Health Department of Heilongjiang Province [2009-022]
- Scientific Research Foundation of The Third Affiliated Hospital of Harbin Medical University [JJ2009-09]
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In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells. (C) 2012 Elsevier B.V. All rights reserved.
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