Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 50, Issue 3, Pages 624-631Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.01.036
Keywords
Aminoethyl-chitooligosaccharides (AE-COS); Oxidative stress; Free radical scavenging; Antioxidant; RAW 264.7 cells
Funding
- Marine Bioprocess Research Center of the Marine Bio 21 Center
- Ministry of Land, Transport and Maritime, Republic of Korea
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The aim of this study is to investigate the inhibitory effects of aminoethyl-chitooligosaccharides (AE-COS) on oxidative stress in mouse macrophages (RAW 264.7 cells). The inhibitory effects of AE-COS on DNA and protein oxidation were studied in RAW 264.7 cells. Furthermore, free radical scavenging effect of AE-COS were determined in RAW264.7 cells by 2',7'-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level. AE-COS also inhibited myeloperoxidase (MPO) activity in human myeloid cells (HL-60). These results suggest that AE-COS acts as a potential free radical scavenger in RAW 264.7 cells. (C) 2012 Elsevier B.V. All rights reserved.
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