Article
Chemistry, Physical
Jie Yu, Xiangrong Li, Hongyi Liu, Yanru Peng, Xuezhen Wang, Yongtao Xu
Summary: This study investigates the binding mechanisms of five classic flavonoids to pepsin, revealing that they mainly bind through hydrophobic interactions, hydrogen bonding, and electrostatic forces. Baicalin shows the strongest binding affinity. These findings are crucial for understanding the digestion caused by flavonoids.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Deepika Singh, Lajpreet Kaur, Afreen J. Rahman, Priya Singh, Anjani Kumar Tiwari, Himanshu Ojha
Summary: This study investigated the binding affinities, enzymatic activity, and structural changes of various serotonin-related compounds with bovine serum albumin. The results showed the effective binding of these compounds with bovine serum albumin, revealing the role of serum albumin in the transport and metabolism of serotonin derivatives.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Fahad M. Almutairi, Mohammad Rehan Ajmal, Mohammad Khursheed Siddiqi, Nabeela Majid, Adel Ibrahim Ahmad Al-Alawy, Ali Saber Abdelhameed, Rizwan Hasan Khan
Summary: The interaction between levocabastine and human serum albumin was found to be weak, with a binding distance of approximately 2.28 nm. Upon binding, there was an increase in alpha-helical structure in the protein, while minimal changes were observed in the tertiary structure.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Spectroscopy
Farid Nasiri, Gholamreza Dehghan, Masoomeh Shaghaghi, Siavash Datmalchi, Mehrdad Iranshahi
Summary: The study revealed that geranyloxycoumarin (AUR) forms a ground state complex with bovine serum albumin (BSA) primarily through hydrogen bonds and van der Waals interactions. AUR binds to subdomain IIIB of BSA, and the secondary structure of BSA remains unchanged in the presence of AUR.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Mohd Aamir Qureshi, Mahmood Akbar, Mohd Amir, Saleem Javed
Summary: This study investigates the binding mode of esculin with bovine serum albumin using spectroscopic studies and molecular docking approaches. Various experiments reveal the formation of ground state complex between esculin and bovine serum albumin, as well as the quenching effect on the fluorescence emission spectra of BSA. It is found that esculin primarily binds to Sudlow's site I on BSA with hydrogen bonding and van der Waals interaction stabilizing the complex.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemical Research Methods
Oktay K. Gasymov, Sefa Celik, Gulshen Agaeva, Sevim Akyuz, Serda Kecel-Gunduz, Niftali M. Qocayev, Aysen E. Ozel, Ulker Agaeva, Matanat Bakhishova, Jamil A. Aliyev
Summary: The study investigated the structure and mechanism of the anti-cancer action of the pentapeptide EQRPR derived from rice bran protein, finding that it showed potential anti-cancer properties. Experimental data was found to align well with theoretical results, confirming the peptide's activity. Additionally, the introduction of D-isomers was shown to enhance activity.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2021)
Article
Chemistry, Physical
Peymaneh Shafaei, Ali Asghar Rastegari, Masoud Fouladgar, Asghar Taheri-Kafrani, Seyed Ali Asghar Moshtaghie
Summary: In this study, the molecular interaction between Elaidic acid (EA) and human serum albumin (HSA) was investigated using spectroscopic, molecular dynamics (MD), and molecular docking techniques. The results showed that EA could quench the fluorescence of HSA through a static quenching mechanism, and the binding interactions between them were spontaneous. Furthermore, the binding interactions altered the structure and flexibility of HSA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biophysics
Narges Ashrafi, Behzad Shareghi, Sadegh Farhadian, Mansoore Hosseini-Koupaei
Summary: This study investigated the effect of polyamine on the compound and function of lysozyme using UV-Visible and fluorescence spectroscopy as well as simulation method. The results showed that increasing polyamine concentration reduced the intrinsic quenching fluorescence of lysozyme and altered its secondary and tertiary structures. Polyamine also inhibited the enzymatic activity of lysozyme.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Shama Yasmeen, Faizan Abul Qais, Manish Rana, Asimul Islam, Rahisuddin
Summary: The interactions between thalidomide and DNA were investigated using various biophysical techniques. The results showed that thalidomide binds to the minor groove of DNA through electrostatic attraction. This study provides a better understanding of the binding affinity and mechanism between thalidomide and DNA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Rasoul Eslami-Farsani, Sadegh Farhadian, Behzad Shareghi, Sanaz Asgharzadeh
Summary: Myoglobin is an iron-rich protein that binds and transports oxygen in muscle tissue. This study investigated the effects of spermidine on the stability, structure, and function of horse heart myoglobin using various techniques.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Spectroscopy
Linna Fu, Guangbin Liu, Dongxin Zhao, Libo Yuan, Kui Lu
Summary: Peptide drugs have rapidly evolved for the treatment of diseases such as AIDS, myeloma, and breast cancer due to their high efficacy and low side effects. The interaction mechanisms between two peptide drugs and two biological macromolecules were investigated using various techniques, revealing key binding forces and changes in molecular structures. Additionally, studies on the interaction between drugs and DNA provided insights into groove binding and major interaction forces involved in the process.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Michael Kemper, Elric Engelage, Christian Merten
Summary: This study demonstrates the efficient transfer of point chirality in side chains of chiral triarylborane-ammonia adducts to the propeller chirality of triarylboranes. By using X-ray crystallography and spectroscopy, the conformational preferences of molecular propellers were elucidated. Interestingly, computationally predicted conformational preferences were found to be opposite to the experimentally observed ones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Razique Anwer, Khalid I. AlQumaizi, Shafiul Haque, Pallavi Somvanshi, Nazia Ahmad, Saleh M. AlOsaimi, Tasneem Fatma
Summary: Glipizide was found to have a high binding constant with human serum albumin (HSA) and exhibits static quenching mode with only one binding site. It interacts preferentially with sub-domain IIA of HSA and is thermodynamically favorable. This interaction results in a decrease in the alpha-helical content of HSA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biology
Manwi Shankar, Majji Sai Sudha Rani, Priyanka Gopi, P. Arsha, Prateek Pandya
Summary: This study investigates the interaction between the food dye BBY and the serum protein BSA. The results show that BBY binds to a specific site on BSA through hydrophobic interactions, affecting the structural stability of the protein. These findings enhance our understanding of the molecular-level interactions between BBY and BSA.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Agriculture, Multidisciplinary
Yaohui You, Liu Yang, Hong Chen, Linying Xiong, Fan Yang
Summary: In this study, soy protein isolate (SPI) was noncovalently modified by (-)-epigallocatechin-3-gallate (EGCG), leading to an improvement in its foaming, emulsifying, and antioxidant properties. The interaction between SPI and EGCG was found to involve hydrophobic force and hydrogen bonds, resulting in looser SPI structure and more active groups exposed. This modification process enhanced the functional properties of SPI significantly.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Correction
Multidisciplinary Sciences
Kritika Singh, Manish Shandilya, Suman Kundu, Arvind M. Kayastha
Article
Biochemical Research Methods
Sheetal Uppal, Amit Kumar, Manish Shandilya, Nitika Mukhi, Amit Kumar Singh, Suneel Kateriya, Jagreet Kaur, Suman Kundu
ANALYTICAL BIOCHEMISTRY
(2016)
Article
Biochemical Research Methods
Aditi Sahu, Poonam Gera, Venkatesh Pai, Abhishek Dubey, Gunjan Tyagi, Mandavi Waghmare, Sandeep Pagare, Manoj Mahimkar, C. Murali Krishna
JOURNAL OF BIOMEDICAL OPTICS
(2017)
Letter
Biochemistry & Molecular Biology
Ranjana Mehrotra, Gunjan Tyagi, Sonika Charak, Bhumika Ray, Geeta Kadayaprath, Harit Chaturvedi, Urmi Mukherjee, Andleeb Abrari
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2018)
Article
Biochemistry & Molecular Biology
Shweta Agarwal, Gunjan Tyagi, Deepti Chadha, Ranjana Mehrotra
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2017)
Article
Chemistry, Analytical
Arti Hole, Gunjan Tyagi, Aditi Sahu, Rubina Shaikh, C. Murali Krishna
VIBRATIONAL SPECTROSCOPY
(2018)
Article
Multidisciplinary Sciences
Kritika Singh, Manish Shandilya, Suman Kundu, Arvind M. Kayastha
Article
Biochemistry & Molecular Biology
Sonika Charak, Manish Shandilya, Ranjana Mehrotra
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Instruments & Instrumentation
Arti Hole, Gunjan Tyagi, Atul Deshmukh, Raviraj Deshpande, Vikram Gota, Pankaj Chaturvedi, C. Murali Krishna
Summary: Saliva, as a clinically informative bio-fluid with easy and multiple sample collection advantages, has recently been explored using optical techniques. Different sampling methods of saliva need to be standardized to prevent loss of analytes in processing. Studies comparing four different saliva sampling methodologies showed that pellet and supernatant exhibit discrete spectroscopic features useful for cancer diagnosis, while air-dried and lyophilized forms retain majority spectroscopic features of whole saliva and are less prone to sampling losses. This study indicates the potential utility of minimally invasive salivary Raman-based diagnostics in oral cancers.
APPLIED SPECTROSCOPY
(2021)
Article
Chemistry, Physical
Sepideh Khodaparast, William N. Sharratt, Gunjan Tyagi, Robert M. Dalgliesh, Eric S. J. Robles, Joao T. Cabral
Summary: This study investigates the micellar phase of pure and mixed aqueous solutions of SDS and DDAO, finding that the viscosity of mixed surfactant solutions increases exponentially with decreasing temperature and increasing DDAO content. A master curve for solution viscosity in terms of micellar aspect ratio is obtained, subsuming the effects of both temperature and DDAO composition in the experimental range investigated. The intrinsic viscosity of mixed micellar solutions is significantly higher than analytical and numerical predictions for Brownian suspensions of ellipsoidal colloids, emphasizing the importance of considering interactions of soft micelles under shear, especially at high concentrations.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Sepideh Khodaparast, Julius Marcos, William N. Sharratt, Gunjan Tyagi, Joao T. Cabral
Summary: This study investigates the impact of confinement on crystallization onset in subcooled micellar solutions of sodium dodecyl sulfate, finding that surface free energy and substrate roughness significantly affect surface-induced crystallization kinetics. Microscale surface roughness is shown to enhance crystal nucleation, particularly for substrates with the lowest surface energy and longest induction time. Tuning surface energy and microscopic roughness can effectively promote or delay nucleation in bulk-like volumes, impacting the stability of surfactant solutions at lower temperatures.
Article
Biochemistry & Molecular Biology
Manish Shandilya, Gaurav Kumar, Ridhima Gomkale, Swati Singh, Mohd Asim Khan, Suneel Kateriya, Suman Kundu
Summary: Hemoglobins may have alternative physiological functions aside from oxygen transport, such as nitric oxide dioxygenase. Algal hemoglobins are expected to have multiple putative methemoglobin reductases to augment their physiological functions. The identified putative methemoglobin reductases can reduce algal methemoglobins in a nonspecific manner under in vitro conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biotechnology & Applied Microbiology
Anushka Agarwal, Gyaneshwar K. Rao, Sudip Majumder, Manish Shandilya, Varun Rawat, Roli Purwar, Monu Verma, Chandra Mohan Srivastava
Summary: Electrospinning is a fiber fabrication technique that uses a strong electric field on polymer solutions or melts to produce fibers with small diameters, excellent pore connectivity, high porosity, and high surface-to-volume ratio. This review focuses on the theory, machine setup, and processing parameters of electrospinning, and discusses the innovative applications of natural protein-based electrospun nanofibers in healthcare. It also highlights technical innovations in electrospinning techniques and the potential commercialization of electrospun nanofibers for large-scale production, as well as the applications of these nanofibers in wound dressings.
Article
Polymer Science
William N. Sharratt, Carlos G. Lopez, Miriam Sarkis, Gunjan Tyagi, Roisin O'Connell, Sarah E. Rogers, Joao T. Cabral
Summary: This research investigates the gelation process of sodium carboxymethyl cellulose with Fe3+ cations in water, utilizing FTIR and SANS techniques to reveal the gelation mechanism and structural evolution, providing a foundation for designing HMP particles with specified morphologies.
Article
Biochemistry & Molecular Biology
Sujata Kumari, Pratibha Sharma, Debasree Ghosh, Manish Shandilya, Pooja Rawat, Md Imtaiyaz Hassan, Ranjita Ghosh Moulick, Jaydeep Bhattacharya, Chandramohan Srivastava, Sudip Majumder
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
