Article
Biochemistry & Molecular Biology
Jiang-Jiang Tang, Cong Guo, Xiao-Na Peng, Xiao-Chen Guo, Qiang Zhang, Jun-Mian Tian, Jin-Ming Gao
Summary: A fire broke out on the sixth floor of a building in London, with multiple people jumping out of windows on the south side for rescue.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Won -Young Bae, Do-Un Lee, Hyung-Seok Yu, Na-Kyoung Lee, Hyun-Dong Paik
Summary: This study aimed to increase the levels of epigallocatechin gallate (EGCG) and reduce the toxicity in Inulabritannica by fermenting it using Lactobacillus plantarum SY12. The optimal medium consisted of 10 g of I. britannica, 4 g of xylose, 5 g of soytone, and 5 g of beef extract. Fermented I. britannica extracts (FIE) showed increased cell viability and regulation of gene expression compared to the non-fermented extracts (IE). These effects were attributed to changes in the chemical composition of FIE. Fermentation was found to mitigate the toxicity in I. britannica.
Article
Biochemistry & Molecular Biology
Chi Rac Hong, Eun Ha Lee, Young Hoon Jung, Ju-Hoon Lee, Hyun-Dong Paik, Sung-Chul Hong, Seung Jun Choi
Summary: We investigated the potential of encapsulated Inula britannica extract as a functional food ingredient with enhanced bioavailability and stability. The liposomes exhibited improved anti-inflammatory effects and modulation of inflammatory signaling pathways. These findings suggest that liposomal encapsulation could serve as a valuable approach for utilizing the beneficial properties of Inula britannica extract for managing inflammation-related disorders.
Article
Biochemistry & Molecular Biology
Jang Hoon Kim, Yea-In Park, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung Cheol Koo, Her Yun-Chan, Ik Soo Lee, Junsoo Park
Summary: Four methoxy flavonoids were isolated from Inula britannica flower extract and showed inhibitory activity against SARS-CoV-2 3CLpro. Inhibitors 1-3 also suppressed HCoV-OC43 coronavirus proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Jelena Stanojkovic, Sladana Todorovic, Ilinka Pecinar, Steva Levic, Snezana Calic, Dusica Janosevic
Summary: Glandular trichomes are secretory organs with diverse characteristics, such as shape, size, location, and composition of secondary metabolites. Sucrose has an impact on the development, density, and chemical composition of leaf glandular trichomes of in vitro cultured Inula britannica, affecting growth and biomass accumulation. A lack of sugar does not affect growth, but a high sugar concentration inhibits biomass production in vitro. Differences in the chemical profiles of glandular trichomes grown in different sugar concentrations mainly come from phenolic compounds.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Ruo-Yu Qi, Cong Guo, Xiao-Na Peng, Jiang-Jiang Tang
Summary: This study investigated the potential effects of sesquiterpenoids from Inula britannica flowers' extract against triple-negative breast cancer (TNBC) cells. Eight structurally diverse sesquiterpenoids were isolated, including a sesquiterpenoid dimer and seven sesquiterpenoid monomers. Compound 5 displayed strong antiproliferative potency against TNBC cells with a high selective index. It is the first sesquiterpenoid targeting TNBC cells.
Article
Biochemistry & Molecular Biology
Jin Young Hong, Hyunseong Kim, Junseon Lee, Wan-Jin Jeon, Seung Ho Baek, In-Hyuk Ha
Summary: This study demonstrates that IBC exerts neuroprotective effects on cortical neurons by reducing oxidative stress and improving mitochondrial function, leading to increased cell survival rates. The mechanisms involve the upregulation of neurotrophic factors and the modulation of synaptic vesicle proteins, ultimately facilitating neuronal survival.
Article
Biochemistry & Molecular Biology
Sandra Jose, Sreevidya S. Devi, P. Shakthi, Khattab Al-Khafaji
Summary: In silico studies identified eupatin and chrysoeriol as potential drug candidates for inhibiting Shigella dysenteriae type 1, suggesting the need for further validation through in vivo and in vitro experiments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Endocrinology & Metabolism
Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo
Summary: The study revealed that hormones produced by ovaries play crucial roles in regulating hepatic glucose and lipid metabolism as well as communicating with the gut microbiota in females.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Li Wang, Song-Xia Lin, Yuan Wang, Tao Liang, Tao Jiang, Peng Liu, Xiao-Yi Li, Deng-Qin Lang, Qiang Liu, Chun-Yan Shen
Summary: p-Synephrine has significant antioxidant effects and can ameliorate diabetes mellitus by inhibiting oxidative stress.
Article
Chemistry, Applied
Damin Kim, Jean Duhamel
Summary: By analyzing fluorescently labeled glycogen samples and conducting molecular mechanics optimizations, it was discovered that the density at the center of glycogen particles is maximum, contrary to previous expectations.
CARBOHYDRATE POLYMERS
(2023)
Article
Biology
Matthieu Colpaert, Derifa Kadouche, Mathieu Ducatez, Trestan Pillonel, Carole Kebbi-Beghdadi, Ugo Cenci, Binquan Huang, Malika Chabi, Emmanuel Maes, Bernadette Coddeville, Loic Couderc, Helene Touzet, Fabrice Bray, Catherine Tirtiaux, Steven Ball, Gilbert Greub, Christophe Colleoni
Summary: The glycogen metabolism pathway is conserved in all Chlamydiales species and a new trehalose-dependent glycogen synthesis pathway has been identified, pointing to the importance of glycogen degradation for survival and virulence.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Kalina Danova, Antoaneta Trendafilova, Milka Todorova, Miroslav Rangelov, Daniela Antonova, Kamelia Gechovska, Viktorya Ivanova
Summary: A study on the effect of vitamins and plant growth regulators treatments on Inula britannica L. shoot cultures revealed their differential impact on biomass formation, physiological status, and secondary metabolite productivity. Bulgarian accessions of the plant showed potential for modification of growth and development in vitro to target desired phytopharmaceuticals.
PLANT CELL TISSUE AND ORGAN CULTURE
(2021)
Review
Biochemistry & Molecular Biology
Xia Deng, Chenxi Wang, Yue Xia, Guoyue Yuan
Summary: Protein phosphorylation and dephosphorylation play crucial roles in cell function regulation, especially in the regulation of liver glucose and lipid metabolism. PTG, a protein phosphatase, serves as an important regulator in glucose and lipid metabolism.
Article
Biotechnology & Applied Microbiology
W. -Y. Bae, H. -Y. Kim, H. -S. Yu, K. -H. Chang, Y. -H. Hong, N. -K. Lee, H. -D. Paik
Summary: This study demonstrated the synergistic effects of three herbs on Salmonella by increasing membrane permeability and inducing apoptosis. The results showed the potential of natural antimicrobial agents in inhibiting Salmonella growth through apoptosis, highlighting their significance in the poultry industry.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)